Nudix hydrolase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NUDIX family hydrolase, putative

Species:

Leishmania major

UniProt:

Q4QIR0_LEIMA

TriTrypDb:

LmjF.07.0335 , LMJLV39_070009300 , LMJSD75_070009500

Length:

786

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QIR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIR0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006163	purine nucleotide metabolic process	5	2
GO:0006195	purine nucleotide catabolic process	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006753	nucleoside phosphate metabolic process	4	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009117	nucleotide metabolic process	5	2
GO:0009150	purine ribonucleotide metabolic process	6	2
GO:0009154	purine ribonucleotide catabolic process	6	2
GO:0009166	nucleotide catabolic process	6	2
GO:0009259	ribonucleotide metabolic process	5	2
GO:0009261	ribonucleotide catabolic process	5	2
GO:0009987	cellular process	1	2
GO:0015936	coenzyme A metabolic process	6	2
GO:0015938	coenzyme A catabolic process	7	2
GO:0019439	aromatic compound catabolic process	4	2
GO:0019637	organophosphate metabolic process	3	2
GO:0019693	ribose phosphate metabolic process	4	2
GO:0033865	nucleoside bisphosphate metabolic process	5	2
GO:0033869	nucleoside bisphosphate catabolic process	6	2
GO:0033875	ribonucleoside bisphosphate metabolic process	6	2
GO:0034031	ribonucleoside bisphosphate catabolic process	7	2
GO:0034032	purine nucleoside bisphosphate metabolic process	5	2
GO:0034034	purine nucleoside bisphosphate catabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034655	nucleobase-containing compound catabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044270	cellular nitrogen compound catabolic process	4	2
GO:0044281	small molecule metabolic process	2	2
GO:0046434	organophosphate catabolic process	4	2
GO:0046483	heterocycle metabolic process	3	2
GO:0046700	heterocycle catabolic process	4	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0072521	purine-containing compound metabolic process	4	2
GO:0072523	purine-containing compound catabolic process	5	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901136	carbohydrate derivative catabolic process	4	2
GO:1901292	nucleoside phosphate catabolic process	5	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901361	organic cyclic compound catabolic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0003986	acetyl-CoA hydrolase activity	6	2
GO:0010945	CoA pyrophosphatase activity	6	7
GO:0016289	CoA hydrolase activity	5	2
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016790	thiolester hydrolase activity	4	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.698
CLV_C14_Caspase3-7	588	592	PF00656	0.693
CLV_C14_Caspase3-7	598	602	PF00656	0.741
CLV_MEL_PAP_1	39	45	PF00089	0.393
CLV_NRD_NRD_1	135	137	PF00675	0.374
CLV_NRD_NRD_1	165	167	PF00675	0.467
CLV_NRD_NRD_1	177	179	PF00675	0.348
CLV_NRD_NRD_1	23	25	PF00675	0.431
CLV_NRD_NRD_1	33	35	PF00675	0.342
CLV_NRD_NRD_1	468	470	PF00675	0.372
CLV_NRD_NRD_1	478	480	PF00675	0.400
CLV_NRD_NRD_1	547	549	PF00675	0.433
CLV_NRD_NRD_1	563	565	PF00675	0.488
CLV_NRD_NRD_1	656	658	PF00675	0.572
CLV_PCSK_FUR_1	466	470	PF00082	0.356
CLV_PCSK_FUR_1	561	565	PF00082	0.531
CLV_PCSK_KEX2_1	135	137	PF00082	0.374
CLV_PCSK_KEX2_1	165	167	PF00082	0.432
CLV_PCSK_KEX2_1	177	179	PF00082	0.348
CLV_PCSK_KEX2_1	23	25	PF00082	0.431
CLV_PCSK_KEX2_1	33	35	PF00082	0.342
CLV_PCSK_KEX2_1	468	470	PF00082	0.361
CLV_PCSK_KEX2_1	478	480	PF00082	0.396
CLV_PCSK_KEX2_1	546	548	PF00082	0.441
CLV_PCSK_KEX2_1	563	565	PF00082	0.488
CLV_PCSK_KEX2_1	655	657	PF00082	0.570
CLV_PCSK_PC7_1	464	470	PF00082	0.361
CLV_PCSK_SKI1_1	205	209	PF00082	0.365
CLV_PCSK_SKI1_1	232	236	PF00082	0.314
CLV_PCSK_SKI1_1	261	265	PF00082	0.443
CLV_PCSK_SKI1_1	468	472	PF00082	0.385
CLV_PCSK_SKI1_1	49	53	PF00082	0.374
CLV_PCSK_SKI1_1	59	63	PF00082	0.380
DEG_SCF_FBW7_2	495	501	PF00400	0.666
DEG_SPOP_SBC_1	313	317	PF00917	0.783
DEG_SPOP_SBC_1	700	704	PF00917	0.691
DOC_ANK_TNKS_1	113	120	PF00023	0.686
DOC_CKS1_1	495	500	PF01111	0.670
DOC_MAPK_gen_1	165	173	PF00069	0.627
DOC_MAPK_gen_1	33	41	PF00069	0.587
DOC_MAPK_MEF2A_6	34	43	PF00069	0.538
DOC_MAPK_MEF2A_6	767	776	PF00069	0.644
DOC_MAPK_RevD_3	8	24	PF00069	0.552
DOC_PP1_RVXF_1	121	128	PF00149	0.525
DOC_PP2B_LxvP_1	306	309	PF13499	0.595
DOC_PP4_FxxP_1	280	283	PF00568	0.699
DOC_PP4_FxxP_1	376	379	PF00568	0.592
DOC_USP7_MATH_1	108	112	PF00917	0.605
DOC_USP7_MATH_1	113	117	PF00917	0.579
DOC_USP7_MATH_1	148	152	PF00917	0.503
DOC_USP7_MATH_1	276	280	PF00917	0.681
DOC_USP7_MATH_1	314	318	PF00917	0.703
DOC_USP7_MATH_1	681	685	PF00917	0.729
DOC_USP7_MATH_1	84	88	PF00917	0.708
DOC_USP7_MATH_1	97	101	PF00917	0.621
DOC_WW_Pin1_4	239	244	PF00397	0.588
DOC_WW_Pin1_4	279	284	PF00397	0.549
DOC_WW_Pin1_4	345	350	PF00397	0.775
DOC_WW_Pin1_4	494	499	PF00397	0.666
DOC_WW_Pin1_4	552	557	PF00397	0.620
DOC_WW_Pin1_4	679	684	PF00397	0.735
DOC_WW_Pin1_4	80	85	PF00397	0.650
LIG_14-3-3_CanoR_1	18	27	PF00244	0.591
LIG_14-3-3_CanoR_1	191	195	PF00244	0.500
LIG_14-3-3_CanoR_1	261	268	PF00244	0.584
LIG_14-3-3_CanoR_1	33	41	PF00244	0.591
LIG_14-3-3_CanoR_1	410	419	PF00244	0.600
LIG_14-3-3_CanoR_1	452	456	PF00244	0.770
LIG_14-3-3_CanoR_1	49	58	PF00244	0.481
LIG_14-3-3_CanoR_1	59	67	PF00244	0.628
LIG_14-3-3_CanoR_1	619	627	PF00244	0.727
LIG_14-3-3_CanoR_1	632	638	PF00244	0.689
LIG_14-3-3_CanoR_1	655	665	PF00244	0.755
LIG_14-3-3_CanoR_1	699	707	PF00244	0.691
LIG_14-3-3_CanoR_1	89	95	PF00244	0.667
LIG_APCC_ABBAyCdc20_2	538	544	PF00400	0.582
LIG_BRCT_BRCA1_1	224	228	PF00533	0.678
LIG_BRCT_BRCA1_1	90	94	PF00533	0.775
LIG_Clathr_ClatBox_1	367	371	PF01394	0.533
LIG_Clathr_ClatBox_1	643	647	PF01394	0.653
LIG_deltaCOP1_diTrp_1	118	127	PF00928	0.651
LIG_deltaCOP1_diTrp_1	377	380	PF00928	0.633
LIG_deltaCOP1_diTrp_1	53	58	PF00928	0.515
LIG_eIF4E_1	397	403	PF01652	0.467
LIG_FHA_1	120	126	PF00498	0.673
LIG_FHA_1	15	21	PF00498	0.632
LIG_FHA_1	240	246	PF00498	0.587
LIG_FHA_1	414	420	PF00498	0.566
LIG_FHA_1	632	638	PF00498	0.771
LIG_FHA_1	702	708	PF00498	0.750
LIG_FHA_1	713	719	PF00498	0.672
LIG_FHA_2	158	164	PF00498	0.632
LIG_FHA_2	190	196	PF00498	0.585
LIG_FHA_2	338	344	PF00498	0.819
LIG_FHA_2	361	367	PF00498	0.657
LIG_FHA_2	48	54	PF00498	0.496
LIG_FHA_2	619	625	PF00498	0.686
LIG_FHA_2	658	664	PF00498	0.754
LIG_FHA_2	680	686	PF00498	0.760
LIG_FHA_2	700	706	PF00498	0.628
LIG_FHA_2	71	77	PF00498	0.669
LIG_FHA_2	718	724	PF00498	0.645
LIG_FXI_DFP_1	183	187	PF00024	0.463
LIG_LIR_Apic_2	118	124	PF02991	0.673
LIG_LIR_Apic_2	279	283	PF02991	0.694
LIG_LIR_Apic_2	374	379	PF02991	0.593
LIG_LIR_Gen_1	184	194	PF02991	0.560
LIG_LIR_Gen_1	206	214	PF02991	0.542
LIG_LIR_Gen_1	299	308	PF02991	0.542
LIG_LIR_Gen_1	477	487	PF02991	0.571
LIG_LIR_Gen_1	52	63	PF02991	0.523
LIG_LIR_Nem_3	126	130	PF02991	0.624
LIG_LIR_Nem_3	184	189	PF02991	0.564
LIG_LIR_Nem_3	192	197	PF02991	0.554
LIG_LIR_Nem_3	206	210	PF02991	0.475
LIG_LIR_Nem_3	254	260	PF02991	0.556
LIG_LIR_Nem_3	299	303	PF02991	0.541
LIG_LIR_Nem_3	377	381	PF02991	0.634
LIG_LIR_Nem_3	401	407	PF02991	0.535
LIG_LIR_Nem_3	477	483	PF02991	0.560
LIG_LIR_Nem_3	52	58	PF02991	0.514
LIG_MLH1_MIPbox_1	91	95	PF16413	0.694
LIG_PCNA_PIPBox_1	664	673	PF02747	0.733
LIG_Pex14_2	376	380	PF04695	0.661
LIG_SH2_CRK	480	484	PF00017	0.664
LIG_SH2_NCK_1	194	198	PF00017	0.638
LIG_SH2_NCK_1	518	522	PF00017	0.385
LIG_SH2_NCK_1	67	71	PF00017	0.730
LIG_SH2_SRC	194	197	PF00017	0.594
LIG_SH2_SRC	67	70	PF00017	0.728
LIG_SH2_STAP1	400	404	PF00017	0.530
LIG_SH2_STAP1	518	522	PF00017	0.385
LIG_SH2_STAT3	779	782	PF00017	0.719
LIG_SH2_STAT5	130	133	PF00017	0.646
LIG_SH2_STAT5	300	303	PF00017	0.524
LIG_SH2_STAT5	518	521	PF00017	0.453
LIG_SH3_1	492	498	PF00018	0.595
LIG_SH3_3	24	30	PF00018	0.640
LIG_SH3_3	270	276	PF00018	0.588
LIG_SH3_3	346	352	PF00018	0.705
LIG_SH3_3	389	395	PF00018	0.527
LIG_SH3_3	492	498	PF00018	0.576
LIG_SH3_3	686	692	PF00018	0.705
LIG_SH3_3	744	750	PF00018	0.736
LIG_Sin3_3	487	494	PF02671	0.544
LIG_SUMO_SIM_anti_2	9	14	PF11976	0.650
LIG_SUMO_SIM_par_1	366	372	PF11976	0.541
LIG_SUMO_SIM_par_1	714	720	PF11976	0.722
LIG_TRAF2_1	193	196	PF00917	0.595
LIG_TYR_ITSM	190	197	PF00017	0.480
LIG_UBA3_1	154	158	PF00899	0.528
LIG_WRC_WIRS_1	277	282	PF05994	0.678
MOD_CDK_SPxxK_3	348	355	PF00069	0.645
MOD_CK1_1	100	106	PF00069	0.646
MOD_CK1_1	279	285	PF00069	0.552
MOD_CK1_1	302	308	PF00069	0.659
MOD_CK1_1	315	321	PF00069	0.681
MOD_CK1_1	32	38	PF00069	0.651
MOD_CK1_1	345	351	PF00069	0.712
MOD_CK1_1	369	375	PF00069	0.709
MOD_CK1_1	446	452	PF00069	0.786
MOD_CK1_1	458	464	PF00069	0.583
MOD_CK1_1	596	602	PF00069	0.713
MOD_CK1_1	659	665	PF00069	0.657
MOD_CK1_1	698	704	PF00069	0.811
MOD_CK1_1	711	717	PF00069	0.663
MOD_CK1_1	87	93	PF00069	0.683
MOD_CK2_1	157	163	PF00069	0.634
MOD_CK2_1	189	195	PF00069	0.585
MOD_CK2_1	360	366	PF00069	0.546
MOD_CK2_1	47	53	PF00069	0.496
MOD_CK2_1	471	477	PF00069	0.581
MOD_CK2_1	618	624	PF00069	0.690
MOD_CK2_1	630	636	PF00069	0.681
MOD_CK2_1	657	663	PF00069	0.811
MOD_CK2_1	70	76	PF00069	0.668
MOD_CK2_1	717	723	PF00069	0.704
MOD_CMANNOS	354	357	PF00535	0.357
MOD_CMANNOS	409	412	PF00535	0.352
MOD_Cter_Amidation	175	178	PF01082	0.369
MOD_GlcNHglycan	115	118	PF01048	0.366
MOD_GlcNHglycan	167	170	PF01048	0.482
MOD_GlcNHglycan	2	5	PF01048	0.441
MOD_GlcNHglycan	317	320	PF01048	0.525
MOD_GlcNHglycan	34	37	PF01048	0.337
MOD_GlcNHglycan	345	348	PF01048	0.493
MOD_GlcNHglycan	448	451	PF01048	0.550
MOD_GlcNHglycan	453	456	PF01048	0.483
MOD_GlcNHglycan	485	488	PF01048	0.393
MOD_GlcNHglycan	587	590	PF01048	0.487
MOD_GlcNHglycan	627	630	PF01048	0.554
MOD_GlcNHglycan	647	650	PF01048	0.393
MOD_GlcNHglycan	675	678	PF01048	0.547
MOD_GlcNHglycan	710	713	PF01048	0.595
MOD_GlcNHglycan	725	728	PF01048	0.439
MOD_GlcNHglycan	86	89	PF01048	0.537
MOD_GlcNHglycan	95	98	PF01048	0.457
MOD_GlcNHglycan	99	102	PF01048	0.455
MOD_GSK3_1	14	21	PF00069	0.513
MOD_GSK3_1	185	192	PF00069	0.484
MOD_GSK3_1	308	315	PF00069	0.708
MOD_GSK3_1	317	324	PF00069	0.646
MOD_GSK3_1	337	344	PF00069	0.618
MOD_GSK3_1	439	446	PF00069	0.782
MOD_GSK3_1	451	458	PF00069	0.681
MOD_GSK3_1	49	56	PF00069	0.587
MOD_GSK3_1	593	600	PF00069	0.817
MOD_GSK3_1	669	676	PF00069	0.736
MOD_GSK3_1	691	698	PF00069	0.797
MOD_GSK3_1	701	708	PF00069	0.697
MOD_GSK3_1	80	87	PF00069	0.807
MOD_GSK3_1	89	96	PF00069	0.726
MOD_N-GLC_1	577	582	PF02516	0.499
MOD_NEK2_1	157	162	PF00069	0.603
MOD_NEK2_1	380	385	PF00069	0.558
MOD_NEK2_1	413	418	PF00069	0.530
MOD_NEK2_1	444	449	PF00069	0.780
MOD_NEK2_1	471	476	PF00069	0.627
MOD_NEK2_1	610	615	PF00069	0.732
MOD_NEK2_1	707	712	PF00069	0.788
MOD_NEK2_2	357	362	PF00069	0.643
MOD_NEK2_2	54	59	PF00069	0.548
MOD_PIKK_1	11	17	PF00454	0.638
MOD_PIKK_1	44	50	PF00454	0.659
MOD_PKA_1	165	171	PF00069	0.657
MOD_PKA_1	656	662	PF00069	0.673
MOD_PKA_2	113	119	PF00069	0.684
MOD_PKA_2	165	171	PF00069	0.584
MOD_PKA_2	190	196	PF00069	0.638
MOD_PKA_2	32	38	PF00069	0.618
MOD_PKA_2	451	457	PF00069	0.741
MOD_PKA_2	596	602	PF00069	0.718
MOD_PKA_2	610	616	PF00069	0.710
MOD_PKA_2	618	624	PF00069	0.683
MOD_PKA_2	631	637	PF00069	0.689
MOD_PKA_2	656	662	PF00069	0.673
MOD_PKA_2	695	701	PF00069	0.699
MOD_PKA_2	88	94	PF00069	0.773
MOD_PKB_1	339	347	PF00069	0.699
MOD_PKB_1	655	663	PF00069	0.744
MOD_PKB_1	778	786	PF00069	0.720
MOD_Plk_2-3	366	372	PF00069	0.600
MOD_Plk_2-3	572	578	PF00069	0.728
MOD_Plk_4	276	282	PF00069	0.584
MOD_Plk_4	296	302	PF00069	0.560
MOD_Plk_4	555	561	PF00069	0.636
MOD_Plk_4	582	588	PF00069	0.735
MOD_Plk_4	639	645	PF00069	0.650
MOD_ProDKin_1	239	245	PF00069	0.587
MOD_ProDKin_1	279	285	PF00069	0.548
MOD_ProDKin_1	345	351	PF00069	0.765
MOD_ProDKin_1	494	500	PF00069	0.666
MOD_ProDKin_1	552	558	PF00069	0.621
MOD_ProDKin_1	679	685	PF00069	0.735
MOD_ProDKin_1	80	86	PF00069	0.649
MOD_SUMO_rev_2	765	775	PF00179	0.702
TRG_DiLeu_BaEn_3	770	776	PF01217	0.740
TRG_DiLeu_BaLyEn_6	383	388	PF01217	0.645
TRG_ENDOCYTIC_2	194	197	PF00928	0.642
TRG_ENDOCYTIC_2	300	303	PF00928	0.524
TRG_ENDOCYTIC_2	390	393	PF00928	0.614
TRG_ENDOCYTIC_2	399	402	PF00928	0.485
TRG_ENDOCYTIC_2	480	483	PF00928	0.555
TRG_ER_diArg_1	164	166	PF00400	0.663
TRG_ER_diArg_1	23	25	PF00400	0.631
TRG_ER_diArg_1	270	273	PF00400	0.671
TRG_ER_diArg_1	338	341	PF00400	0.726
TRG_ER_diArg_1	417	420	PF00400	0.672
TRG_ER_diArg_1	464	467	PF00400	0.598
TRG_ER_diArg_1	468	470	PF00400	0.563
TRG_ER_diArg_1	478	480	PF00400	0.563
TRG_ER_diArg_1	546	548	PF00400	0.641
TRG_ER_diArg_1	560	563	PF00400	0.689
TRG_ER_diArg_1	655	657	PF00400	0.783
TRG_Pf-PMV_PEXEL_1	18	22	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6E0	Leptomonas seymouri	37%	100%
A0A3S7WPU2	Leishmania donovani	88%	100%
A4H4X9	Leishmania braziliensis	61%	95%
A4HT52	Leishmania infantum	87%	86%
E9AL44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%