Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF3735)/Abscisic acid G-protein coupled receptor, putative

Species:

Leishmania major

UniProt:

Q4QIR1_LEIMA

TriTrypDb:

LmjF.07.0330 , LMJLV39_070009200 , LMJSD75_070009400

Length:

835

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QIR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIR1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	144	146	PF00675	0.498
CLV_NRD_NRD_1	155	157	PF00675	0.389
CLV_NRD_NRD_1	246	248	PF00675	0.654
CLV_NRD_NRD_1	333	335	PF00675	0.740
CLV_NRD_NRD_1	400	402	PF00675	0.275
CLV_NRD_NRD_1	671	673	PF00675	0.475
CLV_PCSK_KEX2_1	144	146	PF00082	0.525
CLV_PCSK_KEX2_1	155	157	PF00082	0.404
CLV_PCSK_KEX2_1	246	248	PF00082	0.654
CLV_PCSK_KEX2_1	333	335	PF00082	0.741
CLV_PCSK_KEX2_1	670	672	PF00082	0.475
CLV_PCSK_PC7_1	140	146	PF00082	0.445
CLV_PCSK_SKI1_1	108	112	PF00082	0.460
CLV_PCSK_SKI1_1	207	211	PF00082	0.331
CLV_PCSK_SKI1_1	362	366	PF00082	0.529
CLV_PCSK_SKI1_1	614	618	PF00082	0.329
CLV_PCSK_SKI1_1	709	713	PF00082	0.312
DEG_APCC_DBOX_1	206	214	PF00400	0.529
DEG_APCC_DBOX_1	708	716	PF00400	0.312
DEG_APCC_DBOX_1	814	822	PF00400	0.571
DOC_ANK_TNKS_1	289	296	PF00023	0.470
DOC_ANK_TNKS_1	670	677	PF00023	0.329
DOC_CYCLIN_RxL_1	589	597	PF00134	0.602
DOC_MAPK_gen_1	205	213	PF00069	0.474
DOC_MAPK_HePTP_8	105	117	PF00069	0.260
DOC_MAPK_MEF2A_6	108	117	PF00069	0.260
DOC_MAPK_MEF2A_6	205	213	PF00069	0.495
DOC_MAPK_MEF2A_6	362	370	PF00069	0.275
DOC_MAPK_MEF2A_6	621	630	PF00069	0.475
DOC_MAPK_MEF2A_6	729	737	PF00069	0.475
DOC_PP1_RVXF_1	203	209	PF00149	0.643
DOC_PP2B_LxvP_1	259	262	PF13499	0.473
DOC_PP2B_LxvP_1	455	458	PF13499	0.622
DOC_PP4_FxxP_1	386	389	PF00568	0.312
DOC_USP7_MATH_1	278	282	PF00917	0.530
DOC_USP7_MATH_1	344	348	PF00917	0.551
DOC_USP7_MATH_1	358	362	PF00917	0.208
DOC_USP7_MATH_1	500	504	PF00917	0.682
DOC_USP7_MATH_1	58	62	PF00917	0.386
DOC_USP7_MATH_1	66	70	PF00917	0.399
DOC_WW_Pin1_4	379	384	PF00397	0.317
DOC_WW_Pin1_4	436	441	PF00397	0.660
DOC_WW_Pin1_4	443	448	PF00397	0.655
DOC_WW_Pin1_4	453	458	PF00397	0.665
DOC_WW_Pin1_4	526	531	PF00397	0.825
DOC_WW_Pin1_4	559	564	PF00397	0.692
DOC_WW_Pin1_4	760	765	PF00397	0.317
LIG_14-3-3_CanoR_1	104	112	PF00244	0.387
LIG_14-3-3_CanoR_1	144	151	PF00244	0.689
LIG_14-3-3_CanoR_1	156	165	PF00244	0.577
LIG_14-3-3_CanoR_1	180	189	PF00244	0.672
LIG_14-3-3_CanoR_1	238	245	PF00244	0.470
LIG_14-3-3_CanoR_1	280	284	PF00244	0.460
LIG_14-3-3_CanoR_1	290	297	PF00244	0.408
LIG_14-3-3_CanoR_1	362	367	PF00244	0.364
LIG_14-3-3_CanoR_1	451	456	PF00244	0.722
LIG_14-3-3_CanoR_1	580	585	PF00244	0.572
LIG_14-3-3_CanoR_1	592	597	PF00244	0.521
LIG_14-3-3_CanoR_1	614	619	PF00244	0.555
LIG_14-3-3_CanoR_1	753	757	PF00244	0.329
LIG_14-3-3_CanoR_1	793	801	PF00244	0.295
LIG_Actin_WH2_2	595	612	PF00022	0.535
LIG_Actin_WH2_2	739	755	PF00022	0.388
LIG_BIR_II_1	1	5	PF00653	0.473
LIG_BIR_III_4	321	325	PF00653	0.517
LIG_BRCT_BRCA1_1	173	177	PF00533	0.720
LIG_BRCT_BRCA1_1	185	189	PF00533	0.615
LIG_BRCT_BRCA1_1	438	442	PF00533	0.658
LIG_deltaCOP1_diTrp_1	435	442	PF00928	0.604
LIG_deltaCOP1_diTrp_1	796	799	PF00928	0.312
LIG_EH1_1	602	610	PF00400	0.559
LIG_EH1_1	743	751	PF00400	0.312
LIG_eIF4E_1	15	21	PF01652	0.316
LIG_eIF4E_1	744	750	PF01652	0.312
LIG_FHA_1	109	115	PF00498	0.246
LIG_FHA_1	118	124	PF00498	0.312
LIG_FHA_1	129	135	PF00498	0.183
LIG_FHA_1	254	260	PF00498	0.446
LIG_FHA_1	358	364	PF00498	0.287
LIG_FHA_1	40	46	PF00498	0.312
LIG_FHA_1	562	568	PF00498	0.782
LIG_FHA_1	655	661	PF00498	0.275
LIG_FHA_1	664	670	PF00498	0.275
LIG_FHA_1	687	693	PF00498	0.295
LIG_FHA_1	730	736	PF00498	0.460
LIG_FHA_1	773	779	PF00498	0.243
LIG_FHA_1	93	99	PF00498	0.479
LIG_FHA_2	659	665	PF00498	0.260
LIG_FHA_2	681	687	PF00498	0.329
LIG_GBD_Chelix_1	244	252	PF00786	0.568
LIG_IBAR_NPY_1	475	477	PF08397	0.686
LIG_LIR_Apic_2	435	440	PF02991	0.591
LIG_LIR_Gen_1	109	118	PF02991	0.309
LIG_LIR_Gen_1	2	12	PF02991	0.285
LIG_LIR_Gen_1	375	385	PF02991	0.388
LIG_LIR_Gen_1	48	58	PF02991	0.312
LIG_LIR_Gen_1	591	600	PF02991	0.567
LIG_LIR_Gen_1	631	640	PF02991	0.267
LIG_LIR_Gen_1	795	801	PF02991	0.315
LIG_LIR_Gen_1	90	99	PF02991	0.400
LIG_LIR_Nem_3	109	115	PF02991	0.355
LIG_LIR_Nem_3	2	7	PF02991	0.384
LIG_LIR_Nem_3	375	380	PF02991	0.388
LIG_LIR_Nem_3	48	53	PF02991	0.312
LIG_LIR_Nem_3	591	596	PF02991	0.568
LIG_LIR_Nem_3	597	602	PF02991	0.517
LIG_LIR_Nem_3	631	636	PF02991	0.267
LIG_LIR_Nem_3	785	791	PF02991	0.324
LIG_LIR_Nem_3	795	800	PF02991	0.265
LIG_LIR_Nem_3	9	13	PF02991	0.296
LIG_NRBOX	112	118	PF00104	0.315
LIG_NRBOX	209	215	PF00104	0.388
LIG_Pex14_2	39	43	PF04695	0.312
LIG_PTB_Apo_2	540	547	PF02174	0.603
LIG_PTB_Phospho_1	540	546	PF10480	0.601
LIG_SH2_CRK	249	253	PF00017	0.476
LIG_SH2_CRK	377	381	PF00017	0.312
LIG_SH2_CRK	430	434	PF00017	0.554
LIG_SH2_CRK	471	475	PF00017	0.698
LIG_SH2_CRK	477	481	PF00017	0.717
LIG_SH2_CRK	623	627	PF00017	0.312
LIG_SH2_CRK	633	637	PF00017	0.312
LIG_SH2_CRK	791	795	PF00017	0.275
LIG_SH2_NCK_1	377	381	PF00017	0.312
LIG_SH2_NCK_1	471	475	PF00017	0.621
LIG_SH2_SRC	471	474	PF00017	0.620
LIG_SH2_STAP1	10	14	PF00017	0.312
LIG_SH2_STAT3	493	496	PF00017	0.640
LIG_SH2_STAT3	789	792	PF00017	0.275
LIG_SH2_STAT5	15	18	PF00017	0.340
LIG_SH2_STAT5	249	252	PF00017	0.494
LIG_SH2_STAT5	390	393	PF00017	0.475
LIG_SH2_STAT5	413	416	PF00017	0.540
LIG_SH2_STAT5	599	602	PF00017	0.536
LIG_SH2_STAT5	744	747	PF00017	0.312
LIG_SH2_STAT5	823	826	PF00017	0.628
LIG_SH3_1	557	563	PF00018	0.684
LIG_SH3_2	329	334	PF14604	0.544
LIG_SH3_3	120	126	PF00018	0.340
LIG_SH3_3	22	28	PF00018	0.475
LIG_SH3_3	301	307	PF00018	0.457
LIG_SH3_3	310	316	PF00018	0.470
LIG_SH3_3	326	332	PF00018	0.450
LIG_SH3_3	377	383	PF00018	0.351
LIG_SH3_3	470	476	PF00018	0.700
LIG_SH3_3	512	518	PF00018	0.677
LIG_SH3_3	557	563	PF00018	0.676
LIG_SH3_3	564	570	PF00018	0.655
LIG_Sin3_3	50	57	PF02671	0.307
LIG_SUMO_SIM_anti_2	111	117	PF11976	0.332
LIG_SUMO_SIM_anti_2	240	246	PF11976	0.362
LIG_SUMO_SIM_par_1	113	120	PF11976	0.368
LIG_SUMO_SIM_par_1	748	755	PF11976	0.312
LIG_TRAF2_1	282	285	PF00917	0.511
LIG_TRAF2_1	827	830	PF00917	0.547
LIG_TRFH_1	453	457	PF08558	0.630
LIG_TYR_ITIM	428	433	PF00017	0.548
LIG_TYR_ITSM	629	636	PF00017	0.255
LIG_WRC_WIRS_1	677	682	PF05994	0.243
MOD_CDC14_SPxK_1	448	451	PF00782	0.716
MOD_CDC14_SPxK_1	456	459	PF00782	0.669
MOD_CDK_SPxK_1	445	451	PF00069	0.790
MOD_CDK_SPxK_1	453	459	PF00069	0.724
MOD_CK1_1	106	112	PF00069	0.226
MOD_CK1_1	183	189	PF00069	0.660
MOD_CK1_1	2	8	PF00069	0.226
MOD_CK1_1	30	36	PF00069	0.592
MOD_CK1_1	48	54	PF00069	0.278
MOD_CK1_1	562	568	PF00069	0.664
MOD_CK1_1	588	594	PF00069	0.599
MOD_CK1_1	90	96	PF00069	0.438
MOD_CK2_1	178	184	PF00069	0.644
MOD_CK2_1	279	285	PF00069	0.513
MOD_CK2_1	288	294	PF00069	0.438
MOD_CK2_1	658	664	PF00069	0.260
MOD_CK2_1	680	686	PF00069	0.329
MOD_CK2_1	823	829	PF00069	0.579
MOD_CMANNOS	88	91	PF00535	0.662
MOD_Cter_Amidation	142	145	PF01082	0.471
MOD_GlcNHglycan	105	108	PF01048	0.595
MOD_GlcNHglycan	141	144	PF01048	0.417
MOD_GlcNHglycan	159	162	PF01048	0.450
MOD_GlcNHglycan	167	170	PF01048	0.449
MOD_GlcNHglycan	270	273	PF01048	0.830
MOD_GlcNHglycan	291	294	PF01048	0.692
MOD_GlcNHglycan	31	35	PF01048	0.494
MOD_GlcNHglycan	346	349	PF01048	0.706
MOD_GlcNHglycan	374	377	PF01048	0.388
MOD_GlcNHglycan	465	468	PF01048	0.465
MOD_GlcNHglycan	485	489	PF01048	0.499
MOD_GlcNHglycan	490	493	PF01048	0.495
MOD_GlcNHglycan	50	53	PF01048	0.247
MOD_GlcNHglycan	552	555	PF01048	0.491
MOD_GlcNHglycan	564	567	PF01048	0.575
MOD_GlcNHglycan	587	590	PF01048	0.361
MOD_GlcNHglycan	64	67	PF01048	0.611
MOD_GlcNHglycan	69	72	PF01048	0.524
MOD_GlcNHglycan	722	725	PF01048	0.281
MOD_GlcNHglycan	818	821	PF01048	0.371
MOD_GlcNHglycan	826	829	PF01048	0.380
MOD_GSK3_1	139	146	PF00069	0.688
MOD_GSK3_1	151	158	PF00069	0.626
MOD_GSK3_1	172	179	PF00069	0.662
MOD_GSK3_1	180	187	PF00069	0.689
MOD_GSK3_1	2	9	PF00069	0.226
MOD_GSK3_1	247	254	PF00069	0.435
MOD_GSK3_1	274	281	PF00069	0.610
MOD_GSK3_1	358	365	PF00069	0.360
MOD_GSK3_1	39	46	PF00069	0.341
MOD_GSK3_1	484	491	PF00069	0.697
MOD_GSK3_1	524	531	PF00069	0.826
MOD_GSK3_1	561	568	PF00069	0.659
MOD_GSK3_1	579	586	PF00069	0.471
MOD_GSK3_1	58	65	PF00069	0.385
MOD_GSK3_1	588	595	PF00069	0.534
MOD_GSK3_1	654	661	PF00069	0.255
MOD_GSK3_1	676	683	PF00069	0.329
MOD_GSK3_1	716	723	PF00069	0.475
MOD_GSK3_1	731	738	PF00069	0.475
MOD_GSK3_1	752	759	PF00069	0.312
MOD_NEK2_1	103	108	PF00069	0.415
MOD_NEK2_1	116	121	PF00069	0.265
MOD_NEK2_1	129	134	PF00069	0.301
MOD_NEK2_1	151	156	PF00069	0.656
MOD_NEK2_1	157	162	PF00069	0.606
MOD_NEK2_1	172	177	PF00069	0.639
MOD_NEK2_1	39	44	PF00069	0.312
MOD_NEK2_1	428	433	PF00069	0.620
MOD_NEK2_1	45	50	PF00069	0.312
MOD_NEK2_1	484	489	PF00069	0.675
MOD_NEK2_1	505	510	PF00069	0.722
MOD_NEK2_1	541	546	PF00069	0.618
MOD_NEK2_1	594	599	PF00069	0.544
MOD_NEK2_1	648	653	PF00069	0.274
MOD_NEK2_1	663	668	PF00069	0.271
MOD_NEK2_1	680	685	PF00069	0.205
MOD_NEK2_1	704	709	PF00069	0.304
MOD_NEK2_1	716	721	PF00069	0.502
MOD_NEK2_1	722	727	PF00069	0.567
MOD_NEK2_1	751	756	PF00069	0.312
MOD_NEK2_1	814	819	PF00069	0.624
MOD_NEK2_1	92	97	PF00069	0.398
MOD_NEK2_2	58	63	PF00069	0.362
MOD_PIKK_1	247	253	PF00454	0.452
MOD_PIKK_1	524	530	PF00454	0.725
MOD_PIKK_1	649	655	PF00454	0.260
MOD_PK_1	238	244	PF00069	0.451
MOD_PKA_1	155	161	PF00069	0.639
MOD_PKA_2	103	109	PF00069	0.393
MOD_PKA_2	139	145	PF00069	0.748
MOD_PKA_2	155	161	PF00069	0.568
MOD_PKA_2	237	243	PF00069	0.445
MOD_PKA_2	254	260	PF00069	0.376
MOD_PKA_2	279	285	PF00069	0.523
MOD_PKA_2	289	295	PF00069	0.431
MOD_PKA_2	505	511	PF00069	0.721
MOD_PKA_2	579	585	PF00069	0.561
MOD_PKA_2	752	758	PF00069	0.329
MOD_PKA_2	792	798	PF00069	0.295
MOD_PKA_2	814	820	PF00069	0.590
MOD_PKB_1	176	184	PF00069	0.624
MOD_Plk_1	183	189	PF00069	0.724
MOD_Plk_1	30	36	PF00069	0.570
MOD_Plk_1	58	64	PF00069	0.435
MOD_Plk_1	663	669	PF00069	0.329
MOD_Plk_4	117	123	PF00069	0.312
MOD_Plk_4	129	135	PF00069	0.311
MOD_Plk_4	184	190	PF00069	0.667
MOD_Plk_4	254	260	PF00069	0.500
MOD_Plk_4	388	394	PF00069	0.549
MOD_Plk_4	428	434	PF00069	0.553
MOD_Plk_4	45	51	PF00069	0.449
MOD_Plk_4	58	64	PF00069	0.381
MOD_Plk_4	594	600	PF00069	0.542
MOD_Plk_4	614	620	PF00069	0.529
MOD_Plk_4	628	634	PF00069	0.300
MOD_Plk_4	641	647	PF00069	0.288
MOD_Plk_4	658	664	PF00069	0.272
MOD_Plk_4	735	741	PF00069	0.312
MOD_Plk_4	87	93	PF00069	0.462
MOD_ProDKin_1	379	385	PF00069	0.317
MOD_ProDKin_1	436	442	PF00069	0.666
MOD_ProDKin_1	443	449	PF00069	0.655
MOD_ProDKin_1	453	459	PF00069	0.664
MOD_ProDKin_1	526	532	PF00069	0.821
MOD_ProDKin_1	559	565	PF00069	0.690
MOD_ProDKin_1	760	766	PF00069	0.317
MOD_SUMO_for_1	311	314	PF00179	0.527
MOD_SUMO_rev_2	264	270	PF00179	0.507
MOD_SUMO_rev_2	306	313	PF00179	0.470
TRG_ENDOCYTIC_2	10	13	PF00928	0.312
TRG_ENDOCYTIC_2	249	252	PF00928	0.423
TRG_ENDOCYTIC_2	377	380	PF00928	0.312
TRG_ENDOCYTIC_2	430	433	PF00928	0.551
TRG_ENDOCYTIC_2	471	474	PF00928	0.755
TRG_ENDOCYTIC_2	481	484	PF00928	0.646
TRG_ENDOCYTIC_2	599	602	PF00928	0.536
TRG_ENDOCYTIC_2	623	626	PF00928	0.312
TRG_ENDOCYTIC_2	633	636	PF00928	0.312
TRG_ENDOCYTIC_2	791	794	PF00928	0.275
TRG_ER_diArg_1	155	157	PF00400	0.619
TRG_ER_diArg_1	177	180	PF00400	0.644
TRG_ER_diArg_1	205	208	PF00400	0.665
TRG_ER_diArg_1	245	247	PF00400	0.428
TRG_ER_diArg_1	332	334	PF00400	0.533
TRG_ER_diArg_1	393	396	PF00400	0.475
TRG_ER_diArg_1	669	672	PF00400	0.275
TRG_Pf-PMV_PEXEL_1	246	251	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7R5	Leptomonas seymouri	46%	100%
A0A3S7WPT2	Leishmania donovani	91%	100%
A4H4X8	Leishmania braziliensis	70%	100%
A4HT51	Leishmania infantum	91%	100%
E9AL43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%