Splicing factor ptsr1-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

splicing factor ptsr1-like protein

Species:

Leishmania major

UniProt:

Q4QIK0_LEIMA

TriTrypDb:

LmjF.07.0870 , LMJLV39_070015700 , LMJSD75_070016000

Length:

372

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	yes	yes: 3
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QIK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIK0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	159	161	PF00675	0.762
CLV_NRD_NRD_1	214	216	PF00675	0.655
CLV_NRD_NRD_1	230	232	PF00675	0.608
CLV_NRD_NRD_1	254	256	PF00675	0.811
CLV_NRD_NRD_1	269	271	PF00675	0.627
CLV_NRD_NRD_1	284	286	PF00675	0.651
CLV_NRD_NRD_1	293	295	PF00675	0.730
CLV_NRD_NRD_1	299	301	PF00675	0.660
CLV_NRD_NRD_1	323	325	PF00675	0.859
CLV_NRD_NRD_1	336	338	PF00675	0.683
CLV_NRD_NRD_1	339	341	PF00675	0.651
CLV_NRD_NRD_1	349	351	PF00675	0.692
CLV_NRD_NRD_1	360	362	PF00675	0.702
CLV_NRD_NRD_1	363	365	PF00675	0.665
CLV_NRD_NRD_1	368	370	PF00675	0.580
CLV_PCSK_FUR_1	297	301	PF00082	0.861
CLV_PCSK_FUR_1	321	325	PF00082	0.862
CLV_PCSK_FUR_1	334	338	PF00082	0.859
CLV_PCSK_FUR_1	361	365	PF00082	0.850
CLV_PCSK_KEX2_1	159	161	PF00082	0.762
CLV_PCSK_KEX2_1	214	216	PF00082	0.655
CLV_PCSK_KEX2_1	230	232	PF00082	0.716
CLV_PCSK_KEX2_1	256	258	PF00082	0.845
CLV_PCSK_KEX2_1	269	271	PF00082	0.689
CLV_PCSK_KEX2_1	283	285	PF00082	0.709
CLV_PCSK_KEX2_1	292	294	PF00082	0.747
CLV_PCSK_KEX2_1	299	301	PF00082	0.647
CLV_PCSK_KEX2_1	323	325	PF00082	0.859
CLV_PCSK_KEX2_1	336	338	PF00082	0.683
CLV_PCSK_KEX2_1	339	341	PF00082	0.651
CLV_PCSK_KEX2_1	348	350	PF00082	0.702
CLV_PCSK_KEX2_1	360	362	PF00082	0.691
CLV_PCSK_KEX2_1	363	365	PF00082	0.655
CLV_PCSK_KEX2_1	368	370	PF00082	0.570
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.762
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.845
CLV_PCSK_PC7_1	265	271	PF00082	0.850
CLV_PCSK_PC7_1	289	295	PF00082	0.826
CLV_PCSK_PC7_1	356	362	PF00082	0.851
CLV_PCSK_PC7_1	364	370	PF00082	0.736
CLV_PCSK_SKI1_1	113	117	PF00082	0.631
CLV_PCSK_SKI1_1	181	185	PF00082	0.638
CLV_PCSK_SKI1_1	84	88	PF00082	0.673
DEG_APCC_KENBOX_2	155	159	PF00400	0.751
DEG_SPOP_SBC_1	117	121	PF00917	0.622
DEG_SPOP_SBC_1	55	59	PF00917	0.665
DOC_MAPK_gen_1	138	145	PF00069	0.660
DOC_MAPK_gen_1	211	221	PF00069	0.508
DOC_MAPK_MEF2A_6	138	147	PF00069	0.662
DOC_MAPK_MEF2A_6	214	223	PF00069	0.507
DOC_MAPK_MEF2A_6	70	79	PF00069	0.675
DOC_MAPK_RevD_3	244	257	PF00069	0.615
DOC_USP7_MATH_1	15	19	PF00917	0.871
DOC_USP7_MATH_1	205	209	PF00917	0.617
DOC_USP7_MATH_1	23	27	PF00917	0.892
DOC_WW_Pin1_4	257	262	PF00397	0.831
DOC_WW_Pin1_4	300	305	PF00397	0.855
DOC_WW_Pin1_4	324	329	PF00397	0.856
LIG_14-3-3_CanoR_1	27	35	PF00244	0.853
LIG_14-3-3_CanoR_1	297	303	PF00244	0.817
LIG_14-3-3_CanoR_1	307	313	PF00244	0.727
LIG_14-3-3_CanoR_1	321	327	PF00244	0.863
LIG_14-3-3_CanoR_1	84	89	PF00244	0.701
LIG_BIR_II_1	1	5	PF00653	0.851
LIG_FHA_1	117	123	PF00498	0.635
LIG_FHA_1	227	233	PF00498	0.668
LIG_FHA_1	83	89	PF00498	0.682
LIG_FHA_1	90	96	PF00498	0.561
LIG_FHA_2	118	124	PF00498	0.635
LIG_FHA_2	149	155	PF00498	0.735
LIG_FHA_2	223	229	PF00498	0.605
LIG_FHA_2	42	48	PF00498	0.830
LIG_FHA_2	55	61	PF00498	0.669
LIG_FHA_2	85	91	PF00498	0.661
LIG_GBD_Chelix_1	232	240	PF00786	0.674
LIG_Integrin_RGD_1	364	366	PF01839	0.784
LIG_NRP_CendR_1	369	372	PF00754	0.826
LIG_PTB_Apo_2	131	138	PF02174	0.651
LIG_PTB_Phospho_1	131	137	PF10480	0.632
LIG_SH2_GRB2like	176	179	PF00017	0.726
LIG_SH2_PTP2	220	223	PF00017	0.491
LIG_SH2_SRC	220	223	PF00017	0.618
LIG_SH2_STAT5	176	179	PF00017	0.726
LIG_SH2_STAT5	217	220	PF00017	0.647
LIG_SH2_STAT5	302	305	PF00017	0.874
LIG_SH2_STAT5	94	97	PF00017	0.653
LIG_SH3_2	65	70	PF14604	0.822
LIG_SH3_3	218	224	PF00018	0.495
LIG_SH3_3	42	48	PF00018	0.735
LIG_SH3_3	62	68	PF00018	0.901
LIG_SUMO_SIM_par_1	84	90	PF11976	0.689
LIG_TRAF2_1	121	124	PF00917	0.684
MOD_CDC14_SPxK_1	260	263	PF00782	0.846
MOD_CDK_SPxK_1	257	263	PF00069	0.835
MOD_CDK_SPxxK_3	300	307	PF00069	0.857
MOD_CK1_1	148	154	PF00069	0.723
MOD_CK1_1	26	32	PF00069	0.898
MOD_CK1_1	298	304	PF00069	0.900
MOD_CK1_1	305	311	PF00069	0.828
MOD_CK1_1	313	319	PF00069	0.901
MOD_CK1_1	327	333	PF00069	0.850
MOD_CK2_1	117	123	PF00069	0.634
MOD_CK2_1	148	154	PF00069	0.723
MOD_CK2_1	198	204	PF00069	0.656
MOD_CK2_1	41	47	PF00069	0.776
MOD_CK2_1	84	90	PF00069	0.673
MOD_Cter_Amidation	290	293	PF01082	0.758
MOD_Cter_Amidation	321	324	PF01082	0.872
MOD_DYRK1A_RPxSP_1	300	304	PF00069	0.853
MOD_DYRK1A_RPxSP_1	324	328	PF00069	0.852
MOD_GlcNHglycan	17	20	PF01048	0.721
MOD_GlcNHglycan	21	24	PF01048	0.667
MOD_GlcNHglycan	41	44	PF01048	0.690
MOD_GlcNHglycan	7	10	PF01048	0.857
MOD_GSK3_1	1	8	PF00069	0.873
MOD_GSK3_1	13	20	PF00069	0.753
MOD_GSK3_1	21	28	PF00069	0.624
MOD_GSK3_1	222	229	PF00069	0.649
MOD_GSK3_1	298	305	PF00069	0.904
MOD_GSK3_1	306	313	PF00069	0.807
MOD_LATS_1	281	287	PF00433	0.863
MOD_N-GLC_1	195	200	PF02516	0.519
MOD_NEK2_1	1	6	PF00069	0.869
MOD_NEK2_1	116	121	PF00069	0.624
MOD_NEK2_2	195	200	PF00069	0.519
MOD_PIKK_1	7	13	PF00454	0.822
MOD_PKA_1	283	289	PF00069	0.863
MOD_PKA_2	165	171	PF00069	0.816
MOD_PKA_2	26	32	PF00069	0.856
MOD_PKA_2	276	282	PF00069	0.837
MOD_PKA_2	283	289	PF00069	0.767
MOD_PKA_2	298	304	PF00069	0.652
MOD_PKA_2	306	312	PF00069	0.755
MOD_PKA_2	322	328	PF00069	0.857
MOD_PKA_2	335	341	PF00069	0.798
MOD_PKA_2	355	361	PF00069	0.629
MOD_PKB_1	283	291	PF00069	0.860
MOD_PKB_1	315	323	PF00069	0.862
MOD_Plk_1	117	123	PF00069	0.645
MOD_Plk_1	195	201	PF00069	0.519
MOD_Plk_2-3	118	124	PF00069	0.637
MOD_Plk_2-3	56	62	PF00069	0.668
MOD_Plk_4	205	211	PF00069	0.459
MOD_Plk_4	249	255	PF00069	0.658
MOD_Plk_4	71	77	PF00069	0.673
MOD_ProDKin_1	257	263	PF00069	0.835
MOD_ProDKin_1	300	306	PF00069	0.855
MOD_ProDKin_1	324	330	PF00069	0.855
TRG_DiLeu_BaEn_1	124	129	PF01217	0.641
TRG_DiLeu_BaEn_1	243	248	PF01217	0.603
TRG_ENDOCYTIC_2	220	223	PF00928	0.618
TRG_ER_diArg_1	108	111	PF00400	0.655
TRG_ER_diArg_1	199	202	PF00400	0.472
TRG_ER_diArg_1	230	232	PF00400	0.589
TRG_ER_diArg_1	254	257	PF00400	0.792
TRG_ER_diArg_1	268	270	PF00400	0.636
TRG_ER_diArg_1	283	285	PF00400	0.651
TRG_ER_diArg_1	292	294	PF00400	0.728
TRG_ER_diArg_1	297	300	PF00400	0.671
TRG_ER_diArg_1	321	324	PF00400	0.872
TRG_ER_diArg_1	336	339	PF00400	0.861
TRG_ER_diArg_1	348	350	PF00400	0.702
TRG_ER_diArg_1	368	371	PF00400	0.615
TRG_NLS_MonoCore_2	158	163	PF00514	0.764
TRG_NLS_MonoExtC_3	158	164	PF00514	0.765
TRG_NLS_MonoExtN_4	156	163	PF00514	0.763
TRG_Pf-PMV_PEXEL_1	126	131	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPZ1	Leishmania donovani	95%	99%
A4H537	Leishmania braziliensis	82%	99%
A4HTB3	Leishmania infantum	95%	99%
E9ALA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%