Bms1-type G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-rrna-processing protein tsr1 homolog

Species:

Leishmania major

UniProt:

Q4QIP6_LEIMA

TriTrypDb:

LmjF.07.0470 , LMJLV39_070010800 , LMJSD75_070011000

Length:

807

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0030684	preribosome	3	2
GO:0030688	preribosome, small subunit precursor	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4QIP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIP6

Function

Biological processes
Term	Name	Level	Count
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	2
GO:0000469	cleavage involved in rRNA processing	7	2
GO:0000478	endonucleolytic cleavage involved in rRNA processing	8	2
GO:0000479	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0030490	maturation of SSU-rRNA	9	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	2
GO:0090501	RNA phosphodiester bond hydrolysis	6	2
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	7	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:0022613	ribonucleoprotein complex biogenesis	4	9
GO:0042254	ribosome biogenesis	5	9
GO:0044085	cellular component biogenesis	3	9
GO:0071840	cellular component organization or biogenesis	2	9

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003824	catalytic activity	1	2
GO:0003924	GTPase activity	7	2
GO:0005488	binding	1	2
GO:0005525	GTP binding	5	2
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0019001	guanyl nucleotide binding	5	2
GO:0030515	snoRNA binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032561	guanyl ribonucleotide binding	5	2
GO:0034511	U3 snoRNA binding	6	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	545	549	PF00656	0.342
CLV_NRD_NRD_1	142	144	PF00675	0.458
CLV_NRD_NRD_1	349	351	PF00675	0.521
CLV_NRD_NRD_1	622	624	PF00675	0.264
CLV_NRD_NRD_1	746	748	PF00675	0.264
CLV_NRD_NRD_1	91	93	PF00675	0.538
CLV_PCSK_FUR_1	80	84	PF00082	0.542
CLV_PCSK_KEX2_1	704	706	PF00082	0.264
CLV_PCSK_KEX2_1	746	748	PF00082	0.264
CLV_PCSK_KEX2_1	780	782	PF00082	0.285
CLV_PCSK_KEX2_1	82	84	PF00082	0.434
CLV_PCSK_KEX2_1	91	93	PF00082	0.438
CLV_PCSK_PC1ET2_1	704	706	PF00082	0.264
CLV_PCSK_PC1ET2_1	780	782	PF00082	0.285
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.434
CLV_PCSK_SKI1_1	144	148	PF00082	0.390
CLV_PCSK_SKI1_1	191	195	PF00082	0.508
CLV_PCSK_SKI1_1	250	254	PF00082	0.412
CLV_PCSK_SKI1_1	291	295	PF00082	0.320
CLV_PCSK_SKI1_1	41	45	PF00082	0.522
CLV_PCSK_SKI1_1	505	509	PF00082	0.285
CLV_PCSK_SKI1_1	578	582	PF00082	0.415
CLV_PCSK_SKI1_1	653	657	PF00082	0.377
CLV_PCSK_SKI1_1	705	709	PF00082	0.264
CLV_PCSK_SKI1_1	723	727	PF00082	0.264
CLV_PCSK_SKI1_1	761	765	PF00082	0.354
CLV_PCSK_SKI1_1	780	784	PF00082	0.195
CLV_PCSK_SKI1_1	85	89	PF00082	0.493
DEG_APCC_DBOX_1	365	373	PF00400	0.451
DEG_Nend_UBRbox_3	1	3	PF02207	0.416
DOC_CDC14_PxL_1	670	678	PF14671	0.264
DOC_CKS1_1	228	233	PF01111	0.359
DOC_CKS1_1	494	499	PF01111	0.264
DOC_CYCLIN_RxL_1	575	584	PF00134	0.342
DOC_MAPK_gen_1	246	254	PF00069	0.342
DOC_MAPK_gen_1	350	358	PF00069	0.549
DOC_MAPK_MEF2A_6	165	174	PF00069	0.307
DOC_PP1_RVXF_1	289	296	PF00149	0.264
DOC_PP4_FxxP_1	657	660	PF00568	0.295
DOC_PP4_FxxP_1	671	674	PF00568	0.264
DOC_USP7_MATH_1	108	112	PF00917	0.379
DOC_USP7_MATH_1	164	168	PF00917	0.399
DOC_USP7_MATH_1	224	228	PF00917	0.464
DOC_USP7_MATH_1	271	275	PF00917	0.448
DOC_USP7_MATH_1	405	409	PF00917	0.557
DOC_USP7_MATH_1	45	49	PF00917	0.627
DOC_USP7_MATH_1	609	613	PF00917	0.285
DOC_USP7_MATH_1	62	66	PF00917	0.562
DOC_USP7_UBL2_3	69	73	PF12436	0.611
DOC_WW_Pin1_4	227	232	PF00397	0.363
DOC_WW_Pin1_4	493	498	PF00397	0.264
DOC_WW_Pin1_4	611	616	PF00397	0.299
DOC_WW_Pin1_4	625	630	PF00397	0.264
LIG_14-3-3_CanoR_1	24	29	PF00244	0.524
LIG_14-3-3_CanoR_1	257	263	PF00244	0.376
LIG_14-3-3_CanoR_1	448	457	PF00244	0.577
LIG_14-3-3_CanoR_1	467	475	PF00244	0.525
LIG_14-3-3_CanoR_1	510	516	PF00244	0.265
LIG_14-3-3_CanoR_1	602	610	PF00244	0.314
LIG_14-3-3_CanoR_1	653	658	PF00244	0.299
LIG_BRCT_BRCA1_1	3	7	PF00533	0.406
LIG_BRCT_BRCA1_1	627	631	PF00533	0.264
LIG_BRCT_BRCA1_1	8	12	PF00533	0.399
LIG_deltaCOP1_diTrp_1	590	598	PF00928	0.264
LIG_Dynein_DLC8_1	446	452	PF01221	0.630
LIG_eIF4E_1	663	669	PF01652	0.377
LIG_FHA_1	112	118	PF00498	0.368
LIG_FHA_1	216	222	PF00498	0.379
LIG_FHA_1	228	234	PF00498	0.368
LIG_FHA_1	264	270	PF00498	0.440
LIG_FHA_1	277	283	PF00498	0.240
LIG_FHA_1	3	9	PF00498	0.408
LIG_FHA_1	311	317	PF00498	0.393
LIG_FHA_1	328	334	PF00498	0.176
LIG_FHA_1	338	344	PF00498	0.234
LIG_FHA_1	396	402	PF00498	0.564
LIG_FHA_1	612	618	PF00498	0.305
LIG_FHA_1	698	704	PF00498	0.319
LIG_FHA_1	749	755	PF00498	0.292
LIG_FHA_2	181	187	PF00498	0.449
LIG_FHA_2	192	198	PF00498	0.555
LIG_FHA_2	240	246	PF00498	0.388
LIG_FHA_2	375	381	PF00498	0.553
LIG_FHA_2	383	389	PF00498	0.515
LIG_FHA_2	431	437	PF00498	0.679
LIG_FHA_2	448	454	PF00498	0.553
LIG_FHA_2	467	473	PF00498	0.501
LIG_FHA_2	799	805	PF00498	0.608
LIG_FXI_DFP_1	126	130	PF00024	0.441
LIG_LIR_Apic_2	656	660	PF02991	0.264
LIG_LIR_Apic_2	731	737	PF02991	0.280
LIG_LIR_Gen_1	133	142	PF02991	0.504
LIG_LIR_Gen_1	167	174	PF02991	0.330
LIG_LIR_Gen_1	204	214	PF02991	0.515
LIG_LIR_Gen_1	276	285	PF02991	0.310
LIG_LIR_Gen_1	590	600	PF02991	0.264
LIG_LIR_Gen_1	628	638	PF02991	0.290
LIG_LIR_Gen_1	640	646	PF02991	0.256
LIG_LIR_Gen_1	9	20	PF02991	0.409
LIG_LIR_Nem_3	133	139	PF02991	0.520
LIG_LIR_Nem_3	167	172	PF02991	0.328
LIG_LIR_Nem_3	204	210	PF02991	0.466
LIG_LIR_Nem_3	276	281	PF02991	0.305
LIG_LIR_Nem_3	590	596	PF02991	0.264
LIG_LIR_Nem_3	628	634	PF02991	0.290
LIG_LIR_Nem_3	640	645	PF02991	0.256
LIG_LIR_Nem_3	656	661	PF02991	0.334
LIG_LIR_Nem_3	739	744	PF02991	0.356
LIG_LIR_Nem_3	777	782	PF02991	0.278
LIG_LIR_Nem_3	9	15	PF02991	0.410
LIG_LRP6_Inhibitor_1	179	185	PF00058	0.526
LIG_MYND_3	673	677	PF01753	0.264
LIG_Pex14_2	642	646	PF04695	0.264
LIG_Pex14_2	779	783	PF04695	0.410
LIG_SH2_CRK	278	282	PF00017	0.299
LIG_SH2_CRK	530	534	PF00017	0.280
LIG_SH2_CRK	539	543	PF00017	0.253
LIG_SH2_GRB2like	258	261	PF00017	0.395
LIG_SH2_PTP2	626	629	PF00017	0.278
LIG_SH2_SRC	530	533	PF00017	0.280
LIG_SH2_STAP1	217	221	PF00017	0.469
LIG_SH2_STAP1	278	282	PF00017	0.356
LIG_SH2_STAP1	530	534	PF00017	0.280
LIG_SH2_STAT3	534	537	PF00017	0.280
LIG_SH2_STAT5	217	220	PF00017	0.475
LIG_SH2_STAT5	258	261	PF00017	0.373
LIG_SH2_STAT5	278	281	PF00017	0.401
LIG_SH2_STAT5	532	535	PF00017	0.287
LIG_SH2_STAT5	626	629	PF00017	0.278
LIG_SH2_STAT5	741	744	PF00017	0.356
LIG_SH3_3	491	497	PF00018	0.264
LIG_SH3_3	563	569	PF00018	0.290
LIG_SH3_3	692	698	PF00018	0.265
LIG_SUMO_SIM_anti_2	232	238	PF11976	0.311
LIG_SUMO_SIM_par_1	170	175	PF11976	0.315
LIG_SUMO_SIM_par_1	736	742	PF11976	0.280
LIG_TRAF2_1	303	306	PF00917	0.307
LIG_TRAF2_1	469	472	PF00917	0.445
LIG_TRAF2_1	484	487	PF00917	0.412
LIG_TRAF2_1	675	678	PF00917	0.264
LIG_UBA3_1	281	289	PF00899	0.299
LIG_UBA3_1	474	481	PF00899	0.551
LIG_UBA3_1	616	624	PF00899	0.280
LIG_WRC_WIRS_1	15	20	PF05994	0.410
LIG_WRC_WIRS_1	240	245	PF05994	0.366
LIG_WRC_WIRS_1	512	517	PF05994	0.280
LIG_WRC_WIRS_1	654	659	PF05994	0.264
LIG_WW_1	527	530	PF00397	0.324
MOD_CK1_1	11	17	PF00069	0.440
MOD_CK1_1	111	117	PF00069	0.371
MOD_CK1_1	137	143	PF00069	0.443
MOD_CK1_1	227	233	PF00069	0.420
MOD_CK1_1	261	267	PF00069	0.515
MOD_CK1_1	446	452	PF00069	0.538
MOD_CK1_1	514	520	PF00069	0.264
MOD_CK1_1	632	638	PF00069	0.268
MOD_CK2_1	180	186	PF00069	0.418
MOD_CK2_1	373	379	PF00069	0.645
MOD_CK2_1	466	472	PF00069	0.468
MOD_CK2_1	481	487	PF00069	0.418
MOD_CK2_1	672	678	PF00069	0.264
MOD_CK2_1	798	804	PF00069	0.586
MOD_Cter_Amidation	744	747	PF01082	0.264
MOD_GlcNHglycan	110	113	PF01048	0.360
MOD_GlcNHglycan	327	330	PF01048	0.310
MOD_GlcNHglycan	424	427	PF01048	0.556
MOD_GlcNHglycan	544	547	PF01048	0.379
MOD_GlcNHglycan	583	586	PF01048	0.262
MOD_GlcNHglycan	635	638	PF01048	0.401
MOD_GlcNHglycan	64	67	PF01048	0.618
MOD_GlcNHglycan	708	711	PF01048	0.356
MOD_GlcNHglycan	8	11	PF01048	0.409
MOD_GlcNHglycan	94	97	PF01048	0.429
MOD_GSK3_1	170	177	PF00069	0.346
MOD_GSK3_1	187	194	PF00069	0.523
MOD_GSK3_1	198	205	PF00069	0.567
MOD_GSK3_1	2	9	PF00069	0.409
MOD_GSK3_1	285	292	PF00069	0.343
MOD_GSK3_1	310	317	PF00069	0.377
MOD_GSK3_1	333	340	PF00069	0.264
MOD_GSK3_1	443	450	PF00069	0.551
MOD_GSK3_1	481	488	PF00069	0.343
MOD_GSK3_1	625	632	PF00069	0.264
MOD_GSK3_1	633	640	PF00069	0.266
MOD_GSK3_1	785	792	PF00069	0.481
MOD_LATS_1	67	73	PF00433	0.507
MOD_N-GLC_1	108	113	PF02516	0.372
MOD_N-GLC_1	374	379	PF02516	0.559
MOD_N-GLC_2	574	576	PF02516	0.384
MOD_NEK2_1	1	6	PF00069	0.436
MOD_NEK2_1	121	126	PF00069	0.442
MOD_NEK2_1	174	179	PF00069	0.343
MOD_NEK2_1	187	192	PF00069	0.465
MOD_NEK2_1	212	217	PF00069	0.345
MOD_NEK2_1	263	268	PF00069	0.446
MOD_NEK2_1	285	290	PF00069	0.330
MOD_NEK2_1	316	321	PF00069	0.368
MOD_NEK2_1	327	332	PF00069	0.356
MOD_NEK2_1	581	586	PF00069	0.356
MOD_NEK2_1	690	695	PF00069	0.391
MOD_NEK2_1	8	13	PF00069	0.444
MOD_NEK2_2	511	516	PF00069	0.377
MOD_PIKK_1	174	180	PF00454	0.359
MOD_PIKK_1	224	230	PF00454	0.464
MOD_PIKK_1	271	277	PF00454	0.482
MOD_PIKK_1	310	316	PF00454	0.393
MOD_PIKK_1	327	333	PF00454	0.243
MOD_PIKK_1	447	453	PF00454	0.594
MOD_PKA_2	365	371	PF00069	0.509
MOD_PKA_2	447	453	PF00069	0.580
MOD_PKA_2	466	472	PF00069	0.454
MOD_PKA_2	542	548	PF00069	0.401
MOD_PKA_2	601	607	PF00069	0.311
MOD_PKB_1	651	659	PF00069	0.377
MOD_Plk_1	314	320	PF00069	0.426
MOD_Plk_1	374	380	PF00069	0.572
MOD_Plk_1	485	491	PF00069	0.358
MOD_Plk_2-3	466	472	PF00069	0.458
MOD_Plk_4	14	20	PF00069	0.373
MOD_Plk_4	2	8	PF00069	0.410
MOD_Plk_4	202	208	PF00069	0.510
MOD_Plk_4	229	235	PF00069	0.359
MOD_Plk_4	258	264	PF00069	0.326
MOD_Plk_4	568	574	PF00069	0.356
MOD_Plk_4	653	659	PF00069	0.282
MOD_Plk_4	697	703	PF00069	0.401
MOD_ProDKin_1	227	233	PF00069	0.361
MOD_ProDKin_1	493	499	PF00069	0.264
MOD_ProDKin_1	611	617	PF00069	0.299
MOD_ProDKin_1	625	631	PF00069	0.264
MOD_SUMO_for_1	457	460	PF00179	0.523
MOD_SUMO_rev_2	137	146	PF00179	0.405
MOD_SUMO_rev_2	584	594	PF00179	0.283
MOD_SUMO_rev_2	729	735	PF00179	0.401
TRG_DiLeu_BaEn_1	577	582	PF01217	0.377
TRG_DiLeu_BaLyEn_6	664	669	PF01217	0.401
TRG_ENDOCYTIC_2	278	281	PF00928	0.280
TRG_ENDOCYTIC_2	301	304	PF00928	0.264
TRG_ENDOCYTIC_2	509	512	PF00928	0.264
TRG_ENDOCYTIC_2	530	533	PF00928	0.274
TRG_ENDOCYTIC_2	539	542	PF00928	0.264
TRG_ENDOCYTIC_2	724	727	PF00928	0.264
TRG_ENDOCYTIC_2	741	744	PF00928	0.264
TRG_ER_diArg_1	503	506	PF00400	0.280
TRG_ER_diArg_1	91	93	PF00400	0.491
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	473	478	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	481	485	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD92	Leptomonas seymouri	83%	100%
A0A0S4JNZ2	Bodo saltans	54%	100%
A0A1X0NPB7	Trypanosomatidae	63%	100%
A0A3S5H5Y1	Leishmania donovani	97%	100%
A0A422NAK8	Trypanosoma rangeli	60%	100%
A4H4Z3	Leishmania braziliensis	89%	100%
C9ZUQ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AL58	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O13956	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
Q07381	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q19329	Caenorhabditis elegans	31%	100%
Q2NL82	Homo sapiens	29%	100%
Q5R434	Pongo abelii	29%	100%
Q5SWD9	Mus musculus	30%	100%
Q5XGY1	Xenopus laevis	29%	99%
Q61WR2	Caenorhabditis briggsae	31%	100%
Q9VP47	Drosophila melanogaster	29%	99%
V5BHC1	Trypanosoma cruzi	59%	100%