Homoserine dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

homoserine dehydrogenase-like protein

Species:

Leishmania major

UniProt:

Q4QIR8_LEIMA

TriTrypDb:

LmjF.07.0260 , LMJLV39_070008500 , LMJSD75_070008700

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QIR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIR8

Function

Biological processes
Term	Name	Level	Count
GO:0000096	sulfur amino acid metabolic process	4	5
GO:0000097	sulfur amino acid biosynthetic process	5	5
GO:0006082	organic acid metabolic process	3	6
GO:0006520	amino acid metabolic process	3	6
GO:0006549	isoleucine metabolic process	5	5
GO:0006555	methionine metabolic process	5	5
GO:0006566	threonine metabolic process	6	5
GO:0006790	sulfur compound metabolic process	3	5
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0008652	amino acid biosynthetic process	4	5
GO:0009058	biosynthetic process	2	5
GO:0009066	aspartate family amino acid metabolic process	5	5
GO:0009067	aspartate family amino acid biosynthetic process	6	5
GO:0009081	branched-chain amino acid metabolic process	4	5
GO:0009082	branched-chain amino acid biosynthetic process	5	5
GO:0009086	methionine biosynthetic process	6	5
GO:0009088	threonine biosynthetic process	7	5
GO:0009097	isoleucine biosynthetic process	6	5
GO:0009987	cellular process	1	6
GO:0016053	organic acid biosynthetic process	4	5
GO:0019752	carboxylic acid metabolic process	5	6
GO:0043436	oxoacid metabolic process	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044249	cellular biosynthetic process	3	5
GO:0044272	sulfur compound biosynthetic process	4	5
GO:0044281	small molecule metabolic process	2	6
GO:0044283	small molecule biosynthetic process	3	5
GO:0046394	carboxylic acid biosynthetic process	5	5
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:1901566	organonitrogen compound biosynthetic process	4	5
GO:1901576	organic substance biosynthetic process	3	5
GO:1901605	alpha-amino acid metabolic process	4	5
GO:1901607	alpha-amino acid biosynthetic process	5	5

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003824	catalytic activity	1	6
GO:0004412	homoserine dehydrogenase activity	5	6
GO:0005488	binding	1	5
GO:0016491	oxidoreductase activity	2	6
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	6
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	6
GO:0036094	small molecule binding	2	5
GO:0050661	NADP binding	4	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901265	nucleoside phosphate binding	3	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	166	168	PF00675	0.331
CLV_NRD_NRD_1	25	27	PF00675	0.452
CLV_NRD_NRD_1	364	366	PF00675	0.636
CLV_NRD_NRD_1	48	50	PF00675	0.328
CLV_PCSK_KEX2_1	25	27	PF00082	0.452
CLV_PCSK_KEX2_1	364	366	PF00082	0.636
CLV_PCSK_KEX2_1	50	52	PF00082	0.330
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.307
CLV_PCSK_PC7_1	46	52	PF00082	0.331
CLV_PCSK_SKI1_1	111	115	PF00082	0.367
CLV_PCSK_SKI1_1	306	310	PF00082	0.362
CLV_PCSK_SKI1_1	5	9	PF00082	0.353
CLV_PCSK_SKI1_1	64	68	PF00082	0.331
DEG_SPOP_SBC_1	273	277	PF00917	0.319
DOC_ANK_TNKS_1	52	59	PF00023	0.258
DOC_CKS1_1	292	297	PF01111	0.234
DOC_MAPK_MEF2A_6	221	230	PF00069	0.331
DOC_MAPK_MEF2A_6	75	82	PF00069	0.331
DOC_PP1_RVXF_1	109	115	PF00149	0.331
DOC_PP4_FxxP_1	363	366	PF00568	0.475
DOC_USP7_MATH_1	130	134	PF00917	0.586
DOC_USP7_MATH_1	188	192	PF00917	0.234
DOC_USP7_MATH_1	234	238	PF00917	0.379
DOC_USP7_MATH_1	273	277	PF00917	0.426
DOC_USP7_MATH_1	279	283	PF00917	0.345
DOC_WW_Pin1_4	126	131	PF00397	0.491
DOC_WW_Pin1_4	245	250	PF00397	0.379
DOC_WW_Pin1_4	291	296	PF00397	0.278
LIG_14-3-3_CanoR_1	116	122	PF00244	0.249
LIG_14-3-3_CanoR_1	236	240	PF00244	0.283
LIG_14-3-3_CanoR_1	300	306	PF00244	0.307
LIG_FHA_1	208	214	PF00498	0.331
LIG_FHA_1	236	242	PF00498	0.418
LIG_FHA_1	292	298	PF00498	0.363
LIG_FHA_1	300	306	PF00498	0.261
LIG_FHA_1	321	327	PF00498	0.362
LIG_FHA_1	328	334	PF00498	0.324
LIG_FHA_1	65	71	PF00498	0.331
LIG_FHA_2	118	124	PF00498	0.234
LIG_FHA_2	240	246	PF00498	0.361
LIG_FHA_2	83	89	PF00498	0.331
LIG_GBD_Chelix_1	40	48	PF00786	0.331
LIG_LIR_Apic_2	361	366	PF02991	0.460
LIG_LIR_Gen_1	189	196	PF02991	0.331
LIG_LIR_Gen_1	217	227	PF02991	0.331
LIG_LIR_Gen_1	89	100	PF02991	0.343
LIG_LIR_Nem_3	137	143	PF02991	0.400
LIG_LIR_Nem_3	189	195	PF02991	0.331
LIG_LIR_Nem_3	217	222	PF02991	0.331
LIG_LIR_Nem_3	327	332	PF02991	0.377
LIG_LIR_Nem_3	89	95	PF02991	0.343
LIG_Pex14_1	359	363	PF04695	0.397
LIG_SH2_CRK	19	23	PF00017	0.234
LIG_SH2_NCK_1	204	208	PF00017	0.379
LIG_SH2_SRC	204	207	PF00017	0.379
LIG_SH2_STAP1	356	360	PF00017	0.382
LIG_SH2_STAP1	59	63	PF00017	0.234
LIG_SH2_STAT5	140	143	PF00017	0.419
LIG_SH2_STAT5	179	182	PF00017	0.379
LIG_SH2_STAT5	332	335	PF00017	0.500
LIG_SH2_STAT5	346	349	PF00017	0.272
LIG_SH2_STAT5	94	97	PF00017	0.331
LIG_SH3_3	289	295	PF00018	0.242
LIG_SH3_3	309	315	PF00018	0.355
LIG_SUMO_SIM_anti_2	37	42	PF11976	0.428
LIG_SUMO_SIM_par_1	334	339	PF11976	0.379
LIG_TRAF2_1	120	123	PF00917	0.331
LIG_TRAF2_1	191	194	PF00917	0.355
LIG_TYR_ITIM	260	265	PF00017	0.379
LIG_TYR_ITSM	328	335	PF00017	0.379
MOD_CK1_1	105	111	PF00069	0.415
MOD_CK1_1	235	241	PF00069	0.331
MOD_CK1_1	324	330	PF00069	0.331
MOD_CK2_1	117	123	PF00069	0.234
MOD_CK2_1	188	194	PF00069	0.391
MOD_CK2_1	280	286	PF00069	0.337
MOD_CK2_1	82	88	PF00069	0.331
MOD_GlcNHglycan	212	216	PF01048	0.403
MOD_GlcNHglycan	266	269	PF01048	0.428
MOD_GlcNHglycan	282	285	PF01048	0.410
MOD_GlcNHglycan	323	326	PF01048	0.331
MOD_GlcNHglycan	338	341	PF01048	0.213
MOD_GlcNHglycan	349	352	PF01048	0.244
MOD_GSK3_1	124	131	PF00069	0.474
MOD_GSK3_1	207	214	PF00069	0.409
MOD_GSK3_1	235	242	PF00069	0.331
MOD_GSK3_1	320	327	PF00069	0.331
MOD_N-GLC_1	173	178	PF02516	0.379
MOD_N-GLC_2	159	161	PF02516	0.331
MOD_NEK2_1	124	129	PF00069	0.576
MOD_NEK2_1	143	148	PF00069	0.440
MOD_NEK2_1	280	285	PF00069	0.234
MOD_NEK2_1	301	306	PF00069	0.379
MOD_NEK2_1	319	324	PF00069	0.194
MOD_NEK2_1	345	350	PF00069	0.358
MOD_NEK2_1	82	87	PF00069	0.377
MOD_PIKK_1	196	202	PF00454	0.277
MOD_PKA_1	49	55	PF00069	0.319
MOD_PKA_2	235	241	PF00069	0.379
MOD_PKA_2	299	305	PF00069	0.307
MOD_Plk_1	143	149	PF00069	0.352
MOD_Plk_1	188	194	PF00069	0.307
MOD_Plk_1	82	88	PF00069	0.331
MOD_Plk_4	102	108	PF00069	0.439
MOD_Plk_4	324	330	PF00069	0.331
MOD_ProDKin_1	126	132	PF00069	0.488
MOD_ProDKin_1	245	251	PF00069	0.379
MOD_ProDKin_1	291	297	PF00069	0.278
MOD_SUMO_rev_2	57	66	PF00179	0.331
TRG_ENDOCYTIC_2	140	143	PF00928	0.365
TRG_ENDOCYTIC_2	19	22	PF00928	0.234
TRG_ENDOCYTIC_2	262	265	PF00928	0.470
TRG_ENDOCYTIC_2	332	335	PF00928	0.409
TRG_ER_diArg_1	363	365	PF00400	0.594
TRG_ER_diArg_1	48	51	PF00400	0.331
TRG_NLS_MonoExtC_3	48	53	PF00514	0.307
TRG_NLS_MonoExtN_4	46	53	PF00514	0.307
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.331
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.331

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPS1	Leishmania donovani	94%	100%
A4H4X1	Leishmania braziliensis	71%	100%
A4HT44	Leishmania infantum	94%	100%
E9AL36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P08499	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	30%	82%
P19582	Bacillus subtilis (strain 168)	34%	85%
P29365	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	31%	84%
P37143	Methylobacillus glycogenes	25%	84%
P37144	Methylobacillus glycogenes	29%	89%
P46806	Mycobacterium leprae (strain TN)	32%	83%
P52985	Lactococcus lactis subsp. cremoris	33%	86%
P52986	Synechocystis sp. (strain PCC 6803 / Kazusa)	34%	85%
P56429	Helicobacter pylori (strain ATCC 700392 / 26695)	30%	87%
P63630	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	32%	83%
P9WPX0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	32%	83%
P9WPX1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	32%	83%
Q9CGD8	Lactococcus lactis subsp. lactis (strain IL1403)	32%	86%
Q9ZL20	Helicobacter pylori (strain J99 / ATCC 700824)	30%	87%