DNAJ-domain transmembrane-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNAJ-domain transmembrane-like protein

Species:

Leishmania major

UniProt:

Q4QIL2_LEIMA

TriTrypDb:

LmjF.07.0770 , LMJLV39_070014400 , LMJSD75_070014500

Length:

402

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QIL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIL2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.765
CLV_C14_Caspase3-7	215	219	PF00656	0.640
CLV_NRD_NRD_1	64	66	PF00675	0.586
CLV_PCSK_KEX2_1	64	66	PF00082	0.586
CLV_PCSK_SKI1_1	367	371	PF00082	0.411
DEG_COP1_1	138	148	PF00400	0.685
DEG_Nend_UBRbox_1	1	4	PF02207	0.684
DEG_SPOP_SBC_1	120	124	PF00917	0.783
DEG_SPOP_SBC_1	44	48	PF00917	0.789
DOC_CYCLIN_RxL_1	153	164	PF00134	0.615
DOC_MAPK_MEF2A_6	367	376	PF00069	0.389
DOC_PP1_RVXF_1	317	323	PF00149	0.441
DOC_PP2B_LxvP_1	347	350	PF13499	0.523
DOC_USP7_MATH_1	105	109	PF00917	0.736
DOC_USP7_MATH_1	119	123	PF00917	0.710
DOC_USP7_MATH_1	144	148	PF00917	0.635
DOC_USP7_MATH_1	327	331	PF00917	0.582
DOC_USP7_MATH_1	40	44	PF00917	0.694
DOC_USP7_MATH_1	56	60	PF00917	0.640
DOC_USP7_MATH_1	97	101	PF00917	0.688
DOC_WW_Pin1_4	12	17	PF00397	0.782
DOC_WW_Pin1_4	21	26	PF00397	0.753
DOC_WW_Pin1_4	278	283	PF00397	0.481
DOC_WW_Pin1_4	72	77	PF00397	0.662
DOC_WW_Pin1_4	83	88	PF00397	0.739
LIG_14-3-3_CanoR_1	247	253	PF00244	0.704
LIG_14-3-3_CanoR_1	319	323	PF00244	0.566
LIG_14-3-3_CanoR_1	324	330	PF00244	0.504
LIG_CSL_BTD_1	347	350	PF09270	0.523
LIG_EH1_1	354	362	PF00400	0.459
LIG_FHA_1	13	19	PF00498	0.738
LIG_FHA_1	140	146	PF00498	0.684
LIG_FHA_1	155	161	PF00498	0.557
LIG_FHA_1	278	284	PF00498	0.523
LIG_FHA_1	380	386	PF00498	0.447
LIG_FHA_2	129	135	PF00498	0.761
LIG_FHA_2	202	208	PF00498	0.616
LIG_FHA_2	224	230	PF00498	0.609
LIG_FHA_2	247	253	PF00498	0.708
LIG_GBD_Chelix_1	372	380	PF00786	0.447
LIG_HP1_1	16	20	PF01393	0.675
LIG_LIR_Apic_2	345	351	PF02991	0.523
LIG_LIR_Gen_1	147	155	PF02991	0.629
LIG_LIR_Gen_1	204	214	PF02991	0.644
LIG_LIR_Gen_1	354	361	PF02991	0.502
LIG_LIR_Nem_3	147	151	PF02991	0.638
LIG_LIR_Nem_3	153	158	PF02991	0.586
LIG_LIR_Nem_3	204	209	PF02991	0.640
LIG_LIR_Nem_3	266	271	PF02991	0.389
LIG_LIR_Nem_3	354	358	PF02991	0.504
LIG_Pex14_1	274	278	PF04695	0.487
LIG_SH2_CRK	180	184	PF00017	0.653
LIG_SH2_CRK	206	210	PF00017	0.639
LIG_SH2_CRK	337	341	PF00017	0.526
LIG_SH2_NCK_1	67	71	PF00017	0.746
LIG_SH2_STAP1	206	210	PF00017	0.639
LIG_SH2_STAP1	368	372	PF00017	0.447
LIG_SH2_STAP1	67	71	PF00017	0.746
LIG_SH3_3	50	56	PF00018	0.752
LIG_SUMO_SIM_anti_2	15	22	PF11976	0.675
LIG_SUMO_SIM_par_1	15	22	PF11976	0.675
LIG_TRAF2_1	131	134	PF00917	0.790
LIG_TYR_ITIM	335	340	PF00017	0.529
LIG_WRC_WIRS_1	145	150	PF05994	0.620
MOD_CK1_1	100	106	PF00069	0.673
MOD_CK1_1	12	18	PF00069	0.733
MOD_CK1_1	122	128	PF00069	0.760
MOD_CK1_1	246	252	PF00069	0.713
MOD_CK1_1	28	34	PF00069	0.679
MOD_CK1_1	43	49	PF00069	0.714
MOD_CK1_1	59	65	PF00069	0.641
MOD_CK1_1	69	75	PF00069	0.717
MOD_CK1_1	91	97	PF00069	0.715
MOD_CK2_1	122	128	PF00069	0.776
MOD_CK2_1	144	150	PF00069	0.635
MOD_CK2_1	223	229	PF00069	0.613
MOD_CK2_1	246	252	PF00069	0.713
MOD_GlcNHglycan	11	14	PF01048	0.452
MOD_GlcNHglycan	116	120	PF01048	0.457
MOD_GlcNHglycan	21	24	PF01048	0.510
MOD_GlcNHglycan	212	215	PF01048	0.450
MOD_GlcNHglycan	265	268	PF01048	0.447
MOD_GlcNHglycan	295	298	PF01048	0.749
MOD_GlcNHglycan	344	347	PF01048	0.767
MOD_GlcNHglycan	36	39	PF01048	0.465
MOD_GlcNHglycan	399	402	PF01048	0.474
MOD_GlcNHglycan	42	45	PF01048	0.541
MOD_GlcNHglycan	68	71	PF01048	0.541
MOD_GlcNHglycan	83	86	PF01048	0.527
MOD_GlcNHglycan	90	93	PF01048	0.542
MOD_GlcNHglycan	99	102	PF01048	0.445
MOD_GSK3_1	115	122	PF00069	0.767
MOD_GSK3_1	21	28	PF00069	0.734
MOD_GSK3_1	243	250	PF00069	0.651
MOD_GSK3_1	289	296	PF00069	0.561
MOD_GSK3_1	338	345	PF00069	0.531
MOD_GSK3_1	36	43	PF00069	0.629
MOD_GSK3_1	65	72	PF00069	0.706
MOD_GSK3_1	74	81	PF00069	0.726
MOD_N-GLC_1	202	207	PF02516	0.441
MOD_NEK2_1	19	24	PF00069	0.776
MOD_NEK2_1	243	248	PF00069	0.714
MOD_NEK2_1	277	282	PF00069	0.524
MOD_NEK2_1	360	365	PF00069	0.452
MOD_NEK2_2	56	61	PF00069	0.740
MOD_PIKK_1	7	13	PF00454	0.739
MOD_PKA_2	128	134	PF00069	0.732
MOD_PKA_2	246	252	PF00069	0.713
MOD_PKA_2	318	324	PF00069	0.569
MOD_Plk_1	202	208	PF00069	0.641
MOD_Plk_2-3	128	134	PF00069	0.774
MOD_Plk_4	31	37	PF00069	0.740
MOD_Plk_4	379	385	PF00069	0.447
MOD_ProDKin_1	12	18	PF00069	0.781
MOD_ProDKin_1	21	27	PF00069	0.754
MOD_ProDKin_1	278	284	PF00069	0.484
MOD_ProDKin_1	72	78	PF00069	0.664
MOD_ProDKin_1	83	89	PF00069	0.737
MOD_SUMO_rev_2	128	136	PF00179	0.793
TRG_DiLeu_BaEn_1	252	257	PF01217	0.659
TRG_ENDOCYTIC_2	152	155	PF00928	0.622
TRG_ENDOCYTIC_2	180	183	PF00928	0.655
TRG_ENDOCYTIC_2	206	209	PF00928	0.638
TRG_ENDOCYTIC_2	337	340	PF00928	0.525
TRG_NES_CRM1_1	150	164	PF08389	0.650
TRG_Pf-PMV_PEXEL_1	181	186	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPX9	Leishmania donovani	90%	96%
A4H529	Leishmania braziliensis	71%	77%
A4HTA3	Leishmania infantum	90%	66%
E9AL92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%