RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania major

UniProt:

Q4QIQ6_LEIMA

TriTrypDb:

LmjF.07.0370 , LMJLV39_070009800 , LMJSD75_070010000

Length:

923

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QIQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIQ6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0008270	zinc ion binding	6	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046914	transition metal ion binding	5	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	249	251	PF00675	0.839
CLV_NRD_NRD_1	266	268	PF00675	0.538
CLV_NRD_NRD_1	420	422	PF00675	0.530
CLV_NRD_NRD_1	58	60	PF00675	0.792
CLV_NRD_NRD_1	714	716	PF00675	0.807
CLV_PCSK_FUR_1	247	251	PF00082	0.770
CLV_PCSK_KEX2_1	247	249	PF00082	0.844
CLV_PCSK_KEX2_1	266	268	PF00082	0.509
CLV_PCSK_KEX2_1	420	422	PF00082	0.530
CLV_PCSK_KEX2_1	58	60	PF00082	0.792
CLV_PCSK_KEX2_1	713	715	PF00082	0.828
CLV_PCSK_SKI1_1	249	253	PF00082	0.768
CLV_PCSK_SKI1_1	275	279	PF00082	0.743
CLV_PCSK_SKI1_1	431	435	PF00082	0.452
CLV_PCSK_SKI1_1	646	650	PF00082	0.575
CLV_PCSK_SKI1_1	715	719	PF00082	0.551
CLV_PCSK_SKI1_1	824	828	PF00082	0.521
CLV_PCSK_SKI1_1	862	866	PF00082	0.587
CLV_Separin_Metazoa	546	550	PF03568	0.608
CLV_Separin_Metazoa	586	590	PF03568	0.661
DEG_Nend_UBRbox_1	1	4	PF02207	0.770
DEG_SPOP_SBC_1	124	128	PF00917	0.725
DEG_SPOP_SBC_1	351	355	PF00917	0.737
DEG_SPOP_SBC_1	39	43	PF00917	0.733
DOC_MAPK_MEF2A_6	439	446	PF00069	0.521
DOC_MAPK_MEF2A_6	527	534	PF00069	0.524
DOC_PP1_RVXF_1	856	862	PF00149	0.621
DOC_PP2B_LxvP_1	251	254	PF13499	0.843
DOC_PP2B_PxIxI_1	529	535	PF00149	0.593
DOC_PP4_FxxP_1	754	757	PF00568	0.688
DOC_PP4_FxxP_1	773	776	PF00568	0.792
DOC_USP7_MATH_1	10	14	PF00917	0.750
DOC_USP7_MATH_1	104	108	PF00917	0.769
DOC_USP7_MATH_1	124	128	PF00917	0.860
DOC_USP7_MATH_1	194	198	PF00917	0.642
DOC_USP7_MATH_1	216	220	PF00917	0.734
DOC_USP7_MATH_1	228	232	PF00917	0.613
DOC_USP7_MATH_1	255	259	PF00917	0.837
DOC_USP7_MATH_1	261	265	PF00917	0.723
DOC_USP7_MATH_1	350	354	PF00917	0.785
DOC_USP7_MATH_1	366	370	PF00917	0.703
DOC_USP7_MATH_1	614	618	PF00917	0.767
DOC_USP7_MATH_1	67	71	PF00917	0.620
DOC_USP7_MATH_1	759	763	PF00917	0.650
DOC_WW_Pin1_4	108	113	PF00397	0.594
DOC_WW_Pin1_4	126	131	PF00397	0.768
DOC_WW_Pin1_4	199	204	PF00397	0.732
DOC_WW_Pin1_4	217	222	PF00397	0.635
DOC_WW_Pin1_4	284	289	PF00397	0.769
DOC_WW_Pin1_4	295	300	PF00397	0.628
DOC_WW_Pin1_4	317	322	PF00397	0.812
DOC_WW_Pin1_4	328	333	PF00397	0.624
DOC_WW_Pin1_4	343	348	PF00397	0.656
DOC_WW_Pin1_4	437	442	PF00397	0.650
DOC_WW_Pin1_4	6	11	PF00397	0.677
DOC_WW_Pin1_4	63	68	PF00397	0.706
DOC_WW_Pin1_4	646	651	PF00397	0.790
DOC_WW_Pin1_4	658	663	PF00397	0.648
DOC_WW_Pin1_4	747	752	PF00397	0.689
LIG_14-3-3_CanoR_1	266	272	PF00244	0.819
LIG_14-3-3_CanoR_1	275	284	PF00244	0.677
LIG_14-3-3_CanoR_1	310	318	PF00244	0.755
LIG_14-3-3_CanoR_1	365	373	PF00244	0.545
LIG_14-3-3_CanoR_1	38	46	PF00244	0.777
LIG_14-3-3_CanoR_1	421	427	PF00244	0.355
LIG_14-3-3_CanoR_1	431	436	PF00244	0.365
LIG_14-3-3_CanoR_1	463	469	PF00244	0.564
LIG_14-3-3_CanoR_1	470	476	PF00244	0.550
LIG_14-3-3_CanoR_1	512	516	PF00244	0.593
LIG_14-3-3_CanoR_1	676	685	PF00244	0.570
LIG_14-3-3_CanoR_1	714	724	PF00244	0.764
LIG_14-3-3_CanoR_1	747	751	PF00244	0.586
LIG_14-3-3_CanoR_1	824	834	PF00244	0.539
LIG_14-3-3_CanoR_1	898	902	PF00244	0.524
LIG_APCC_ABBA_1	848	853	PF00400	0.595
LIG_APCC_ABBA_1	863	868	PF00400	0.510
LIG_APCC_ABBAyCdc20_2	862	868	PF00400	0.515
LIG_BIR_III_4	499	503	PF00653	0.720
LIG_BRCT_BRCA1_1	822	826	PF00533	0.625
LIG_BRCT_MDC1_1	919	923	PF00533	0.645
LIG_FHA_1	289	295	PF00498	0.697
LIG_FHA_1	356	362	PF00498	0.769
LIG_FHA_1	432	438	PF00498	0.377
LIG_FHA_1	628	634	PF00498	0.653
LIG_FHA_1	666	672	PF00498	0.765
LIG_FHA_1	741	747	PF00498	0.753
LIG_FHA_1	770	776	PF00498	0.791
LIG_FHA_2	276	282	PF00498	0.743
LIG_FHA_2	355	361	PF00498	0.825
LIG_FHA_2	488	494	PF00498	0.713
LIG_Integrin_RGD_1	501	503	PF01839	0.798
LIG_LIR_Apic_2	683	687	PF02991	0.804
LIG_LIR_Apic_2	772	776	PF02991	0.792
LIG_LIR_Gen_1	291	299	PF02991	0.693
LIG_LIR_Gen_1	805	815	PF02991	0.506
LIG_LIR_Nem_3	291	295	PF02991	0.698
LIG_LIR_Nem_3	336	340	PF02991	0.802
LIG_LIR_Nem_3	683	689	PF02991	0.734
LIG_LIR_Nem_3	805	810	PF02991	0.499
LIG_LIR_Nem_3	860	864	PF02991	0.589
LIG_Pex14_1	881	885	PF04695	0.694
LIG_Pex14_2	895	899	PF04695	0.624
LIG_SH2_CRK	292	296	PF00017	0.738
LIG_SH2_NCK_1	292	296	PF00017	0.700
LIG_SH2_PTP2	531	534	PF00017	0.513
LIG_SH2_SRC	531	534	PF00017	0.513
LIG_SH2_STAP1	292	296	PF00017	0.700
LIG_SH2_STAP1	619	623	PF00017	0.723
LIG_SH2_STAP1	822	826	PF00017	0.547
LIG_SH2_STAT5	292	295	PF00017	0.738
LIG_SH2_STAT5	531	534	PF00017	0.513
LIG_SH2_STAT5	834	837	PF00017	0.585
LIG_SH2_STAT5	849	852	PF00017	0.581
LIG_SH2_STAT5	885	888	PF00017	0.610
LIG_SH3_3	117	123	PF00018	0.774
LIG_SH3_3	302	308	PF00018	0.718
LIG_SH3_3	323	329	PF00018	0.763
LIG_SH3_3	595	601	PF00018	0.704
LIG_SH3_3	667	673	PF00018	0.755
LIG_SH3_3	679	685	PF00018	0.672
LIG_SH3_3	691	697	PF00018	0.715
LIG_SH3_3	916	922	PF00018	0.485
LIG_SUMO_SIM_anti_2	562	568	PF11976	0.628
LIG_SUMO_SIM_anti_2	584	589	PF11976	0.655
LIG_SUMO_SIM_par_1	357	362	PF11976	0.674
LIG_SUMO_SIM_par_1	384	389	PF11976	0.587
LIG_SUMO_SIM_par_1	562	568	PF11976	0.499
LIG_SUMO_SIM_par_1	596	602	PF11976	0.673
LIG_SUMO_SIM_par_1	649	654	PF11976	0.711
LIG_TRAF2_2	390	395	PF00917	0.659
MOD_CDC14_SPxK_1	666	669	PF00782	0.766
MOD_CDK_SPK_2	295	300	PF00069	0.693
MOD_CDK_SPxK_1	437	443	PF00069	0.522
MOD_CDK_SPxK_1	663	669	PF00069	0.721
MOD_CK1_1	107	113	PF00069	0.769
MOD_CK1_1	129	135	PF00069	0.683
MOD_CK1_1	219	225	PF00069	0.677
MOD_CK1_1	24	30	PF00069	0.798
MOD_CK1_1	270	276	PF00069	0.773
MOD_CK1_1	314	320	PF00069	0.818
MOD_CK1_1	346	352	PF00069	0.747
MOD_CK1_1	355	361	PF00069	0.648
MOD_CK1_1	364	370	PF00069	0.654
MOD_CK1_1	375	381	PF00069	0.316
MOD_CK1_1	469	475	PF00069	0.640
MOD_CK1_1	617	623	PF00069	0.782
MOD_CK1_1	661	667	PF00069	0.827
MOD_CK1_1	70	76	PF00069	0.669
MOD_CK1_1	77	83	PF00069	0.676
MOD_CK1_1	825	831	PF00069	0.571
MOD_CK2_1	275	281	PF00069	0.706
MOD_CK2_1	354	360	PF00069	0.825
MOD_Cter_Amidation	264	267	PF01082	0.749
MOD_DYRK1A_RPxSP_1	6	10	PF00069	0.679
MOD_GlcNHglycan	160	163	PF01048	0.595
MOD_GlcNHglycan	166	169	PF01048	0.705
MOD_GlcNHglycan	171	174	PF01048	0.645
MOD_GlcNHglycan	197	200	PF01048	0.830
MOD_GlcNHglycan	211	215	PF01048	0.589
MOD_GlcNHglycan	261	264	PF01048	0.746
MOD_GlcNHglycan	275	278	PF01048	0.578
MOD_GlcNHglycan	29	32	PF01048	0.666
MOD_GlcNHglycan	313	316	PF01048	0.764
MOD_GlcNHglycan	348	351	PF01048	0.788
MOD_GlcNHglycan	354	357	PF01048	0.621
MOD_GlcNHglycan	368	371	PF01048	0.539
MOD_GlcNHglycan	480	483	PF01048	0.762
MOD_GlcNHglycan	543	546	PF01048	0.561
MOD_GlcNHglycan	663	666	PF01048	0.762
MOD_GlcNHglycan	678	681	PF01048	0.718
MOD_GlcNHglycan	68	72	PF01048	0.631
MOD_GlcNHglycan	730	733	PF01048	0.651
MOD_GlcNHglycan	788	791	PF01048	0.727
MOD_GlcNHglycan	799	802	PF01048	0.547
MOD_GlcNHglycan	908	911	PF01048	0.567
MOD_GlcNHglycan	919	922	PF01048	0.513
MOD_GSK3_1	104	111	PF00069	0.750
MOD_GSK3_1	124	131	PF00069	0.693
MOD_GSK3_1	195	202	PF00069	0.636
MOD_GSK3_1	216	223	PF00069	0.714
MOD_GSK3_1	229	236	PF00069	0.680
MOD_GSK3_1	255	262	PF00069	0.789
MOD_GSK3_1	267	274	PF00069	0.669
MOD_GSK3_1	280	287	PF00069	0.603
MOD_GSK3_1	342	349	PF00069	0.778
MOD_GSK3_1	350	357	PF00069	0.681
MOD_GSK3_1	6	13	PF00069	0.716
MOD_GSK3_1	63	70	PF00069	0.656
MOD_GSK3_1	642	649	PF00069	0.647
MOD_GSK3_1	661	668	PF00069	0.661
MOD_GSK3_1	701	708	PF00069	0.686
MOD_GSK3_1	73	80	PF00069	0.697
MOD_GSK3_1	741	748	PF00069	0.798
MOD_GSK3_1	759	766	PF00069	0.646
MOD_GSK3_1	809	816	PF00069	0.631
MOD_GSK3_1	820	827	PF00069	0.480
MOD_N-GLC_1	104	109	PF02516	0.675
MOD_N-GLC_1	39	44	PF02516	0.775
MOD_N-GLC_2	26	28	PF02516	0.748
MOD_NEK2_1	1	6	PF00069	0.720
MOD_NEK2_1	164	169	PF00069	0.636
MOD_NEK2_1	209	214	PF00069	0.654
MOD_NEK2_1	226	231	PF00069	0.743
MOD_NEK2_1	342	347	PF00069	0.733
MOD_NEK2_1	361	366	PF00069	0.821
MOD_NEK2_1	565	570	PF00069	0.609
MOD_NEK2_1	689	694	PF00069	0.792
MOD_NEK2_1	746	751	PF00069	0.801
MOD_NEK2_1	837	842	PF00069	0.502
MOD_NEK2_1	906	911	PF00069	0.499
MOD_NEK2_2	308	313	PF00069	0.749
MOD_NEK2_2	614	619	PF00069	0.724
MOD_PIKK_1	129	135	PF00454	0.785
MOD_PIKK_1	171	177	PF00454	0.769
MOD_PIKK_1	469	475	PF00454	0.640
MOD_PIKK_1	565	571	PF00454	0.630
MOD_PIKK_1	687	693	PF00454	0.672
MOD_PIKK_1	705	711	PF00454	0.640
MOD_PKA_2	1	7	PF00069	0.780
MOD_PKA_2	141	147	PF00069	0.750
MOD_PKA_2	209	215	PF00069	0.776
MOD_PKA_2	216	222	PF00069	0.665
MOD_PKA_2	265	271	PF00069	0.745
MOD_PKA_2	364	370	PF00069	0.569
MOD_PKA_2	469	475	PF00069	0.640
MOD_PKA_2	511	517	PF00069	0.593
MOD_PKA_2	746	752	PF00069	0.596
MOD_PKA_2	77	83	PF00069	0.740
MOD_PKA_2	897	903	PF00069	0.529
MOD_PKB_1	713	721	PF00069	0.557
MOD_Plk_1	280	286	PF00069	0.741
MOD_Plk_1	733	739	PF00069	0.758
MOD_Plk_1	741	747	PF00069	0.648
MOD_Plk_4	147	153	PF00069	0.668
MOD_Plk_4	290	296	PF00069	0.697
MOD_Plk_4	372	378	PF00069	0.675
MOD_Plk_4	422	428	PF00069	0.398
MOD_Plk_4	614	620	PF00069	0.667
MOD_Plk_4	85	91	PF00069	0.686
MOD_ProDKin_1	108	114	PF00069	0.592
MOD_ProDKin_1	126	132	PF00069	0.768
MOD_ProDKin_1	199	205	PF00069	0.732
MOD_ProDKin_1	217	223	PF00069	0.633
MOD_ProDKin_1	284	290	PF00069	0.769
MOD_ProDKin_1	295	301	PF00069	0.628
MOD_ProDKin_1	317	323	PF00069	0.812
MOD_ProDKin_1	328	334	PF00069	0.625
MOD_ProDKin_1	343	349	PF00069	0.656
MOD_ProDKin_1	437	443	PF00069	0.658
MOD_ProDKin_1	6	12	PF00069	0.671
MOD_ProDKin_1	63	69	PF00069	0.705
MOD_ProDKin_1	646	652	PF00069	0.793
MOD_ProDKin_1	658	664	PF00069	0.649
MOD_ProDKin_1	747	753	PF00069	0.688
MOD_SUMO_rev_2	331	340	PF00179	0.630
TRG_DiLeu_BaEn_2	901	907	PF01217	0.618
TRG_ENDOCYTIC_2	292	295	PF00928	0.738
TRG_ENDOCYTIC_2	531	534	PF00928	0.513
TRG_ENDOCYTIC_2	834	837	PF00928	0.585
TRG_ER_diArg_1	247	250	PF00400	0.771
TRG_ER_diArg_1	46	49	PF00400	0.790
TRG_ER_diArg_1	57	59	PF00400	0.648
TRG_ER_diArg_1	588	591	PF00400	0.676
TRG_ER_diArg_1	712	715	PF00400	0.667
TRG_Pf-PMV_PEXEL_1	579	584	PF00026	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPU3	Leishmania donovani	91%	100%
A4H4Y3	Leishmania braziliensis	67%	100%
A4HT31	Leishmania infantum	90%	100%
E9AL48	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%