GRIP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIM9_LEIMA

TriTrypDb:

LmjF.07.0620 , LMJLV39_070012500 , LMJSD75_070012700

Length:

618

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIM9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	505	507	PF00675	0.586
CLV_NRD_NRD_1	586	588	PF00675	0.456
CLV_PCSK_KEX2_1	375	377	PF00082	0.482
CLV_PCSK_KEX2_1	586	588	PF00082	0.495
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.482
CLV_PCSK_PC7_1	371	377	PF00082	0.458
CLV_PCSK_SKI1_1	221	225	PF00082	0.458
CLV_PCSK_SKI1_1	371	375	PF00082	0.459
CLV_PCSK_SKI1_1	376	380	PF00082	0.449
CLV_PCSK_SKI1_1	399	403	PF00082	0.469
CLV_PCSK_SKI1_1	436	440	PF00082	0.447
CLV_Separin_Metazoa	601	605	PF03568	0.472
DEG_APCC_DBOX_1	15	23	PF00400	0.498
DEG_APCC_DBOX_1	220	228	PF00400	0.529
DEG_SPOP_SBC_1	158	162	PF00917	0.529
DEG_SPOP_SBC_1	251	255	PF00917	0.568
DEG_SPOP_SBC_1	499	503	PF00917	0.625
DEG_SPOP_SBC_1	62	66	PF00917	0.632
DOC_PP2B_LxvP_1	248	251	PF13499	0.675
DOC_PP2B_LxvP_1	264	267	PF13499	0.549
DOC_PP2B_LxvP_1	57	60	PF13499	0.514
DOC_PP4_FxxP_1	165	168	PF00568	0.565
DOC_USP7_MATH_1	152	156	PF00917	0.593
DOC_USP7_MATH_1	158	162	PF00917	0.558
DOC_USP7_MATH_1	179	183	PF00917	0.602
DOC_USP7_MATH_1	193	197	PF00917	0.485
DOC_USP7_MATH_1	252	256	PF00917	0.567
DOC_USP7_MATH_1	362	366	PF00917	0.477
DOC_USP7_MATH_1	431	435	PF00917	0.511
DOC_USP7_MATH_1	500	504	PF00917	0.567
DOC_USP7_MATH_1	517	521	PF00917	0.489
DOC_USP7_MATH_1	52	56	PF00917	0.662
DOC_USP7_MATH_1	62	66	PF00917	0.597
DOC_USP7_MATH_1	68	72	PF00917	0.645
DOC_USP7_MATH_1	77	81	PF00917	0.467
DOC_WW_Pin1_4	173	178	PF00397	0.690
DOC_WW_Pin1_4	556	561	PF00397	0.623
DOC_WW_Pin1_4	63	68	PF00397	0.651
DOC_WW_Pin1_4	72	77	PF00397	0.651
LIG_14-3-3_CanoR_1	36	44	PF00244	0.501
LIG_14-3-3_CanoR_1	376	385	PF00244	0.488
LIG_Actin_WH2_2	374	391	PF00022	0.456
LIG_Actin_WH2_2	535	551	PF00022	0.505
LIG_BRCT_BRCA1_1	161	165	PF00533	0.561
LIG_EVH1_1	266	270	PF00568	0.623
LIG_FHA_1	183	189	PF00498	0.524
LIG_FHA_1	235	241	PF00498	0.707
LIG_FHA_1	261	267	PF00498	0.688
LIG_FHA_1	4	10	PF00498	0.544
LIG_FHA_1	569	575	PF00498	0.440
LIG_FHA_1	97	103	PF00498	0.499
LIG_FHA_2	202	208	PF00498	0.457
LIG_FHA_2	252	258	PF00498	0.660
LIG_FHA_2	319	325	PF00498	0.475
LIG_FHA_2	392	398	PF00498	0.387
LIG_FHA_2	439	445	PF00498	0.388
LIG_FHA_2	48	54	PF00498	0.514
LIG_FHA_2	500	506	PF00498	0.619
LIG_FHA_2	88	94	PF00498	0.556
LIG_LIR_Apic_2	162	168	PF02991	0.562
LIG_LIR_Gen_1	115	123	PF02991	0.614
LIG_LIR_Nem_3	115	119	PF02991	0.608
LIG_PCNA_yPIPBox_3	580	592	PF02747	0.433
LIG_Pex14_2	165	169	PF04695	0.566
LIG_PTAP_UEV_1	612	617	PF05743	0.566
LIG_SH2_CRK	116	120	PF00017	0.631
LIG_SH3_3	192	198	PF00018	0.562
LIG_SH3_3	264	270	PF00018	0.594
LIG_SH3_3	554	560	PF00018	0.627
LIG_SH3_3	606	612	PF00018	0.553
LIG_SUMO_SIM_par_1	559	565	PF11976	0.625
LIG_TRAF2_1	136	139	PF00917	0.511
LIG_TRAF2_1	198	201	PF00917	0.544
LIG_TRAF2_1	255	258	PF00917	0.639
LIG_TRAF2_1	51	54	PF00917	0.540
LIG_TRAF2_1	90	93	PF00917	0.434
LIG_UBA3_1	19	25	PF00899	0.502
MOD_CK1_1	159	165	PF00069	0.691
MOD_CK1_1	182	188	PF00069	0.530
MOD_CK1_1	242	248	PF00069	0.708
MOD_CK1_1	253	259	PF00069	0.668
MOD_CK1_1	3	9	PF00069	0.686
MOD_CK1_1	369	375	PF00069	0.374
MOD_CK1_1	520	526	PF00069	0.618
MOD_CK1_1	556	562	PF00069	0.530
MOD_CK1_1	72	78	PF00069	0.663
MOD_CK2_1	100	106	PF00069	0.420
MOD_CK2_1	201	207	PF00069	0.521
MOD_CK2_1	251	257	PF00069	0.658
MOD_CK2_1	288	294	PF00069	0.473
MOD_CK2_1	35	41	PF00069	0.541
MOD_CK2_1	362	368	PF00069	0.619
MOD_CK2_1	391	397	PF00069	0.373
MOD_CK2_1	438	444	PF00069	0.522
MOD_CK2_1	448	454	PF00069	0.535
MOD_CK2_1	47	53	PF00069	0.423
MOD_CK2_1	481	487	PF00069	0.653
MOD_CK2_1	87	93	PF00069	0.602
MOD_GlcNHglycan	102	105	PF01048	0.402
MOD_GlcNHglycan	161	164	PF01048	0.713
MOD_GlcNHglycan	195	198	PF01048	0.627
MOD_GlcNHglycan	221	224	PF01048	0.499
MOD_GlcNHglycan	229	232	PF01048	0.695
MOD_GlcNHglycan	241	244	PF01048	0.656
MOD_GlcNHglycan	37	40	PF01048	0.497
MOD_GlcNHglycan	403	406	PF01048	0.469
MOD_GlcNHglycan	50	53	PF01048	0.399
MOD_GlcNHglycan	519	522	PF01048	0.528
MOD_GlcNHglycan	613	616	PF01048	0.567
MOD_GlcNHglycan	79	82	PF01048	0.535
MOD_GSK3_1	152	159	PF00069	0.585
MOD_GSK3_1	179	186	PF00069	0.548
MOD_GSK3_1	227	234	PF00069	0.655
MOD_GSK3_1	362	369	PF00069	0.504
MOD_GSK3_1	43	50	PF00069	0.510
MOD_GSK3_1	517	524	PF00069	0.637
MOD_GSK3_1	611	618	PF00069	0.579
MOD_GSK3_1	68	75	PF00069	0.730
MOD_GSK3_1	96	103	PF00069	0.580
MOD_N-GLC_1	62	67	PF02516	0.629
MOD_N-GLC_1	69	74	PF02516	0.652
MOD_NEK2_1	43	48	PF00069	0.510
MOD_NEK2_1	568	573	PF00069	0.450
MOD_NEK2_1	96	101	PF00069	0.483
MOD_NEK2_2	431	436	PF00069	0.513
MOD_PIKK_1	183	189	PF00454	0.550
MOD_PIKK_1	211	217	PF00454	0.578
MOD_PIKK_1	508	514	PF00454	0.619
MOD_PIKK_1	568	574	PF00454	0.447
MOD_PIKK_1	79	85	PF00454	0.558
MOD_PK_1	448	454	PF00069	0.452
MOD_PKA_2	100	106	PF00069	0.539
MOD_PKA_2	35	41	PF00069	0.611
MOD_Plk_1	52	58	PF00069	0.675
MOD_Plk_2-3	201	207	PF00069	0.521
MOD_Plk_4	179	185	PF00069	0.581
MOD_Plk_4	448	454	PF00069	0.426
MOD_Plk_4	52	58	PF00069	0.469
MOD_ProDKin_1	173	179	PF00069	0.687
MOD_ProDKin_1	556	562	PF00069	0.622
MOD_ProDKin_1	63	69	PF00069	0.652
MOD_ProDKin_1	72	78	PF00069	0.646
MOD_SUMO_rev_2	443	447	PF00179	0.466
MOD_SUMO_rev_2	501	509	PF00179	0.610
TRG_ENDOCYTIC_2	116	119	PF00928	0.636
TRG_ER_diArg_1	586	588	PF00400	0.456
TRG_Pf-PMV_PEXEL_1	142	147	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	356	360	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	376	380	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	461	466	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPV9	Leishmania donovani	87%	97%
A0A422N655	Trypanosoma rangeli	28%	100%
A4H513	Leishmania braziliensis	60%	100%
A4HT87	Leishmania infantum	87%	97%
E9AL75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%