Flavoprotein subunit-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flavoprotein subunit-like protein

Species:

Leishmania major

UniProt:

Q4QIK9_LEIMA

TriTrypDb:

LmjF.07.0800 , LMJLV39_070014700 , LMJSD75_070014800

Length:

670

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIK9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0016491	oxidoreductase activity	2	8
GO:0020037	heme binding	4	6
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046906	tetrapyrrole binding	3	6
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0000166	nucleotide binding	3	2
GO:0010181	FMN binding	4	2
GO:0032553	ribonucleotide binding	3	2
GO:0036094	small molecule binding	2	2
GO:0043168	anion binding	3	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	474	478	PF00656	0.353
CLV_NRD_NRD_1	312	314	PF00675	0.294
CLV_PCSK_KEX2_1	312	314	PF00082	0.352
CLV_PCSK_KEX2_1	355	357	PF00082	0.358
CLV_PCSK_KEX2_1	403	405	PF00082	0.404
CLV_PCSK_KEX2_1	414	416	PF00082	0.314
CLV_PCSK_KEX2_1	594	596	PF00082	0.582
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.358
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.311
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.222
CLV_PCSK_PC1ET2_1	594	596	PF00082	0.461
CLV_PCSK_PC7_1	351	357	PF00082	0.301
CLV_PCSK_SKI1_1	170	174	PF00082	0.313
CLV_PCSK_SKI1_1	415	419	PF00082	0.360
CLV_PCSK_SKI1_1	43	47	PF00082	0.253
CLV_PCSK_SKI1_1	436	440	PF00082	0.294
CLV_PCSK_SKI1_1	524	528	PF00082	0.443
CLV_PCSK_SKI1_1	591	595	PF00082	0.529
CLV_PCSK_SKI1_1	76	80	PF00082	0.285
DEG_ODPH_VHL_1	456	469	PF01847	0.331
DOC_CYCLIN_RxL_1	521	529	PF00134	0.427
DOC_CYCLIN_RxL_1	612	623	PF00134	0.331
DOC_MAPK_gen_1	142	150	PF00069	0.353
DOC_PP1_RVXF_1	124	130	PF00149	0.331
DOC_USP7_MATH_1	100	104	PF00917	0.361
DOC_USP7_MATH_1	28	32	PF00917	0.276
DOC_USP7_MATH_1	423	427	PF00917	0.342
DOC_USP7_MATH_1	567	571	PF00917	0.675
DOC_WW_Pin1_4	324	329	PF00397	0.357
DOC_WW_Pin1_4	427	432	PF00397	0.428
DOC_WW_Pin1_4	577	582	PF00397	0.703
DOC_WW_Pin1_4	58	63	PF00397	0.242
DOC_WW_Pin1_4	657	662	PF00397	0.353
DOC_WW_Pin1_4	96	101	PF00397	0.331
LIG_14-3-3_CanoR_1	404	409	PF00244	0.331
LIG_APCC_ABBA_1	75	80	PF00400	0.285
LIG_BIR_III_2	578	582	PF00653	0.627
LIG_Clathr_ClatBox_1	260	264	PF01394	0.353
LIG_deltaCOP1_diTrp_1	114	120	PF00928	0.294
LIG_eIF4E_1	348	354	PF01652	0.294
LIG_EVH1_1	551	555	PF00568	0.488
LIG_FHA_1	149	155	PF00498	0.294
LIG_FHA_1	188	194	PF00498	0.335
LIG_FHA_1	521	527	PF00498	0.411
LIG_FHA_1	620	626	PF00498	0.353
LIG_FHA_2	154	160	PF00498	0.437
LIG_FHA_2	238	244	PF00498	0.294
LIG_FHA_2	367	373	PF00498	0.359
LIG_FHA_2	595	601	PF00498	0.261
LIG_GBD_Chelix_1	613	621	PF00786	0.331
LIG_LIR_Apic_2	529	533	PF02991	0.523
LIG_LIR_Gen_1	151	160	PF02991	0.371
LIG_LIR_Gen_1	327	338	PF02991	0.410
LIG_LIR_Gen_1	541	551	PF02991	0.596
LIG_LIR_Gen_1	608	619	PF02991	0.357
LIG_LIR_Gen_1	644	655	PF02991	0.353
LIG_LIR_Nem_3	151	155	PF02991	0.331
LIG_LIR_Nem_3	327	333	PF02991	0.390
LIG_LIR_Nem_3	377	381	PF02991	0.294
LIG_LIR_Nem_3	437	442	PF02991	0.342
LIG_LIR_Nem_3	541	546	PF02991	0.535
LIG_LIR_Nem_3	608	614	PF02991	0.357
LIG_LIR_Nem_3	644	650	PF02991	0.353
LIG_LIR_Nem_3	85	89	PF02991	0.331
LIG_MAD2	176	184	PF02301	0.366
LIG_PCNA_yPIPBox_3	500	513	PF02747	0.308
LIG_Pex14_1	115	119	PF04695	0.331
LIG_Pex14_2	215	219	PF04695	0.353
LIG_SH2_CRK	152	156	PF00017	0.331
LIG_SH2_CRK	514	518	PF00017	0.358
LIG_SH2_CRK	530	534	PF00017	0.546
LIG_SH2_GRB2like	119	122	PF00017	0.301
LIG_SH2_NCK_1	152	156	PF00017	0.331
LIG_SH2_NCK_1	596	600	PF00017	0.331
LIG_SH2_STAP1	543	547	PF00017	0.509
LIG_SH2_STAT5	119	122	PF00017	0.331
LIG_SH2_STAT5	330	333	PF00017	0.464
LIG_SH2_STAT5	348	351	PF00017	0.147
LIG_SH2_STAT5	452	455	PF00017	0.275
LIG_SH2_STAT5	462	465	PF00017	0.237
LIG_SH2_STAT5	488	491	PF00017	0.331
LIG_SH2_STAT5	525	528	PF00017	0.389
LIG_SH2_STAT5	596	599	PF00017	0.331
LIG_SH2_STAT5	659	662	PF00017	0.353
LIG_SH3_1	94	100	PF00018	0.285
LIG_SH3_3	178	184	PF00018	0.386
LIG_SH3_3	273	279	PF00018	0.294
LIG_SH3_3	549	555	PF00018	0.601
LIG_SH3_3	557	563	PF00018	0.607
LIG_SH3_3	623	629	PF00018	0.353
LIG_SH3_3	647	653	PF00018	0.331
LIG_SH3_3	94	100	PF00018	0.285
LIG_SUMO_SIM_anti_2	37	42	PF11976	0.271
LIG_SUMO_SIM_par_1	37	42	PF11976	0.271
LIG_TYR_ITIM	150	155	PF00017	0.331
LIG_TYR_ITIM	512	517	PF00017	0.360
LIG_UBA3_1	154	163	PF00899	0.294
MOD_CK1_1	109	115	PF00069	0.264
MOD_CK1_1	427	433	PF00069	0.430
MOD_CK1_1	577	583	PF00069	0.747
MOD_CK2_1	153	159	PF00069	0.464
MOD_CK2_1	334	340	PF00069	0.410
MOD_CK2_1	356	362	PF00069	0.287
MOD_CK2_1	366	372	PF00069	0.237
MOD_CK2_1	594	600	PF00069	0.316
MOD_GlcNHglycan	108	111	PF01048	0.294
MOD_GlcNHglycan	270	273	PF01048	0.404
MOD_GlcNHglycan	316	319	PF01048	0.377
MOD_GlcNHglycan	324	327	PF01048	0.353
MOD_GlcNHglycan	335	339	PF01048	0.383
MOD_GlcNHglycan	358	361	PF01048	0.294
MOD_GlcNHglycan	395	398	PF01048	0.331
MOD_GlcNHglycan	42	46	PF01048	0.296
MOD_GlcNHglycan	55	58	PF01048	0.239
MOD_GSK3_1	131	138	PF00069	0.285
MOD_GSK3_1	232	239	PF00069	0.381
MOD_GSK3_1	362	369	PF00069	0.292
MOD_GSK3_1	423	430	PF00069	0.423
MOD_GSK3_1	48	55	PF00069	0.239
MOD_GSK3_1	96	103	PF00069	0.314
MOD_LATS_1	133	139	PF00433	0.353
MOD_N-GLC_1	49	54	PF02516	0.258
MOD_N-GLC_1	619	624	PF02516	0.331
MOD_N-GLC_1	82	87	PF02516	0.271
MOD_NEK2_1	148	153	PF00069	0.294
MOD_NEK2_1	237	242	PF00069	0.316
MOD_NEK2_1	41	46	PF00069	0.437
MOD_NEK2_1	434	439	PF00069	0.467
MOD_NEK2_1	526	531	PF00069	0.414
MOD_PIKK_1	1	7	PF00454	0.574
MOD_PIKK_1	60	66	PF00454	0.271
MOD_PKA_1	594	600	PF00069	0.294
MOD_PKA_2	106	112	PF00069	0.294
MOD_PKA_2	594	600	PF00069	0.331
MOD_PKB_1	168	176	PF00069	0.301
MOD_Plk_1	221	227	PF00069	0.308
MOD_Plk_1	41	47	PF00069	0.246
MOD_Plk_1	82	88	PF00069	0.271
MOD_Plk_2-3	443	449	PF00069	0.331
MOD_Plk_4	222	228	PF00069	0.271
MOD_Plk_4	34	40	PF00069	0.254
MOD_Plk_4	434	440	PF00069	0.289
MOD_Plk_4	504	510	PF00069	0.267
MOD_Plk_4	526	532	PF00069	0.434
MOD_Plk_4	538	544	PF00069	0.510
MOD_Plk_4	631	637	PF00069	0.353
MOD_ProDKin_1	324	330	PF00069	0.357
MOD_ProDKin_1	427	433	PF00069	0.428
MOD_ProDKin_1	577	583	PF00069	0.702
MOD_ProDKin_1	58	64	PF00069	0.242
MOD_ProDKin_1	657	663	PF00069	0.353
MOD_ProDKin_1	96	102	PF00069	0.331
MOD_SUMO_rev_2	471	480	PF00179	0.331
TRG_ENDOCYTIC_2	152	155	PF00928	0.353
TRG_ENDOCYTIC_2	330	333	PF00928	0.416
TRG_ENDOCYTIC_2	514	517	PF00928	0.362
TRG_ENDOCYTIC_2	543	546	PF00928	0.539
TRG_ER_diArg_1	168	171	PF00400	0.301
TRG_NES_CRM1_1	66	81	PF08389	0.285

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5C0	Leptomonas seymouri	38%	100%
A0A0S4IHN0	Bodo saltans	39%	100%
A0A0S4KND3	Bodo saltans	53%	100%
A0A1X0NPF8	Trypanosomatidae	58%	99%
A0A3S7WPX2	Leishmania donovani	95%	100%
A0A3S7X915	Leishmania donovani	36%	100%
A0A422MX37	Trypanosoma rangeli	35%	100%
A4HME0	Leishmania braziliensis	35%	100%
A4HME1	Leishmania braziliensis	34%	100%
A4HTA6	Leishmania infantum	95%	100%
A4IB13	Leishmania infantum	36%	100%
B2GCE0	Limosilactobacillus fermentum (strain NBRC 3956 / LMG 18251)	27%	100%
B5XRB0	Klebsiella pneumoniae (strain 342)	30%	72%
C8WLE3	Eggerthella lenta (strain ATCC 25559 / DSM 2243 / CCUG 17323 / JCM 9979 / KCTC 3265 / NCTC 11813 / VPI 0255 / 1899 B)	27%	100%
C9ZQ34	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	74%
E9AEU2	Leishmania major	36%	93%
E9AL95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9B5Z8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
O13755	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
P0C278	Shewanella frigidimarina	31%	100%
P21375	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
P32614	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
P83223	Shewanella oneidensis (strain MR-1)	33%	100%
Q07WU7	Shewanella frigidimarina (strain NCIMB 400)	31%	100%
Q8CVD0	Shewanella oneidensis (strain MR-1)	30%	100%
Q9Z4P0	Shewanella frigidimarina (strain NCIMB 400)	31%	100%
Q9ZMP0	Helicobacter pylori (strain J99 / ATCC 700824)	23%	94%