Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIL4_LEIMA

TriTrypDb:

LmjF.07.0750 , LMJLV39_070014200 , LMJSD75_070014300

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QIL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIL4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.559
CLV_NRD_NRD_1	101	103	PF00675	0.721
CLV_NRD_NRD_1	118	120	PF00675	0.600
CLV_NRD_NRD_1	12	14	PF00675	0.691
CLV_NRD_NRD_1	287	289	PF00675	0.489
CLV_NRD_NRD_1	68	70	PF00675	0.823
CLV_PCSK_FUR_1	64	68	PF00082	0.789
CLV_PCSK_KEX2_1	100	102	PF00082	0.728
CLV_PCSK_KEX2_1	117	119	PF00082	0.594
CLV_PCSK_KEX2_1	12	14	PF00082	0.691
CLV_PCSK_KEX2_1	286	288	PF00082	0.487
CLV_PCSK_KEX2_1	66	68	PF00082	0.812
CLV_PCSK_PC7_1	64	70	PF00082	0.768
CLV_PCSK_SKI1_1	250	254	PF00082	0.576
DEG_APCC_DBOX_1	249	257	PF00400	0.381
DEG_Nend_UBRbox_1	1	4	PF02207	0.484
DOC_MAPK_HePTP_8	243	255	PF00069	0.462
DOC_MAPK_JIP1_4	250	256	PF00069	0.331
DOC_MAPK_MEF2A_6	171	180	PF00069	0.535
DOC_MAPK_MEF2A_6	246	255	PF00069	0.459
DOC_PP4_FxxP_1	38	41	PF00568	0.573
DOC_USP7_MATH_1	140	144	PF00917	0.537
DOC_USP7_MATH_1	146	150	PF00917	0.671
LIG_Actin_WH2_2	176	191	PF00022	0.443
LIG_FHA_1	109	115	PF00498	0.375
LIG_FHA_1	171	177	PF00498	0.491
LIG_FHA_1	183	189	PF00498	0.479
LIG_FHA_2	137	143	PF00498	0.554
LIG_FHA_2	47	53	PF00498	0.537
LIG_LIR_Apic_2	207	212	PF02991	0.554
LIG_LIR_Gen_1	5	16	PF02991	0.506
LIG_LIR_Gen_1	51	60	PF02991	0.524
LIG_LIR_Nem_3	5	11	PF02991	0.501
LIG_LIR_Nem_3	51	56	PF02991	0.519
LIG_NRBOX	252	258	PF00104	0.384
LIG_SH2_CRK	209	213	PF00017	0.553
LIG_SH2_CRK	53	57	PF00017	0.518
LIG_SH2_CRK	8	12	PF00017	0.505
LIG_SH2_GRB2like	131	134	PF00017	0.518
LIG_SH2_GRB2like	209	212	PF00017	0.499
LIG_SH2_NCK_1	53	57	PF00017	0.518
LIG_SH2_SRC	209	212	PF00017	0.499
LIG_SH2_STAT5	231	234	PF00017	0.502
LIG_SH3_3	245	251	PF00018	0.463
LIG_TRAF2_1	49	52	PF00917	0.545
MOD_CK1_1	145	151	PF00069	0.646
MOD_CK2_1	184	190	PF00069	0.409
MOD_CK2_1	46	52	PF00069	0.541
MOD_Cter_Amidation	98	101	PF01082	0.721
MOD_GlcNHglycan	144	147	PF01048	0.846
MOD_GlcNHglycan	148	151	PF01048	0.842
MOD_GlcNHglycan	213	216	PF01048	0.746
MOD_GlcNHglycan	261	264	PF01048	0.420
MOD_GlcNHglycan	28	31	PF01048	0.690
MOD_GlcNHglycan	75	79	PF01048	0.780
MOD_GSK3_1	136	143	PF00069	0.644
MOD_N-GLC_1	181	186	PF02516	0.693
MOD_N-GLC_1	44	49	PF02516	0.698
MOD_NEK2_1	170	175	PF00069	0.451
MOD_NEK2_1	181	186	PF00069	0.493
MOD_NEK2_1	194	199	PF00069	0.405
MOD_NEK2_1	204	209	PF00069	0.487
MOD_NEK2_1	233	238	PF00069	0.461
MOD_NEK2_1	257	262	PF00069	0.527
MOD_NEK2_1	268	273	PF00069	0.345
MOD_PKA_2	170	176	PF00069	0.503
MOD_Plk_1	44	50	PF00069	0.500
MOD_Plk_2-3	205	211	PF00069	0.497
MOD_Plk_2-3	93	99	PF00069	0.527
TRG_DiLeu_BaEn_1	6	11	PF01217	0.497
TRG_DiLeu_BaLyEn_6	248	253	PF01217	0.456
TRG_ENDOCYTIC_2	231	234	PF00928	0.516
TRG_ENDOCYTIC_2	53	56	PF00928	0.514
TRG_ENDOCYTIC_2	8	11	PF00928	0.499
TRG_ER_diArg_1	100	102	PF00400	0.528
TRG_ER_diArg_1	11	13	PF00400	0.483
TRG_ER_diArg_1	116	119	PF00400	0.400
TRG_ER_diArg_1	195	198	PF00400	0.512
TRG_ER_diArg_1	275	278	PF00400	0.664
TRG_ER_diArg_1	285	288	PF00400	0.620
TRG_ER_diArg_1	34	37	PF00400	0.540
TRG_ER_diArg_1	64	67	PF00400	0.602
TRG_ER_diArg_1	68	71	PF00400	0.596
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.728

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5Z9	Leishmania donovani	94%	100%
A4H527	Leishmania braziliensis	68%	80%
A4HTA1	Leishmania infantum	94%	100%
E9AL90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%