Phosphoacetylglucosamine mutase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

N-acetylglucosamine-phosphate mutase, putative

Species:

Leishmania major

UniProt:

Q4QIK7_LEIMA

TriTrypDb:

LmjF.07.0805 , LMJLV39_070014900 , LMJSD75_070015000

Length:

597

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QIK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIK7

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	11
GO:0006040	amino sugar metabolic process	4	11
GO:0006041	glucosamine metabolic process	6	2
GO:0006047	UDP-N-acetylglucosamine metabolic process	4	11
GO:0006048	UDP-N-acetylglucosamine biosynthetic process	5	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009225	nucleotide-sugar metabolic process	4	11
GO:0009226	nucleotide-sugar biosynthetic process	5	11
GO:0009987	cellular process	1	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0044281	small molecule metabolic process	2	11
GO:0046349	amino sugar biosynthetic process	5	11
GO:0046483	heterocycle metabolic process	3	11
GO:0055086	nucleobase-containing small molecule metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:1901071	glucosamine-containing compound metabolic process	5	2
GO:1901135	carbohydrate derivative metabolic process	3	11
GO:1901137	carbohydrate derivative biosynthetic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	6
GO:0003824	catalytic activity	1	11
GO:0004610	phosphoacetylglucosamine mutase activity	5	11
GO:0005488	binding	1	11
GO:0016853	isomerase activity	2	11
GO:0016866	intramolecular transferase activity	3	11
GO:0016868	intramolecular transferase activity, phosphotransferases	4	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.303
CLV_C14_Caspase3-7	540	544	PF00656	0.311
CLV_MEL_PAP_1	59	65	PF00089	0.450
CLV_NRD_NRD_1	470	472	PF00675	0.509
CLV_NRD_NRD_1	530	532	PF00675	0.330
CLV_NRD_NRD_1	75	77	PF00675	0.527
CLV_PCSK_KEX2_1	355	357	PF00082	0.537
CLV_PCSK_KEX2_1	470	472	PF00082	0.509
CLV_PCSK_KEX2_1	530	532	PF00082	0.319
CLV_PCSK_KEX2_1	77	79	PF00082	0.597
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.537
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.561
CLV_PCSK_SKI1_1	359	363	PF00082	0.500
CLV_PCSK_SKI1_1	462	466	PF00082	0.442
CLV_PCSK_SKI1_1	511	515	PF00082	0.333
CLV_PCSK_SKI1_1	530	534	PF00082	0.268
DEG_Nend_UBRbox_2	1	3	PF02207	0.641
DOC_CKS1_1	195	200	PF01111	0.372
DOC_CYCLIN_RxL_1	489	500	PF00134	0.467
DOC_CYCLIN_yCln2_LP_2	55	58	PF00134	0.367
DOC_MAPK_gen_1	355	363	PF00069	0.546
DOC_MAPK_gen_1	429	437	PF00069	0.432
DOC_MAPK_gen_1	508	517	PF00069	0.410
DOC_MAPK_MEF2A_6	429	437	PF00069	0.432
DOC_MAPK_MEF2A_6	508	517	PF00069	0.383
DOC_PP1_RVXF_1	344	351	PF00149	0.333
DOC_PP2B_LxvP_1	55	58	PF13499	0.345
DOC_PP4_FxxP_1	559	562	PF00568	0.311
DOC_USP7_MATH_1	127	131	PF00917	0.479
DOC_USP7_MATH_1	213	217	PF00917	0.567
DOC_USP7_MATH_1	313	317	PF00917	0.483
DOC_USP7_MATH_1	321	325	PF00917	0.483
DOC_USP7_MATH_1	544	548	PF00917	0.315
DOC_USP7_MATH_1	61	65	PF00917	0.436
DOC_USP7_MATH_1	68	72	PF00917	0.379
DOC_USP7_UBL2_3	355	359	PF12436	0.531
DOC_WW_Pin1_4	194	199	PF00397	0.351
DOC_WW_Pin1_4	215	220	PF00397	0.525
DOC_WW_Pin1_4	311	316	PF00397	0.477
DOC_WW_Pin1_4	37	42	PF00397	0.519
DOC_WW_Pin1_4	523	528	PF00397	0.317
LIG_14-3-3_CanoR_1	185	194	PF00244	0.483
LIG_14-3-3_CanoR_1	273	281	PF00244	0.474
LIG_14-3-3_CanoR_1	62	66	PF00244	0.394
LIG_Actin_WH2_2	11	26	PF00022	0.525
LIG_Actin_WH2_2	171	187	PF00022	0.463
LIG_Actin_WH2_2	56	72	PF00022	0.340
LIG_APCC_ABBA_1	433	438	PF00400	0.351
LIG_APCC_ABBA_1	569	574	PF00400	0.311
LIG_BRCT_BRCA1_1	16	20	PF00533	0.521
LIG_BRCT_BRCA1_1	401	405	PF00533	0.469
LIG_deltaCOP1_diTrp_1	117	122	PF00928	0.378
LIG_FHA_1	178	184	PF00498	0.477
LIG_FHA_1	401	407	PF00498	0.361
LIG_FHA_1	442	448	PF00498	0.386
LIG_FHA_1	563	569	PF00498	0.311
LIG_FHA_1	86	92	PF00498	0.425
LIG_FHA_2	281	287	PF00498	0.508
LIG_FHA_2	495	501	PF00498	0.496
LIG_FHA_2	524	530	PF00498	0.310
LIG_IBAR_NPY_1	98	100	PF08397	0.456
LIG_KLC1_Yacidic_2	503	507	PF13176	0.300
LIG_LIR_Gen_1	156	162	PF02991	0.447
LIG_LIR_Gen_1	17	27	PF02991	0.487
LIG_LIR_Gen_1	220	229	PF02991	0.438
LIG_LIR_Gen_1	276	285	PF02991	0.539
LIG_LIR_Gen_1	357	368	PF02991	0.402
LIG_LIR_Gen_1	369	380	PF02991	0.376
LIG_LIR_Gen_1	500	509	PF02991	0.334
LIG_LIR_Nem_3	102	108	PF02991	0.362
LIG_LIR_Nem_3	156	160	PF02991	0.488
LIG_LIR_Nem_3	17	23	PF02991	0.499
LIG_LIR_Nem_3	191	195	PF02991	0.427
LIG_LIR_Nem_3	220	225	PF02991	0.393
LIG_LIR_Nem_3	276	281	PF02991	0.545
LIG_LIR_Nem_3	283	287	PF02991	0.388
LIG_LIR_Nem_3	334	340	PF02991	0.363
LIG_LIR_Nem_3	357	363	PF02991	0.402
LIG_LIR_Nem_3	369	375	PF02991	0.338
LIG_LIR_Nem_3	500	504	PF02991	0.334
LIG_LYPXL_yS_3	192	195	PF13949	0.544
LIG_MAD2	346	354	PF02301	0.490
LIG_MLH1_MIPbox_1	16	20	PF16413	0.521
LIG_Pex14_1	501	505	PF04695	0.311
LIG_Pex14_2	15	19	PF04695	0.526
LIG_Rb_pABgroove_1	346	354	PF01858	0.490
LIG_SH2_CRK	157	161	PF00017	0.445
LIG_SH2_CRK	372	376	PF00017	0.372
LIG_SH2_GRB2like	221	224	PF00017	0.445
LIG_SH2_GRB2like	397	400	PF00017	0.344
LIG_SH2_NCK_1	415	419	PF00017	0.378
LIG_SH2_NCK_1	572	576	PF00017	0.384
LIG_SH2_SRC	397	400	PF00017	0.344
LIG_SH2_SRC	572	575	PF00017	0.354
LIG_SH2_STAP1	372	376	PF00017	0.313
LIG_SH2_STAT3	308	311	PF00017	0.497
LIG_SH2_STAT5	100	103	PF00017	0.378
LIG_SH2_STAT5	157	160	PF00017	0.450
LIG_SH2_STAT5	415	418	PF00017	0.377
LIG_SH2_STAT5	436	439	PF00017	0.325
LIG_SH2_STAT5	476	479	PF00017	0.474
LIG_SH2_STAT5	505	508	PF00017	0.273
LIG_SH2_STAT5	73	76	PF00017	0.487
LIG_SH3_3	146	152	PF00018	0.542
LIG_SH3_3	192	198	PF00018	0.475
LIG_SH3_3	35	41	PF00018	0.467
LIG_SH3_3	503	509	PF00018	0.318
LIG_SUMO_SIM_anti_2	366	372	PF11976	0.299
LIG_SUMO_SIM_anti_2	389	395	PF11976	0.495
LIG_SUMO_SIM_par_1	106	111	PF11976	0.307
LIG_SUMO_SIM_par_1	443	449	PF11976	0.495
LIG_TRAF2_1	118	121	PF00917	0.401
LIG_TYR_ITIM	370	375	PF00017	0.367
LIG_UBA3_1	370	378	PF00899	0.449
LIG_WRC_WIRS_1	281	286	PF05994	0.461
MOD_CDK_SPxxK_3	523	530	PF00069	0.332
MOD_CK1_1	130	136	PF00069	0.469
MOD_CK1_1	163	169	PF00069	0.454
MOD_CK1_1	40	46	PF00069	0.529
MOD_CK2_1	115	121	PF00069	0.351
MOD_CK2_1	166	172	PF00069	0.462
MOD_CK2_1	280	286	PF00069	0.518
MOD_CK2_1	523	529	PF00069	0.311
MOD_CK2_1	548	554	PF00069	0.385
MOD_CK2_1	560	566	PF00069	0.188
MOD_CK2_1	576	582	PF00069	0.372
MOD_CMANNOS	119	122	PF00535	0.423
MOD_GlcNHglycan	130	133	PF01048	0.527
MOD_GlcNHglycan	168	171	PF01048	0.396
MOD_GlcNHglycan	237	240	PF01048	0.638
MOD_GlcNHglycan	315	318	PF01048	0.531
MOD_GlcNHglycan	319	322	PF01048	0.485
MOD_GlcNHglycan	416	419	PF01048	0.467
MOD_GlcNHglycan	456	459	PF01048	0.384
MOD_GlcNHglycan	562	565	PF01048	0.358
MOD_GlcNHglycan	584	587	PF01048	0.456
MOD_GSK3_1	184	191	PF00069	0.487
MOD_GSK3_1	213	220	PF00069	0.604
MOD_GSK3_1	22	29	PF00069	0.409
MOD_GSK3_1	235	242	PF00069	0.525
MOD_GSK3_1	269	276	PF00069	0.477
MOD_GSK3_1	295	302	PF00069	0.511
MOD_GSK3_1	313	320	PF00069	0.358
MOD_GSK3_1	441	448	PF00069	0.407
MOD_GSK3_1	544	551	PF00069	0.317
MOD_GSK3_1	81	88	PF00069	0.550
MOD_N-GLC_1	127	132	PF02516	0.411
MOD_N-GLC_1	185	190	PF02516	0.564
MOD_N-GLC_1	269	274	PF02516	0.490
MOD_N-GLC_1	494	499	PF02516	0.508
MOD_NEK2_1	184	189	PF00069	0.515
MOD_NEK2_1	235	240	PF00069	0.484
MOD_NEK2_1	299	304	PF00069	0.469
MOD_NEK2_1	494	499	PF00069	0.475
MOD_NEK2_1	548	553	PF00069	0.425
MOD_NEK2_1	6	11	PF00069	0.564
MOD_NEK2_2	177	182	PF00069	0.527
MOD_NEK2_2	280	285	PF00069	0.517
MOD_NEK2_2	68	73	PF00069	0.395
MOD_PIKK_1	471	477	PF00454	0.335
MOD_PKA_1	355	361	PF00069	0.432
MOD_PKA_2	163	169	PF00069	0.366
MOD_PKA_2	184	190	PF00069	0.481
MOD_PKA_2	355	361	PF00069	0.487
MOD_PKA_2	366	372	PF00069	0.317
MOD_PKA_2	521	527	PF00069	0.377
MOD_PKA_2	560	566	PF00069	0.308
MOD_PKA_2	61	67	PF00069	0.421
MOD_Plk_1	295	301	PF00069	0.481
MOD_Plk_1	494	500	PF00069	0.478
MOD_Plk_4	14	20	PF00069	0.439
MOD_Plk_4	145	151	PF00069	0.542
MOD_Plk_4	217	223	PF00069	0.536
MOD_Plk_4	22	28	PF00069	0.406
MOD_Plk_4	259	265	PF00069	0.360
MOD_Plk_4	280	286	PF00069	0.497
MOD_Plk_4	295	301	PF00069	0.442
MOD_Plk_4	441	447	PF00069	0.329
MOD_Plk_4	61	67	PF00069	0.387
MOD_ProDKin_1	194	200	PF00069	0.349
MOD_ProDKin_1	215	221	PF00069	0.512
MOD_ProDKin_1	311	317	PF00069	0.483
MOD_ProDKin_1	37	43	PF00069	0.519
MOD_ProDKin_1	523	529	PF00069	0.317
MOD_SUMO_rev_2	353	361	PF00179	0.503
TRG_ENDOCYTIC_2	157	160	PF00928	0.450
TRG_ENDOCYTIC_2	192	195	PF00928	0.456
TRG_ENDOCYTIC_2	222	225	PF00928	0.520
TRG_ENDOCYTIC_2	372	375	PF00928	0.371
TRG_ER_diArg_1	469	471	PF00400	0.513
TRG_ER_diArg_1	520	523	PF00400	0.433
TRG_NES_CRM1_1	21	36	PF08389	0.501
TRG_NLS_MonoExtC_3	75	81	PF00514	0.331
TRG_Pf-PMV_PEXEL_1	378	382	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	470	475	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5G0	Leptomonas seymouri	53%	100%
A0A0S4KHH8	Bodo saltans	37%	100%
A0A1X0NPH2	Trypanosomatidae	44%	99%
A0A3R7KD29	Trypanosoma rangeli	45%	98%
A0A3S5H601	Leishmania donovani	93%	100%
A4H3S0	Leishmania braziliensis	84%	100%
A4HTA8	Leishmania infantum	93%	100%
C9ZUL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	99%
E9AL97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
F1RQM2	Sus scrofa	39%	100%
O95394	Homo sapiens	38%	100%
P38628	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
P57750	Arabidopsis thaliana	35%	100%
Q09687	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
Q09770	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
Q5Z1H8	Nocardia farcinica (strain IFM 10152)	24%	100%
Q6ZDQ1	Oryza sativa subsp. japonica	35%	100%
Q8SSL7	Encephalitozoon cuniculi (strain GB-M1)	32%	100%
Q9CYR6	Mus musculus	37%	100%
Q9P4V2	Candida albicans	35%	100%
V5B892	Trypanosoma cruzi	44%	98%