BHLH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QIJ8_LEIMA

TriTrypDb:

LmjF.07.0890 , LMJLV39_070015900 , LMJSD75_070015800

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIJ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	524	528	PF00656	0.558
CLV_C14_Caspase3-7	559	563	PF00656	0.578
CLV_C14_Caspase3-7	83	87	PF00656	0.588
CLV_C14_Caspase3-7	92	96	PF00656	0.535
CLV_NRD_NRD_1	150	152	PF00675	0.677
CLV_NRD_NRD_1	229	231	PF00675	0.578
CLV_NRD_NRD_1	443	445	PF00675	0.647
CLV_NRD_NRD_1	619	621	PF00675	0.562
CLV_NRD_NRD_1	80	82	PF00675	0.663
CLV_PCSK_KEX2_1	149	151	PF00082	0.682
CLV_PCSK_KEX2_1	221	223	PF00082	0.663
CLV_PCSK_KEX2_1	229	231	PF00082	0.597
CLV_PCSK_KEX2_1	510	512	PF00082	0.690
CLV_PCSK_KEX2_1	80	82	PF00082	0.663
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.652
CLV_PCSK_PC1ET2_1	510	512	PF00082	0.570
CLV_PCSK_PC7_1	506	512	PF00082	0.575
CLV_PCSK_SKI1_1	151	155	PF00082	0.674
CLV_PCSK_SKI1_1	371	375	PF00082	0.769
CLV_PCSK_SKI1_1	389	393	PF00082	0.559
CLV_PCSK_SKI1_1	416	420	PF00082	0.580
CLV_PCSK_SKI1_1	621	625	PF00082	0.624
DEG_SPOP_SBC_1	90	94	PF00917	0.576
DOC_CDC14_PxL_1	429	437	PF14671	0.652
DOC_CKS1_1	265	270	PF01111	0.783
DOC_MAPK_DCC_7	422	432	PF00069	0.542
DOC_MAPK_gen_1	170	178	PF00069	0.684
DOC_MAPK_gen_1	414	423	PF00069	0.568
DOC_MAPK_MEF2A_6	170	178	PF00069	0.660
DOC_MAPK_MEF2A_6	431	439	PF00069	0.562
DOC_PP2B_LxvP_1	237	240	PF13499	0.567
DOC_PP2B_LxvP_1	552	555	PF13499	0.616
DOC_USP7_MATH_1	159	163	PF00917	0.808
DOC_USP7_MATH_1	165	169	PF00917	0.715
DOC_USP7_MATH_1	347	351	PF00917	0.775
DOC_USP7_MATH_1	476	480	PF00917	0.686
DOC_USP7_MATH_1	533	537	PF00917	0.705
DOC_USP7_MATH_1	568	572	PF00917	0.649
DOC_USP7_MATH_1	591	595	PF00917	0.688
DOC_USP7_MATH_1	74	78	PF00917	0.694
DOC_USP7_UBL2_3	448	452	PF12436	0.675
DOC_WW_Pin1_4	235	240	PF00397	0.716
DOC_WW_Pin1_4	261	266	PF00397	0.758
DOC_WW_Pin1_4	305	310	PF00397	0.660
DOC_WW_Pin1_4	403	408	PF00397	0.671
DOC_WW_Pin1_4	492	497	PF00397	0.597
DOC_WW_Pin1_4	566	571	PF00397	0.791
LIG_14-3-3_CanoR_1	110	118	PF00244	0.711
LIG_14-3-3_CanoR_1	229	239	PF00244	0.690
LIG_14-3-3_CanoR_1	343	352	PF00244	0.590
LIG_14-3-3_CanoR_1	371	376	PF00244	0.818
LIG_14-3-3_CanoR_1	389	397	PF00244	0.590
LIG_BIR_II_1	1	5	PF00653	0.623
LIG_BRCT_BRCA1_1	211	215	PF00533	0.570
LIG_BRCT_BRCA1_1	250	254	PF00533	0.611
LIG_BRCT_BRCA1_1	39	43	PF00533	0.562
LIG_BRCT_BRCA1_1	552	556	PF00533	0.557
LIG_BRCT_BRCA1_1	581	585	PF00533	0.572
LIG_CtBP_PxDLS_1	135	139	PF00389	0.589
LIG_EH_1	212	216	PF12763	0.566
LIG_FHA_1	22	28	PF00498	0.621
LIG_FHA_1	232	238	PF00498	0.788
LIG_FHA_1	274	280	PF00498	0.668
LIG_FHA_1	73	79	PF00498	0.622
LIG_FHA_2	243	249	PF00498	0.682
LIG_FHA_2	557	563	PF00498	0.574
LIG_Integrin_isoDGR_2	87	89	PF01839	0.648
LIG_LIR_Gen_1	258	268	PF02991	0.555
LIG_LIR_Nem_3	258	263	PF02991	0.549
LIG_SH2_STAP1	250	254	PF00017	0.611
LIG_SH2_STAP1	292	296	PF00017	0.598
LIG_SH3_3	130	136	PF00018	0.588
LIG_SH3_3	259	265	PF00018	0.648
LIG_SH3_3	398	404	PF00018	0.657
LIG_SH3_3	450	456	PF00018	0.709
LIG_SH3_3	457	463	PF00018	0.690
LIG_SUMO_SIM_anti_2	23	31	PF11976	0.553
LIG_SUMO_SIM_anti_2	75	80	PF11976	0.646
LIG_SUMO_SIM_par_1	433	438	PF11976	0.653
MOD_CAAXbox	626	629	PF01239	0.676
MOD_CDC14_SPxK_1	569	572	PF00782	0.687
MOD_CDK_SPxK_1	566	572	PF00069	0.704
MOD_CK1_1	104	110	PF00069	0.678
MOD_CK1_1	233	239	PF00069	0.697
MOD_CK1_1	264	270	PF00069	0.712
MOD_CK1_1	36	42	PF00069	0.702
MOD_CK1_1	377	383	PF00069	0.680
MOD_CK1_1	467	473	PF00069	0.840
MOD_CK1_1	519	525	PF00069	0.682
MOD_CK1_1	560	566	PF00069	0.660
MOD_CK1_1	609	615	PF00069	0.653
MOD_CK2_1	134	140	PF00069	0.784
MOD_CK2_1	305	311	PF00069	0.634
MOD_CK2_1	465	471	PF00069	0.674
MOD_CK2_1	605	611	PF00069	0.683
MOD_Cter_Amidation	219	222	PF01082	0.572
MOD_GlcNHglycan	186	189	PF01048	0.678
MOD_GlcNHglycan	223	226	PF01048	0.735
MOD_GlcNHglycan	248	253	PF01048	0.721
MOD_GlcNHglycan	286	289	PF01048	0.699
MOD_GlcNHglycan	376	379	PF01048	0.686
MOD_GlcNHglycan	407	410	PF01048	0.597
MOD_GlcNHglycan	521	524	PF01048	0.668
MOD_GlcNHglycan	536	539	PF01048	0.730
MOD_GlcNHglycan	581	584	PF01048	0.729
MOD_GlcNHglycan	608	611	PF01048	0.633
MOD_GSK3_1	114	121	PF00069	0.598
MOD_GSK3_1	134	141	PF00069	0.719
MOD_GSK3_1	159	166	PF00069	0.617
MOD_GSK3_1	231	238	PF00069	0.731
MOD_GSK3_1	244	251	PF00069	0.564
MOD_GSK3_1	269	276	PF00069	0.712
MOD_GSK3_1	297	304	PF00069	0.577
MOD_GSK3_1	33	40	PF00069	0.767
MOD_GSK3_1	343	350	PF00069	0.767
MOD_GSK3_1	363	370	PF00069	0.612
MOD_GSK3_1	389	396	PF00069	0.661
MOD_GSK3_1	443	450	PF00069	0.655
MOD_GSK3_1	466	473	PF00069	0.720
MOD_GSK3_1	53	60	PF00069	0.711
MOD_GSK3_1	556	563	PF00069	0.613
MOD_GSK3_1	605	612	PF00069	0.697
MOD_GSK3_1	68	75	PF00069	0.670
MOD_N-GLC_1	118	123	PF02516	0.582
MOD_N-GLC_1	184	189	PF02516	0.633
MOD_N-GLC_1	36	41	PF02516	0.700
MOD_N-GLC_1	476	481	PF02516	0.684
MOD_N-GLC_1	516	521	PF02516	0.645
MOD_N-GLC_1	560	565	PF02516	0.664
MOD_N-GLC_1	57	62	PF02516	0.571
MOD_NEK2_1	1	6	PF00069	0.689
MOD_NEK2_1	118	123	PF00069	0.589
MOD_NEK2_1	138	143	PF00069	0.684
MOD_NEK2_1	319	324	PF00069	0.593
MOD_NEK2_1	50	55	PF00069	0.670
MOD_NEK2_1	521	526	PF00069	0.712
MOD_NEK2_1	556	561	PF00069	0.596
MOD_NEK2_2	139	144	PF00069	0.623
MOD_NEK2_2	165	170	PF00069	0.625
MOD_NEK2_2	252	257	PF00069	0.616
MOD_PIKK_1	192	198	PF00454	0.630
MOD_PIKK_1	37	43	PF00454	0.656
MOD_PIKK_1	379	385	PF00454	0.686
MOD_PIKK_1	50	56	PF00454	0.579
MOD_PIKK_1	560	566	PF00454	0.725
MOD_PIKK_1	60	66	PF00454	0.629
MOD_PKA_1	221	227	PF00069	0.644
MOD_PKA_2	111	117	PF00069	0.584
MOD_PKA_2	21	27	PF00069	0.646
MOD_PKA_2	221	227	PF00069	0.649
MOD_PKA_2	342	348	PF00069	0.664
MOD_PKA_2	443	449	PF00069	0.653
MOD_PKA_2	499	505	PF00069	0.641
MOD_Plk_1	118	124	PF00069	0.582
MOD_Plk_1	139	145	PF00069	0.621
MOD_Plk_1	184	190	PF00069	0.620
MOD_Plk_1	22	28	PF00069	0.554
MOD_Plk_1	252	258	PF00069	0.644
MOD_Plk_1	319	325	PF00069	0.558
MOD_Plk_1	476	482	PF00069	0.678
MOD_Plk_1	560	566	PF00069	0.580
MOD_Plk_2-3	301	307	PF00069	0.589
MOD_Plk_4	286	292	PF00069	0.579
MOD_Plk_4	319	325	PF00069	0.558
MOD_Plk_4	516	522	PF00069	0.726
MOD_Plk_4	74	80	PF00069	0.633
MOD_Plk_4	8	14	PF00069	0.598
MOD_ProDKin_1	235	241	PF00069	0.715
MOD_ProDKin_1	261	267	PF00069	0.758
MOD_ProDKin_1	305	311	PF00069	0.658
MOD_ProDKin_1	403	409	PF00069	0.672
MOD_ProDKin_1	492	498	PF00069	0.600
MOD_ProDKin_1	566	572	PF00069	0.792
TRG_ER_diArg_1	110	113	PF00400	0.810
TRG_ER_diArg_1	149	151	PF00400	0.750
TRG_ER_diArg_1	206	209	PF00400	0.569
TRG_ER_diArg_1	414	417	PF00400	0.572
TRG_ER_diArg_1	597	600	PF00400	0.661
TRG_ER_diArg_1	79	81	PF00400	0.639
TRG_NLS_MonoExtC_3	619	624	PF00514	0.629
TRG_NLS_MonoExtN_4	620	625	PF00514	0.626
TRG_Pf-PMV_PEXEL_1	599	603	PF00026	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WQ13	Leishmania donovani	72%	99%
A4H538	Leishmania braziliensis	25%	86%
A4HTE6	Leishmania infantum	72%	99%
E9ALA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%