Putative ubiquitin-protein ligase-like

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-protein ligase-like, putative

Species:

Leishmania major

UniProt:

Q4QIR6_LEIMA

TriTrypDb:

LmjF.07.0280 , LMJLV39_070008700 , LMJSD75_070008900

Length:

6260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4QIR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0000209	protein polyubiquitination	8	2
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010498	proteasomal protein catabolic process	5	2
GO:0016567	protein ubiquitination	7	2

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003824	catalytic activity	1	6
GO:0004842	ubiquitin-protein transferase activity	4	6
GO:0005488	binding	1	2
GO:0016740	transferase activity	2	6
GO:0016874	ligase activity	2	6
GO:0019787	ubiquitin-like protein transferase activity	3	6
GO:0061630	ubiquitin protein ligase activity	5	2
GO:0061659	ubiquitin-like protein ligase activity	4	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1392	1396	PF00656	0.723
CLV_C14_Caspase3-7	163	167	PF00656	0.640
CLV_C14_Caspase3-7	1647	1651	PF00656	0.648
CLV_C14_Caspase3-7	1744	1748	PF00656	0.694
CLV_C14_Caspase3-7	1792	1796	PF00656	0.701
CLV_C14_Caspase3-7	1856	1860	PF00656	0.506
CLV_C14_Caspase3-7	2106	2110	PF00656	0.681
CLV_C14_Caspase3-7	212	216	PF00656	0.649
CLV_C14_Caspase3-7	2543	2547	PF00656	0.632
CLV_C14_Caspase3-7	27	31	PF00656	0.586

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5X1	Leishmania donovani	92%	100%
A4H4X3	Leishmania braziliensis	76%	99%
A4HT46	Leishmania infantum	92%	100%
E9AL38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%

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