Putative QA-SNARE protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

QA-SNARE protein putative

Species:

Leishmania major

UniProt:

Q4QIP0_LEIMA

TriTrypDb:

LmjF.07.0520 , LMJLV39_070011400 , LMJSD75_070011600

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0005794	Golgi apparatus	5	2
GO:0010008	endosome membrane	5	2
GO:0012506	vesicle membrane	4	2
GO:0012507	ER to Golgi transport vesicle membrane	6	2
GO:0016020	membrane	2	11
GO:0030658	transport vesicle membrane	5	2
GO:0030659	cytoplasmic vesicle membrane	5	2
GO:0030662	coated vesicle membrane	5	2
GO:0031090	organelle membrane	3	2
GO:0031201	SNARE complex	3	2
GO:0031902	late endosome membrane	6	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0098796	membrane protein complex	2	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QIP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIP0

Function

Biological processes
Term	Name	Level	Count
GO:0006906	vesicle fusion	6	2
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2
GO:0048284	organelle fusion	5	2
GO:0061024	membrane organization	4	2
GO:0061025	membrane fusion	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090174	organelle membrane fusion	6	2

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	2
GO:0005484	SNAP receptor activity	3	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030674	protein-macromolecule adaptor activity	2	2
GO:0060090	molecular adaptor activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	9	13	PF00656	0.643
CLV_NRD_NRD_1	60	62	PF00675	0.405
CLV_PCSK_KEX2_1	230	232	PF00082	0.572
CLV_PCSK_KEX2_1	60	62	PF00082	0.405
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.578
CLV_PCSK_PC7_1	56	62	PF00082	0.402
CLV_PCSK_SKI1_1	140	144	PF00082	0.384
CLV_PCSK_SKI1_1	206	210	PF00082	0.344
DEG_APCC_DBOX_1	48	56	PF00400	0.666
DEG_Nend_UBRbox_2	1	3	PF02207	0.692
DOC_ANK_TNKS_1	116	123	PF00023	0.573
DOC_CYCLIN_RxL_1	56	66	PF00134	0.624
DOC_MAPK_gen_1	19	27	PF00069	0.649
DOC_MAPK_gen_1	204	211	PF00069	0.562
DOC_MAPK_RevD_3	20	35	PF00069	0.626
DOC_MAPK_RevD_3	217	231	PF00069	0.366
DOC_PP1_RVXF_1	191	198	PF00149	0.576
DOC_USP7_MATH_1	142	146	PF00917	0.635
DOC_USP7_MATH_1	95	99	PF00917	0.732
LIG_14-3-3_CanoR_1	60	64	PF00244	0.657
LIG_14-3-3_CanoR_1	96	106	PF00244	0.713
LIG_FHA_1	147	153	PF00498	0.674
LIG_FHA_1	160	166	PF00498	0.591
LIG_FHA_1	227	233	PF00498	0.400
LIG_FHA_1	26	32	PF00498	0.687
LIG_FHA_1	60	66	PF00498	0.681
LIG_FHA_2	103	109	PF00498	0.640
LIG_FHA_2	161	167	PF00498	0.627
LIG_LIR_Gen_1	205	216	PF02991	0.476
LIG_LIR_Nem_3	205	211	PF02991	0.476
LIG_Pex14_2	208	212	PF04695	0.326
LIG_SH2_CRK	199	203	PF00017	0.602
LIG_SH2_STAP1	228	232	PF00017	0.297
LIG_SH2_STAP1	85	89	PF00017	0.650
LIG_SH2_STAT3	106	109	PF00017	0.717
LIG_SH2_STAT5	228	231	PF00017	0.297
LIG_SUMO_SIM_par_1	23	30	PF11976	0.628
LIG_SUMO_SIM_par_1	61	66	PF11976	0.722
LIG_TRAF2_1	105	108	PF00917	0.712
LIG_WRC_WIRS_1	1	6	PF05994	0.691
MOD_CK1_1	226	232	PF00069	0.558
MOD_CK2_1	102	108	PF00069	0.625
MOD_CK2_1	160	166	PF00069	0.622
MOD_GlcNHglycan	97	100	PF01048	0.549
MOD_GSK3_1	142	149	PF00069	0.626
MOD_N-GLC_1	153	158	PF02516	0.487
MOD_NEK2_1	11	16	PF00069	0.595
MOD_NEK2_1	125	130	PF00069	0.640
MOD_NEK2_2	207	212	PF00069	0.340
MOD_PIKK_1	88	94	PF00454	0.596
MOD_PKA_2	59	65	PF00069	0.620
MOD_PKA_2	95	101	PF00069	0.763
MOD_Plk_1	11	17	PF00069	0.622
MOD_Plk_1	78	84	PF00069	0.683
MOD_Plk_4	160	166	PF00069	0.656
MOD_Plk_4	207	213	PF00069	0.342
MOD_Plk_4	223	229	PF00069	0.344
MOD_SUMO_for_1	20	23	PF00179	0.575
MOD_SUMO_rev_2	86	91	PF00179	0.674
TRG_DiLeu_BaEn_4	179	185	PF01217	0.670
TRG_ENDOCYTIC_2	199	202	PF00928	0.572
TRG_NES_CRM1_1	9	23	PF08389	0.653
TRG_Pf-PMV_PEXEL_1	200	205	PF00026	0.370
TRG_Pf-PMV_PEXEL_1	42	47	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	61	66	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYF5	Leptomonas seymouri	75%	100%
A0A0S4IUP1	Bodo saltans	45%	100%
A0A1X0NPE9	Trypanosomatidae	60%	100%
A0A3R7MA41	Trypanosoma rangeli	56%	100%
A0A3S7WPV3	Leishmania donovani	96%	100%
A4H502	Leishmania braziliensis	83%	100%
A4HT76	Leishmania infantum	96%	100%
C9ZUP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	98%
E9AL64	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5B8J0	Trypanosoma cruzi	57%	100%