Leucine-rich repeat-containing protein 51

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIR4_LEIMA

TriTrypDb:

LmjF.07.0300 , LMJLV39_070008900 , LMJSD75_070009100

Length:

851

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	7
GO:0005737	cytoplasm	2	5
GO:0005929	cilium	4	5
GO:0042995	cell projection	2	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0120025	plasma membrane bounded cell projection	3	5

Expansion

Sequence features

Q4QIR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIR4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.648
CLV_C14_Caspase3-7	178	182	PF00656	0.538
CLV_C14_Caspase3-7	504	508	PF00656	0.662
CLV_NRD_NRD_1	10	12	PF00675	0.400
CLV_NRD_NRD_1	122	124	PF00675	0.575
CLV_NRD_NRD_1	145	147	PF00675	0.581
CLV_NRD_NRD_1	214	216	PF00675	0.597
CLV_NRD_NRD_1	353	355	PF00675	0.450
CLV_NRD_NRD_1	421	423	PF00675	0.439
CLV_NRD_NRD_1	476	478	PF00675	0.612
CLV_NRD_NRD_1	660	662	PF00675	0.363
CLV_PCSK_KEX2_1	10	12	PF00082	0.400
CLV_PCSK_KEX2_1	121	123	PF00082	0.582
CLV_PCSK_KEX2_1	214	216	PF00082	0.599
CLV_PCSK_KEX2_1	296	298	PF00082	0.664
CLV_PCSK_KEX2_1	421	423	PF00082	0.439
CLV_PCSK_KEX2_1	478	480	PF00082	0.676
CLV_PCSK_KEX2_1	660	662	PF00082	0.363
CLV_PCSK_KEX2_1	771	773	PF00082	0.511
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.582
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.664
CLV_PCSK_PC1ET2_1	478	480	PF00082	0.676
CLV_PCSK_PC1ET2_1	771	773	PF00082	0.486
CLV_PCSK_PC7_1	118	124	PF00082	0.652
CLV_PCSK_SKI1_1	11	15	PF00082	0.396
CLV_PCSK_SKI1_1	125	129	PF00082	0.585
CLV_PCSK_SKI1_1	355	359	PF00082	0.513
CLV_PCSK_SKI1_1	408	412	PF00082	0.444
CLV_PCSK_SKI1_1	421	425	PF00082	0.322
CLV_PCSK_SKI1_1	756	760	PF00082	0.703
CLV_PCSK_SKI1_1	771	775	PF00082	0.386
DEG_Nend_UBRbox_2	1	3	PF02207	0.453
DEG_ODPH_VHL_1	711	722	PF01847	0.365
DOC_CDC14_PxL_1	680	688	PF14671	0.414
DOC_CDC14_PxL_1	711	719	PF14671	0.368
DOC_CYCLIN_RxL_1	121	132	PF00134	0.576
DOC_MAPK_DCC_7	710	719	PF00069	0.423
DOC_MAPK_FxFP_2	39	42	PF00069	0.429
DOC_MAPK_gen_1	771	778	PF00069	0.433
DOC_MAPK_HePTP_8	707	719	PF00069	0.429
DOC_MAPK_MEF2A_6	343	351	PF00069	0.352
DOC_MAPK_MEF2A_6	710	719	PF00069	0.423
DOC_MAPK_MEF2A_6	771	778	PF00069	0.433
DOC_MAPK_NFAT4_5	771	779	PF00069	0.439
DOC_MAPK_RevD_3	342	355	PF00069	0.427
DOC_PP1_RVXF_1	393	399	PF00149	0.382
DOC_PP1_RVXF_1	786	793	PF00149	0.473
DOC_PP2B_LxvP_1	260	263	PF13499	0.669
DOC_PP2B_LxvP_1	364	367	PF13499	0.506
DOC_PP4_FxxP_1	39	42	PF00568	0.429
DOC_USP7_MATH_1	16	20	PF00917	0.303
DOC_USP7_MATH_1	40	44	PF00917	0.472
DOC_USP7_MATH_1	435	439	PF00917	0.591
DOC_USP7_MATH_1	485	489	PF00917	0.449
DOC_USP7_MATH_1	571	575	PF00917	0.606
DOC_USP7_MATH_1	690	694	PF00917	0.448
DOC_USP7_MATH_1	737	741	PF00917	0.625
DOC_USP7_MATH_1	80	84	PF00917	0.654
DOC_USP7_UBL2_3	579	583	PF12436	0.510
DOC_USP7_UBL2_3	838	842	PF12436	0.580
DOC_WW_Pin1_4	27	32	PF00397	0.402
DOC_WW_Pin1_4	436	441	PF00397	0.649
DOC_WW_Pin1_4	451	456	PF00397	0.567
DOC_WW_Pin1_4	530	535	PF00397	0.458
DOC_WW_Pin1_4	777	782	PF00397	0.441
LIG_14-3-3_CanoR_1	10	18	PF00244	0.370
LIG_14-3-3_CanoR_1	135	142	PF00244	0.622
LIG_14-3-3_CanoR_1	268	273	PF00244	0.669
LIG_14-3-3_CanoR_1	421	427	PF00244	0.460
LIG_14-3-3_CanoR_1	552	559	PF00244	0.599
LIG_14-3-3_CanoR_1	90	94	PF00244	0.536
LIG_14-3-3_CanoR_1	98	108	PF00244	0.529
LIG_BRCT_BRCA1_1	320	324	PF00533	0.413
LIG_DLG_GKlike_1	141	148	PF00625	0.591
LIG_eIF4E_1	322	328	PF01652	0.420
LIG_EVH1_1	447	451	PF00568	0.628
LIG_FHA_1	12	18	PF00498	0.378
LIG_FHA_1	398	404	PF00498	0.418
LIG_FHA_1	670	676	PF00498	0.394
LIG_FHA_1	812	818	PF00498	0.476
LIG_FHA_2	206	212	PF00498	0.720
LIG_FHA_2	310	316	PF00498	0.466
LIG_FHA_2	370	376	PF00498	0.512
LIG_FHA_2	423	429	PF00498	0.467
LIG_FHA_2	441	447	PF00498	0.513
LIG_FHA_2	502	508	PF00498	0.598
LIG_FHA_2	729	735	PF00498	0.648
LIG_FHA_2	794	800	PF00498	0.465
LIG_LIR_Apic_2	37	42	PF02991	0.414
LIG_LIR_Gen_1	2	8	PF02991	0.412
LIG_LIR_Gen_1	24	34	PF02991	0.388
LIG_LIR_Gen_1	375	384	PF02991	0.478
LIG_LIR_Gen_1	489	499	PF02991	0.503
LIG_LIR_Gen_1	510	521	PF02991	0.423
LIG_LIR_Gen_1	791	800	PF02991	0.468
LIG_LIR_Nem_3	143	148	PF02991	0.585
LIG_LIR_Nem_3	2	6	PF02991	0.416
LIG_LIR_Nem_3	24	29	PF02991	0.370
LIG_LIR_Nem_3	321	327	PF02991	0.461
LIG_LIR_Nem_3	375	380	PF02991	0.499
LIG_LIR_Nem_3	489	495	PF02991	0.507
LIG_LIR_Nem_3	496	501	PF02991	0.528
LIG_LIR_Nem_3	510	516	PF02991	0.412
LIG_LIR_Nem_3	517	521	PF02991	0.383
LIG_LIR_Nem_3	703	707	PF02991	0.409
LIG_LIR_Nem_3	767	773	PF02991	0.440
LIG_LIR_Nem_3	791	795	PF02991	0.489
LIG_MAD2	705	713	PF02301	0.407
LIG_NRBOX	772	778	PF00104	0.430
LIG_PCNA_PIPBox_1	32	41	PF02747	0.470
LIG_PCNA_yPIPBox_3	642	656	PF02747	0.403
LIG_SH2_CRK	26	30	PF00017	0.445
LIG_SH2_CRK	377	381	PF00017	0.567
LIG_SH2_NCK_1	3	7	PF00017	0.410
LIG_SH2_NCK_1	800	804	PF00017	0.461
LIG_SH2_SRC	307	310	PF00017	0.599
LIG_SH2_SRC	601	604	PF00017	0.672
LIG_SH2_STAP1	307	311	PF00017	0.582
LIG_SH2_STAP1	806	810	PF00017	0.380
LIG_SH2_STAT3	590	593	PF00017	0.578
LIG_SH2_STAT5	716	719	PF00017	0.457
LIG_SH3_1	195	201	PF00018	0.647
LIG_SH3_1	445	451	PF00018	0.644
LIG_SH3_3	195	201	PF00018	0.685
LIG_SH3_3	360	366	PF00018	0.550
LIG_SH3_3	434	440	PF00018	0.635
LIG_SH3_3	445	451	PF00018	0.695
LIG_SH3_3	562	568	PF00018	0.642
LIG_SH3_4	838	845	PF00018	0.555
LIG_SUMO_SIM_anti_2	685	690	PF11976	0.443
LIG_SUMO_SIM_par_1	32	37	PF11976	0.385
LIG_SUMO_SIM_par_1	345	350	PF11976	0.493
LIG_SUMO_SIM_par_1	422	428	PF11976	0.396
LIG_SUMO_SIM_par_1	666	672	PF11976	0.357
LIG_TRAF2_1	372	375	PF00917	0.591
LIG_TRAF2_1	744	747	PF00917	0.537
LIG_TYR_ITIM	714	719	PF00017	0.456
LIG_WRC_WIRS_1	142	147	PF05994	0.627
MOD_CDC14_SPxK_1	439	442	PF00782	0.535
MOD_CDC14_SPxK_1	780	783	PF00782	0.440
MOD_CDK_SPxK_1	436	442	PF00069	0.529
MOD_CDK_SPxK_1	777	783	PF00069	0.437
MOD_CDK_SPxxK_3	451	458	PF00069	0.629
MOD_CK1_1	116	122	PF00069	0.569
MOD_CK1_1	275	281	PF00069	0.606
MOD_CK1_1	45	51	PF00069	0.478
MOD_CK1_1	454	460	PF00069	0.602
MOD_CK1_1	464	470	PF00069	0.580
MOD_CK1_1	573	579	PF00069	0.595
MOD_CK1_1	740	746	PF00069	0.617
MOD_CK2_1	309	315	PF00069	0.487
MOD_CK2_1	369	375	PF00069	0.506
MOD_CK2_1	422	428	PF00069	0.396
MOD_CK2_1	440	446	PF00069	0.614
MOD_CK2_1	728	734	PF00069	0.632
MOD_Cter_Amidation	8	11	PF01082	0.381
MOD_GlcNHglycan	101	104	PF01048	0.486
MOD_GlcNHglycan	115	118	PF01048	0.515
MOD_GlcNHglycan	223	226	PF01048	0.674
MOD_GlcNHglycan	234	237	PF01048	0.627
MOD_GlcNHglycan	279	283	PF01048	0.679
MOD_GlcNHglycan	42	45	PF01048	0.644
MOD_GlcNHglycan	463	466	PF01048	0.622
MOD_GlcNHglycan	483	486	PF01048	0.566
MOD_GlcNHglycan	535	538	PF01048	0.526
MOD_GlcNHglycan	602	607	PF01048	0.647
MOD_GlcNHglycan	643	646	PF01048	0.406
MOD_GlcNHglycan	71	74	PF01048	0.548
MOD_GlcNHglycan	83	86	PF01048	0.443
MOD_GSK3_1	264	271	PF00069	0.698
MOD_GSK3_1	331	338	PF00069	0.616
MOD_GSK3_1	436	443	PF00069	0.717
MOD_GSK3_1	450	457	PF00069	0.626
MOD_GSK3_1	481	488	PF00069	0.479
MOD_GSK3_1	669	676	PF00069	0.360
MOD_GSK3_1	819	826	PF00069	0.488
MOD_GSK3_1	833	840	PF00069	0.595
MOD_LATS_1	420	426	PF00433	0.448
MOD_N-GLC_1	678	683	PF02516	0.447
MOD_N-GLC_1	738	743	PF02516	0.600
MOD_NEK2_1	151	156	PF00069	0.594
MOD_NEK2_1	318	323	PF00069	0.350
MOD_NEK2_1	34	39	PF00069	0.378
MOD_NEK2_1	415	420	PF00069	0.342
MOD_NEK2_1	516	521	PF00069	0.439
MOD_NEK2_1	673	678	PF00069	0.374
MOD_NEK2_1	823	828	PF00069	0.678
MOD_NEK2_2	666	671	PF00069	0.428
MOD_NEK2_2	690	695	PF00069	0.453
MOD_NEK2_2	718	723	PF00069	0.423
MOD_PIKK_1	116	122	PF00454	0.654
MOD_PIKK_1	134	140	PF00454	0.439
MOD_PIKK_1	16	22	PF00454	0.436
MOD_PIKK_1	375	381	PF00454	0.608
MOD_PIKK_1	551	557	PF00454	0.598
MOD_PIKK_1	591	597	PF00454	0.675
MOD_PIKK_1	614	620	PF00454	0.573
MOD_PIKK_1	673	679	PF00454	0.383
MOD_PIKK_1	825	831	PF00454	0.671
MOD_PKA_2	134	140	PF00069	0.619
MOD_PKA_2	267	273	PF00069	0.680
MOD_PKA_2	457	463	PF00069	0.697
MOD_PKA_2	551	557	PF00069	0.598
MOD_PKA_2	641	647	PF00069	0.388
MOD_PKA_2	89	95	PF00069	0.588
MOD_PKB_1	266	274	PF00069	0.656
MOD_Plk_1	516	522	PF00069	0.429
MOD_Plk_1	636	642	PF00069	0.390
MOD_Plk_1	678	684	PF00069	0.479
MOD_Plk_2-3	309	315	PF00069	0.487
MOD_Plk_4	268	274	PF00069	0.665
MOD_Plk_4	524	530	PF00069	0.523
MOD_Plk_4	684	690	PF00069	0.526
MOD_ProDKin_1	27	33	PF00069	0.397
MOD_ProDKin_1	436	442	PF00069	0.653
MOD_ProDKin_1	451	457	PF00069	0.569
MOD_ProDKin_1	530	536	PF00069	0.457
MOD_ProDKin_1	777	783	PF00069	0.437
MOD_SUMO_rev_2	309	319	PF00179	0.499
MOD_SUMO_rev_2	333	339	PF00179	0.523
MOD_SUMO_rev_2	401	410	PF00179	0.390
TRG_DiLeu_BaEn_1	315	320	PF01217	0.383
TRG_DiLeu_BaEn_1	525	530	PF01217	0.403
TRG_DiLeu_BaLyEn_6	769	774	PF01217	0.512
TRG_ENDOCYTIC_2	142	145	PF00928	0.554
TRG_ENDOCYTIC_2	25	28	PF00928	0.396
TRG_ENDOCYTIC_2	3	6	PF00928	0.418
TRG_ENDOCYTIC_2	322	325	PF00928	0.460
TRG_ENDOCYTIC_2	377	380	PF00928	0.497
TRG_ENDOCYTIC_2	492	495	PF00928	0.504
TRG_ENDOCYTIC_2	716	719	PF00928	0.457
TRG_ENDOCYTIC_2	806	809	PF00928	0.516
TRG_ER_diArg_1	10	12	PF00400	0.400
TRG_ER_diArg_1	122	125	PF00400	0.726
TRG_ER_diArg_1	266	269	PF00400	0.597
TRG_ER_diArg_1	421	423	PF00400	0.439
TRG_ER_diArg_1	659	661	PF00400	0.363
TRG_NLS_MonoExtC_3	120	125	PF00514	0.578
TRG_NLS_MonoExtN_4	118	125	PF00514	0.652
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.607
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	442	446	PF00026	0.657
TRG_Pf-PMV_PEXEL_1	623	628	PF00026	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I156	Leptomonas seymouri	46%	100%
A0A3S7WPS7	Leishmania donovani	93%	100%
A4H4X5	Leishmania braziliensis	68%	100%
A4HT48	Leishmania infantum	93%	100%
E9AL40	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	98%