Importin N-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIL9_LEIMA

TriTrypDb:

LmjF.07.0720 , LMJLV39_070013700 , LMJSD75_070013800

Length:

1257

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0005737	cytoplasm	2	11
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QIL9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIL9

Function

Biological processes
Term	Name	Level	Count
GO:0006606	protein import into nucleus	5	11
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0006913	nucleocytoplasmic transport	5	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0033365	protein localization to organelle	5	11
GO:0034504	protein localization to nucleus	6	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051169	nuclear transport	4	11
GO:0051170	import into nucleus	6	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0072594	establishment of protein localization to organelle	4	11

Molecular functions
Term	Name	Level	Count
GO:0005048	signal sequence binding	4	2
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0008139	nuclear localization sequence binding	5	2
GO:0019899	enzyme binding	3	11
GO:0031267	small GTPase binding	5	11
GO:0033218	amide binding	2	2
GO:0042277	peptide binding	3	2
GO:0051020	GTPase binding	4	11
GO:0061608	nuclear import signal receptor activity	3	2
GO:0140104	molecular carrier activity	1	2
GO:0140142	nucleocytoplasmic carrier activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1128	1132	PF00656	0.501
CLV_C14_Caspase3-7	734	738	PF00656	0.558
CLV_C14_Caspase3-7	844	848	PF00656	0.553
CLV_C14_Caspase3-7	879	883	PF00656	0.690
CLV_MEL_PAP_1	418	424	PF00089	0.492
CLV_NRD_NRD_1	30	32	PF00675	0.497
CLV_NRD_NRD_1	399	401	PF00675	0.359
CLV_NRD_NRD_1	420	422	PF00675	0.405
CLV_NRD_NRD_1	483	485	PF00675	0.314
CLV_NRD_NRD_1	76	78	PF00675	0.368
CLV_NRD_NRD_1	865	867	PF00675	0.703
CLV_NRD_NRD_1	916	918	PF00675	0.676
CLV_PCSK_KEX2_1	29	31	PF00082	0.500
CLV_PCSK_KEX2_1	419	421	PF00082	0.420
CLV_PCSK_KEX2_1	482	484	PF00082	0.298
CLV_PCSK_KEX2_1	78	80	PF00082	0.475
CLV_PCSK_KEX2_1	865	867	PF00082	0.703
CLV_PCSK_KEX2_1	916	918	PF00082	0.676
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.475
CLV_PCSK_SKI1_1	121	125	PF00082	0.471
CLV_PCSK_SKI1_1	1249	1253	PF00082	0.502
CLV_PCSK_SKI1_1	214	218	PF00082	0.420
CLV_PCSK_SKI1_1	375	379	PF00082	0.388
CLV_PCSK_SKI1_1	400	404	PF00082	0.456
CLV_PCSK_SKI1_1	583	587	PF00082	0.432
CLV_PCSK_SKI1_1	754	758	PF00082	0.421
CLV_PCSK_SKI1_1	78	82	PF00082	0.405
CLV_PCSK_SKI1_1	85	89	PF00082	0.437
CLV_PCSK_SKI1_1	96	100	PF00082	0.299
CLV_Separin_Metazoa	550	554	PF03568	0.536
DEG_COP1_1	498	507	PF00400	0.515
DEG_MDM2_SWIB_1	1112	1119	PF02201	0.484
DEG_Nend_UBRbox_3	1	3	PF02207	0.723
DEG_ODPH_VHL_1	1059	1071	PF01847	0.497
DEG_SCF_FBW7_1	53	60	PF00400	0.542
DOC_ANK_TNKS_1	1090	1097	PF00023	0.444
DOC_CDC14_PxL_1	201	209	PF14671	0.523
DOC_CDC14_PxL_1	303	311	PF14671	0.436
DOC_CKS1_1	558	563	PF01111	0.492
DOC_CYCLIN_yCln2_LP_2	1000	1006	PF00134	0.517
DOC_CYCLIN_yCln2_LP_2	1144	1150	PF00134	0.301
DOC_CYCLIN_yCln2_LP_2	507	513	PF00134	0.434
DOC_CYCLIN_yCln2_LP_2	552	558	PF00134	0.411
DOC_MAPK_DCC_7	1142	1151	PF00069	0.292
DOC_MAPK_gen_1	398	407	PF00069	0.358
DOC_MAPK_gen_1	419	428	PF00069	0.452
DOC_MAPK_gen_1	799	808	PF00069	0.527
DOC_MAPK_HePTP_8	798	810	PF00069	0.520
DOC_MAPK_MEF2A_6	1142	1151	PF00069	0.418
DOC_MAPK_MEF2A_6	238	245	PF00069	0.401
DOC_MAPK_MEF2A_6	465	473	PF00069	0.465
DOC_MAPK_MEF2A_6	801	810	PF00069	0.525
DOC_MAPK_RevD_3	468	484	PF00069	0.426
DOC_PP1_RVXF_1	107	114	PF00149	0.431
DOC_PP2B_LxvP_1	1058	1061	PF13499	0.515
DOC_PP2B_LxvP_1	1144	1147	PF13499	0.302
DOC_PP2B_LxvP_1	962	965	PF13499	0.665
DOC_SPAK_OSR1_1	112	116	PF12202	0.428
DOC_USP7_MATH_1	1039	1043	PF00917	0.510
DOC_USP7_MATH_1	1136	1140	PF00917	0.375
DOC_USP7_MATH_1	1191	1195	PF00917	0.599
DOC_USP7_MATH_1	177	181	PF00917	0.498
DOC_USP7_MATH_1	447	451	PF00917	0.415
DOC_USP7_MATH_1	516	520	PF00917	0.470
DOC_USP7_MATH_1	540	544	PF00917	0.544
DOC_USP7_MATH_1	654	658	PF00917	0.617
DOC_USP7_MATH_1	756	760	PF00917	0.410
DOC_USP7_MATH_1	782	786	PF00917	0.716
DOC_USP7_MATH_1	924	928	PF00917	0.658
DOC_WW_Pin1_4	1049	1054	PF00397	0.612
DOC_WW_Pin1_4	53	58	PF00397	0.516
DOC_WW_Pin1_4	557	562	PF00397	0.464
LIG_14-3-3_CanoR_1	1083	1092	PF00244	0.496
LIG_14-3-3_CanoR_1	387	395	PF00244	0.559
LIG_14-3-3_CanoR_1	400	405	PF00244	0.387
LIG_14-3-3_CanoR_1	567	577	PF00244	0.385
LIG_14-3-3_CanoR_1	79	84	PF00244	0.422
LIG_14-3-3_CanoR_1	85	95	PF00244	0.476
LIG_Actin_WH2_2	795	813	PF00022	0.500
LIG_AP2alpha_2	912	914	PF02296	0.642
LIG_APCC_ABBA_1	1012	1017	PF00400	0.528
LIG_APCC_ABBA_1	1059	1064	PF00400	0.507
LIG_APCC_ABBA_1	459	464	PF00400	0.483
LIG_APCC_ABBA_1	710	715	PF00400	0.453
LIG_APCC_Cbox_2	501	507	PF00515	0.538
LIG_BIR_III_2	435	439	PF00653	0.502
LIG_BIR_III_4	1044	1048	PF00653	0.500
LIG_BRCT_BRCA1_1	373	377	PF00533	0.507
LIG_BRCT_BRCA1_1	537	541	PF00533	0.474
LIG_BRCT_BRCA1_1	611	615	PF00533	0.351
LIG_CORNRBOX	13	21	PF00104	0.520
LIG_DLG_GKlike_1	609	616	PF00625	0.354
LIG_eIF4E_1	1088	1094	PF01652	0.380
LIG_FHA_1	106	112	PF00498	0.476
LIG_FHA_1	1188	1194	PF00498	0.579
LIG_FHA_1	324	330	PF00498	0.475
LIG_FHA_1	35	41	PF00498	0.529
LIG_FHA_1	376	382	PF00498	0.369
LIG_FHA_1	475	481	PF00498	0.381
LIG_FHA_1	561	567	PF00498	0.439
LIG_FHA_1	569	575	PF00498	0.362
LIG_FHA_1	695	701	PF00498	0.421
LIG_FHA_2	1210	1216	PF00498	0.468
LIG_FHA_2	146	152	PF00498	0.523
LIG_FHA_2	204	210	PF00498	0.528
LIG_FHA_2	489	495	PF00498	0.298
LIG_FHA_2	639	645	PF00498	0.425
LIG_FHA_2	7	13	PF00498	0.495
LIG_FHA_2	732	738	PF00498	0.465
LIG_FHA_2	810	816	PF00498	0.480
LIG_FHA_2	898	904	PF00498	0.751
LIG_GBD_Chelix_1	268	276	PF00786	0.452
LIG_GBD_Chelix_1	853	861	PF00786	0.579
LIG_Integrin_RGD_1	896	898	PF01839	0.624
LIG_LIR_Gen_1	1070	1075	PF02991	0.490
LIG_LIR_Gen_1	247	257	PF02991	0.512
LIG_LIR_Gen_1	374	385	PF02991	0.481
LIG_LIR_Nem_3	132	137	PF02991	0.480
LIG_LIR_Nem_3	162	166	PF02991	0.535
LIG_LIR_Nem_3	247	252	PF02991	0.457
LIG_LIR_Nem_3	374	380	PF02991	0.452
LIG_LIR_Nem_3	588	593	PF02991	0.349
LIG_LIR_Nem_3	610	616	PF02991	0.337
LIG_LIR_Nem_3	625	630	PF02991	0.384
LIG_LIR_Nem_3	738	744	PF02991	0.476
LIG_LIR_Nem_3	82	87	PF02991	0.403
LIG_LIR_Nem_3	885	889	PF02991	0.640
LIG_LYPXL_yS_3	741	744	PF13949	0.528
LIG_MYND_1	1006	1010	PF01753	0.460
LIG_MYND_1	505	509	PF01753	0.495
LIG_MYND_3	471	475	PF01753	0.381
LIG_NRBOX	1177	1183	PF00104	0.414
LIG_NRBOX	804	810	PF00104	0.461
LIG_NRBOX	94	100	PF00104	0.488
LIG_PCNA_yPIPBox_3	85	99	PF02747	0.519
LIG_Pex14_2	1112	1116	PF04695	0.485
LIG_Pex14_2	163	167	PF04695	0.543
LIG_Pex14_2	249	253	PF04695	0.371
LIG_Pex14_2	623	627	PF04695	0.494
LIG_PTAP_UEV_1	61	66	PF05743	0.389
LIG_PTB_Apo_2	2	9	PF02174	0.571
LIG_PTB_Phospho_1	2	8	PF10480	0.581
LIG_REV1ctd_RIR_1	912	921	PF16727	0.667
LIG_SH2_CRK	261	265	PF00017	0.514
LIG_SH2_CRK	889	893	PF00017	0.722
LIG_SH2_CRK	960	964	PF00017	0.632
LIG_SH2_CRK	997	1001	PF00017	0.492
LIG_SH2_GRB2like	630	633	PF00017	0.462
LIG_SH2_STAT5	1007	1010	PF00017	0.442
LIG_SH2_STAT5	1088	1091	PF00017	0.386
LIG_SH2_STAT5	1180	1183	PF00017	0.450
LIG_SH2_STAT5	384	387	PF00017	0.484
LIG_SH2_STAT5	417	420	PF00017	0.392
LIG_SH2_STAT5	424	427	PF00017	0.372
LIG_SH2_STAT5	503	506	PF00017	0.434
LIG_SH2_STAT5	630	633	PF00017	0.414
LIG_SH2_STAT5	708	711	PF00017	0.368
LIG_SH2_STAT5	8	11	PF00017	0.558
LIG_SH2_STAT5	836	839	PF00017	0.402
LIG_SH2_STAT5	907	910	PF00017	0.625
LIG_SH3_2	107	112	PF14604	0.327
LIG_SH3_3	1000	1006	PF00018	0.492
LIG_SH3_3	104	110	PF00018	0.334
LIG_SH3_3	1144	1150	PF00018	0.373
LIG_SH3_3	1151	1157	PF00018	0.373
LIG_SH3_3	199	205	PF00018	0.408
LIG_SH3_3	301	307	PF00018	0.495
LIG_SH3_3	377	383	PF00018	0.434
LIG_SH3_3	59	65	PF00018	0.532
LIG_SH3_3	969	975	PF00018	0.698
LIG_SUMO_SIM_anti_2	547	553	PF11976	0.469
LIG_SUMO_SIM_anti_2	828	835	PF11976	0.398
LIG_SUMO_SIM_par_1	156	162	PF11976	0.475
LIG_SUMO_SIM_par_1	200	206	PF11976	0.494
LIG_SUMO_SIM_par_1	244	250	PF11976	0.347
LIG_SUMO_SIM_par_1	322	331	PF11976	0.474
LIG_SUMO_SIM_par_1	424	429	PF11976	0.506
LIG_SUMO_SIM_par_1	794	800	PF11976	0.312
LIG_TRAF2_1	812	815	PF00917	0.516
LIG_UBA3_1	1158	1165	PF00899	0.503
LIG_UBA3_1	252	260	PF00899	0.493
LIG_UBA3_1	749	757	PF00899	0.449
LIG_Vh1_VBS_1	515	533	PF01044	0.472
LIG_WRC_WIRS_1	160	165	PF05994	0.522
LIG_WRC_WIRS_1	448	453	PF05994	0.423
LIG_WW_1	957	960	PF00397	0.646
MOD_CK1_1	1052	1058	PF00069	0.509
MOD_CK1_1	1077	1083	PF00069	0.504
MOD_CK1_1	1099	1105	PF00069	0.452
MOD_CK1_1	386	392	PF00069	0.454
MOD_CK1_1	519	525	PF00069	0.379
MOD_CK1_1	657	663	PF00069	0.638
MOD_CK1_1	785	791	PF00069	0.562
MOD_CK2_1	145	151	PF00069	0.477
MOD_CK2_1	159	165	PF00069	0.355
MOD_CK2_1	203	209	PF00069	0.525
MOD_CK2_1	488	494	PF00069	0.298
MOD_CK2_1	515	521	PF00069	0.440
MOD_CK2_1	6	12	PF00069	0.551
MOD_CK2_1	638	644	PF00069	0.409
MOD_CK2_1	809	815	PF00069	0.461
MOD_GlcNHglycan	1085	1088	PF01048	0.391
MOD_GlcNHglycan	1134	1137	PF01048	0.345
MOD_GlcNHglycan	173	176	PF01048	0.485
MOD_GlcNHglycan	230	233	PF01048	0.471
MOD_GlcNHglycan	333	336	PF01048	0.737
MOD_GlcNHglycan	355	358	PF01048	0.469
MOD_GlcNHglycan	365	368	PF01048	0.362
MOD_GlcNHglycan	537	540	PF01048	0.495
MOD_GlcNHglycan	578	581	PF01048	0.484
MOD_GlcNHglycan	658	662	PF01048	0.642
MOD_GlcNHglycan	704	707	PF01048	0.348
MOD_GlcNHglycan	758	761	PF01048	0.482
MOD_GlcNHglycan	784	788	PF01048	0.662
MOD_GlcNHglycan	900	903	PF01048	0.742
MOD_GlcNHglycan	926	929	PF01048	0.658
MOD_GlcNHglycan	951	954	PF01048	0.689
MOD_GSK3_1	1025	1032	PF00069	0.429
MOD_GSK3_1	1074	1081	PF00069	0.436
MOD_GSK3_1	1132	1139	PF00069	0.359
MOD_GSK3_1	1187	1194	PF00069	0.606
MOD_GSK3_1	12	19	PF00069	0.387
MOD_GSK3_1	228	235	PF00069	0.418
MOD_GSK3_1	319	326	PF00069	0.461
MOD_GSK3_1	327	334	PF00069	0.595
MOD_GSK3_1	363	370	PF00069	0.364
MOD_GSK3_1	371	378	PF00069	0.378
MOD_GSK3_1	396	403	PF00069	0.485
MOD_GSK3_1	515	522	PF00069	0.410
MOD_GSK3_1	53	60	PF00069	0.576
MOD_GSK3_1	731	738	PF00069	0.485
MOD_GSK3_1	945	952	PF00069	0.727
MOD_LATS_1	692	698	PF00433	0.484
MOD_N-GLC_1	631	636	PF02516	0.463
MOD_N-GLC_1	882	887	PF02516	0.732
MOD_N-GLC_2	618	620	PF02516	0.342
MOD_NEK2_1	1	6	PF00069	0.590
MOD_NEK2_1	1069	1074	PF00069	0.501
MOD_NEK2_1	159	164	PF00069	0.388
MOD_NEK2_1	228	233	PF00069	0.487
MOD_NEK2_1	241	246	PF00069	0.388
MOD_NEK2_1	352	357	PF00069	0.511
MOD_NEK2_1	368	373	PF00069	0.264
MOD_NEK2_1	426	431	PF00069	0.409
MOD_NEK2_1	446	451	PF00069	0.165
MOD_NEK2_1	535	540	PF00069	0.447
MOD_NEK2_1	631	636	PF00069	0.435
MOD_NEK2_1	857	862	PF00069	0.512
MOD_NEK2_1	989	994	PF00069	0.420
MOD_PIKK_1	1099	1105	PF00454	0.495
MOD_PIKK_1	519	525	PF00454	0.371
MOD_PIKK_1	836	842	PF00454	0.432
MOD_PIKK_1	945	951	PF00454	0.557
MOD_PKA_1	400	406	PF00069	0.416
MOD_PKA_2	386	392	PF00069	0.544
MOD_PKA_2	857	863	PF00069	0.549
MOD_PKB_1	398	406	PF00069	0.466
MOD_PKB_1	77	85	PF00069	0.500
MOD_Plk_1	323	329	PF00069	0.507
MOD_Plk_1	609	615	PF00069	0.357
MOD_Plk_1	631	637	PF00069	0.363
MOD_Plk_1	882	888	PF00069	0.723
MOD_Plk_2-3	640	646	PF00069	0.536
MOD_Plk_2-3	677	683	PF00069	0.703
MOD_Plk_2-3	873	879	PF00069	0.738
MOD_Plk_2-3	882	888	PF00069	0.712
MOD_Plk_4	1032	1038	PF00069	0.387
MOD_Plk_4	1096	1102	PF00069	0.419
MOD_Plk_4	1136	1142	PF00069	0.335
MOD_Plk_4	1192	1198	PF00069	0.516
MOD_Plk_4	12	18	PF00069	0.480
MOD_Plk_4	1224	1230	PF00069	0.463
MOD_Plk_4	177	183	PF00069	0.446
MOD_Plk_4	187	193	PF00069	0.404
MOD_Plk_4	241	247	PF00069	0.395
MOD_Plk_4	400	406	PF00069	0.416
MOD_Plk_4	413	419	PF00069	0.404
MOD_Plk_4	48	54	PF00069	0.471
MOD_Plk_4	503	509	PF00069	0.458
MOD_Plk_4	785	791	PF00069	0.590
MOD_Plk_4	828	834	PF00069	0.407
MOD_ProDKin_1	1049	1055	PF00069	0.600
MOD_ProDKin_1	53	59	PF00069	0.526
MOD_ProDKin_1	557	563	PF00069	0.457
MOD_SUMO_rev_2	230	240	PF00179	0.473
MOD_SUMO_rev_2	699	705	PF00179	0.374
TRG_DiLeu_BaEn_1	804	809	PF01217	0.526
TRG_DiLeu_BaLyEn_6	1007	1012	PF01217	0.439
TRG_DiLeu_BaLyEn_6	1144	1149	PF01217	0.498
TRG_DiLeu_BaLyEn_6	469	474	PF01217	0.318
TRG_ENDOCYTIC_2	1040	1043	PF00928	0.506
TRG_ENDOCYTIC_2	261	264	PF00928	0.522
TRG_ENDOCYTIC_2	589	592	PF00928	0.457
TRG_ENDOCYTIC_2	741	744	PF00928	0.457
TRG_ENDOCYTIC_2	889	892	PF00928	0.634
TRG_ENDOCYTIC_2	960	963	PF00928	0.631
TRG_ENDOCYTIC_2	997	1000	PF00928	0.498
TRG_ER_diArg_1	283	286	PF00400	0.416
TRG_ER_diArg_1	29	31	PF00400	0.567
TRG_ER_diArg_1	418	421	PF00400	0.387
TRG_ER_diArg_1	481	484	PF00400	0.314
TRG_ER_diArg_1	693	696	PF00400	0.565
TRG_ER_diArg_1	76	79	PF00400	0.478
TRG_ER_diArg_1	915	917	PF00400	0.682
TRG_NES_CRM1_1	1153	1167	PF08389	0.508
TRG_NES_CRM1_1	800	814	PF08389	0.532
TRG_Pf-PMV_PEXEL_1	1091	1095	PF00026	0.373
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	811	815	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	85	90	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	96	101	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4K3	Leptomonas seymouri	73%	100%
A0A0S4J3W9	Bodo saltans	37%	100%
A0A1X0NRZ8	Trypanosomatidae	46%	100%
A0A3S5H5Z4	Leishmania donovani	96%	99%
A0A422P327	Trypanosoma rangeli	45%	100%
A4H524	Leishmania braziliensis	84%	100%
A4HT97	Leishmania infantum	96%	100%
D0AAL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AL86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
P40069	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	100%