EamA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EamA-like transporter family, putative

Species:

Leishmania major

UniProt:

Q4QIQ3_LEIMA

TriTrypDb:

LmjF.07.0400 , LMJLV39_070010100 , LMJSD75_070010300

Length:

611

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QIQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIQ3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.699
CLV_C14_Caspase3-7	329	333	PF00656	0.655
CLV_C14_Caspase3-7	455	459	PF00656	0.361
CLV_NRD_NRD_1	123	125	PF00675	0.367
CLV_NRD_NRD_1	341	343	PF00675	0.436
CLV_NRD_NRD_1	362	364	PF00675	0.472
CLV_NRD_NRD_1	369	371	PF00675	0.441
CLV_NRD_NRD_1	374	376	PF00675	0.266
CLV_NRD_NRD_1	379	381	PF00675	0.312
CLV_PCSK_FUR_1	121	125	PF00082	0.366
CLV_PCSK_FUR_1	367	371	PF00082	0.448
CLV_PCSK_FUR_1	372	376	PF00082	0.266
CLV_PCSK_KEX2_1	123	125	PF00082	0.367
CLV_PCSK_KEX2_1	341	343	PF00082	0.436
CLV_PCSK_KEX2_1	361	363	PF00082	0.470
CLV_PCSK_KEX2_1	369	371	PF00082	0.441
CLV_PCSK_KEX2_1	374	376	PF00082	0.266
CLV_PCSK_KEX2_1	379	381	PF00082	0.327
CLV_PCSK_PC7_1	365	371	PF00082	0.489
CLV_PCSK_PC7_1	375	381	PF00082	0.238
CLV_PCSK_SKI1_1	268	272	PF00082	0.523
CLV_PCSK_SKI1_1	383	387	PF00082	0.358
CLV_PCSK_SKI1_1	97	101	PF00082	0.482
DEG_APCC_DBOX_1	34	42	PF00400	0.567
DEG_APCC_DBOX_1	374	382	PF00400	0.466
DOC_ANK_TNKS_1	9	16	PF00023	0.609
DOC_CKS1_1	249	254	PF01111	0.711
DOC_CKS1_1	572	577	PF01111	0.299
DOC_CYCLIN_RxL_1	265	275	PF00134	0.673
DOC_CYCLIN_yClb5_NLxxxL_5	544	553	PF00134	0.299
DOC_CYCLIN_yCln2_LP_2	430	436	PF00134	0.458
DOC_CYCLIN_yCln2_LP_2	560	566	PF00134	0.299
DOC_CYCLIN_yCln2_LP_2	572	578	PF00134	0.299
DOC_MAPK_gen_1	379	388	PF00069	0.508
DOC_MAPK_MEF2A_6	316	324	PF00069	0.665
DOC_MAPK_MEF2A_6	438	446	PF00069	0.275
DOC_MAPK_MEF2A_6	51	60	PF00069	0.556
DOC_MAPK_MEF2A_6	64	73	PF00069	0.509
DOC_PP4_FxxP_1	512	515	PF00568	0.282
DOC_PP4_FxxP_1	528	531	PF00568	0.381
DOC_PP4_FxxP_1	95	98	PF00568	0.368
DOC_USP7_MATH_1	172	176	PF00917	0.677
DOC_USP7_MATH_1	308	312	PF00917	0.631
DOC_USP7_MATH_1	481	485	PF00917	0.299
DOC_WW_Pin1_4	122	127	PF00397	0.582
DOC_WW_Pin1_4	179	184	PF00397	0.689
DOC_WW_Pin1_4	205	210	PF00397	0.683
DOC_WW_Pin1_4	244	249	PF00397	0.726
DOC_WW_Pin1_4	3	8	PF00397	0.681
DOC_WW_Pin1_4	559	564	PF00397	0.299
DOC_WW_Pin1_4	571	576	PF00397	0.299
LIG_14-3-3_CanoR_1	202	209	PF00244	0.650
LIG_14-3-3_CanoR_1	291	298	PF00244	0.690
LIG_14-3-3_CanoR_1	374	379	PF00244	0.469
LIG_14-3-3_CanoR_1	57	63	PF00244	0.552
LIG_BIR_III_4	24	28	PF00653	0.660
LIG_BIR_III_4	264	268	PF00653	0.633
LIG_BIR_III_4	458	462	PF00653	0.393
LIG_BRCT_BRCA1_1	474	478	PF00533	0.303
LIG_BRCT_BRCA1_1	91	95	PF00533	0.355
LIG_BRCT_BRCA1_2	91	97	PF00533	0.353
LIG_Clathr_ClatBox_1	260	264	PF01394	0.639
LIG_FHA_1	131	137	PF00498	0.721
LIG_FHA_1	17	23	PF00498	0.754
LIG_FHA_1	249	255	PF00498	0.733
LIG_FHA_1	291	297	PF00498	0.692
LIG_FHA_1	415	421	PF00498	0.299
LIG_FHA_1	447	453	PF00498	0.299
LIG_FHA_1	481	487	PF00498	0.299
LIG_FHA_1	559	565	PF00498	0.299
LIG_FHA_1	571	577	PF00498	0.299
LIG_FHA_2	123	129	PF00498	0.575
LIG_FHA_2	323	329	PF00498	0.648
LIG_FHA_2	338	344	PF00498	0.736
LIG_FHA_2	521	527	PF00498	0.385
LIG_GBD_Chelix_1	564	572	PF00786	0.299
LIG_LIR_Apic_2	526	531	PF02991	0.337
LIG_LIR_Apic_2	92	98	PF02991	0.347
LIG_LIR_Gen_1	418	429	PF02991	0.282
LIG_LIR_Gen_1	532	541	PF02991	0.308
LIG_LIR_Nem_3	418	424	PF02991	0.282
LIG_LIR_Nem_3	532	536	PF02991	0.369
LIG_LIR_Nem_3	82	88	PF02991	0.518
LIG_MLH1_MIPbox_1	474	478	PF16413	0.299
LIG_MYND_1	252	256	PF01753	0.703
LIG_PDZ_Class_2	606	611	PF00595	0.321
LIG_Pex14_1	112	116	PF04695	0.299
LIG_Pex14_2	100	104	PF04695	0.278
LIG_Pex14_2	388	392	PF04695	0.299
LIG_Pex14_2	95	99	PF04695	0.338
LIG_PTB_Apo_2	110	117	PF02174	0.299
LIG_PTB_Apo_2	393	400	PF02174	0.299
LIG_PTB_Apo_2	506	513	PF02174	0.277
LIG_SH2_CRK	482	486	PF00017	0.299
LIG_SH2_GRB2like	103	106	PF00017	0.299
LIG_SH2_NCK_1	305	309	PF00017	0.639
LIG_SH2_STAP1	482	486	PF00017	0.299
LIG_SH2_STAT5	103	106	PF00017	0.243
LIG_SH2_STAT5	397	400	PF00017	0.299
LIG_SH2_STAT5	482	485	PF00017	0.299
LIG_SH2_STAT5	593	596	PF00017	0.358
LIG_SH2_STAT5	88	91	PF00017	0.419
LIG_SH3_3	246	252	PF00018	0.741
LIG_SH3_3	384	390	PF00018	0.311
LIG_SUMO_SIM_anti_2	317	329	PF11976	0.662
LIG_SUMO_SIM_par_1	259	264	PF11976	0.640
LIG_SUMO_SIM_par_1	442	447	PF11976	0.311
LIG_SUMO_SIM_par_1	469	475	PF11976	0.277
LIG_SUMO_SIM_par_1	516	521	PF11976	0.358
LIG_SUMO_SIM_par_1	537	543	PF11976	0.229
LIG_TRAF2_1	150	153	PF00917	0.740
LIG_TRAF2_1	315	318	PF00917	0.697
LIG_UBA3_1	58	64	PF00899	0.424
LIG_UBA3_1	89	97	PF00899	0.401
LIG_WW_1	224	227	PF00397	0.672
LIG_WW_3	358	362	PF00397	0.640
MOD_CDK_SPK_2	248	253	PF00069	0.610
MOD_CDK_SPxxK_3	3	10	PF00069	0.605
MOD_CK1_1	179	185	PF00069	0.658
MOD_CK1_1	205	211	PF00069	0.590
MOD_CK1_1	235	241	PF00069	0.627
MOD_CK1_1	3	9	PF00069	0.543
MOD_CK1_1	306	312	PF00069	0.561
MOD_CK1_1	404	410	PF00069	0.299
MOD_CK1_1	415	421	PF00069	0.299
MOD_CK1_1	571	577	PF00069	0.299
MOD_CK2_1	146	152	PF00069	0.781
MOD_CK2_1	266	272	PF00069	0.591
MOD_CK2_1	311	317	PF00069	0.561
MOD_CK2_1	337	343	PF00069	0.576
MOD_CK2_1	520	526	PF00069	0.397
MOD_CMANNOS	530	533	PF00535	0.450
MOD_GlcNHglycan	11	14	PF01048	0.660
MOD_GlcNHglycan	118	121	PF01048	0.493
MOD_GlcNHglycan	178	181	PF01048	0.669
MOD_GlcNHglycan	234	237	PF01048	0.675
MOD_GlcNHglycan	240	243	PF01048	0.558
MOD_GlcNHglycan	284	287	PF01048	0.630
MOD_GlcNHglycan	310	313	PF01048	0.558
MOD_GlcNHglycan	446	449	PF01048	0.372
MOD_GlcNHglycan	474	477	PF01048	0.416
MOD_GlcNHglycan	589	592	PF01048	0.313
MOD_GSK3_1	142	149	PF00069	0.649
MOD_GSK3_1	172	179	PF00069	0.730
MOD_GSK3_1	181	188	PF00069	0.614
MOD_GSK3_1	208	215	PF00069	0.611
MOD_GSK3_1	244	251	PF00069	0.699
MOD_GSK3_1	259	266	PF00069	0.683
MOD_GSK3_1	26	33	PF00069	0.418
MOD_GSK3_1	278	285	PF00069	0.603
MOD_GSK3_1	303	310	PF00069	0.571
MOD_GSK3_1	318	325	PF00069	0.559
MOD_GSK3_1	399	406	PF00069	0.299
MOD_GSK3_1	409	416	PF00069	0.299
MOD_GSK3_1	442	449	PF00069	0.448
MOD_GSK3_1	540	547	PF00069	0.402
MOD_GSK3_1	554	561	PF00069	0.228
MOD_GSK3_1	564	571	PF00069	0.299
MOD_GSK3_1	99	106	PF00069	0.307
MOD_LATS_1	174	180	PF00433	0.591
MOD_N-GLC_1	104	109	PF02516	0.305
MOD_N-GLC_1	353	358	PF02516	0.637
MOD_N-GLC_1	399	404	PF02516	0.299
MOD_N-GLC_1	46	51	PF02516	0.346
MOD_N-GLC_1	547	552	PF02516	0.299
MOD_NEK2_1	116	121	PF00069	0.465
MOD_NEK2_1	185	190	PF00069	0.631
MOD_NEK2_1	200	205	PF00069	0.601
MOD_NEK2_1	232	237	PF00069	0.666
MOD_NEK2_1	307	312	PF00069	0.562
MOD_NEK2_1	399	404	PF00069	0.299
MOD_NEK2_1	414	419	PF00069	0.299
MOD_NEK2_1	423	428	PF00069	0.299
MOD_NEK2_1	444	449	PF00069	0.358
MOD_NEK2_1	520	525	PF00069	0.402
MOD_NEK2_1	540	545	PF00069	0.183
MOD_NEK2_1	568	573	PF00069	0.299
MOD_NEK2_1	58	63	PF00069	0.549
MOD_NEK2_1	73	78	PF00069	0.257
MOD_NEK2_1	99	104	PF00069	0.301
MOD_NEK2_2	46	51	PF00069	0.346
MOD_PIKK_1	130	136	PF00454	0.599
MOD_PIKK_1	219	225	PF00454	0.674
MOD_PIKK_1	30	36	PF00454	0.432
MOD_PKA_1	374	380	PF00069	0.358
MOD_PKA_2	290	296	PF00069	0.619
MOD_PKA_2	374	380	PF00069	0.299
MOD_PKA_2	9	15	PF00069	0.569
MOD_PKB_1	372	380	PF00069	0.358
MOD_Plk_1	161	167	PF00069	0.590
MOD_Plk_1	303	309	PF00069	0.608
MOD_Plk_1	399	405	PF00069	0.299
MOD_Plk_1	46	52	PF00069	0.351
MOD_Plk_4	26	32	PF00069	0.490
MOD_Plk_4	318	324	PF00069	0.578
MOD_Plk_4	409	415	PF00069	0.299
MOD_Plk_4	416	422	PF00069	0.299
MOD_Plk_4	425	431	PF00069	0.299
MOD_Plk_4	446	452	PF00069	0.289
MOD_Plk_4	481	487	PF00069	0.299
MOD_Plk_4	540	546	PF00069	0.358
MOD_Plk_4	73	79	PF00069	0.296
MOD_Plk_4	80	86	PF00069	0.294
MOD_Plk_4	99	105	PF00069	0.183
MOD_ProDKin_1	122	128	PF00069	0.462
MOD_ProDKin_1	179	185	PF00069	0.611
MOD_ProDKin_1	205	211	PF00069	0.602
MOD_ProDKin_1	244	250	PF00069	0.664
MOD_ProDKin_1	3	9	PF00069	0.602
MOD_ProDKin_1	559	565	PF00069	0.299
MOD_ProDKin_1	571	577	PF00069	0.299
TRG_DiLeu_BaLyEn_6	535	540	PF01217	0.299
TRG_DiLeu_BaLyEn_6	54	59	PF01217	0.438
TRG_ENDOCYTIC_2	482	485	PF00928	0.299
TRG_ER_diArg_1	122	124	PF00400	0.439
TRG_ER_diArg_1	35	38	PF00400	0.509
TRG_ER_diArg_1	360	363	PF00400	0.585
TRG_ER_diArg_1	364	367	PF00400	0.571
TRG_ER_diArg_1	369	372	PF00400	0.533
TRG_ER_diArg_1	373	375	PF00400	0.289
TRG_ER_diArg_1	378	380	PF00400	0.349
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	268	272	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM12	Leptomonas seymouri	58%	94%
A0A3S7WPT7	Leishmania donovani	93%	100%
A4H4Y6	Leishmania braziliensis	69%	95%
A4HT28	Leishmania infantum	93%	100%
E9AL51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%