Major sperm protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Major sperm protein

Gene product:

Nucleolar protein 54, putative

Species:

Leishmania major

UniProt:

Q4QIN5_LEIMA

TriTrypDb:

LmjF.07.0570 , LMJLV39_070011900 , LMJSD75_070012100

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QIN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIN5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.747
CLV_C14_Caspase3-7	90	94	PF00656	0.524
CLV_NRD_NRD_1	104	106	PF00675	0.686
CLV_NRD_NRD_1	23	25	PF00675	0.384
CLV_NRD_NRD_1	309	311	PF00675	0.684
CLV_NRD_NRD_1	31	33	PF00675	0.568
CLV_NRD_NRD_1	39	41	PF00675	0.475
CLV_NRD_NRD_1	411	413	PF00675	0.505
CLV_NRD_NRD_1	414	416	PF00675	0.493
CLV_NRD_NRD_1	6	8	PF00675	0.547
CLV_NRD_NRD_1	96	98	PF00675	0.755
CLV_PCSK_FUR_1	37	41	PF00082	0.649
CLV_PCSK_KEX2_1	311	313	PF00082	0.649
CLV_PCSK_KEX2_1	39	41	PF00082	0.542
CLV_PCSK_KEX2_1	432	434	PF00082	0.477
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.649
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.477
CLV_PCSK_PC7_1	35	41	PF00082	0.613
CLV_PCSK_SKI1_1	144	148	PF00082	0.407
CLV_PCSK_SKI1_1	183	187	PF00082	0.461
CLV_PCSK_SKI1_1	190	194	PF00082	0.500
CLV_PCSK_SKI1_1	255	259	PF00082	0.533
CLV_PCSK_SKI1_1	296	300	PF00082	0.614
CLV_PCSK_SKI1_1	334	338	PF00082	0.617
CLV_PCSK_SKI1_1	393	397	PF00082	0.575
CLV_PCSK_SKI1_1	433	437	PF00082	0.496
DEG_COP1_1	128	136	PF00400	0.561
DEG_SPOP_SBC_1	126	130	PF00917	0.651
DOC_CYCLIN_RxL_1	233	245	PF00134	0.495
DOC_CYCLIN_RxL_1	430	440	PF00134	0.554
DOC_MAPK_gen_1	143	151	PF00069	0.358
DOC_MAPK_gen_1	180	186	PF00069	0.373
DOC_MAPK_gen_1	233	242	PF00069	0.466
DOC_MAPK_gen_1	243	252	PF00069	0.477
DOC_MAPK_gen_1	62	69	PF00069	0.577
DOC_MAPK_MEF2A_6	144	153	PF00069	0.347
DOC_PP1_RVXF_1	236	243	PF00149	0.476
DOC_PP1_RVXF_1	455	462	PF00149	0.546
DOC_PP2B_LxvP_1	184	187	PF13499	0.382
DOC_SPAK_OSR1_1	241	245	PF12202	0.539
DOC_USP7_MATH_1	112	116	PF00917	0.720
DOC_USP7_MATH_1	119	123	PF00917	0.659
DOC_USP7_MATH_1	126	130	PF00917	0.478
DOC_USP7_MATH_1	351	355	PF00917	0.665
DOC_USP7_MATH_1	358	362	PF00917	0.554
DOC_USP7_MATH_1	437	441	PF00917	0.532
DOC_USP7_MATH_1	56	60	PF00917	0.716
DOC_USP7_UBL2_3	229	233	PF12436	0.505
DOC_USP7_UBL2_3	299	303	PF12436	0.722
DOC_USP7_UBL2_3	355	359	PF12436	0.707
DOC_USP7_UBL2_3	416	420	PF12436	0.480
DOC_WW_Pin1_4	107	112	PF00397	0.638
DOC_WW_Pin1_4	303	308	PF00397	0.697
DOC_WW_Pin1_4	321	326	PF00397	0.741
DOC_WW_Pin1_4	444	449	PF00397	0.591
DOC_WW_Pin1_4	91	96	PF00397	0.621
LIG_14-3-3_CanoR_1	438	442	PF00244	0.510
LIG_FHA_1	166	172	PF00498	0.453
LIG_FHA_1	326	332	PF00498	0.719
LIG_FHA_1	406	412	PF00498	0.546
LIG_FHA_1	447	453	PF00498	0.580
LIG_FHA_2	282	288	PF00498	0.734
LIG_Integrin_RGD_1	280	282	PF01839	0.626
LIG_LIR_Gen_1	423	428	PF02991	0.461
LIG_LIR_LC3C_4	168	173	PF02991	0.414
LIG_LIR_Nem_3	179	185	PF02991	0.455
LIG_LIR_Nem_3	423	427	PF02991	0.463
LIG_SH2_CRK	182	186	PF00017	0.431
LIG_SH3_4	355	362	PF00018	0.642
LIG_TRAF2_1	401	404	PF00917	0.554
LIG_TRAF2_2	157	162	PF00917	0.486
MOD_CDC14_SPxK_1	110	113	PF00782	0.466
MOD_CDC14_SPxK_1	94	97	PF00782	0.617
MOD_CDK_SPK_2	303	308	PF00069	0.654
MOD_CDK_SPxK_1	107	113	PF00069	0.475
MOD_CDK_SPxK_1	91	97	PF00069	0.620
MOD_CDK_SPxxK_3	107	114	PF00069	0.488
MOD_CDK_SPxxK_3	303	310	PF00069	0.679
MOD_CDK_SPxxK_3	444	451	PF00069	0.485
MOD_CDK_SPxxK_3	91	98	PF00069	0.622
MOD_CK1_1	128	134	PF00069	0.509
MOD_CK1_1	306	312	PF00069	0.747
MOD_CK1_1	321	327	PF00069	0.516
MOD_CK1_1	87	93	PF00069	0.654
MOD_CK2_1	283	289	PF00069	0.737
MOD_CK2_1	384	390	PF00069	0.496
MOD_CK2_1	398	404	PF00069	0.554
MOD_GlcNHglycan	114	117	PF01048	0.698
MOD_GlcNHglycan	331	334	PF01048	0.793
MOD_GlcNHglycan	454	457	PF01048	0.667
MOD_GlcNHglycan	58	61	PF01048	0.573
MOD_GlcNHglycan	86	89	PF01048	0.640
MOD_GSK3_1	128	135	PF00069	0.537
MOD_GSK3_1	161	168	PF00069	0.483
MOD_GSK3_1	172	179	PF00069	0.371
MOD_GSK3_1	306	313	PF00069	0.741
MOD_GSK3_1	321	328	PF00069	0.768
MOD_GSK3_1	345	352	PF00069	0.593
MOD_GSK3_1	52	59	PF00069	0.669
MOD_GSK3_1	87	94	PF00069	0.698
MOD_N-GLC_1	452	457	PF02516	0.726
MOD_NEK2_2	248	253	PF00069	0.603
MOD_PIKK_1	257	263	PF00454	0.674
MOD_PKA_1	310	316	PF00069	0.724
MOD_PKA_2	242	248	PF00069	0.531
MOD_PKA_2	437	443	PF00069	0.510
MOD_PKA_2	96	102	PF00069	0.650
MOD_Plk_1	248	254	PF00069	0.608
MOD_Plk_2-3	283	289	PF00069	0.599
MOD_Plk_4	128	134	PF00069	0.614
MOD_ProDKin_1	107	113	PF00069	0.639
MOD_ProDKin_1	303	309	PF00069	0.694
MOD_ProDKin_1	321	327	PF00069	0.741
MOD_ProDKin_1	444	450	PF00069	0.593
MOD_ProDKin_1	91	97	PF00069	0.622
MOD_SUMO_rev_2	315	324	PF00179	0.679
TRG_ENDOCYTIC_2	182	185	PF00928	0.403
TRG_ER_diArg_1	252	255	PF00400	0.523
TRG_ER_diArg_1	61	64	PF00400	0.620
TRG_ER_diArg_1	76	79	PF00400	0.425
TRG_NLS_MonoExtC_3	309	314	PF00514	0.757
TRG_NLS_MonoExtC_3	358	363	PF00514	0.694
TRG_NLS_MonoExtC_3	96	101	PF00514	0.688
TRG_NLS_MonoExtN_4	307	314	PF00514	0.789
TRG_NLS_MonoExtN_4	356	363	PF00514	0.689
TRG_NLS_MonoExtN_4	95	101	PF00514	0.682
TRG_Pf-PMV_PEXEL_1	409	414	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	426	430	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB51	Leptomonas seymouri	61%	100%
A0A0S4IW25	Bodo saltans	31%	100%
A0A3R7ME95	Trypanosoma rangeli	39%	100%
A0A3S7WPV8	Leishmania donovani	91%	100%
A4H507	Leishmania braziliensis	72%	99%
A4HT71	Leishmania infantum	92%	100%
C9ZUP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	83%
E9AL69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
V5BY30	Trypanosoma cruzi	42%	97%