Protein phosphatase inhibitor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase inhibitor, putative

Species:

Leishmania major

UniProt:

Q4QIL6_LEIMA

TriTrypDb:

LmjF.07.0743 , LMJLV39_070014000 , LMJSD75_070014100

Length:

138

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QIL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIL6

Function

Biological processes
Term	Name	Level	Count
GO:0009892	negative regulation of metabolic process	4	10
GO:0010563	negative regulation of phosphorus metabolic process	6	10
GO:0010605	negative regulation of macromolecule metabolic process	5	10
GO:0010921	regulation of phosphatase activity	5	10
GO:0010923	negative regulation of phosphatase activity	6	10
GO:0019220	regulation of phosphate metabolic process	6	10
GO:0019222	regulation of metabolic process	3	10
GO:0031323	regulation of cellular metabolic process	4	10
GO:0031324	negative regulation of cellular metabolic process	5	10
GO:0031399	regulation of protein modification process	6	10
GO:0031400	negative regulation of protein modification process	7	10
GO:0032515	negative regulation of phosphoprotein phosphatase activity	7	10
GO:0035303	regulation of dephosphorylation	7	10
GO:0035304	regulation of protein dephosphorylation	7	10
GO:0035305	negative regulation of dephosphorylation	8	10
GO:0035308	negative regulation of protein dephosphorylation	8	10
GO:0043086	negative regulation of catalytic activity	4	10
GO:0043666	regulation of phosphoprotein phosphatase activity	6	10
GO:0044092	negative regulation of molecular function	3	10
GO:0045936	negative regulation of phosphate metabolic process	7	10
GO:0048519	negative regulation of biological process	3	10
GO:0048523	negative regulation of cellular process	4	10
GO:0050789	regulation of biological process	2	10
GO:0050790	regulation of catalytic activity	3	10
GO:0050794	regulation of cellular process	3	10
GO:0051171	regulation of nitrogen compound metabolic process	4	10
GO:0051172	negative regulation of nitrogen compound metabolic process	5	10
GO:0051174	regulation of phosphorus metabolic process	5	10
GO:0051246	regulation of protein metabolic process	5	10
GO:0051248	negative regulation of protein metabolic process	6	10
GO:0051336	regulation of hydrolase activity	4	10
GO:0051346	negative regulation of hydrolase activity	5	10
GO:0060255	regulation of macromolecule metabolic process	4	10
GO:0065007	biological regulation	1	10
GO:0065009	regulation of molecular function	2	10
GO:0080090	regulation of primary metabolic process	4	10

Molecular functions
Term	Name	Level	Count
GO:0004857	enzyme inhibitor activity	3	10
GO:0004864	protein phosphatase inhibitor activity	5	10
GO:0004865	protein serine/threonine phosphatase inhibitor activity	6	10
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008157	protein phosphatase 1 binding	6	2
GO:0019208	phosphatase regulator activity	3	10
GO:0019212	phosphatase inhibitor activity	4	10
GO:0019888	protein phosphatase regulator activity	4	10
GO:0019899	enzyme binding	3	2
GO:0019902	phosphatase binding	4	2
GO:0019903	protein phosphatase binding	5	2
GO:0030234	enzyme regulator activity	2	10
GO:0098772	molecular function regulator activity	1	10
GO:0140678	molecular function inhibitor activity	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	79	83	PF00656	0.425
CLV_C14_Caspase3-7	86	90	PF00656	0.642
CLV_C14_Caspase3-7	93	97	PF00656	0.599
CLV_NRD_NRD_1	119	121	PF00675	0.514
CLV_PCSK_SKI1_1	73	77	PF00082	0.274
DEG_Nend_UBRbox_2	1	3	PF02207	0.710
DOC_CYCLIN_RxL_1	70	80	PF00134	0.292
DOC_MAPK_gen_1	40	49	PF00069	0.461
DOC_PP1_RVXF_1	46	52	PF00149	0.276
DOC_USP7_UBL2_3	121	125	PF12436	0.458
LIG_14-3-3_CanoR_1	48	52	PF00244	0.281
LIG_APCC_ABBAyCdc20_2	72	78	PF00400	0.274
LIG_FHA_1	14	20	PF00498	0.481
LIG_FHA_1	22	28	PF00498	0.515
LIG_FHA_2	32	38	PF00498	0.405
LIG_HCF-1_HBM_1	129	132	PF13415	0.552
LIG_SH2_STAT3	109	112	PF00017	0.477
LIG_SH2_STAT5	132	135	PF00017	0.535
LIG_SH3_3	52	58	PF00018	0.405
LIG_TRAF2_1	34	37	PF00917	0.350
LIG_WW_3	117	121	PF00397	0.550
MOD_CK1_1	80	86	PF00069	0.311
MOD_CK1_1	87	93	PF00069	0.598
MOD_CK2_1	31	37	PF00069	0.355
MOD_GlcNHglycan	96	99	PF01048	0.634
MOD_GSK3_1	76	83	PF00069	0.308
MOD_GSK3_1	84	91	PF00069	0.584
MOD_NEK2_1	47	52	PF00069	0.350
MOD_NEK2_1	76	81	PF00069	0.292
MOD_PKA_2	47	53	PF00069	0.330
TRG_NLS_MonoExtC_3	119	124	PF00514	0.571
TRG_NLS_MonoExtN_4	118	124	PF00514	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4K2	Leptomonas seymouri	59%	97%
A0A0S4JN47	Bodo saltans	36%	93%
A0A1X0NPH1	Trypanosomatidae	40%	81%
A0A3R7K085	Trypanosoma rangeli	49%	100%
A0A3S5H5Z7	Leishmania donovani	75%	92%
A4HTA0	Leishmania infantum	75%	92%
C9ZUM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	96%
E9AL89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	92%