Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIM5_LEIMA

TriTrypDb:

LmjF.07.0660 , LMJLV39_070013000 , LMJSD75_070013100

Length:

517

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QIM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIM5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.456
CLV_C14_Caspase3-7	332	336	PF00656	0.503
CLV_C14_Caspase3-7	503	507	PF00656	0.668
CLV_C14_Caspase3-7	52	56	PF00656	0.766
CLV_PCSK_SKI1_1	467	471	PF00082	0.525
DEG_APCC_DBOX_1	462	470	PF00400	0.581
DEG_APCC_DBOX_1	74	82	PF00400	0.487
DEG_Nend_Nbox_1	1	3	PF02207	0.615
DOC_CDC14_PxL_1	146	154	PF14671	0.522
DOC_CYCLIN_RxL_1	463	474	PF00134	0.522
DOC_CYCLIN_yCln2_LP_2	42	45	PF00134	0.603
DOC_MAPK_DCC_7	369	379	PF00069	0.525
DOC_MAPK_DCC_7	75	83	PF00069	0.519
DOC_MAPK_FxFP_2	74	77	PF00069	0.443
DOC_MAPK_gen_1	483	490	PF00069	0.633
DOC_MAPK_HePTP_8	366	378	PF00069	0.576
DOC_MAPK_MEF2A_6	369	378	PF00069	0.551
DOC_MAPK_MEF2A_6	404	412	PF00069	0.527
DOC_PP1_RVXF_1	485	491	PF00149	0.631
DOC_PP2B_LxvP_1	41	44	PF13499	0.572
DOC_PP4_FxxP_1	74	77	PF00568	0.443
DOC_USP7_MATH_1	101	105	PF00917	0.732
DOC_USP7_MATH_1	12	16	PF00917	0.515
DOC_USP7_MATH_1	189	193	PF00917	0.522
DOC_USP7_MATH_1	228	232	PF00917	0.593
DOC_USP7_MATH_1	240	244	PF00917	0.626
DOC_USP7_MATH_1	306	310	PF00917	0.514
DOC_USP7_MATH_1	323	327	PF00917	0.576
DOC_USP7_MATH_1	422	426	PF00917	0.716
DOC_USP7_MATH_1	56	60	PF00917	0.692
DOC_WW_Pin1_4	118	123	PF00397	0.727
DOC_WW_Pin1_4	248	253	PF00397	0.740
DOC_WW_Pin1_4	27	32	PF00397	0.684
DOC_WW_Pin1_4	319	324	PF00397	0.519
DOC_WW_Pin1_4	360	365	PF00397	0.621
DOC_WW_Pin1_4	396	401	PF00397	0.645
DOC_WW_Pin1_4	96	101	PF00397	0.582
LIG_14-3-3_CanoR_1	229	233	PF00244	0.525
LIG_14-3-3_CanoR_1	237	246	PF00244	0.529
LIG_14-3-3_CanoR_1	26	33	PF00244	0.636
LIG_14-3-3_CanoR_1	304	314	PF00244	0.528
LIG_APCC_ABBA_1	411	416	PF00400	0.539
LIG_eIF4E_1	146	152	PF01652	0.432
LIG_eIF4E_1	37	43	PF01652	0.484
LIG_EVH1_2	32	36	PF00568	0.521
LIG_FHA_1	136	142	PF00498	0.527
LIG_FHA_1	459	465	PF00498	0.523
LIG_FHA_1	58	64	PF00498	0.741
LIG_FHA_2	155	161	PF00498	0.595
LIG_FHA_2	330	336	PF00498	0.521
LIG_FHA_2	360	366	PF00498	0.587
LIG_FHA_2	426	432	PF00498	0.636
LIG_FHA_2	479	485	PF00498	0.532
LIG_HP1_1	258	262	PF01393	0.524
LIG_LIR_Apic_2	451	456	PF02991	0.397
LIG_LIR_Gen_1	143	153	PF02991	0.416
LIG_LIR_Gen_1	35	45	PF02991	0.554
LIG_LIR_Gen_1	458	466	PF02991	0.474
LIG_LIR_Nem_3	137	142	PF02991	0.418
LIG_LIR_Nem_3	143	149	PF02991	0.443
LIG_LIR_Nem_3	284	289	PF02991	0.330
LIG_LIR_Nem_3	34	40	PF02991	0.561
LIG_LIR_Nem_3	458	462	PF02991	0.467
LIG_LIR_Nem_3	474	480	PF02991	0.619
LIG_MYND_1	118	122	PF01753	0.690
LIG_Pex14_1	282	286	PF04695	0.373
LIG_SH2_CRK	142	146	PF00017	0.435
LIG_SH2_CRK	307	311	PF00017	0.456
LIG_SH2_CRK	38	42	PF00017	0.521
LIG_SH2_CRK	446	450	PF00017	0.527
LIG_SH2_CRK	453	457	PF00017	0.580
LIG_SH2_NCK_1	146	150	PF00017	0.438
LIG_SH2_NCK_1	222	226	PF00017	0.578
LIG_SH2_NCK_1	307	311	PF00017	0.528
LIG_SH2_SRC	146	149	PF00017	0.445
LIG_SH2_STAP1	142	146	PF00017	0.416
LIG_SH2_STAP1	222	226	PF00017	0.571
LIG_SH2_STAP1	283	287	PF00017	0.471
LIG_SH2_STAP1	38	42	PF00017	0.552
LIG_SH2_STAT5	283	286	PF00017	0.478
LIG_SH2_STAT5	307	310	PF00017	0.471
LIG_SH2_STAT5	480	483	PF00017	0.643
LIG_SH3_3	116	122	PF00018	0.654
LIG_SH3_3	147	153	PF00018	0.524
LIG_SH3_3	213	219	PF00018	0.493
LIG_SH3_3	300	306	PF00018	0.354
LIG_SH3_3	459	465	PF00018	0.539
LIG_SH3_3	67	73	PF00018	0.547
LIG_SH3_3	74	80	PF00018	0.443
LIG_SUMO_SIM_anti_2	39	44	PF11976	0.578
LIG_SUMO_SIM_par_1	256	263	PF11976	0.412
LIG_SUMO_SIM_par_1	375	382	PF11976	0.487
LIG_TRFH_1	76	80	PF08558	0.531
LIG_TYR_ITIM	144	149	PF00017	0.430
LIG_TYR_ITIM	305	310	PF00017	0.449
LIG_UBA3_1	1	8	PF00899	0.706
MOD_CK1_1	180	186	PF00069	0.557
MOD_CK1_1	192	198	PF00069	0.484
MOD_CK1_1	248	254	PF00069	0.709
MOD_CK1_1	309	315	PF00069	0.543
MOD_CK1_1	322	328	PF00069	0.485
MOD_CK1_1	425	431	PF00069	0.639
MOD_CK1_1	46	52	PF00069	0.653
MOD_CK1_1	59	65	PF00069	0.716
MOD_CK1_1	99	105	PF00069	0.695
MOD_CK2_1	118	124	PF00069	0.574
MOD_CK2_1	359	365	PF00069	0.536
MOD_CK2_1	425	431	PF00069	0.697
MOD_CK2_1	445	451	PF00069	0.327
MOD_CK2_1	478	484	PF00069	0.540
MOD_CK2_1	7	13	PF00069	0.462
MOD_GlcNHglycan	103	106	PF01048	0.793
MOD_GlcNHglycan	107	110	PF01048	0.771
MOD_GlcNHglycan	206	209	PF01048	0.514
MOD_GlcNHglycan	223	226	PF01048	0.532
MOD_GlcNHglycan	247	250	PF01048	0.725
MOD_GlcNHglycan	325	328	PF01048	0.702
MOD_GlcNHglycan	386	389	PF01048	0.464
MOD_GlcNHglycan	396	399	PF01048	0.536
MOD_GlcNHglycan	427	431	PF01048	0.690
MOD_GlcNHglycan	438	441	PF01048	0.584
MOD_GlcNHglycan	48	51	PF01048	0.693
MOD_GSK3_1	101	108	PF00069	0.735
MOD_GSK3_1	118	125	PF00069	0.616
MOD_GSK3_1	176	183	PF00069	0.544
MOD_GSK3_1	185	192	PF00069	0.546
MOD_GSK3_1	247	254	PF00069	0.744
MOD_GSK3_1	27	34	PF00069	0.614
MOD_GSK3_1	305	312	PF00069	0.482
MOD_GSK3_1	319	326	PF00069	0.516
MOD_GSK3_1	355	362	PF00069	0.473
MOD_GSK3_1	422	429	PF00069	0.732
MOD_GSK3_1	44	51	PF00069	0.566
MOD_GSK3_1	92	99	PF00069	0.626
MOD_N-GLC_2	489	491	PF02516	0.519
MOD_NEK2_1	25	30	PF00069	0.538
MOD_NEK2_1	355	360	PF00069	0.418
MOD_NEK2_1	36	41	PF00069	0.418
MOD_NEK2_1	394	399	PF00069	0.562
MOD_NEK2_2	389	394	PF00069	0.334
MOD_PIKK_1	12	18	PF00454	0.509
MOD_PIKK_1	94	100	PF00454	0.458
MOD_PKA_2	135	141	PF00069	0.552
MOD_PKA_2	228	234	PF00069	0.601
MOD_PKA_2	25	31	PF00069	0.557
MOD_PKA_2	65	71	PF00069	0.601
MOD_Plk_1	478	484	PF00069	0.652
MOD_Plk_2-3	478	484	PF00069	0.643
MOD_Plk_4	273	279	PF00069	0.472
MOD_Plk_4	290	296	PF00069	0.303
MOD_Plk_4	309	315	PF00069	0.225
MOD_Plk_4	36	42	PF00069	0.563
MOD_Plk_4	389	395	PF00069	0.500
MOD_ProDKin_1	118	124	PF00069	0.725
MOD_ProDKin_1	248	254	PF00069	0.735
MOD_ProDKin_1	27	33	PF00069	0.677
MOD_ProDKin_1	319	325	PF00069	0.523
MOD_ProDKin_1	360	366	PF00069	0.616
MOD_ProDKin_1	396	402	PF00069	0.642
MOD_ProDKin_1	96	102	PF00069	0.591
TRG_DiLeu_BaEn_2	338	344	PF01217	0.377
TRG_DiLeu_BaLyEn_6	147	152	PF01217	0.528
TRG_ENDOCYTIC_2	142	145	PF00928	0.425
TRG_ENDOCYTIC_2	146	149	PF00928	0.426
TRG_ENDOCYTIC_2	283	286	PF00928	0.398
TRG_ENDOCYTIC_2	307	310	PF00928	0.439
TRG_ENDOCYTIC_2	352	355	PF00928	0.538
TRG_ENDOCYTIC_2	37	40	PF00928	0.491
TRG_ENDOCYTIC_2	446	449	PF00928	0.527
TRG_ER_diArg_1	3	6	PF00400	0.587
TRG_ER_diArg_1	485	488	PF00400	0.631
TRG_NES_CRM1_1	346	360	PF08389	0.504
TRG_Pf-PMV_PEXEL_1	132	137	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHX1	Leptomonas seymouri	54%	100%
A0A1X0NPG1	Trypanosomatidae	26%	100%
A0A3S5H5Z0	Leishmania donovani	89%	100%
A0A422N3S3	Trypanosoma rangeli	28%	100%
A4H517	Leishmania braziliensis	65%	100%
A4HT90	Leishmania infantum	89%	100%
C9ZUN4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AL79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
V5BTD2	Trypanosoma cruzi	29%	100%