NPL domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIN1_LEIMA

TriTrypDb:

LmjF.07.0610 , LMJLV39_070012300 , LMJSD75_070012500

Length:

196

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIN1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_Nbox_1	1	3	PF02207	0.597
DEG_SPOP_SBC_1	115	119	PF00917	0.754
DOC_MAPK_HePTP_8	54	66	PF00069	0.573
DOC_MAPK_MEF2A_6	11	19	PF00069	0.522
DOC_MAPK_MEF2A_6	57	66	PF00069	0.540
DOC_PP1_RVXF_1	95	102	PF00149	0.391
DOC_PP4_FxxP_1	19	22	PF00568	0.535
DOC_PP4_FxxP_1	95	98	PF00568	0.471
DOC_SPAK_OSR1_1	74	78	PF12202	0.502
DOC_USP7_MATH_1	114	118	PF00917	0.747
DOC_USP7_MATH_1	33	37	PF00917	0.477
DOC_USP7_MATH_1	40	44	PF00917	0.647
DOC_USP7_MATH_1	46	50	PF00917	0.690
DOC_USP7_MATH_1	76	80	PF00917	0.495
DOC_WW_Pin1_4	116	121	PF00397	0.768
DOC_WW_Pin1_4	48	53	PF00397	0.677
DOC_WW_Pin1_4	78	83	PF00397	0.439
LIG_eIF4E_1	88	94	PF01652	0.439
LIG_FHA_1	154	160	PF00498	0.457
LIG_FHA_1	23	29	PF00498	0.419
LIG_FHA_1	33	39	PF00498	0.405
LIG_FHA_1	61	67	PF00498	0.433
LIG_LIR_Apic_2	18	22	PF02991	0.567
LIG_LIR_Gen_1	100	105	PF02991	0.400
LIG_LIR_Nem_3	100	104	PF02991	0.374
LIG_LIR_Nem_3	151	157	PF02991	0.507
LIG_LIR_Nem_3	87	91	PF02991	0.420
LIG_LYPXL_S_1	153	157	PF13949	0.490
LIG_LYPXL_yS_3	154	157	PF13949	0.481
LIG_SH2_CRK	59	63	PF00017	0.504
LIG_SH2_CRK	88	92	PF00017	0.465
LIG_SH2_NCK_1	163	167	PF00017	0.609
LIG_SH2_NCK_1	59	63	PF00017	0.504
LIG_SH2_STAP1	163	167	PF00017	0.597
LIG_SH2_STAT5	88	91	PF00017	0.431
LIG_SH3_3	34	40	PF00018	0.572
LIG_SH3_3	99	105	PF00018	0.512
LIG_SUMO_SIM_par_1	25	30	PF11976	0.479
LIG_TRAF2_2	40	45	PF00917	0.687
LIG_TRFH_1	101	105	PF08558	0.471
LIG_TYR_ITIM	86	91	PF00017	0.414
MOD_CK1_1	118	124	PF00069	0.721
MOD_CK1_1	137	143	PF00069	0.704
MOD_CK2_1	190	196	PF00069	0.676
MOD_Cter_Amidation	126	129	PF01082	0.732
MOD_GSK3_1	114	121	PF00069	0.748
MOD_GSK3_1	153	160	PF00069	0.460
MOD_GSK3_1	23	30	PF00069	0.383
MOD_GSK3_1	93	100	PF00069	0.409
MOD_NEK2_1	27	32	PF00069	0.370
MOD_NEK2_1	93	98	PF00069	0.431
MOD_PIKK_1	27	33	PF00454	0.459
MOD_Plk_1	148	154	PF00069	0.419
MOD_Plk_2-3	190	196	PF00069	0.690
MOD_Plk_4	23	29	PF00069	0.383
MOD_Plk_4	33	39	PF00069	0.440
MOD_Plk_4	97	103	PF00069	0.467
MOD_ProDKin_1	116	122	PF00069	0.768
MOD_ProDKin_1	48	54	PF00069	0.673
MOD_ProDKin_1	78	84	PF00069	0.445
TRG_ENDOCYTIC_2	154	157	PF00928	0.463
TRG_ENDOCYTIC_2	59	62	PF00928	0.510
TRG_ENDOCYTIC_2	88	91	PF00928	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E4	Leptomonas seymouri	63%	99%
A0A0S4JAK6	Bodo saltans	35%	100%
A0A1X0NPD6	Trypanosomatidae	34%	100%
A0A3S7WPW4	Leishmania donovani	94%	100%
A0A422N682	Trypanosoma rangeli	42%	93%
A4H511	Leishmania braziliensis	80%	99%
A4HT85	Leishmania infantum	94%	100%
C9ZUN9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AL73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B8I1	Trypanosoma cruzi	38%	71%