LeishMANIAdb
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Importin N-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Importin N-terminal domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QIL9_LEIMA
TriTrypDb:
LmjF.07.0720 , LMJLV39_070013700 * , LMJSD75_070013800 *
Length:
1257

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 7
GO:0005737 cytoplasm 2 11
GO:0043226 organelle 2 7
GO:0043227 membrane-bounded organelle 3 7
GO:0043229 intracellular organelle 3 7
GO:0043231 intracellular membrane-bounded organelle 4 7
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

Q4QIL9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIL9

Function

Biological processes
Term Name Level Count
GO:0006606 protein import into nucleus 5 11
GO:0006810 transport 3 11
GO:0006886 intracellular protein transport 4 11
GO:0006913 nucleocytoplasmic transport 5 11
GO:0008104 protein localization 4 11
GO:0009987 cellular process 1 11
GO:0015031 protein transport 4 11
GO:0033036 macromolecule localization 2 11
GO:0033365 protein localization to organelle 5 11
GO:0034504 protein localization to nucleus 6 11
GO:0045184 establishment of protein localization 3 11
GO:0046907 intracellular transport 3 11
GO:0051169 nuclear transport 4 11
GO:0051170 import into nucleus 6 11
GO:0051179 localization 1 11
GO:0051234 establishment of localization 2 11
GO:0051641 cellular localization 2 11
GO:0051649 establishment of localization in cell 3 11
GO:0070727 cellular macromolecule localization 3 11
GO:0071702 organic substance transport 4 11
GO:0071705 nitrogen compound transport 4 11
GO:0072594 establishment of protein localization to organelle 4 11
Molecular functions
Term Name Level Count
GO:0005048 signal sequence binding 4 2
GO:0005488 binding 1 11
GO:0005515 protein binding 2 11
GO:0008139 nuclear localization sequence binding 5 2
GO:0019899 enzyme binding 3 11
GO:0031267 small GTPase binding 5 11
GO:0033218 amide binding 2 2
GO:0042277 peptide binding 3 2
GO:0051020 GTPase binding 4 11
GO:0061608 nuclear import signal receptor activity 3 2
GO:0140104 molecular carrier activity 1 2
GO:0140142 nucleocytoplasmic carrier activity 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 1128 1132 PF00656 0.501
CLV_C14_Caspase3-7 734 738 PF00656 0.558
CLV_C14_Caspase3-7 844 848 PF00656 0.553
CLV_C14_Caspase3-7 879 883 PF00656 0.690
CLV_MEL_PAP_1 418 424 PF00089 0.492
CLV_NRD_NRD_1 30 32 PF00675 0.497
CLV_NRD_NRD_1 399 401 PF00675 0.359
CLV_NRD_NRD_1 420 422 PF00675 0.405
CLV_NRD_NRD_1 483 485 PF00675 0.314
CLV_NRD_NRD_1 76 78 PF00675 0.368
CLV_NRD_NRD_1 865 867 PF00675 0.703
CLV_NRD_NRD_1 916 918 PF00675 0.676
CLV_PCSK_KEX2_1 29 31 PF00082 0.500
CLV_PCSK_KEX2_1 419 421 PF00082 0.420
CLV_PCSK_KEX2_1 482 484 PF00082 0.298
CLV_PCSK_KEX2_1 78 80 PF00082 0.475
CLV_PCSK_KEX2_1 865 867 PF00082 0.703
CLV_PCSK_KEX2_1 916 918 PF00082 0.676
CLV_PCSK_PC1ET2_1 78 80 PF00082 0.475
CLV_PCSK_SKI1_1 121 125 PF00082 0.471
CLV_PCSK_SKI1_1 1249 1253 PF00082 0.502
CLV_PCSK_SKI1_1 214 218 PF00082 0.420
CLV_PCSK_SKI1_1 375 379 PF00082 0.388
CLV_PCSK_SKI1_1 400 404 PF00082 0.456
CLV_PCSK_SKI1_1 583 587 PF00082 0.432
CLV_PCSK_SKI1_1 754 758 PF00082 0.421
CLV_PCSK_SKI1_1 78 82 PF00082 0.405
CLV_PCSK_SKI1_1 85 89 PF00082 0.437
CLV_PCSK_SKI1_1 96 100 PF00082 0.299
CLV_Separin_Metazoa 550 554 PF03568 0.536
DEG_COP1_1 498 507 PF00400 0.515
DEG_MDM2_SWIB_1 1112 1119 PF02201 0.484
DEG_Nend_UBRbox_3 1 3 PF02207 0.723
DEG_ODPH_VHL_1 1059 1071 PF01847 0.497
DEG_SCF_FBW7_1 53 60 PF00400 0.542
DOC_ANK_TNKS_1 1090 1097 PF00023 0.444
DOC_CDC14_PxL_1 201 209 PF14671 0.523
DOC_CDC14_PxL_1 303 311 PF14671 0.436
DOC_CKS1_1 558 563 PF01111 0.492
DOC_CYCLIN_yCln2_LP_2 1000 1006 PF00134 0.517
DOC_CYCLIN_yCln2_LP_2 1144 1150 PF00134 0.301
DOC_CYCLIN_yCln2_LP_2 507 513 PF00134 0.434
DOC_CYCLIN_yCln2_LP_2 552 558 PF00134 0.411
DOC_MAPK_DCC_7 1142 1151 PF00069 0.292
DOC_MAPK_gen_1 398 407 PF00069 0.358
DOC_MAPK_gen_1 419 428 PF00069 0.452
DOC_MAPK_gen_1 799 808 PF00069 0.527
DOC_MAPK_HePTP_8 798 810 PF00069 0.520
DOC_MAPK_MEF2A_6 1142 1151 PF00069 0.418
DOC_MAPK_MEF2A_6 238 245 PF00069 0.401
DOC_MAPK_MEF2A_6 465 473 PF00069 0.465
DOC_MAPK_MEF2A_6 801 810 PF00069 0.525
DOC_MAPK_RevD_3 468 484 PF00069 0.426
DOC_PP1_RVXF_1 107 114 PF00149 0.431
DOC_PP2B_LxvP_1 1058 1061 PF13499 0.515
DOC_PP2B_LxvP_1 1144 1147 PF13499 0.302
DOC_PP2B_LxvP_1 962 965 PF13499 0.665
DOC_SPAK_OSR1_1 112 116 PF12202 0.428
DOC_USP7_MATH_1 1039 1043 PF00917 0.510
DOC_USP7_MATH_1 1136 1140 PF00917 0.375
DOC_USP7_MATH_1 1191 1195 PF00917 0.599
DOC_USP7_MATH_1 177 181 PF00917 0.498
DOC_USP7_MATH_1 447 451 PF00917 0.415
DOC_USP7_MATH_1 516 520 PF00917 0.470
DOC_USP7_MATH_1 540 544 PF00917 0.544
DOC_USP7_MATH_1 654 658 PF00917 0.617
DOC_USP7_MATH_1 756 760 PF00917 0.410
DOC_USP7_MATH_1 782 786 PF00917 0.716
DOC_USP7_MATH_1 924 928 PF00917 0.658
DOC_WW_Pin1_4 1049 1054 PF00397 0.612
DOC_WW_Pin1_4 53 58 PF00397 0.516
DOC_WW_Pin1_4 557 562 PF00397 0.464
LIG_14-3-3_CanoR_1 1083 1092 PF00244 0.496
LIG_14-3-3_CanoR_1 387 395 PF00244 0.559
LIG_14-3-3_CanoR_1 400 405 PF00244 0.387
LIG_14-3-3_CanoR_1 567 577 PF00244 0.385
LIG_14-3-3_CanoR_1 79 84 PF00244 0.422
LIG_14-3-3_CanoR_1 85 95 PF00244 0.476
LIG_Actin_WH2_2 795 813 PF00022 0.500
LIG_AP2alpha_2 912 914 PF02296 0.642
LIG_APCC_ABBA_1 1012 1017 PF00400 0.528
LIG_APCC_ABBA_1 1059 1064 PF00400 0.507
LIG_APCC_ABBA_1 459 464 PF00400 0.483
LIG_APCC_ABBA_1 710 715 PF00400 0.453
LIG_APCC_Cbox_2 501 507 PF00515 0.538
LIG_BIR_III_2 435 439 PF00653 0.502
LIG_BIR_III_4 1044 1048 PF00653 0.500
LIG_BRCT_BRCA1_1 373 377 PF00533 0.507
LIG_BRCT_BRCA1_1 537 541 PF00533 0.474
LIG_BRCT_BRCA1_1 611 615 PF00533 0.351
LIG_CORNRBOX 13 21 PF00104 0.520
LIG_DLG_GKlike_1 609 616 PF00625 0.354
LIG_eIF4E_1 1088 1094 PF01652 0.380
LIG_FHA_1 106 112 PF00498 0.476
LIG_FHA_1 1188 1194 PF00498 0.579
LIG_FHA_1 324 330 PF00498 0.475
LIG_FHA_1 35 41 PF00498 0.529
LIG_FHA_1 376 382 PF00498 0.369
LIG_FHA_1 475 481 PF00498 0.381
LIG_FHA_1 561 567 PF00498 0.439
LIG_FHA_1 569 575 PF00498 0.362
LIG_FHA_1 695 701 PF00498 0.421
LIG_FHA_2 1210 1216 PF00498 0.468
LIG_FHA_2 146 152 PF00498 0.523
LIG_FHA_2 204 210 PF00498 0.528
LIG_FHA_2 489 495 PF00498 0.298
LIG_FHA_2 639 645 PF00498 0.425
LIG_FHA_2 7 13 PF00498 0.495
LIG_FHA_2 732 738 PF00498 0.465
LIG_FHA_2 810 816 PF00498 0.480
LIG_FHA_2 898 904 PF00498 0.751
LIG_GBD_Chelix_1 268 276 PF00786 0.452
LIG_GBD_Chelix_1 853 861 PF00786 0.579
LIG_Integrin_RGD_1 896 898 PF01839 0.624
LIG_LIR_Gen_1 1070 1075 PF02991 0.490
LIG_LIR_Gen_1 247 257 PF02991 0.512
LIG_LIR_Gen_1 374 385 PF02991 0.481
LIG_LIR_Nem_3 132 137 PF02991 0.480
LIG_LIR_Nem_3 162 166 PF02991 0.535
LIG_LIR_Nem_3 247 252 PF02991 0.457
LIG_LIR_Nem_3 374 380 PF02991 0.452
LIG_LIR_Nem_3 588 593 PF02991 0.349
LIG_LIR_Nem_3 610 616 PF02991 0.337
LIG_LIR_Nem_3 625 630 PF02991 0.384
LIG_LIR_Nem_3 738 744 PF02991 0.476
LIG_LIR_Nem_3 82 87 PF02991 0.403
LIG_LIR_Nem_3 885 889 PF02991 0.640
LIG_LYPXL_yS_3 741 744 PF13949 0.528
LIG_MYND_1 1006 1010 PF01753 0.460
LIG_MYND_1 505 509 PF01753 0.495
LIG_MYND_3 471 475 PF01753 0.381
LIG_NRBOX 1177 1183 PF00104 0.414
LIG_NRBOX 804 810 PF00104 0.461
LIG_NRBOX 94 100 PF00104 0.488
LIG_PCNA_yPIPBox_3 85 99 PF02747 0.519
LIG_Pex14_2 1112 1116 PF04695 0.485
LIG_Pex14_2 163 167 PF04695 0.543
LIG_Pex14_2 249 253 PF04695 0.371
LIG_Pex14_2 623 627 PF04695 0.494
LIG_PTAP_UEV_1 61 66 PF05743 0.389
LIG_PTB_Apo_2 2 9 PF02174 0.571
LIG_PTB_Phospho_1 2 8 PF10480 0.581
LIG_REV1ctd_RIR_1 912 921 PF16727 0.667
LIG_SH2_CRK 261 265 PF00017 0.514
LIG_SH2_CRK 889 893 PF00017 0.722
LIG_SH2_CRK 960 964 PF00017 0.632
LIG_SH2_CRK 997 1001 PF00017 0.492
LIG_SH2_GRB2like 630 633 PF00017 0.462
LIG_SH2_STAT5 1007 1010 PF00017 0.442
LIG_SH2_STAT5 1088 1091 PF00017 0.386
LIG_SH2_STAT5 1180 1183 PF00017 0.450
LIG_SH2_STAT5 384 387 PF00017 0.484
LIG_SH2_STAT5 417 420 PF00017 0.392
LIG_SH2_STAT5 424 427 PF00017 0.372
LIG_SH2_STAT5 503 506 PF00017 0.434
LIG_SH2_STAT5 630 633 PF00017 0.414
LIG_SH2_STAT5 708 711 PF00017 0.368
LIG_SH2_STAT5 8 11 PF00017 0.558
LIG_SH2_STAT5 836 839 PF00017 0.402
LIG_SH2_STAT5 907 910 PF00017 0.625
LIG_SH3_2 107 112 PF14604 0.327
LIG_SH3_3 1000 1006 PF00018 0.492
LIG_SH3_3 104 110 PF00018 0.334
LIG_SH3_3 1144 1150 PF00018 0.373
LIG_SH3_3 1151 1157 PF00018 0.373
LIG_SH3_3 199 205 PF00018 0.408
LIG_SH3_3 301 307 PF00018 0.495
LIG_SH3_3 377 383 PF00018 0.434
LIG_SH3_3 59 65 PF00018 0.532
LIG_SH3_3 969 975 PF00018 0.698
LIG_SUMO_SIM_anti_2 547 553 PF11976 0.469
LIG_SUMO_SIM_anti_2 828 835 PF11976 0.398
LIG_SUMO_SIM_par_1 156 162 PF11976 0.475
LIG_SUMO_SIM_par_1 200 206 PF11976 0.494
LIG_SUMO_SIM_par_1 244 250 PF11976 0.347
LIG_SUMO_SIM_par_1 322 331 PF11976 0.474
LIG_SUMO_SIM_par_1 424 429 PF11976 0.506
LIG_SUMO_SIM_par_1 794 800 PF11976 0.312
LIG_TRAF2_1 812 815 PF00917 0.516
LIG_UBA3_1 1158 1165 PF00899 0.503
LIG_UBA3_1 252 260 PF00899 0.493
LIG_UBA3_1 749 757 PF00899 0.449
LIG_Vh1_VBS_1 515 533 PF01044 0.472
LIG_WRC_WIRS_1 160 165 PF05994 0.522
LIG_WRC_WIRS_1 448 453 PF05994 0.423
LIG_WW_1 957 960 PF00397 0.646
MOD_CK1_1 1052 1058 PF00069 0.509
MOD_CK1_1 1077 1083 PF00069 0.504
MOD_CK1_1 1099 1105 PF00069 0.452
MOD_CK1_1 386 392 PF00069 0.454
MOD_CK1_1 519 525 PF00069 0.379
MOD_CK1_1 657 663 PF00069 0.638
MOD_CK1_1 785 791 PF00069 0.562
MOD_CK2_1 145 151 PF00069 0.477
MOD_CK2_1 159 165 PF00069 0.355
MOD_CK2_1 203 209 PF00069 0.525
MOD_CK2_1 488 494 PF00069 0.298
MOD_CK2_1 515 521 PF00069 0.440
MOD_CK2_1 6 12 PF00069 0.551
MOD_CK2_1 638 644 PF00069 0.409
MOD_CK2_1 809 815 PF00069 0.461
MOD_GlcNHglycan 1085 1088 PF01048 0.391
MOD_GlcNHglycan 1134 1137 PF01048 0.345
MOD_GlcNHglycan 173 176 PF01048 0.485
MOD_GlcNHglycan 230 233 PF01048 0.471
MOD_GlcNHglycan 333 336 PF01048 0.737
MOD_GlcNHglycan 355 358 PF01048 0.469
MOD_GlcNHglycan 365 368 PF01048 0.362
MOD_GlcNHglycan 537 540 PF01048 0.495
MOD_GlcNHglycan 578 581 PF01048 0.484
MOD_GlcNHglycan 658 662 PF01048 0.642
MOD_GlcNHglycan 704 707 PF01048 0.348
MOD_GlcNHglycan 758 761 PF01048 0.482
MOD_GlcNHglycan 784 788 PF01048 0.662
MOD_GlcNHglycan 900 903 PF01048 0.742
MOD_GlcNHglycan 926 929 PF01048 0.658
MOD_GlcNHglycan 951 954 PF01048 0.689
MOD_GSK3_1 1025 1032 PF00069 0.429
MOD_GSK3_1 1074 1081 PF00069 0.436
MOD_GSK3_1 1132 1139 PF00069 0.359
MOD_GSK3_1 1187 1194 PF00069 0.606
MOD_GSK3_1 12 19 PF00069 0.387
MOD_GSK3_1 228 235 PF00069 0.418
MOD_GSK3_1 319 326 PF00069 0.461
MOD_GSK3_1 327 334 PF00069 0.595
MOD_GSK3_1 363 370 PF00069 0.364
MOD_GSK3_1 371 378 PF00069 0.378
MOD_GSK3_1 396 403 PF00069 0.485
MOD_GSK3_1 515 522 PF00069 0.410
MOD_GSK3_1 53 60 PF00069 0.576
MOD_GSK3_1 731 738 PF00069 0.485
MOD_GSK3_1 945 952 PF00069 0.727
MOD_LATS_1 692 698 PF00433 0.484
MOD_N-GLC_1 631 636 PF02516 0.463
MOD_N-GLC_1 882 887 PF02516 0.732
MOD_N-GLC_2 618 620 PF02516 0.342
MOD_NEK2_1 1 6 PF00069 0.590
MOD_NEK2_1 1069 1074 PF00069 0.501
MOD_NEK2_1 159 164 PF00069 0.388
MOD_NEK2_1 228 233 PF00069 0.487
MOD_NEK2_1 241 246 PF00069 0.388
MOD_NEK2_1 352 357 PF00069 0.511
MOD_NEK2_1 368 373 PF00069 0.264
MOD_NEK2_1 426 431 PF00069 0.409
MOD_NEK2_1 446 451 PF00069 0.165
MOD_NEK2_1 535 540 PF00069 0.447
MOD_NEK2_1 631 636 PF00069 0.435
MOD_NEK2_1 857 862 PF00069 0.512
MOD_NEK2_1 989 994 PF00069 0.420
MOD_PIKK_1 1099 1105 PF00454 0.495
MOD_PIKK_1 519 525 PF00454 0.371
MOD_PIKK_1 836 842 PF00454 0.432
MOD_PIKK_1 945 951 PF00454 0.557
MOD_PKA_1 400 406 PF00069 0.416
MOD_PKA_2 386 392 PF00069 0.544
MOD_PKA_2 857 863 PF00069 0.549
MOD_PKB_1 398 406 PF00069 0.466
MOD_PKB_1 77 85 PF00069 0.500
MOD_Plk_1 323 329 PF00069 0.507
MOD_Plk_1 609 615 PF00069 0.357
MOD_Plk_1 631 637 PF00069 0.363
MOD_Plk_1 882 888 PF00069 0.723
MOD_Plk_2-3 640 646 PF00069 0.536
MOD_Plk_2-3 677 683 PF00069 0.703
MOD_Plk_2-3 873 879 PF00069 0.738
MOD_Plk_2-3 882 888 PF00069 0.712
MOD_Plk_4 1032 1038 PF00069 0.387
MOD_Plk_4 1096 1102 PF00069 0.419
MOD_Plk_4 1136 1142 PF00069 0.335
MOD_Plk_4 1192 1198 PF00069 0.516
MOD_Plk_4 12 18 PF00069 0.480
MOD_Plk_4 1224 1230 PF00069 0.463
MOD_Plk_4 177 183 PF00069 0.446
MOD_Plk_4 187 193 PF00069 0.404
MOD_Plk_4 241 247 PF00069 0.395
MOD_Plk_4 400 406 PF00069 0.416
MOD_Plk_4 413 419 PF00069 0.404
MOD_Plk_4 48 54 PF00069 0.471
MOD_Plk_4 503 509 PF00069 0.458
MOD_Plk_4 785 791 PF00069 0.590
MOD_Plk_4 828 834 PF00069 0.407
MOD_ProDKin_1 1049 1055 PF00069 0.600
MOD_ProDKin_1 53 59 PF00069 0.526
MOD_ProDKin_1 557 563 PF00069 0.457
MOD_SUMO_rev_2 230 240 PF00179 0.473
MOD_SUMO_rev_2 699 705 PF00179 0.374
TRG_DiLeu_BaEn_1 804 809 PF01217 0.526
TRG_DiLeu_BaLyEn_6 1007 1012 PF01217 0.439
TRG_DiLeu_BaLyEn_6 1144 1149 PF01217 0.498
TRG_DiLeu_BaLyEn_6 469 474 PF01217 0.318
TRG_ENDOCYTIC_2 1040 1043 PF00928 0.506
TRG_ENDOCYTIC_2 261 264 PF00928 0.522
TRG_ENDOCYTIC_2 589 592 PF00928 0.457
TRG_ENDOCYTIC_2 741 744 PF00928 0.457
TRG_ENDOCYTIC_2 889 892 PF00928 0.634
TRG_ENDOCYTIC_2 960 963 PF00928 0.631
TRG_ENDOCYTIC_2 997 1000 PF00928 0.498
TRG_ER_diArg_1 283 286 PF00400 0.416
TRG_ER_diArg_1 29 31 PF00400 0.567
TRG_ER_diArg_1 418 421 PF00400 0.387
TRG_ER_diArg_1 481 484 PF00400 0.314
TRG_ER_diArg_1 693 696 PF00400 0.565
TRG_ER_diArg_1 76 79 PF00400 0.478
TRG_ER_diArg_1 915 917 PF00400 0.682
TRG_NES_CRM1_1 1153 1167 PF08389 0.508
TRG_NES_CRM1_1 800 814 PF08389 0.532
TRG_Pf-PMV_PEXEL_1 1091 1095 PF00026 0.373
TRG_Pf-PMV_PEXEL_1 183 187 PF00026 0.500
TRG_Pf-PMV_PEXEL_1 811 815 PF00026 0.482
TRG_Pf-PMV_PEXEL_1 85 90 PF00026 0.506
TRG_Pf-PMV_PEXEL_1 96 101 PF00026 0.497

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4K3 Leptomonas seymouri 73% 100%
A0A0S4J3W9 Bodo saltans 37% 100%
A0A1X0NRZ8 Trypanosomatidae 46% 100%
A0A3S5H5Z4 Leishmania donovani 96% 99%
A0A422P327 Trypanosoma rangeli 45% 100%
A4H524 Leishmania braziliensis 84% 100%
A4HT97 Leishmania infantum 96% 100%
D0AAL4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
E9AL86 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
P40069 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 21% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS