Putative acyl-CoA dehydrogenase, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyl-CoA dehydrogenase, mitochondrial precursor, putative

Species:

Leishmania major

UniProt:

Q4QIP7_LEIMA

TriTrypDb:

LmjF.07.0460 , LMJLV39_070010700 , LMJSD75_070010900

Length:

519

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIP7

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006629	lipid metabolic process	3	2
GO:0006631	fatty acid metabolic process	4	2
GO:0006635	fatty acid beta-oxidation	6	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009062	fatty acid catabolic process	5	2
GO:0009987	cellular process	1	2
GO:0016042	lipid catabolic process	4	2
GO:0016054	organic acid catabolic process	4	2
GO:0019395	fatty acid oxidation	5	2
GO:0019605	butyrate metabolic process	6	2
GO:0019626	short-chain fatty acid catabolic process	6	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0030258	lipid modification	4	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase	7	2
GO:0034440	lipid oxidation	5	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044242	cellular lipid catabolic process	4	2
GO:0044248	cellular catabolic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044282	small molecule catabolic process	3	2
GO:0046359	butyrate catabolic process	7	2
GO:0046395	carboxylic acid catabolic process	5	2
GO:0046459	short-chain fatty acid metabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0072329	monocarboxylic acid catabolic process	6	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0003995	acyl-CoA dehydrogenase activity	5	2
GO:0004085	butyryl-CoA dehydrogenase activity	6	2
GO:0005488	binding	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0050660	flavin adenine dinucleotide binding	4	12
GO:0052890	oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor	4	2
GO:0097159	organic cyclic compound binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.538
CLV_C14_Caspase3-7	407	411	PF00656	0.477
CLV_C14_Caspase3-7	92	96	PF00656	0.425
CLV_NRD_NRD_1	10	12	PF00675	0.581
CLV_NRD_NRD_1	2	4	PF00675	0.590
CLV_PCSK_KEX2_1	10	12	PF00082	0.581
CLV_PCSK_KEX2_1	168	170	PF00082	0.367
CLV_PCSK_KEX2_1	2	4	PF00082	0.590
CLV_PCSK_KEX2_1	261	263	PF00082	0.357
CLV_PCSK_KEX2_1	464	466	PF00082	0.551
CLV_PCSK_KEX2_1	506	508	PF00082	0.408
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.367
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.373
CLV_PCSK_PC1ET2_1	464	466	PF00082	0.551
CLV_PCSK_PC1ET2_1	506	508	PF00082	0.421
CLV_PCSK_SKI1_1	118	122	PF00082	0.320
CLV_PCSK_SKI1_1	123	127	PF00082	0.320
CLV_PCSK_SKI1_1	161	165	PF00082	0.473
CLV_PCSK_SKI1_1	184	188	PF00082	0.448
CLV_PCSK_SKI1_1	2	6	PF00082	0.661
CLV_PCSK_SKI1_1	208	212	PF00082	0.510
CLV_PCSK_SKI1_1	241	245	PF00082	0.465
CLV_PCSK_SKI1_1	348	352	PF00082	0.388
CLV_PCSK_SKI1_1	68	72	PF00082	0.385
CLV_Separin_Metazoa	515	519	PF03568	0.481
DEG_APCC_DBOX_1	347	355	PF00400	0.468
DEG_Nend_UBRbox_1	1	4	PF02207	0.639
DEG_SPOP_SBC_1	319	323	PF00917	0.476
DOC_MAPK_FxFP_2	33	36	PF00069	0.401
DOC_PP2B_LxvP_1	301	304	PF13499	0.485
DOC_PP4_FxxP_1	33	36	PF00568	0.401
DOC_USP7_MATH_1	289	293	PF00917	0.324
DOC_USP7_MATH_1	313	317	PF00917	0.423
DOC_USP7_MATH_1	34	38	PF00917	0.514
DOC_USP7_MATH_1	408	412	PF00917	0.435
DOC_USP7_MATH_1	451	455	PF00917	0.329
DOC_USP7_MATH_1	501	505	PF00917	0.533
DOC_WW_Pin1_4	222	227	PF00397	0.418
DOC_WW_Pin1_4	331	336	PF00397	0.516
LIG_14-3-3_CanoR_1	14	19	PF00244	0.384
LIG_14-3-3_CanoR_1	2	12	PF00244	0.610
LIG_14-3-3_CanoR_1	200	204	PF00244	0.396
LIG_14-3-3_CanoR_1	241	246	PF00244	0.465
LIG_14-3-3_CanoR_1	348	354	PF00244	0.437
LIG_14-3-3_CanoR_1	378	383	PF00244	0.482
LIG_14-3-3_CanoR_1	388	394	PF00244	0.468
LIG_14-3-3_CanoR_1	56	64	PF00244	0.451
LIG_14-3-3_CanoR_1	68	76	PF00244	0.121
LIG_Actin_WH2_2	252	270	PF00022	0.482
LIG_APCC_ABBA_1	243	248	PF00400	0.355
LIG_BRCT_BRCA1_1	355	359	PF00533	0.420
LIG_DLG_GKlike_1	14	22	PF00625	0.427
LIG_FHA_1	175	181	PF00498	0.362
LIG_FHA_1	200	206	PF00498	0.450
LIG_FHA_1	275	281	PF00498	0.399
LIG_FHA_1	296	302	PF00498	0.461
LIG_FHA_1	355	361	PF00498	0.409
LIG_FHA_1	377	383	PF00498	0.467
LIG_FHA_1	45	51	PF00498	0.323
LIG_FHA_1	482	488	PF00498	0.369
LIG_FHA_2	187	193	PF00498	0.514
LIG_FHA_2	469	475	PF00498	0.542
LIG_FHA_2	498	504	PF00498	0.462
LIG_FHA_2	90	96	PF00498	0.425
LIG_LIR_Apic_2	30	36	PF02991	0.398
LIG_LIR_Gen_1	177	186	PF02991	0.347
LIG_LIR_Gen_1	323	333	PF02991	0.517
LIG_LIR_Gen_1	477	487	PF02991	0.427
LIG_LIR_Nem_3	177	182	PF02991	0.351
LIG_LIR_Nem_3	202	206	PF02991	0.418
LIG_LIR_Nem_3	323	329	PF02991	0.505
LIG_LIR_Nem_3	370	375	PF02991	0.375
LIG_LIR_Nem_3	502	508	PF02991	0.431
LIG_LIR_Nem_3	71	76	PF02991	0.321
LIG_MAD2	26	34	PF02301	0.448
LIG_SH2_CRK	372	376	PF00017	0.457
LIG_SH2_CRK	505	509	PF00017	0.458
LIG_SH2_CRK	73	77	PF00017	0.320
LIG_SH2_SRC	250	253	PF00017	0.332
LIG_SH2_STAP1	252	256	PF00017	0.323
LIG_SH2_STAP1	295	299	PF00017	0.331
LIG_SH2_STAP1	361	365	PF00017	0.364
LIG_SH2_STAP1	449	453	PF00017	0.323
LIG_SH2_STAT5	110	113	PF00017	0.341
LIG_SH2_STAT5	12	15	PF00017	0.590
LIG_SH2_STAT5	124	127	PF00017	0.239
LIG_SH2_STAT5	162	165	PF00017	0.387
LIG_SH2_STAT5	179	182	PF00017	0.361
LIG_SH2_STAT5	250	253	PF00017	0.315
LIG_SH3_3	513	519	PF00018	0.571
LIG_Sin3_3	347	354	PF02671	0.458
LIG_SUMO_SIM_anti_2	325	332	PF11976	0.495
LIG_SUMO_SIM_par_1	240	248	PF11976	0.340
LIG_UBA3_1	256	261	PF00899	0.360
LIG_UBA3_1	51	60	PF00899	0.419
MOD_CK1_1	148	154	PF00069	0.475
MOD_CK1_1	199	205	PF00069	0.467
MOD_CK1_1	328	334	PF00069	0.454
MOD_CK1_1	42	48	PF00069	0.502
MOD_CK1_1	491	497	PF00069	0.519
MOD_CK2_1	186	192	PF00069	0.534
MOD_CK2_1	267	273	PF00069	0.568
MOD_CK2_1	305	311	PF00069	0.365
MOD_CK2_1	319	325	PF00069	0.339
MOD_CK2_1	349	355	PF00069	0.428
MOD_CK2_1	468	474	PF00069	0.542
MOD_GlcNHglycan	207	211	PF01048	0.456
MOD_GlcNHglycan	362	365	PF01048	0.456
MOD_GlcNHglycan	405	409	PF01048	0.486
MOD_GlcNHglycan	410	413	PF01048	0.438
MOD_GlcNHglycan	451	454	PF01048	0.337
MOD_GlcNHglycan	6	9	PF01048	0.675
MOD_GSK3_1	106	113	PF00069	0.204
MOD_GSK3_1	148	155	PF00069	0.438
MOD_GSK3_1	184	191	PF00069	0.467
MOD_GSK3_1	218	225	PF00069	0.476
MOD_GSK3_1	325	332	PF00069	0.438
MOD_GSK3_1	349	356	PF00069	0.441
MOD_GSK3_1	404	411	PF00069	0.457
MOD_GSK3_1	449	456	PF00069	0.338
MOD_GSK3_1	497	504	PF00069	0.548
MOD_GSK3_1	89	96	PF00069	0.380
MOD_N-GLC_1	426	431	PF02516	0.462
MOD_NEK2_1	111	116	PF00069	0.285
MOD_NEK2_1	186	191	PF00069	0.458
MOD_NEK2_1	196	201	PF00069	0.478
MOD_NEK2_1	206	211	PF00069	0.363
MOD_NEK2_1	22	27	PF00069	0.480
MOD_NEK2_1	257	262	PF00069	0.375
MOD_NEK2_1	267	272	PF00069	0.467
MOD_NEK2_1	290	295	PF00069	0.333
MOD_NEK2_1	318	323	PF00069	0.396
MOD_NEK2_1	349	354	PF00069	0.387
MOD_NEK2_1	359	364	PF00069	0.321
MOD_NEK2_1	376	381	PF00069	0.383
MOD_NEK2_1	404	409	PF00069	0.467
MOD_NEK2_1	460	465	PF00069	0.470
MOD_NEK2_1	475	480	PF00069	0.334
MOD_NEK2_1	78	83	PF00069	0.304
MOD_NEK2_1	98	103	PF00069	0.345
MOD_NEK2_2	313	318	PF00069	0.471
MOD_PIKK_1	184	190	PF00454	0.420
MOD_PIKK_1	426	432	PF00454	0.441
MOD_PK_1	211	217	PF00069	0.523
MOD_PKA_2	199	205	PF00069	0.386
MOD_PKA_2	267	273	PF00069	0.568
MOD_PKA_2	377	383	PF00069	0.496
MOD_PKA_2	55	61	PF00069	0.451
MOD_Plk_1	145	151	PF00069	0.446
MOD_Plk_1	290	296	PF00069	0.332
MOD_Plk_1	305	311	PF00069	0.379
MOD_Plk_1	404	410	PF00069	0.379
MOD_Plk_1	420	426	PF00069	0.369
MOD_Plk_1	491	497	PF00069	0.548
MOD_Plk_1	501	507	PF00069	0.514
MOD_Plk_2-3	302	308	PF00069	0.497
MOD_Plk_4	106	112	PF00069	0.386
MOD_Plk_4	199	205	PF00069	0.374
MOD_Plk_4	252	258	PF00069	0.292
MOD_Plk_4	290	296	PF00069	0.331
MOD_Plk_4	305	311	PF00069	0.371
MOD_Plk_4	313	319	PF00069	0.323
MOD_Plk_4	325	331	PF00069	0.210
MOD_Plk_4	349	355	PF00069	0.392
MOD_Plk_4	420	426	PF00069	0.400
MOD_Plk_4	443	449	PF00069	0.361
MOD_Plk_4	475	481	PF00069	0.463
MOD_ProDKin_1	222	228	PF00069	0.418
MOD_ProDKin_1	331	337	PF00069	0.510
MOD_SUMO_for_1	469	472	PF00179	0.454
MOD_SUMO_rev_2	129	134	PF00179	0.496
MOD_SUMO_rev_2	89	99	PF00179	0.389
TRG_DiLeu_BaEn_1	370	375	PF01217	0.495
TRG_DiLeu_BaEn_1	443	448	PF01217	0.343
TRG_DiLeu_BaEn_2	354	360	PF01217	0.352
TRG_DiLeu_BaLyEn_6	345	350	PF01217	0.422
TRG_ENDOCYTIC_2	179	182	PF00928	0.447
TRG_ENDOCYTIC_2	372	375	PF00928	0.368
TRG_ENDOCYTIC_2	505	508	PF00928	0.460
TRG_ENDOCYTIC_2	73	76	PF00928	0.304
TRG_ER_diArg_1	1	3	PF00400	0.603
TRG_ER_diArg_1	9	11	PF00400	0.583
TRG_NES_CRM1_1	386	397	PF08389	0.502
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I163	Leptomonas seymouri	83%	100%
A0A0S4JAW1	Bodo saltans	39%	81%
A0A1X0NP97	Trypanosomatidae	57%	99%
A0A3S5H5Y0	Leishmania donovani	97%	100%
A0A422NAN1	Trypanosoma rangeli	55%	99%
A4H4Z2	Leishmania braziliensis	89%	100%
A4HT68	Leishmania infantum	97%	100%
B1WC61	Rattus norvegicus	24%	83%
C9ZUR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AL57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
P45953	Rattus norvegicus	26%	79%
P48818	Bos taurus	25%	79%
P49748	Homo sapiens	24%	79%
P50544	Mus musculus	25%	79%
Q8HXY7	Macaca fascicularis	24%	79%
Q8JZN5	Mus musculus	24%	83%
Q9H845	Homo sapiens	25%	84%
V5BCS4	Trypanosoma cruzi	54%	99%