Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIR2_LEIMA

TriTrypDb:

LmjF.07.0320 , LMJLV39_070009100 , LMJSD75_070009300

Length:

1030

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QIR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIR2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.615
CLV_C14_Caspase3-7	681	685	PF00656	0.752
CLV_C14_Caspase3-7	708	712	PF00656	0.605
CLV_C14_Caspase3-7	756	760	PF00656	0.607
CLV_C14_Caspase3-7	838	842	PF00656	0.557
CLV_C14_Caspase3-7	957	961	PF00656	0.376
CLV_NRD_NRD_1	1001	1003	PF00675	0.431
CLV_NRD_NRD_1	2	4	PF00675	0.497
CLV_NRD_NRD_1	257	259	PF00675	0.458
CLV_NRD_NRD_1	593	595	PF00675	0.724
CLV_NRD_NRD_1	89	91	PF00675	0.544
CLV_NRD_NRD_1	905	907	PF00675	0.532
CLV_PCSK_KEX2_1	1001	1003	PF00082	0.431
CLV_PCSK_KEX2_1	2	4	PF00082	0.499
CLV_PCSK_KEX2_1	593	595	PF00082	0.663
CLV_PCSK_KEX2_1	89	91	PF00082	0.544
CLV_PCSK_SKI1_1	258	262	PF00082	0.409
CLV_PCSK_SKI1_1	423	427	PF00082	0.366
CLV_PCSK_SKI1_1	6	10	PF00082	0.571
CLV_PCSK_SKI1_1	991	995	PF00082	0.349
DEG_APCC_DBOX_1	257	265	PF00400	0.554
DEG_Nend_UBRbox_1	1	4	PF02207	0.538
DEG_SCF_FBW7_2	284	290	PF00400	0.510
DEG_SPOP_SBC_1	116	120	PF00917	0.521
DEG_SPOP_SBC_1	683	687	PF00917	0.601
DOC_CDC14_PxL_1	940	948	PF14671	0.343
DOC_CKS1_1	284	289	PF01111	0.526
DOC_CKS1_1	309	314	PF01111	0.461
DOC_CYCLIN_RxL_1	256	266	PF00134	0.333
DOC_CYCLIN_RxL_1	558	567	PF00134	0.635
DOC_MAPK_gen_1	2	11	PF00069	0.611
DOC_MAPK_gen_1	258	264	PF00069	0.394
DOC_MAPK_gen_1	418	427	PF00069	0.381
DOC_MAPK_gen_1	493	501	PF00069	0.582
DOC_MAPK_gen_1	559	568	PF00069	0.632
DOC_MAPK_gen_1	998	1008	PF00069	0.465
DOC_MAPK_MEF2A_6	998	1007	PF00069	0.404
DOC_PP1_RVXF_1	268	274	PF00149	0.395
DOC_PP1_RVXF_1	559	566	PF00149	0.629
DOC_PP1_RVXF_1	945	952	PF00149	0.370
DOC_PP2B_LxvP_1	157	160	PF13499	0.417
DOC_PP4_FxxP_1	309	312	PF00568	0.399
DOC_PP4_FxxP_1	664	667	PF00568	0.564
DOC_USP7_MATH_1	116	120	PF00917	0.679
DOC_USP7_MATH_1	485	489	PF00917	0.650
DOC_USP7_MATH_1	628	632	PF00917	0.729
DOC_USP7_MATH_1	683	687	PF00917	0.655
DOC_USP7_MATH_1	734	738	PF00917	0.717
DOC_USP7_MATH_1	750	754	PF00917	0.561
DOC_USP7_MATH_1	763	767	PF00917	0.562
DOC_USP7_MATH_1	78	82	PF00917	0.613
DOC_USP7_MATH_1	812	816	PF00917	0.635
DOC_USP7_MATH_1	84	88	PF00917	0.625
DOC_USP7_MATH_1	91	95	PF00917	0.715
DOC_USP7_UBL2_3	165	169	PF12436	0.440
DOC_WW_Pin1_4	1011	1016	PF00397	0.472
DOC_WW_Pin1_4	20	25	PF00397	0.407
DOC_WW_Pin1_4	264	269	PF00397	0.447
DOC_WW_Pin1_4	280	285	PF00397	0.448
DOC_WW_Pin1_4	308	313	PF00397	0.409
DOC_WW_Pin1_4	320	325	PF00397	0.418
DOC_WW_Pin1_4	361	366	PF00397	0.462
DOC_WW_Pin1_4	50	55	PF00397	0.635
DOC_WW_Pin1_4	525	530	PF00397	0.685
DOC_WW_Pin1_4	538	543	PF00397	0.488
DOC_WW_Pin1_4	580	585	PF00397	0.644
DOC_WW_Pin1_4	67	72	PF00397	0.469
DOC_WW_Pin1_4	821	826	PF00397	0.629
DOC_WW_Pin1_4	98	103	PF00397	0.756
LIG_14-3-3_CanoR_1	200	204	PF00244	0.450
LIG_14-3-3_CanoR_1	208	213	PF00244	0.349
LIG_14-3-3_CanoR_1	215	219	PF00244	0.329
LIG_14-3-3_CanoR_1	244	253	PF00244	0.443
LIG_14-3-3_CanoR_1	421	426	PF00244	0.364
LIG_14-3-3_CanoR_1	593	597	PF00244	0.718
LIG_14-3-3_CanoR_1	688	692	PF00244	0.700
LIG_14-3-3_CanoR_1	751	761	PF00244	0.605
LIG_14-3-3_CanoR_1	830	840	PF00244	0.563
LIG_14-3-3_CanoR_1	89	98	PF00244	0.532
LIG_14-3-3_CanoR_1	899	904	PF00244	0.470
LIG_14-3-3_CanoR_1	991	999	PF00244	0.458
LIG_Actin_WH2_2	186	202	PF00022	0.485
LIG_Actin_WH2_2	326	341	PF00022	0.486
LIG_Actin_WH2_2	932	949	PF00022	0.363
LIG_BIR_III_2	518	522	PF00653	0.623
LIG_BIR_III_4	819	823	PF00653	0.640
LIG_BRCT_BRCA1_1	410	414	PF00533	0.422
LIG_BRCT_BRCA1_1	52	56	PF00533	0.451
LIG_deltaCOP1_diTrp_1	4	11	PF00928	0.421
LIG_EH1_1	229	237	PF00400	0.332
LIG_eIF4E_1	256	262	PF01652	0.451
LIG_eIF4E_1	468	474	PF01652	0.416
LIG_FHA_1	102	108	PF00498	0.569
LIG_FHA_1	200	206	PF00498	0.502
LIG_FHA_1	283	289	PF00498	0.535
LIG_FHA_1	325	331	PF00498	0.470
LIG_FHA_1	335	341	PF00498	0.383
LIG_FHA_1	417	423	PF00498	0.517
LIG_FHA_1	628	634	PF00498	0.713
LIG_FHA_1	637	643	PF00498	0.653
LIG_FHA_1	647	653	PF00498	0.687
LIG_FHA_1	795	801	PF00498	0.701
LIG_FHA_1	806	812	PF00498	0.533
LIG_FHA_1	913	919	PF00498	0.399
LIG_FHA_1	992	998	PF00498	0.335
LIG_FHA_2	215	221	PF00498	0.453
LIG_FHA_2	246	252	PF00498	0.439
LIG_FHA_2	276	282	PF00498	0.500
LIG_FHA_2	46	52	PF00498	0.720
LIG_FHA_2	971	977	PF00498	0.516
LIG_GBD_Chelix_1	440	448	PF00786	0.432
LIG_LIR_Apic_2	152	158	PF02991	0.437
LIG_LIR_Apic_2	661	667	PF02991	0.570
LIG_LIR_Gen_1	27	38	PF02991	0.533
LIG_LIR_Gen_1	276	287	PF02991	0.506
LIG_LIR_Gen_1	386	397	PF02991	0.368
LIG_LIR_Gen_1	53	61	PF02991	0.471
LIG_LIR_Nem_3	152	157	PF02991	0.400
LIG_LIR_Nem_3	27	33	PF02991	0.438
LIG_LIR_Nem_3	276	282	PF02991	0.613
LIG_LIR_Nem_3	293	298	PF02991	0.316
LIG_LIR_Nem_3	386	392	PF02991	0.383
LIG_LIR_Nem_3	426	432	PF02991	0.393
LIG_LIR_Nem_3	53	59	PF02991	0.586
LIG_LYPXL_yS_3	380	383	PF13949	0.438
LIG_PCNA_yPIPBox_3	447	457	PF02747	0.442
LIG_Pex14_1	26	30	PF04695	0.388
LIG_Pex14_2	7	11	PF04695	0.395
LIG_Rb_LxCxE_1	364	376	PF01857	0.438
LIG_RPA_C_Fungi	488	500	PF08784	0.643
LIG_SH2_CRK	155	159	PF00017	0.388
LIG_SH2_CRK	265	269	PF00017	0.466
LIG_SH2_GRB2like	950	953	PF00017	0.348
LIG_SH2_NCK_1	265	269	PF00017	0.407
LIG_SH2_NCK_1	966	970	PF00017	0.374
LIG_SH2_SRC	109	112	PF00017	0.593
LIG_SH2_SRC	230	233	PF00017	0.319
LIG_SH2_SRC	300	303	PF00017	0.478
LIG_SH2_STAP1	61	65	PF00017	0.434
LIG_SH2_STAP1	857	861	PF00017	0.558
LIG_SH2_STAT3	468	471	PF00017	0.384
LIG_SH2_STAT3	479	482	PF00017	0.454
LIG_SH2_STAT5	155	158	PF00017	0.399
LIG_SH2_STAT5	216	219	PF00017	0.450
LIG_SH2_STAT5	241	244	PF00017	0.318
LIG_SH2_STAT5	256	259	PF00017	0.369
LIG_SH2_STAT5	265	268	PF00017	0.362
LIG_SH2_STAT5	300	303	PF00017	0.384
LIG_SH2_STAT5	454	457	PF00017	0.427
LIG_SH2_STAT5	468	471	PF00017	0.393
LIG_SH2_STAT5	479	482	PF00017	0.525
LIG_SH2_STAT5	61	64	PF00017	0.461
LIG_SH2_STAT5	903	906	PF00017	0.382
LIG_SH2_STAT5	927	930	PF00017	0.363
LIG_SH2_STAT5	950	953	PF00017	0.348
LIG_SH3_1	906	912	PF00018	0.365
LIG_SH3_2	312	317	PF14604	0.361
LIG_SH3_3	120	126	PF00018	0.544
LIG_SH3_3	257	263	PF00018	0.439
LIG_SH3_3	281	287	PF00018	0.506
LIG_SH3_3	309	315	PF00018	0.369
LIG_SH3_3	404	410	PF00018	0.461
LIG_SH3_3	517	523	PF00018	0.651
LIG_SH3_3	526	532	PF00018	0.563
LIG_SH3_3	578	584	PF00018	0.710
LIG_SH3_3	65	71	PF00018	0.601
LIG_SH3_3	906	912	PF00018	0.386
LIG_SUMO_SIM_par_1	775	780	PF11976	0.483
LIG_TRAF2_1	583	586	PF00917	0.598
LIG_TRAF2_1	730	733	PF00917	0.610
LIG_TRAF2_1	917	920	PF00917	0.475
LIG_TYR_ITIM	277	282	PF00017	0.539
MOD_CDC14_SPxK_1	267	270	PF00782	0.471
MOD_CDC14_SPxK_1	323	326	PF00782	0.601
MOD_CDK_SPxK_1	264	270	PF00069	0.467
MOD_CDK_SPxK_1	320	326	PF00069	0.570
MOD_CK1_1	101	107	PF00069	0.676
MOD_CK1_1	283	289	PF00069	0.486
MOD_CK1_1	531	537	PF00069	0.690
MOD_CK1_1	631	637	PF00069	0.624
MOD_CK1_1	641	647	PF00069	0.643
MOD_CK1_1	682	688	PF00069	0.569
MOD_CK1_1	741	747	PF00069	0.653
MOD_CK1_1	780	786	PF00069	0.697
MOD_CK1_1	94	100	PF00069	0.792
MOD_CK1_1	986	992	PF00069	0.371
MOD_CK2_1	116	122	PF00069	0.523
MOD_CK2_1	245	251	PF00069	0.357
MOD_CK2_1	338	344	PF00069	0.560
MOD_CK2_1	45	51	PF00069	0.563
MOD_CK2_1	580	586	PF00069	0.632
MOD_CK2_1	612	618	PF00069	0.528
MOD_CK2_1	727	733	PF00069	0.660
MOD_CK2_1	750	756	PF00069	0.519
MOD_CK2_1	914	920	PF00069	0.507
MOD_CK2_1	970	976	PF00069	0.390
MOD_GlcNHglycan	458	461	PF01048	0.482
MOD_GlcNHglycan	486	490	PF01048	0.636
MOD_GlcNHglycan	596	599	PF01048	0.703
MOD_GlcNHglycan	620	623	PF01048	0.610
MOD_GlcNHglycan	633	636	PF01048	0.618
MOD_GlcNHglycan	654	657	PF01048	0.701
MOD_GlcNHglycan	664	667	PF01048	0.730
MOD_GlcNHglycan	681	684	PF01048	0.515
MOD_GlcNHglycan	699	702	PF01048	0.717
MOD_GlcNHglycan	716	719	PF01048	0.648
MOD_GlcNHglycan	732	737	PF01048	0.490
MOD_GlcNHglycan	740	743	PF01048	0.608
MOD_GlcNHglycan	772	775	PF01048	0.643
MOD_GlcNHglycan	783	786	PF01048	0.537
MOD_GlcNHglycan	801	804	PF01048	0.570
MOD_GlcNHglycan	813	817	PF01048	0.595
MOD_GlcNHglycan	922	926	PF01048	0.430
MOD_GlcNHglycan	98	101	PF01048	0.689
MOD_GSK3_1	282	289	PF00069	0.620
MOD_GSK3_1	320	327	PF00069	0.523
MOD_GSK3_1	334	341	PF00069	0.456
MOD_GSK3_1	383	390	PF00069	0.382
MOD_GSK3_1	421	428	PF00069	0.355
MOD_GSK3_1	45	52	PF00069	0.625
MOD_GSK3_1	485	492	PF00069	0.605
MOD_GSK3_1	530	537	PF00069	0.699
MOD_GSK3_1	538	545	PF00069	0.748
MOD_GSK3_1	618	625	PF00069	0.623
MOD_GSK3_1	627	634	PF00069	0.614
MOD_GSK3_1	648	655	PF00069	0.753
MOD_GSK3_1	678	685	PF00069	0.597
MOD_GSK3_1	697	704	PF00069	0.678
MOD_GSK3_1	734	741	PF00069	0.676
MOD_GSK3_1	777	784	PF00069	0.624
MOD_GSK3_1	801	808	PF00069	0.612
MOD_GSK3_1	831	838	PF00069	0.645
MOD_GSK3_1	90	97	PF00069	0.779
MOD_N-GLC_1	692	697	PF02516	0.590
MOD_N-GLC_1	952	957	PF02516	0.406
MOD_N-GLC_1	970	975	PF02516	0.305
MOD_NEK2_1	1008	1013	PF00069	0.349
MOD_NEK2_1	199	204	PF00069	0.450
MOD_NEK2_1	214	219	PF00069	0.421
MOD_NEK2_1	224	229	PF00069	0.403
MOD_NEK2_1	33	38	PF00069	0.505
MOD_NEK2_1	338	343	PF00069	0.452
MOD_NEK2_1	414	419	PF00069	0.465
MOD_NEK2_1	439	444	PF00069	0.333
MOD_NEK2_1	448	453	PF00069	0.335
MOD_NEK2_1	638	643	PF00069	0.666
MOD_NEK2_1	697	702	PF00069	0.561
MOD_NEK2_1	745	750	PF00069	0.687
MOD_NEK2_1	777	782	PF00069	0.584
MOD_NEK2_1	831	836	PF00069	0.597
MOD_NEK2_2	763	768	PF00069	0.488
MOD_NEK2_2	84	89	PF00069	0.622
MOD_PIKK_1	45	51	PF00454	0.645
MOD_PIKK_1	78	84	PF00454	0.522
MOD_PIKK_1	794	800	PF00454	0.717
MOD_PKA_1	89	95	PF00069	0.541
MOD_PKA_2	199	205	PF00069	0.509
MOD_PKA_2	214	220	PF00069	0.399
MOD_PKA_2	245	251	PF00069	0.433
MOD_PKA_2	489	495	PF00069	0.642
MOD_PKA_2	592	598	PF00069	0.682
MOD_PKA_2	687	693	PF00069	0.672
MOD_PKA_2	697	703	PF00069	0.716
MOD_PKA_2	750	756	PF00069	0.596
MOD_PKA_2	770	776	PF00069	0.571
MOD_PKA_2	89	95	PF00069	0.701
MOD_PKB_1	421	429	PF00069	0.363
MOD_PKB_1	43	51	PF00069	0.538
MOD_Plk_1	275	281	PF00069	0.579
MOD_Plk_1	33	39	PF00069	0.476
MOD_Plk_1	373	379	PF00069	0.482
MOD_Plk_1	692	698	PF00069	0.672
MOD_Plk_1	912	918	PF00069	0.490
MOD_Plk_1	952	958	PF00069	0.328
MOD_Plk_1	970	976	PF00069	0.462
MOD_Plk_4	1013	1019	PF00069	0.403
MOD_Plk_4	231	237	PF00069	0.336
MOD_Plk_4	440	446	PF00069	0.359
MOD_Plk_4	542	548	PF00069	0.658
MOD_Plk_4	628	634	PF00069	0.668
MOD_Plk_4	763	769	PF00069	0.544
MOD_Plk_4	772	778	PF00069	0.552
MOD_Plk_4	835	841	PF00069	0.549
MOD_Plk_4	876	882	PF00069	0.652
MOD_Plk_4	899	905	PF00069	0.405
MOD_ProDKin_1	1011	1017	PF00069	0.471
MOD_ProDKin_1	20	26	PF00069	0.401
MOD_ProDKin_1	264	270	PF00069	0.452
MOD_ProDKin_1	280	286	PF00069	0.450
MOD_ProDKin_1	308	314	PF00069	0.410
MOD_ProDKin_1	320	326	PF00069	0.426
MOD_ProDKin_1	361	367	PF00069	0.463
MOD_ProDKin_1	50	56	PF00069	0.627
MOD_ProDKin_1	525	531	PF00069	0.685
MOD_ProDKin_1	538	544	PF00069	0.485
MOD_ProDKin_1	580	586	PF00069	0.644
MOD_ProDKin_1	67	73	PF00069	0.474
MOD_ProDKin_1	821	827	PF00069	0.628
MOD_ProDKin_1	98	104	PF00069	0.757
MOD_SUMO_rev_2	385	395	PF00179	0.456
MOD_SUMO_rev_2	399	407	PF00179	0.442
MOD_SUMO_rev_2	511	516	PF00179	0.571
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.473
TRG_ENDOCYTIC_2	279	282	PF00928	0.510
TRG_ENDOCYTIC_2	28	31	PF00928	0.491
TRG_ENDOCYTIC_2	380	383	PF00928	0.438
TRG_ENDOCYTIC_2	389	392	PF00928	0.363
TRG_ENDOCYTIC_2	429	432	PF00928	0.413
TRG_ENDOCYTIC_2	857	860	PF00928	0.616
TRG_ER_diArg_1	1	3	PF00400	0.555
TRG_ER_diArg_1	1001	1003	PF00400	0.431
TRG_ER_diArg_1	243	246	PF00400	0.408
TRG_ER_diArg_1	494	497	PF00400	0.635
TRG_ER_diArg_1	768	771	PF00400	0.699
TRG_ER_diArg_1	88	90	PF00400	0.553
TRG_ER_diArg_1	944	947	PF00400	0.450
TRG_Pf-PMV_PEXEL_1	317	321	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	854	858	PF00026	0.656
TRG_Pf-PMV_PEXEL_1	906	911	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7D4	Leptomonas seymouri	56%	89%
A0A3R7MCX5	Trypanosoma rangeli	41%	100%
A0A3S5H5X2	Leishmania donovani	93%	99%
A4H4X7	Leishmania braziliensis	73%	98%
A4HT50	Leishmania infantum	93%	99%
E9AL42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5D8R0	Trypanosoma cruzi	40%	100%