SIN1_PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIQ2_LEIMA

TriTrypDb:

LmjF.07.0410 , LMJLV39_070010200 , LMJSD75_070010400

Length:

515

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIQ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	64	68	PF00656	0.564
CLV_NRD_NRD_1	21	23	PF00675	0.591
CLV_NRD_NRD_1	476	478	PF00675	0.377
CLV_NRD_NRD_1	479	481	PF00675	0.380
CLV_PCSK_KEX2_1	155	157	PF00082	0.475
CLV_PCSK_KEX2_1	476	478	PF00082	0.397
CLV_PCSK_KEX2_1	481	483	PF00082	0.399
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.488
CLV_PCSK_PC1ET2_1	481	483	PF00082	0.437
CLV_PCSK_PC7_1	477	483	PF00082	0.453
CLV_PCSK_SKI1_1	155	159	PF00082	0.515
CLV_PCSK_SKI1_1	236	240	PF00082	0.534
CLV_PCSK_SKI1_1	243	247	PF00082	0.504
CLV_PCSK_SKI1_1	334	338	PF00082	0.413
CLV_PCSK_SKI1_1	363	367	PF00082	0.732
CLV_PCSK_SKI1_1	424	428	PF00082	0.325
CLV_PCSK_SKI1_1	499	503	PF00082	0.555
CLV_PCSK_SKI1_1	72	76	PF00082	0.656
CLV_Separin_Metazoa	360	364	PF03568	0.665
DEG_Kelch_Keap1_1	205	210	PF01344	0.547
DOC_MAPK_FxFP_2	238	241	PF00069	0.510
DOC_MAPK_gen_1	155	161	PF00069	0.628
DOC_MAPK_gen_1	424	434	PF00069	0.411
DOC_MAPK_MEF2A_6	155	163	PF00069	0.498
DOC_MAPK_MEF2A_6	252	260	PF00069	0.534
DOC_PP1_RVXF_1	111	118	PF00149	0.558
DOC_PP4_FxxP_1	238	241	PF00568	0.510
DOC_SPAK_OSR1_1	341	345	PF12202	0.419
DOC_USP7_MATH_1	136	140	PF00917	0.548
DOC_USP7_MATH_1	412	416	PF00917	0.439
DOC_USP7_MATH_1	45	49	PF00917	0.651
DOC_USP7_UBL2_3	23	27	PF12436	0.615
LIG_14-3-3_CanoR_1	144	150	PF00244	0.453
LIG_14-3-3_CanoR_1	156	162	PF00244	0.412
LIG_14-3-3_CanoR_1	191	199	PF00244	0.441
LIG_14-3-3_CanoR_1	334	340	PF00244	0.411
LIG_14-3-3_CanoR_1	411	419	PF00244	0.318
LIG_14-3-3_CanoR_1	44	54	PF00244	0.515
LIG_14-3-3_CanoR_1	72	80	PF00244	0.647
LIG_APCC_ABBA_1	432	437	PF00400	0.331
LIG_BIR_III_2	135	139	PF00653	0.483
LIG_BRCT_BRCA1_1	128	132	PF00533	0.648
LIG_BRCT_BRCA1_1	448	452	PF00533	0.331
LIG_BRCT_BRCA1_1	505	509	PF00533	0.517
LIG_Clathr_ClatBox_1	399	403	PF01394	0.411
LIG_deltaCOP1_diTrp_1	35	43	PF00928	0.603
LIG_FHA_1	122	128	PF00498	0.666
LIG_FHA_1	138	144	PF00498	0.570
LIG_FHA_1	156	162	PF00498	0.344
LIG_FHA_1	242	248	PF00498	0.511
LIG_FHA_1	249	255	PF00498	0.495
LIG_FHA_1	357	363	PF00498	0.659
LIG_FHA_1	364	370	PF00498	0.449
LIG_FHA_2	206	212	PF00498	0.443
LIG_FHA_2	248	254	PF00498	0.475
LIG_FHA_2	423	429	PF00498	0.376
LIG_FHA_2	59	65	PF00498	0.533
LIG_FHA_2	7	13	PF00498	0.615
LIG_HCF-1_HBM_1	405	408	PF13415	0.411
LIG_Integrin_isoDGR_2	350	352	PF01839	0.540
LIG_LIR_Gen_1	35	45	PF02991	0.675
LIG_LIR_Gen_1	380	389	PF02991	0.302
LIG_LIR_Nem_3	167	171	PF02991	0.511
LIG_LIR_Nem_3	316	320	PF02991	0.461
LIG_LIR_Nem_3	35	40	PF02991	0.655
LIG_LIR_Nem_3	380	384	PF02991	0.302
LIG_PCNA_yPIPBox_3	191	202	PF02747	0.476
LIG_PCNA_yPIPBox_3	44	58	PF02747	0.588
LIG_SH2_CRK	26	30	PF00017	0.553
LIG_SH2_GRB2like	317	320	PF00017	0.461
LIG_SH2_STAT5	408	411	PF00017	0.300
LIG_SH2_STAT5	446	449	PF00017	0.321
LIG_SH3_3	259	265	PF00018	0.476
LIG_SH3_3	324	330	PF00018	0.579
LIG_TRAF2_1	208	211	PF00917	0.428
LIG_TRAF2_1	353	356	PF00917	0.612
LIG_WRC_WIRS_1	146	151	PF05994	0.458
MOD_CK1_1	126	132	PF00069	0.647
MOD_CK2_1	136	142	PF00069	0.596
MOD_CK2_1	205	211	PF00069	0.433
MOD_CK2_1	447	453	PF00069	0.273
MOD_CK2_1	58	64	PF00069	0.511
MOD_Cter_Amidation	153	156	PF01082	0.468
MOD_GlcNHglycan	295	298	PF01048	0.539
MOD_GSK3_1	119	126	PF00069	0.703
MOD_GSK3_1	157	164	PF00069	0.595
MOD_GSK3_1	186	193	PF00069	0.431
MOD_GSK3_1	281	288	PF00069	0.600
MOD_GSK3_1	418	425	PF00069	0.393
MOD_GSK3_1	499	506	PF00069	0.602
MOD_N-GLC_1	161	166	PF02516	0.584
MOD_N-GLC_1	184	189	PF02516	0.411
MOD_N-GLC_1	222	227	PF02516	0.448
MOD_N-GLC_1	247	252	PF02516	0.566
MOD_N-GLC_1	254	259	PF02516	0.457
MOD_N-GLC_1	412	417	PF02516	0.411
MOD_N-GLC_1	45	50	PF02516	0.650
MOD_N-GLC_1	492	497	PF02516	0.506
MOD_NEK2_1	107	112	PF00069	0.484
MOD_NEK2_1	121	126	PF00069	0.497
MOD_NEK2_1	157	162	PF00069	0.528
MOD_NEK2_1	246	251	PF00069	0.597
MOD_NEK2_1	285	290	PF00069	0.531
MOD_NEK2_1	457	462	PF00069	0.393
MOD_PIKK_1	102	108	PF00454	0.677
MOD_PIKK_1	121	127	PF00454	0.477
MOD_PIKK_1	161	167	PF00454	0.611
MOD_PIKK_1	186	192	PF00454	0.560
MOD_PK_1	93	99	PF00069	0.549
MOD_PKA_1	155	161	PF00069	0.470
MOD_PKA_2	107	113	PF00069	0.489
MOD_PKA_2	155	161	PF00069	0.560
MOD_PKA_2	190	196	PF00069	0.470
MOD_Plk_1	184	190	PF00069	0.579
MOD_Plk_1	222	228	PF00069	0.454
MOD_Plk_1	254	260	PF00069	0.477
MOD_Plk_1	285	291	PF00069	0.539
MOD_Plk_1	332	338	PF00069	0.409
MOD_Plk_1	422	428	PF00069	0.393
MOD_Plk_1	492	498	PF00069	0.482
MOD_Plk_4	123	129	PF00069	0.568
MOD_Plk_4	145	151	PF00069	0.537
MOD_Plk_4	335	341	PF00069	0.436
MOD_SUMO_for_1	491	494	PF00179	0.579
MOD_SUMO_rev_2	147	157	PF00179	0.491
TRG_DiLeu_BaLyEn_6	395	400	PF01217	0.411
TRG_ENDOCYTIC_2	168	171	PF00928	0.564
TRG_ENDOCYTIC_2	199	202	PF00928	0.528
TRG_ENDOCYTIC_2	317	320	PF00928	0.505
TRG_ENDOCYTIC_2	441	444	PF00928	0.281
TRG_ER_diArg_1	475	477	PF00400	0.420
TRG_ER_diArg_1	479	482	PF00400	0.444
TRG_ER_diArg_1	504	507	PF00400	0.551
TRG_NES_CRM1_1	364	377	PF08389	0.580
TRG_Pf-PMV_PEXEL_1	113	118	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	261	266	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	398	403	PF00026	0.293
TRG_Pf-PMV_PEXEL_1	424	428	PF00026	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9I2	Leptomonas seymouri	72%	99%
A0A0S4ILP7	Bodo saltans	40%	100%
A0A1X0NPY0	Trypanosomatidae	49%	100%
A0A3R7KA86	Trypanosoma rangeli	51%	100%
A0A3S7WPU9	Leishmania donovani	98%	100%
A4H4Y7	Leishmania braziliensis	85%	100%
C9ZUR3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AG73	Leishmania infantum	98%	100%
E9AL52	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5D8S1	Trypanosoma cruzi	49%	100%