Putative 3-hydroxyacyl-ACP dehydratase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3-hydroxyacyl-ACP dehydratase, putative

Species:

Leishmania major

UniProt:

Q4QIP9_LEIMA

TriTrypDb:

LmjF.07.0440 , LMJLV39_070010500 , LMJSD75_070010700

Length:

157

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 32

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0005739	mitochondrion	5	3
GO:0031974	membrane-enclosed lumen	2	3
GO:0031981	nuclear lumen	5	3
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0043233	organelle lumen	3	3
GO:0070013	intracellular organelle lumen	4	3
GO:0097014	ciliary plasm	5	3
GO:0099568	cytoplasmic region	3	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QIP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIP9

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	3
GO:0006629	lipid metabolic process	3	3
GO:0006631	fatty acid metabolic process	4	3
GO:0006633	fatty acid biosynthetic process	5	3
GO:0008152	metabolic process	1	3
GO:0008610	lipid biosynthetic process	4	3
GO:0009058	biosynthetic process	2	3
GO:0009987	cellular process	1	3
GO:0016053	organic acid biosynthetic process	4	3
GO:0019752	carboxylic acid metabolic process	5	3
GO:0032787	monocarboxylic acid metabolic process	6	3
GO:0043436	oxoacid metabolic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044249	cellular biosynthetic process	3	3
GO:0044255	cellular lipid metabolic process	3	3
GO:0044281	small molecule metabolic process	2	3
GO:0044283	small molecule biosynthetic process	3	3
GO:0046394	carboxylic acid biosynthetic process	5	3
GO:0071704	organic substance metabolic process	2	3
GO:0072330	monocarboxylic acid biosynthetic process	6	3
GO:1901576	organic substance biosynthetic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016829	lyase activity	2	8
GO:0016835	carbon-oxygen lyase activity	3	3
GO:0016836	hydro-lyase activity	4	3
GO:0019171	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	5	3
GO:0004312	fatty acid synthase activity	5	1
GO:0016740	transferase activity	2	1
GO:0016746	acyltransferase activity	3	1
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.332
CLV_NRD_NRD_1	155	157	PF00675	0.437
CLV_NRD_NRD_1	6	8	PF00675	0.405
CLV_PCSK_FUR_1	105	109	PF00082	0.198
CLV_PCSK_KEX2_1	107	109	PF00082	0.303
CLV_PCSK_KEX2_1	155	157	PF00082	0.437
CLV_PCSK_KEX2_1	6	8	PF00082	0.407
CLV_PCSK_SKI1_1	17	21	PF00082	0.270
CLV_PCSK_SKI1_1	89	93	PF00082	0.259
DEG_Nend_UBRbox_3	1	3	PF02207	0.571
DOC_PP1_RVXF_1	141	148	PF00149	0.384
DOC_PP4_FxxP_1	51	54	PF00568	0.338
DOC_PP4_FxxP_1	87	90	PF00568	0.298
DOC_USP7_MATH_1	13	17	PF00917	0.284
DOC_USP7_MATH_1	38	42	PF00917	0.391
DOC_USP7_UBL2_3	121	125	PF12436	0.486
DOC_WW_Pin1_4	50	55	PF00397	0.338
LIG_Actin_RPEL_3	100	119	PF02755	0.281
LIG_BRCT_BRCA1_1	83	87	PF00533	0.244
LIG_FHA_1	16	22	PF00498	0.354
LIG_FHA_1	76	82	PF00498	0.418
LIG_FHA_1	86	92	PF00498	0.388
LIG_FHA_2	130	136	PF00498	0.331
LIG_FHA_2	20	26	PF00498	0.342
LIG_GBD_Chelix_1	60	68	PF00786	0.303
LIG_LIR_Apic_2	84	90	PF02991	0.303
LIG_LIR_Nem_3	28	32	PF02991	0.389
LIG_LIR_Nem_3	63	68	PF02991	0.300
LIG_Rb_LxCxE_1	128	148	PF01857	0.347
LIG_SH2_CRK	57	61	PF00017	0.320
LIG_SH2_STAT3	80	83	PF00017	0.298
LIG_SH2_STAT5	80	83	PF00017	0.314
LIG_SH3_1	121	127	PF00018	0.367
LIG_SH3_3	121	127	PF00018	0.382
LIG_SUMO_SIM_anti_2	95	101	PF11976	0.389
LIG_TYR_ITIM	55	60	PF00017	0.320
LIG_WRC_WIRS_1	26	31	PF05994	0.432
MOD_CK1_1	151	157	PF00069	0.530
MOD_CK1_1	63	69	PF00069	0.298
MOD_CK2_1	129	135	PF00069	0.388
MOD_GlcNHglycan	65	68	PF01048	0.314
MOD_GSK3_1	125	132	PF00069	0.409
MOD_GSK3_1	15	22	PF00069	0.439
MOD_GSK3_1	75	82	PF00069	0.314
MOD_NEK2_1	60	65	PF00069	0.256
MOD_NEK2_1	81	86	PF00069	0.307
MOD_NEK2_2	15	20	PF00069	0.388
MOD_PIKK_1	19	25	PF00454	0.331
MOD_PIKK_1	79	85	PF00454	0.314
MOD_PK_1	125	131	PF00069	0.308
MOD_PKA_2	85	91	PF00069	0.374
MOD_Plk_1	113	119	PF00069	0.377
MOD_Plk_2-3	25	31	PF00069	0.259
MOD_Plk_4	114	120	PF00069	0.358
MOD_Plk_4	60	66	PF00069	0.305
MOD_Plk_4	75	81	PF00069	0.298
MOD_ProDKin_1	50	56	PF00069	0.338
TRG_ENDOCYTIC_2	57	60	PF00928	0.264
TRG_ER_diArg_1	106	108	PF00400	0.285
TRG_ER_diArg_1	155	157	PF00400	0.437
TRG_ER_diArg_1	6	8	PF00400	0.419
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7R8	Leptomonas seymouri	65%	100%
A0A0N1I7V2	Leptomonas seymouri	69%	100%
A0A0S4J3A3	Bodo saltans	48%	96%
A0A1X0NPA8	Trypanosomatidae	55%	97%
A0A3S5H5X9	Leishmania donovani	63%	100%
A0A3S7WPU4	Leishmania donovani	96%	100%
A0A422NAR2	Trypanosoma rangeli	54%	100%
A4H4Z0	Leishmania braziliensis	87%	100%
A4HT65	Leishmania infantum	63%	100%
A4HT66	Leishmania infantum	96%	100%
C9ZUR2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	97%
E9AL54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
E9AL55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O32472	Aeromonas caviae	41%	100%
P86397	Homo sapiens	33%	93%
Q4QIQ0	Leishmania major	64%	100%