Succinate dehydrogenase assembly factor 4, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1674), putative

Species:

Leishmania major

UniProt:

Q4QIQ7_LEIMA

TriTrypDb:

LmjF.07.0360 , LMJLV39_070009700 , LMJSD75_070009900

Length:

185

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 1
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QIQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIQ7

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0033108	mitochondrial respiratory chain complex assembly	6	2
GO:0034552	respiratory chain complex II assembly	6	2
GO:0034553	mitochondrial respiratory chain complex II assembly	7	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	81	83	PF00675	0.470
CLV_PCSK_KEX2_1	130	132	PF00082	0.435
CLV_PCSK_KEX2_1	81	83	PF00082	0.470
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.435
CLV_PCSK_SKI1_1	130	134	PF00082	0.438
DEG_Nend_UBRbox_1	1	4	PF02207	0.481
DOC_CYCLIN_yCln2_LP_2	49	55	PF00134	0.502
DOC_MAPK_gen_1	2	11	PF00069	0.476
DOC_MAPK_gen_1	81	88	PF00069	0.467
DOC_MAPK_HePTP_8	5	17	PF00069	0.473
DOC_MAPK_HePTP_8	78	90	PF00069	0.469
DOC_MAPK_MEF2A_6	2	11	PF00069	0.476
DOC_MAPK_MEF2A_6	41	49	PF00069	0.756
DOC_MAPK_MEF2A_6	81	90	PF00069	0.703
DOC_PP2B_LxvP_1	49	52	PF13499	0.532
DOC_PP4_FxxP_1	70	73	PF00568	0.470
DOC_USP7_MATH_1	45	49	PF00917	0.532
DOC_USP7_MATH_1	58	62	PF00917	0.450
DOC_WW_Pin1_4	18	23	PF00397	0.493
DOC_WW_Pin1_4	69	74	PF00397	0.481
LIG_14-3-3_CanoR_1	131	137	PF00244	0.457
LIG_14-3-3_CanoR_1	46	50	PF00244	0.621
LIG_BRCT_BRCA1_1	63	67	PF00533	0.497
LIG_Clathr_ClatBox_1	87	91	PF01394	0.482
LIG_FHA_1	131	137	PF00498	0.452
LIG_FHA_1	150	156	PF00498	0.402
LIG_FHA_1	157	163	PF00498	0.432
LIG_FHA_2	164	170	PF00498	0.449
LIG_HP1_1	45	49	PF01393	0.532
LIG_Integrin_isoDGR_2	179	181	PF01839	0.250
LIG_LIR_Gen_1	64	74	PF02991	0.482
LIG_LIR_Gen_1	75	84	PF02991	0.462
LIG_LIR_Nem_3	64	70	PF02991	0.493
LIG_LIR_Nem_3	72	77	PF02991	0.431
LIG_PDZ_Class_2	180	185	PF00595	0.449
LIG_Pex14_2	70	74	PF04695	0.469
LIG_PTB_Apo_2	56	63	PF02174	0.477
LIG_SH2_STAT5	104	107	PF00017	0.389
LIG_SH2_STAT5	27	30	PF00017	0.503
LIG_SH3_3	49	55	PF00018	0.502
MOD_CK1_1	135	141	PF00069	0.450
MOD_CK1_1	39	45	PF00069	0.512
MOD_CK1_1	61	67	PF00069	0.556
MOD_CK2_1	69	75	PF00069	0.469
MOD_GlcNHglycan	137	140	PF01048	0.456
MOD_GlcNHglycan	56	59	PF01048	0.485
MOD_GlcNHglycan	96	99	PF01048	0.647
MOD_GSK3_1	131	138	PF00069	0.462
MOD_GSK3_1	54	61	PF00069	0.487
MOD_NEK2_1	132	137	PF00069	0.454
MOD_NEK2_2	45	50	PF00069	0.534
MOD_OFUCOSY	14	20	PF10250	0.497
MOD_PIKK_1	163	169	PF00454	0.269
MOD_PKA_1	130	136	PF00069	0.443
MOD_PKA_2	130	136	PF00069	0.434
MOD_PKA_2	45	51	PF00069	0.532
MOD_Plk_4	138	144	PF00069	0.439
MOD_Plk_4	91	97	PF00069	0.465
MOD_ProDKin_1	18	24	PF00069	0.491
MOD_ProDKin_1	69	75	PF00069	0.478
MOD_SUMO_rev_2	125	132	PF00179	0.419
TRG_DiLeu_BaEn_2	90	96	PF01217	0.473
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.465
TRG_ER_diArg_1	1	4	PF00400	0.506
TRG_ER_diArg_1	80	82	PF00400	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5X5	Leishmania donovani	92%	100%