MYND-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIQ8_LEIMA

TriTrypDb:

LmjF.07.0350 , LMJLV39_070009600 , LMJSD75_070009800

Length:

656

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIQ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.676
CLV_NRD_NRD_1	263	265	PF00675	0.718
CLV_NRD_NRD_1	578	580	PF00675	0.741
CLV_NRD_NRD_1	598	600	PF00675	0.384
CLV_PCSK_KEX2_1	124	126	PF00082	0.676
CLV_PCSK_KEX2_1	247	249	PF00082	0.663
CLV_PCSK_KEX2_1	263	265	PF00082	0.491
CLV_PCSK_KEX2_1	275	277	PF00082	0.581
CLV_PCSK_KEX2_1	47	49	PF00082	0.713
CLV_PCSK_KEX2_1	578	580	PF00082	0.741
CLV_PCSK_KEX2_1	598	600	PF00082	0.384
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.663
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.751
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.713
CLV_PCSK_SKI1_1	148	152	PF00082	0.654
DEG_SCF_FBW7_1	451	457	PF00400	0.635
DOC_ANK_TNKS_1	532	539	PF00023	0.686
DOC_CKS1_1	443	448	PF01111	0.724
DOC_CKS1_1	451	456	PF01111	0.611
DOC_PP1_RVXF_1	41	47	PF00149	0.694
DOC_PP4_FxxP_1	8	11	PF00568	0.732
DOC_USP7_MATH_1	320	324	PF00917	0.732
DOC_USP7_MATH_1	380	384	PF00917	0.729
DOC_USP7_MATH_1	395	399	PF00917	0.559
DOC_USP7_MATH_1	437	441	PF00917	0.729
DOC_USP7_MATH_1	503	507	PF00917	0.791
DOC_USP7_MATH_1	618	622	PF00917	0.742
DOC_USP7_MATH_1	64	68	PF00917	0.714
DOC_USP7_UBL2_3	148	152	PF12436	0.654
DOC_USP7_UBL2_3	188	192	PF12436	0.790
DOC_USP7_UBL2_3	193	197	PF12436	0.658
DOC_USP7_UBL2_3	255	259	PF12436	0.668
DOC_USP7_UBL2_3	43	47	PF12436	0.688
DOC_WW_Pin1_4	311	316	PF00397	0.637
DOC_WW_Pin1_4	442	447	PF00397	0.683
DOC_WW_Pin1_4	450	455	PF00397	0.577
DOC_WW_Pin1_4	499	504	PF00397	0.774
DOC_WW_Pin1_4	537	542	PF00397	0.772
DOC_WW_Pin1_4	579	584	PF00397	0.720
LIG_14-3-3_CanoR_1	382	386	PF00244	0.754
LIG_14-3-3_CanoR_1	623	629	PF00244	0.696
LIG_Actin_WH2_2	151	168	PF00022	0.523
LIG_BIR_II_1	1	5	PF00653	0.737
LIG_BRCT_BRCA1_1	549	553	PF00533	0.750
LIG_BRCT_BRCA1_1	620	624	PF00533	0.750
LIG_BRCT_BRCA1_1	649	653	PF00533	0.612
LIG_deltaCOP1_diTrp_1	33	39	PF00928	0.674
LIG_deltaCOP1_diTrp_1	643	653	PF00928	0.698
LIG_FHA_1	199	205	PF00498	0.652
LIG_FHA_1	511	517	PF00498	0.768
LIG_FHA_1	625	631	PF00498	0.696
LIG_FHA_1	71	77	PF00498	0.701
LIG_FHA_1	90	96	PF00498	0.461
LIG_FHA_2	340	346	PF00498	0.769
LIG_LIR_Apic_2	60	64	PF02991	0.716
LIG_LIR_Apic_2	638	644	PF02991	0.601
LIG_LIR_Apic_2	7	11	PF02991	0.734
LIG_LIR_Gen_1	141	150	PF02991	0.626
LIG_LIR_Gen_1	584	593	PF02991	0.687
LIG_LIR_Gen_1	67	76	PF02991	0.693
LIG_LIR_Nem_3	141	146	PF02991	0.623
LIG_LIR_Nem_3	584	590	PF02991	0.694
LIG_LIR_Nem_3	67	72	PF02991	0.693
LIG_MYND_1	537	541	PF01753	0.705
LIG_PCNA_yPIPBox_3	225	235	PF02747	0.610
LIG_Pex14_1	35	39	PF04695	0.670
LIG_Pex14_2	624	628	PF04695	0.761
LIG_SH2_CRK	132	136	PF00017	0.606
LIG_SH2_CRK	162	166	PF00017	0.583
LIG_SH2_CRK	568	572	PF00017	0.747
LIG_SH2_CRK	587	591	PF00017	0.415
LIG_SH2_PTP2	61	64	PF00017	0.708
LIG_SH2_SRC	61	64	PF00017	0.708
LIG_SH2_STAP1	132	136	PF00017	0.606
LIG_SH2_STAT5	157	160	PF00017	0.585
LIG_SH2_STAT5	524	527	PF00017	0.727
LIG_SH2_STAT5	61	64	PF00017	0.708
LIG_SH3_1	448	454	PF00018	0.740
LIG_SH3_2	443	448	PF14604	0.798
LIG_SH3_3	290	296	PF00018	0.768
LIG_SH3_3	440	446	PF00018	0.787
LIG_SH3_3	448	454	PF00018	0.693
LIG_SxIP_EBH_1	435	448	PF03271	0.682
LIG_TRAF2_1	342	345	PF00917	0.784
LIG_TYR_ITIM	130	135	PF00017	0.590
LIG_UBA3_1	146	152	PF00899	0.643
LIG_UBA3_1	235	244	PF00899	0.622
LIG_UBA3_1	429	436	PF00899	0.654
LIG_WRC_WIRS_1	5	10	PF05994	0.741
LIG_WRC_WIRS_1	94	99	PF05994	0.712
MOD_CDC14_SPxK_1	582	585	PF00782	0.645
MOD_CDK_SPxK_1	442	448	PF00069	0.797
MOD_CDK_SPxK_1	579	585	PF00069	0.718
MOD_CK1_1	288	294	PF00069	0.707
MOD_CK1_1	323	329	PF00069	0.705
MOD_CK1_1	381	387	PF00069	0.756
MOD_CK1_1	435	441	PF00069	0.580
MOD_CK1_1	444	450	PF00069	0.570
MOD_CK1_1	547	553	PF00069	0.748
MOD_CK1_1	635	641	PF00069	0.617
MOD_CK2_1	339	345	PF00069	0.768
MOD_CK2_1	616	622	PF00069	0.741
MOD_GlcNHglycan	174	177	PF01048	0.703
MOD_GlcNHglycan	180	183	PF01048	0.669
MOD_GlcNHglycan	184	187	PF01048	0.631
MOD_GlcNHglycan	322	325	PF01048	0.713
MOD_GlcNHglycan	328	331	PF01048	0.668
MOD_GlcNHglycan	422	425	PF01048	0.648
MOD_GlcNHglycan	486	489	PF01048	0.737
MOD_GlcNHglycan	549	552	PF01048	0.681
MOD_GSK3_1	178	185	PF00069	0.737
MOD_GSK3_1	238	245	PF00069	0.648
MOD_GSK3_1	285	292	PF00069	0.756
MOD_GSK3_1	294	301	PF00069	0.628
MOD_GSK3_1	307	314	PF00069	0.608
MOD_GSK3_1	31	38	PF00069	0.672
MOD_GSK3_1	316	323	PF00069	0.661
MOD_GSK3_1	345	352	PF00069	0.740
MOD_GSK3_1	416	423	PF00069	0.697
MOD_GSK3_1	431	438	PF00069	0.593
MOD_GSK3_1	450	457	PF00069	0.533
MOD_GSK3_1	495	502	PF00069	0.714
MOD_GSK3_1	647	654	PF00069	0.763
MOD_GSK3_1	89	96	PF00069	0.729
MOD_N-GLC_1	182	187	PF02516	0.737
MOD_N-GLC_1	334	339	PF02516	0.695
MOD_N-GLC_1	97	102	PF02516	0.619
MOD_NEK2_1	146	151	PF00069	0.643
MOD_NEK2_1	289	294	PF00069	0.674
MOD_NEK2_1	494	499	PF00069	0.707
MOD_NEK2_1	76	81	PF00069	0.700
MOD_NEK2_1	97	102	PF00069	0.695
MOD_NEK2_2	395	400	PF00069	0.673
MOD_PIKK_1	62	68	PF00454	0.696
MOD_PIKK_1	70	76	PF00454	0.581
MOD_PK_1	608	614	PF00069	0.477
MOD_PKA_1	280	286	PF00069	0.682
MOD_PKA_2	381	387	PF00069	0.756
MOD_Plk_1	334	340	PF00069	0.726
MOD_Plk_1	70	76	PF00069	0.694
MOD_Plk_2-3	87	93	PF00069	0.718
MOD_Plk_4	35	41	PF00069	0.677
MOD_Plk_4	402	408	PF00069	0.656
MOD_ProDKin_1	311	317	PF00069	0.638
MOD_ProDKin_1	442	448	PF00069	0.687
MOD_ProDKin_1	450	456	PF00069	0.575
MOD_ProDKin_1	499	505	PF00069	0.774
MOD_ProDKin_1	537	543	PF00069	0.771
MOD_ProDKin_1	579	585	PF00069	0.718
MOD_SUMO_for_1	274	277	PF00179	0.748
MOD_SUMO_for_1	279	282	PF00179	0.673
MOD_SUMO_for_1	590	593	PF00179	0.604
MOD_SUMO_rev_2	540	547	PF00179	0.690
TRG_ENDOCYTIC_2	132	135	PF00928	0.600
TRG_ENDOCYTIC_2	162	165	PF00928	0.572
TRG_ENDOCYTIC_2	568	571	PF00928	0.750
TRG_ENDOCYTIC_2	587	590	PF00928	0.418
TRG_ER_diArg_1	124	126	PF00400	0.674
TRG_ER_diArg_1	263	265	PF00400	0.718
TRG_ER_diArg_1	578	580	PF00400	0.741
TRG_Pf-PMV_PEXEL_1	263	267	PF00026	0.719

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5X4	Leishmania donovani	95%	100%
A4H4Y1	Leishmania braziliensis	70%	100%
A4HT32	Leishmania infantum	95%	100%
E9AL46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%