WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIP3_LEIMA

TriTrypDb:

LmjF.07.0490 , LMJLV39_070011100 , LMJSD75_070011300

Length:

398

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QIP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIP3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.653
CLV_C14_Caspase3-7	181	185	PF00656	0.631
CLV_NRD_NRD_1	100	102	PF00675	0.355
CLV_NRD_NRD_1	103	105	PF00675	0.376
CLV_NRD_NRD_1	149	151	PF00675	0.441
CLV_NRD_NRD_1	213	215	PF00675	0.391
CLV_NRD_NRD_1	301	303	PF00675	0.413
CLV_PCSK_KEX2_1	149	151	PF00082	0.441
CLV_PCSK_KEX2_1	213	215	PF00082	0.381
CLV_PCSK_KEX2_1	226	228	PF00082	0.271
CLV_PCSK_KEX2_1	301	303	PF00082	0.386
CLV_PCSK_KEX2_1	99	101	PF00082	0.363
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.405
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.403
CLV_PCSK_PC7_1	95	101	PF00082	0.363
CLV_PCSK_SKI1_1	113	117	PF00082	0.480
CLV_PCSK_SKI1_1	301	305	PF00082	0.375
CLV_PCSK_SKI1_1	59	63	PF00082	0.559
CLV_PCSK_SKI1_1	88	92	PF00082	0.368
DEG_SPOP_SBC_1	27	31	PF00917	0.464
DEG_SPOP_SBC_1	384	388	PF00917	0.680
DOC_MAPK_DCC_7	59	69	PF00069	0.361
DOC_MAPK_FxFP_2	207	210	PF00069	0.578
DOC_MAPK_gen_1	162	172	PF00069	0.535
DOC_MAPK_gen_1	313	321	PF00069	0.669
DOC_MAPK_MEF2A_6	156	163	PF00069	0.616
DOC_MAPK_RevD_3	85	100	PF00069	0.515
DOC_PP1_RVXF_1	57	63	PF00149	0.357
DOC_PP2B_LxvP_1	67	70	PF13499	0.336
DOC_PP4_FxxP_1	207	210	PF00568	0.528
DOC_USP7_MATH_1	231	235	PF00917	0.671
DOC_USP7_MATH_1	26	30	PF00917	0.533
DOC_USP7_MATH_1	322	326	PF00917	0.700
DOC_USP7_MATH_1	336	340	PF00917	0.712
DOC_USP7_MATH_1	370	374	PF00917	0.763
DOC_USP7_UBL2_3	213	217	PF12436	0.622
DOC_WW_Pin1_4	248	253	PF00397	0.748
DOC_WW_Pin1_4	276	281	PF00397	0.762
DOC_WW_Pin1_4	5	10	PF00397	0.514
LIG_14-3-3_CanoR_1	156	160	PF00244	0.548
LIG_14-3-3_CanoR_1	175	183	PF00244	0.591
LIG_14-3-3_CanoR_1	190	198	PF00244	0.454
LIG_14-3-3_CanoR_1	235	241	PF00244	0.706
LIG_14-3-3_CanoR_1	301	307	PF00244	0.632
LIG_14-3-3_CanoR_1	32	42	PF00244	0.475
LIG_14-3-3_CanoR_1	375	381	PF00244	0.706
LIG_14-3-3_CanoR_1	383	390	PF00244	0.606
LIG_14-3-3_CanoR_1	47	54	PF00244	0.384
LIG_BRCT_BRCA1_1	296	300	PF00533	0.690
LIG_BRCT_BRCA1_1	338	342	PF00533	0.682
LIG_BRCT_BRCA1_1	37	41	PF00533	0.391
LIG_CaM_NSCaTE_8	44	51	PF13499	0.367
LIG_CSL_BTD_1	67	70	PF09270	0.299
LIG_FHA_1	201	207	PF00498	0.565
LIG_FHA_1	379	385	PF00498	0.681
LIG_FHA_1	53	59	PF00498	0.312
LIG_FHA_1	78	84	PF00498	0.292
LIG_FHA_2	179	185	PF00498	0.599
LIG_FHA_2	51	57	PF00498	0.317
LIG_LIR_Apic_2	205	211	PF02991	0.532
LIG_LIR_Gen_1	103	112	PF02991	0.588
LIG_LIR_Gen_1	257	267	PF02991	0.612
LIG_LIR_Gen_1	80	90	PF02991	0.434
LIG_LIR_Nem_3	103	109	PF02991	0.556
LIG_LIR_Nem_3	184	189	PF02991	0.537
LIG_LIR_Nem_3	257	263	PF02991	0.756
LIG_LIR_Nem_3	297	303	PF02991	0.568
LIG_LIR_Nem_3	379	385	PF02991	0.676
LIG_LIR_Nem_3	80	85	PF02991	0.434
LIG_Pex14_1	45	49	PF04695	0.395
LIG_Pex14_2	300	304	PF04695	0.575
LIG_Pex14_2	41	45	PF04695	0.346
LIG_Pex14_2	90	94	PF04695	0.509
LIG_SH2_CRK	382	386	PF00017	0.682
LIG_SH2_STAT5	306	309	PF00017	0.569
LIG_SH2_STAT5	82	85	PF00017	0.286
LIG_SH3_3	249	255	PF00018	0.608
LIG_UBA3_1	108	116	PF00899	0.571
LIG_WRC_WIRS_1	82	87	PF05994	0.326
MOD_CDC14_SPxK_1	251	254	PF00782	0.730
MOD_CDK_SPxK_1	248	254	PF00069	0.725
MOD_CK1_1	248	254	PF00069	0.727
MOD_CK1_1	30	36	PF00069	0.491
MOD_CK1_1	343	349	PF00069	0.768
MOD_CK1_1	373	379	PF00069	0.798
MOD_CK1_1	386	392	PF00069	0.560
MOD_CK1_1	50	56	PF00069	0.417
MOD_CK2_1	263	269	PF00069	0.728
MOD_CK2_1	321	327	PF00069	0.701
MOD_CK2_1	50	56	PF00069	0.381
MOD_GlcNHglycan	191	194	PF01048	0.353
MOD_GlcNHglycan	20	23	PF01048	0.758
MOD_GlcNHglycan	265	268	PF01048	0.561
MOD_GlcNHglycan	284	288	PF01048	0.446
MOD_GlcNHglycan	3	6	PF01048	0.757
MOD_GlcNHglycan	334	337	PF01048	0.538
MOD_GlcNHglycan	338	341	PF01048	0.516
MOD_GlcNHglycan	342	345	PF01048	0.507
MOD_GlcNHglycan	347	350	PF01048	0.480
MOD_GlcNHglycan	351	354	PF01048	0.455
MOD_GlcNHglycan	359	362	PF01048	0.445
MOD_GlcNHglycan	37	40	PF01048	0.733
MOD_GlcNHglycan	376	379	PF01048	0.583
MOD_GlcNHglycan	49	52	PF01048	0.575
MOD_GSK3_1	1	8	PF00069	0.480
MOD_GSK3_1	244	251	PF00069	0.702
MOD_GSK3_1	259	266	PF00069	0.691
MOD_GSK3_1	26	33	PF00069	0.536
MOD_GSK3_1	322	329	PF00069	0.669
MOD_GSK3_1	332	339	PF00069	0.705
MOD_GSK3_1	345	352	PF00069	0.712
MOD_GSK3_1	370	377	PF00069	0.790
MOD_GSK3_1	73	80	PF00069	0.390
MOD_N-GLC_1	236	241	PF02516	0.474
MOD_N-GLC_1	245	250	PF02516	0.467
MOD_N-GLC_1	276	281	PF02516	0.551
MOD_NEK2_1	155	160	PF00069	0.528
MOD_NEK2_1	178	183	PF00069	0.597
MOD_NEK2_1	188	193	PF00069	0.516
MOD_NEK2_1	245	250	PF00069	0.739
MOD_NEK2_1	263	268	PF00069	0.756
MOD_NEK2_1	283	288	PF00069	0.608
MOD_NEK2_1	296	301	PF00069	0.676
MOD_NEK2_1	321	326	PF00069	0.703
MOD_NEK2_2	81	86	PF00069	0.282
MOD_PIKK_1	200	206	PF00454	0.538
MOD_PIKK_1	254	260	PF00454	0.686
MOD_PK_1	326	332	PF00069	0.728
MOD_PKA_2	155	161	PF00069	0.538
MOD_PKA_2	189	195	PF00069	0.525
MOD_PKA_2	31	37	PF00069	0.515
MOD_PKA_2	322	328	PF00069	0.652
MOD_PKA_2	374	380	PF00069	0.756
MOD_Plk_1	142	148	PF00069	0.616
MOD_Plk_1	236	242	PF00069	0.690
MOD_Plk_1	245	251	PF00069	0.663
MOD_Plk_4	326	332	PF00069	0.728
MOD_Plk_4	77	83	PF00069	0.365
MOD_ProDKin_1	248	254	PF00069	0.749
MOD_ProDKin_1	276	282	PF00069	0.764
MOD_ProDKin_1	5	11	PF00069	0.512
MOD_SUMO_rev_2	305	315	PF00179	0.603
TRG_ENDOCYTIC_2	106	109	PF00928	0.571
TRG_ENDOCYTIC_2	382	385	PF00928	0.684
TRG_ENDOCYTIC_2	82	85	PF00928	0.395
TRG_ER_diArg_1	300	302	PF00400	0.615
TRG_ER_diArg_1	85	88	PF00400	0.376
TRG_ER_diArg_1	99	101	PF00400	0.580
TRG_NES_CRM1_1	167	180	PF08389	0.518
TRG_NLS_Bipartite_1	213	229	PF00514	0.605
TRG_NLS_MonoExtC_3	224	229	PF00514	0.643
TRG_Pf-PMV_PEXEL_1	175	180	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSU4	Leptomonas seymouri	71%	100%
A0A0S4IXL3	Bodo saltans	33%	100%
A0A1X0NPE0	Trypanosomatidae	38%	100%
A0A3R7NBC4	Trypanosoma rangeli	44%	100%
A0A3S7WPV5	Leishmania donovani	96%	100%
A4H4Z9	Leishmania braziliensis	87%	100%
A4HT79	Leishmania infantum	97%	100%
C9ZUQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AL61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5B859	Trypanosoma cruzi	44%	100%