Paraflagellar_rod_protein_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod protein, putative

Species:

Leishmania major

UniProt:

Q4QIR3_LEIMA

TriTrypDb:

LmjF.07.0310 , LMJLV39_070009000 , LMJSD75_070009200

Length:

809

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0031514	motile cilium	5	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11

Expansion

Sequence features

Q4QIR3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIR3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0005516	calmodulin binding	3	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	340	344	PF00656	0.585
CLV_C14_Caspase3-7	549	553	PF00656	0.420
CLV_C14_Caspase3-7	687	691	PF00656	0.743
CLV_NRD_NRD_1	210	212	PF00675	0.468
CLV_NRD_NRD_1	265	267	PF00675	0.641
CLV_NRD_NRD_1	386	388	PF00675	0.597
CLV_NRD_NRD_1	5	7	PF00675	0.586
CLV_NRD_NRD_1	640	642	PF00675	0.300
CLV_NRD_NRD_1	783	785	PF00675	0.524
CLV_PCSK_FUR_1	259	263	PF00082	0.533
CLV_PCSK_FUR_1	578	582	PF00082	0.414
CLV_PCSK_KEX2_1	210	212	PF00082	0.468
CLV_PCSK_KEX2_1	261	263	PF00082	0.564
CLV_PCSK_KEX2_1	335	337	PF00082	0.537
CLV_PCSK_KEX2_1	386	388	PF00082	0.542
CLV_PCSK_KEX2_1	5	7	PF00082	0.586
CLV_PCSK_KEX2_1	580	582	PF00082	0.417
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.535
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.573
CLV_PCSK_PC1ET2_1	580	582	PF00082	0.414
CLV_PCSK_SKI1_1	210	214	PF00082	0.486
CLV_PCSK_SKI1_1	28	32	PF00082	0.619
CLV_PCSK_SKI1_1	315	319	PF00082	0.540
CLV_PCSK_SKI1_1	371	375	PF00082	0.486
CLV_PCSK_SKI1_1	408	412	PF00082	0.454
CLV_PCSK_SKI1_1	419	423	PF00082	0.441
CLV_PCSK_SKI1_1	540	544	PF00082	0.346
CLV_PCSK_SKI1_1	650	654	PF00082	0.394
CLV_PCSK_SKI1_1	801	805	PF00082	0.553
DEG_APCC_DBOX_1	209	217	PF00400	0.450
DEG_APCC_DBOX_1	370	378	PF00400	0.403
DEG_APCC_DBOX_1	407	415	PF00400	0.356
DEG_APCC_DBOX_1	446	454	PF00400	0.420
DEG_APCC_DBOX_1	783	791	PF00400	0.566
DEG_ODPH_VHL_1	223	235	PF01847	0.577
DEG_SCF_FBW7_2	188	194	PF00400	0.586
DEG_SPOP_SBC_1	723	727	PF00917	0.720
DOC_CKS1_1	176	181	PF01111	0.605
DOC_CKS1_1	188	193	PF01111	0.588
DOC_CKS1_1	674	679	PF01111	0.743
DOC_CYCLIN_RxL_1	78	89	PF00134	0.678
DOC_CYCLIN_yCln2_LP_2	217	223	PF00134	0.621
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.669
DOC_MAPK_DCC_7	189	197	PF00069	0.578
DOC_MAPK_gen_1	369	377	PF00069	0.405
DOC_MAPK_gen_1	383	392	PF00069	0.566
DOC_MAPK_MEF2A_6	189	197	PF00069	0.578
DOC_MAPK_MEF2A_6	622	631	PF00069	0.427
DOC_PP1_RVXF_1	456	462	PF00149	0.324
DOC_PP2B_LxvP_1	222	225	PF13499	0.598
DOC_PP2B_LxvP_1	99	102	PF13499	0.670
DOC_PP2B_PxIxI_1	192	198	PF00149	0.511
DOC_PP4_FxxP_1	199	202	PF00568	0.421
DOC_USP7_MATH_1	148	152	PF00917	0.541
DOC_USP7_MATH_1	373	377	PF00917	0.511
DOC_USP7_MATH_1	410	414	PF00917	0.433
DOC_USP7_MATH_1	65	69	PF00917	0.731
DOC_USP7_MATH_1	684	688	PF00917	0.741
DOC_USP7_MATH_1	691	695	PF00917	0.758
DOC_USP7_MATH_1	696	700	PF00917	0.757
DOC_USP7_MATH_1	70	74	PF00917	0.738
DOC_USP7_MATH_1	753	757	PF00917	0.576
DOC_USP7_MATH_2	102	108	PF00917	0.664
DOC_USP7_UBL2_3	257	261	PF12436	0.533
DOC_WW_Pin1_4	175	180	PF00397	0.602
DOC_WW_Pin1_4	187	192	PF00397	0.496
DOC_WW_Pin1_4	216	221	PF00397	0.599
DOC_WW_Pin1_4	673	678	PF00397	0.747
DOC_WW_Pin1_4	694	699	PF00397	0.801
LIG_14-3-3_CanoR_1	170	177	PF00244	0.539
LIG_14-3-3_CanoR_1	426	433	PF00244	0.324
LIG_14-3-3_CanoR_1	581	588	PF00244	0.360
LIG_14-3-3_CanoR_1	593	597	PF00244	0.304
LIG_14-3-3_CanoR_1	601	608	PF00244	0.150
LIG_14-3-3_CanoR_1	655	662	PF00244	0.576
LIG_14-3-3_CanoR_1	88	94	PF00244	0.645
LIG_Actin_WH2_2	766	783	PF00022	0.585
LIG_APCC_ABBA_1	375	380	PF00400	0.474
LIG_BIR_III_2	690	694	PF00653	0.754
LIG_Clathr_ClatBox_1	803	807	PF01394	0.639
LIG_CtBP_PxDLS_1	733	737	PF00389	0.652
LIG_FHA_1	154	160	PF00498	0.584
LIG_FHA_1	249	255	PF00498	0.678
LIG_FHA_1	275	281	PF00498	0.760
LIG_FHA_1	420	426	PF00498	0.420
LIG_FHA_1	674	680	PF00498	0.682
LIG_FHA_1	706	712	PF00498	0.666
LIG_FHA_1	744	750	PF00498	0.514
LIG_FHA_2	176	182	PF00498	0.597
LIG_FHA_2	268	274	PF00498	0.714
LIG_FHA_2	581	587	PF00498	0.427
LIG_FHA_2	661	667	PF00498	0.687
LIG_FHA_2	698	704	PF00498	0.687
LIG_LIR_Apic_2	196	202	PF02991	0.406
LIG_LIR_Nem_3	528	533	PF02991	0.284
LIG_LIR_Nem_3	774	780	PF02991	0.578
LIG_NRBOX	139	145	PF00104	0.538
LIG_NRBOX	212	218	PF00104	0.474
LIG_PDZ_Class_3	804	809	PF00595	0.667
LIG_SH2_STAP1	406	410	PF00017	0.429
LIG_SH2_STAP1	567	571	PF00017	0.420
LIG_SH2_STAP1	8	12	PF00017	0.591
LIG_SH2_STAT3	758	761	PF00017	0.581
LIG_SH2_STAT5	165	168	PF00017	0.501
LIG_SH2_STAT5	221	224	PF00017	0.553
LIG_SH2_STAT5	563	566	PF00017	0.311
LIG_SH2_STAT5	63	66	PF00017	0.707
LIG_SH2_STAT5	630	633	PF00017	0.321
LIG_SH2_STAT5	758	761	PF00017	0.589
LIG_SH3_1	18	24	PF00018	0.714
LIG_SH3_3	18	24	PF00018	0.587
LIG_SH3_3	199	205	PF00018	0.609
LIG_SH3_3	247	253	PF00018	0.726
LIG_SH3_3	605	611	PF00018	0.229
LIG_SH3_3	737	743	PF00018	0.561
LIG_SH3_4	257	264	PF00018	0.724
LIG_SUMO_SIM_anti_2	194	199	PF11976	0.573
LIG_SUMO_SIM_anti_2	363	368	PF11976	0.377
LIG_SUMO_SIM_anti_2	388	396	PF11976	0.577
LIG_SUMO_SIM_par_1	373	382	PF11976	0.514
LIG_SUMO_SIM_par_1	388	396	PF11976	0.517
LIG_TRAF2_1	287	290	PF00917	0.759
LIG_TRAF2_1	547	550	PF00917	0.420
LIG_TRAF2_1	573	576	PF00917	0.302
LIG_TRAF2_1	664	667	PF00917	0.653
LIG_TRAF2_1	789	792	PF00917	0.635
LIG_TRFH_1	221	225	PF08558	0.614
LIG_TYR_ITIM	38	43	PF00017	0.704
MOD_CK1_1	274	280	PF00069	0.654
MOD_CK1_1	376	382	PF00069	0.521
MOD_CK1_1	396	402	PF00069	0.356
MOD_CK1_1	69	75	PF00069	0.714
MOD_CK1_1	694	700	PF00069	0.783
MOD_CK2_1	132	138	PF00069	0.438
MOD_CK2_1	175	181	PF00069	0.654
MOD_CK2_1	267	273	PF00069	0.669
MOD_CK2_1	484	490	PF00069	0.427
MOD_CK2_1	632	638	PF00069	0.470
MOD_CK2_1	660	666	PF00069	0.686
MOD_CK2_1	697	703	PF00069	0.738
MOD_CK2_1	780	786	PF00069	0.558
MOD_Cter_Amidation	259	262	PF01082	0.535
MOD_GlcNHglycan	14	17	PF01048	0.647
MOD_GlcNHglycan	150	153	PF01048	0.625
MOD_GlcNHglycan	244	247	PF01048	0.635
MOD_GlcNHglycan	506	509	PF01048	0.420
MOD_GlcNHglycan	56	59	PF01048	0.599
MOD_GlcNHglycan	68	71	PF01048	0.596
MOD_GlcNHglycan	708	711	PF01048	0.743
MOD_GlcNHglycan	72	75	PF01048	0.525
MOD_GSK3_1	142	149	PF00069	0.594
MOD_GSK3_1	248	255	PF00069	0.765
MOD_GSK3_1	267	274	PF00069	0.655
MOD_GSK3_1	50	57	PF00069	0.678
MOD_GSK3_1	65	72	PF00069	0.493
MOD_GSK3_1	697	704	PF00069	0.588
MOD_GSK3_1	722	729	PF00069	0.662
MOD_GSK3_1	732	739	PF00069	0.593
MOD_GSK3_1	753	760	PF00069	0.608
MOD_GSK3_1	8	15	PF00069	0.608
MOD_GSK3_1	83	90	PF00069	0.504
MOD_LATS_1	129	135	PF00433	0.621
MOD_N-GLC_1	274	279	PF02516	0.608
MOD_NEK2_1	153	158	PF00069	0.580
MOD_NEK2_1	33	38	PF00069	0.582
MOD_NEK2_1	54	59	PF00069	0.675
MOD_NEK2_1	591	596	PF00069	0.321
MOD_NEK2_1	736	741	PF00069	0.611
MOD_NEK2_1	780	785	PF00069	0.391
MOD_NEK2_2	205	210	PF00069	0.514
MOD_NEK2_2	373	378	PF00069	0.508
MOD_PIKK_1	425	431	PF00454	0.349
MOD_PIKK_1	580	586	PF00454	0.427
MOD_PIKK_1	654	660	PF00454	0.505
MOD_PIKK_1	757	763	PF00454	0.583
MOD_PIKK_1	87	93	PF00454	0.699
MOD_PKA_1	580	586	PF00069	0.427
MOD_PKA_2	169	175	PF00069	0.512
MOD_PKA_2	425	431	PF00069	0.324
MOD_PKA_2	580	586	PF00069	0.323
MOD_PKA_2	592	598	PF00069	0.333
MOD_PKA_2	600	606	PF00069	0.150
MOD_PKA_2	654	660	PF00069	0.638
MOD_PKA_2	780	786	PF00069	0.547
MOD_PKA_2	87	93	PF00069	0.739
MOD_Plk_1	267	273	PF00069	0.656
MOD_Plk_4	104	110	PF00069	0.708
MOD_Plk_4	161	167	PF00069	0.554
MOD_Plk_4	231	237	PF00069	0.558
MOD_Plk_4	50	56	PF00069	0.668
MOD_Plk_4	592	598	PF00069	0.420
MOD_ProDKin_1	175	181	PF00069	0.601
MOD_ProDKin_1	187	193	PF00069	0.500
MOD_ProDKin_1	216	222	PF00069	0.596
MOD_ProDKin_1	673	679	PF00069	0.747
MOD_ProDKin_1	694	700	PF00069	0.802
MOD_SUMO_rev_2	311	320	PF00179	0.566
MOD_SUMO_rev_2	635	643	PF00179	0.388
MOD_SUMO_rev_2	687	694	PF00179	0.810
MOD_SUMO_rev_2	769	778	PF00179	0.522
TRG_DiLeu_BaEn_1	139	144	PF01217	0.536
TRG_DiLeu_BaEn_1	463	468	PF01217	0.378
TRG_DiLeu_BaLyEn_6	428	433	PF01217	0.229
TRG_DiLeu_BaLyEn_6	586	591	PF01217	0.427
TRG_DiLeu_BaLyEn_6	745	750	PF01217	0.550
TRG_ENDOCYTIC_2	40	43	PF00928	0.712
TRG_ENDOCYTIC_2	567	570	PF00928	0.305
TRG_ER_diArg_1	209	211	PF00400	0.469
TRG_ER_diArg_1	368	371	PF00400	0.393
TRG_ER_diArg_1	385	387	PF00400	0.568
TRG_ER_diArg_1	478	481	PF00400	0.330
TRG_ER_diArg_1	5	7	PF00400	0.586
TRG_ER_diArg_1	587	590	PF00400	0.432
TRG_NLS_MonoCore_2	255	260	PF00514	0.658
TRG_NLS_MonoExtN_4	253	260	PF00514	0.652
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.631
TRG_Pf-PMV_PEXEL_1	352	357	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	458	462	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	622	626	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCV3	Leptomonas seymouri	53%	100%
A0A1X0NP77	Trypanosomatidae	30%	99%
A0A3R7K8M9	Trypanosoma rangeli	33%	100%
A0A3S7WPT1	Leishmania donovani	95%	100%
A4H4X6	Leishmania braziliensis	78%	99%
A4HT49	Leishmania infantum	95%	100%
C9ZUS6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AL41	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5ASS7	Trypanosoma cruzi	31%	100%