LeishMANIAdb
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RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
RRM domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QIK8_LEIMA
TriTrypDb:
LmjF.07.0802
Length:
352

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

Q4QIK8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIK8

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 5
GO:0003723 RNA binding 4 5
GO:0005488 binding 1 5
GO:0097159 organic cyclic compound binding 2 5
GO:1901363 heterocyclic compound binding 2 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 350 352 PF00675 0.687
CLV_PCSK_KEX2_1 123 125 PF00082 0.689
CLV_PCSK_KEX2_1 272 274 PF00082 0.579
CLV_PCSK_KEX2_1 350 352 PF00082 0.687
CLV_PCSK_PC1ET2_1 123 125 PF00082 0.689
CLV_PCSK_PC1ET2_1 272 274 PF00082 0.572
DOC_CKS1_1 234 239 PF01111 0.672
DOC_CKS1_1 276 281 PF01111 0.658
DOC_MAPK_gen_1 44 51 PF00069 0.503
DOC_PP2B_LxvP_1 280 283 PF13499 0.655
DOC_PP2B_LxvP_1 304 307 PF13499 0.652
DOC_PP4_FxxP_1 341 344 PF00568 0.645
DOC_USP7_MATH_1 162 166 PF00917 0.620
DOC_USP7_MATH_1 284 288 PF00917 0.608
DOC_USP7_MATH_1 329 333 PF00917 0.584
DOC_USP7_UBL2_3 86 90 PF12436 0.718
DOC_WW_Pin1_4 170 175 PF00397 0.743
DOC_WW_Pin1_4 187 192 PF00397 0.576
DOC_WW_Pin1_4 233 238 PF00397 0.673
DOC_WW_Pin1_4 272 277 PF00397 0.705
DOC_WW_Pin1_4 289 294 PF00397 0.542
DOC_WW_Pin1_4 5 10 PF00397 0.582
DOC_WW_Pin1_4 73 78 PF00397 0.523
DOC_WW_Pin1_4 85 90 PF00397 0.562
DOC_WW_Pin1_4 93 98 PF00397 0.497
LIG_14-3-3_CanoR_1 65 73 PF00244 0.515
LIG_EVH1_1 341 345 PF00568 0.646
LIG_FHA_1 138 144 PF00498 0.668
LIG_FHA_1 178 184 PF00498 0.657
LIG_LIR_Gen_1 264 274 PF02991 0.678
LIG_LIR_Gen_1 57 66 PF02991 0.488
LIG_LIR_Nem_3 264 269 PF02991 0.713
LIG_LIR_Nem_3 28 34 PF02991 0.295
LIG_LIR_Nem_3 50 56 PF02991 0.491
LIG_LIR_Nem_3 57 61 PF02991 0.457
LIG_LIR_Nem_3 8 14 PF02991 0.506
LIG_PROFILIN_1 293 299 PF00235 0.639
LIG_PROFILIN_1 318 324 PF00235 0.631
LIG_SH2_CRK 266 270 PF00017 0.717
LIG_SH2_NCK_1 266 270 PF00017 0.680
LIG_SH2_PTP2 253 256 PF00017 0.604
LIG_SH2_SRC 82 85 PF00017 0.475
LIG_SH2_STAT5 118 121 PF00017 0.542
LIG_SH2_STAT5 253 256 PF00017 0.604
LIG_SH2_STAT5 30 33 PF00017 0.490
LIG_SH3_1 253 259 PF00018 0.601
LIG_SH3_1 273 279 PF00018 0.607
LIG_SH3_2 345 350 PF14604 0.648
LIG_SH3_3 146 152 PF00018 0.699
LIG_SH3_3 188 194 PF00018 0.714
LIG_SH3_3 253 259 PF00018 0.679
LIG_SH3_3 273 279 PF00018 0.507
LIG_SH3_3 288 294 PF00018 0.583
LIG_SH3_3 296 302 PF00018 0.618
LIG_SH3_3 309 315 PF00018 0.707
LIG_SH3_3 316 322 PF00018 0.600
LIG_SH3_3 339 345 PF00018 0.701
LIG_SH3_3 94 100 PF00018 0.749
LIG_SH3_CIN85_PxpxPR_1 345 350 PF14604 0.648
LIG_SxIP_EBH_1 330 340 PF03271 0.541
LIG_TRAF2_1 190 193 PF00917 0.579
LIG_TYR_ITIM 51 56 PF00017 0.464
LIG_WW_3 347 351 PF00397 0.660
MOD_CDK_SPK_2 85 90 PF00069 0.678
MOD_CDK_SPxxK_3 5 12 PF00069 0.418
MOD_CK1_1 268 274 PF00069 0.679
MOD_CK1_1 275 281 PF00069 0.603
MOD_CK1_1 332 338 PF00069 0.668
MOD_CK1_1 88 94 PF00069 0.731
MOD_CK2_1 187 193 PF00069 0.697
MOD_CK2_1 66 72 PF00069 0.522
MOD_Cter_Amidation 84 87 PF01082 0.537
MOD_GlcNHglycan 15 18 PF01048 0.460
MOD_GlcNHglycan 22 25 PF01048 0.413
MOD_GlcNHglycan 286 289 PF01048 0.680
MOD_GlcNHglycan 334 337 PF01048 0.674
MOD_GlcNHglycan 35 38 PF01048 0.359
MOD_GSK3_1 1 8 PF00069 0.620
MOD_GSK3_1 133 140 PF00069 0.658
MOD_GSK3_1 219 226 PF00069 0.537
MOD_GSK3_1 229 236 PF00069 0.618
MOD_GSK3_1 261 268 PF00069 0.705
MOD_GSK3_1 327 334 PF00069 0.673
MOD_NEK2_1 13 18 PF00069 0.375
MOD_NEK2_1 308 313 PF00069 0.670
MOD_PIKK_1 100 106 PF00454 0.687
MOD_PIKK_1 107 113 PF00454 0.632
MOD_PIKK_1 223 229 PF00454 0.507
MOD_PIKK_1 66 72 PF00454 0.519
MOD_PIKK_1 88 94 PF00454 0.702
MOD_PKA_2 308 314 PF00069 0.665
MOD_PKB_1 124 132 PF00069 0.682
MOD_Plk_1 126 132 PF00069 0.680
MOD_Plk_4 229 235 PF00069 0.637
MOD_ProDKin_1 170 176 PF00069 0.740
MOD_ProDKin_1 187 193 PF00069 0.570
MOD_ProDKin_1 233 239 PF00069 0.677
MOD_ProDKin_1 272 278 PF00069 0.705
MOD_ProDKin_1 289 295 PF00069 0.540
MOD_ProDKin_1 5 11 PF00069 0.568
MOD_ProDKin_1 73 79 PF00069 0.529
MOD_ProDKin_1 85 91 PF00069 0.566
MOD_ProDKin_1 93 99 PF00069 0.494
TRG_ENDOCYTIC_2 11 14 PF00928 0.522
TRG_ENDOCYTIC_2 266 269 PF00928 0.718
TRG_ENDOCYTIC_2 53 56 PF00928 0.458
TRG_ER_diArg_1 349 351 PF00400 0.674

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H600 Leishmania donovani 87% 95%
A4HTA7 Leishmania infantum 88% 100%
E9AL96 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS