Radial spoke head protein 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIJ4_LEIMA

TriTrypDb:

LmjF.07.0930 , LMJLV39_070016400 , LMJSD75_070016700

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2
GO:0001534	radial spoke	2	2
GO:0032991	protein-containing complex	1	2

Expansion

Sequence features

Q4QIJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIJ4

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0001578	microtubule bundle formation	4	2
GO:0003341	cilium movement	4	4
GO:0006996	organelle organization	4	4
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	4
GO:0007018	microtubule-based movement	3	4
GO:0009987	cellular process	1	4
GO:0016043	cellular component organization	3	4
GO:0022607	cellular component assembly	4	4
GO:0030030	cell projection organization	4	4
GO:0030031	cell projection assembly	5	4
GO:0035082	axoneme assembly	5	2
GO:0044458	motile cilium assembly	7	2
GO:0044782	cilium organization	5	4
GO:0060271	cilium assembly	6	4
GO:0060294	cilium movement involved in cell motility	5	4
GO:0070925	organelle assembly	5	4
GO:0071840	cellular component organization or biogenesis	2	4
GO:0120031	plasma membrane bounded cell projection assembly	6	4
GO:0120036	plasma membrane bounded cell projection organization	5	4

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.639
CLV_PCSK_KEX2_1	182	184	PF00082	0.532
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.532
CLV_PCSK_SKI1_1	183	187	PF00082	0.628
CLV_PCSK_SKI1_1	299	303	PF00082	0.418
DEG_ODPH_VHL_1	178	189	PF01847	0.403
DOC_CKS1_1	126	131	PF01111	0.578
DOC_MAPK_gen_1	181	192	PF00069	0.469
DOC_MAPK_gen_1	35	43	PF00069	0.452
DOC_USP7_MATH_1	153	157	PF00917	0.674
DOC_USP7_MATH_1	227	231	PF00917	0.601
DOC_USP7_MATH_1	67	71	PF00917	0.480
DOC_USP7_UBL2_3	182	186	PF12436	0.518
DOC_WW_Pin1_4	125	130	PF00397	0.622
DOC_WW_Pin1_4	36	41	PF00397	0.452
LIG_14-3-3_CanoR_1	188	193	PF00244	0.516
LIG_14-3-3_CanoR_1	210	214	PF00244	0.390
LIG_14-3-3_CanoR_1	228	233	PF00244	0.595
LIG_FHA_1	268	274	PF00498	0.372
LIG_FHA_1	290	296	PF00498	0.418
LIG_FHA_2	126	132	PF00498	0.478
LIG_FHA_2	16	22	PF00498	0.509
LIG_LIR_Apic_2	270	275	PF02991	0.471
LIG_LIR_Apic_2	306	312	PF02991	0.311
LIG_LIR_Gen_1	106	115	PF02991	0.484
LIG_LIR_Gen_1	244	252	PF02991	0.392
LIG_LIR_Gen_1	78	86	PF02991	0.519
LIG_LIR_Nem_3	70	74	PF02991	0.384
LIG_LIR_Nem_3	78	83	PF02991	0.405
LIG_PDZ_Class_2	330	335	PF00595	0.396
LIG_Pex14_1	285	289	PF04695	0.342
LIG_Pex14_2	329	333	PF04695	0.434
LIG_PTB_Apo_2	297	304	PF02174	0.343
LIG_PTB_Apo_2	3	10	PF02174	0.477
LIG_PTB_Apo_2	59	66	PF02174	0.516
LIG_PTB_Phospho_1	297	303	PF10480	0.380
LIG_PTB_Phospho_1	3	9	PF10480	0.483
LIG_SH2_CRK	101	105	PF00017	0.468
LIG_SH2_CRK	321	325	PF00017	0.401
LIG_SH2_STAP1	107	111	PF00017	0.484
LIG_SH2_STAT3	217	220	PF00017	0.453
LIG_SH2_STAT5	217	220	PF00017	0.393
LIG_SH2_STAT5	246	249	PF00017	0.370
LIG_SH2_STAT5	272	275	PF00017	0.471
LIG_SH2_STAT5	321	324	PF00017	0.366
LIG_SH2_STAT5	9	12	PF00017	0.432
LIG_SH3_3	121	127	PF00018	0.596
LIG_SH3_3	174	180	PF00018	0.620
LIG_SH3_5	268	272	PF00018	0.489
LIG_SUMO_SIM_par_1	188	194	PF11976	0.418
MOD_CAAXbox	332	335	PF01239	0.437
MOD_CK1_1	15	21	PF00069	0.497
MOD_CK1_1	70	76	PF00069	0.401
MOD_CK1_1	78	84	PF00069	0.441
MOD_CK2_1	15	21	PF00069	0.377
MOD_CK2_1	188	194	PF00069	0.478
MOD_GSK3_1	144	151	PF00069	0.571
MOD_N-GLC_1	228	233	PF02516	0.513
MOD_N-GLC_1	289	294	PF02516	0.481
MOD_NEK2_1	12	17	PF00069	0.477
MOD_NEK2_1	25	30	PF00069	0.390
MOD_NEK2_2	209	214	PF00069	0.433
MOD_NEK2_2	283	288	PF00069	0.485
MOD_NEK2_2	303	308	PF00069	0.156
MOD_NEK2_2	67	72	PF00069	0.467
MOD_PIKK_1	30	36	PF00454	0.529
MOD_PK_1	188	194	PF00069	0.512
MOD_PKA_1	241	247	PF00069	0.493
MOD_PKA_2	209	215	PF00069	0.394
MOD_PKA_2	227	233	PF00069	0.594
MOD_Plk_1	20	26	PF00069	0.460
MOD_Plk_1	228	234	PF00069	0.546
MOD_Plk_2-3	148	154	PF00069	0.656
MOD_Plk_4	303	309	PF00069	0.333
MOD_Plk_4	67	73	PF00069	0.430
MOD_ProDKin_1	125	131	PF00069	0.616
MOD_ProDKin_1	36	42	PF00069	0.449
TRG_DiLeu_BaEn_3	255	261	PF01217	0.506
TRG_DiLeu_BaEn_4	88	94	PF01217	0.511
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.376
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.405
TRG_ENDOCYTIC_2	101	104	PF00928	0.483
TRG_ENDOCYTIC_2	107	110	PF00928	0.496
TRG_ENDOCYTIC_2	246	249	PF00928	0.346
TRG_ENDOCYTIC_2	9	12	PF00928	0.498
TRG_ER_diArg_1	180	183	PF00400	0.662
TRG_ER_diArg_1	257	260	PF00400	0.422
TRG_NLS_MonoExtN_4	180	185	PF00514	0.526
TRG_Pf-PMV_PEXEL_1	299	304	PF00026	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL99	Leptomonas seymouri	71%	98%
A0A0S4J8G1	Bodo saltans	39%	100%
A0A1X0NQ76	Trypanosomatidae	49%	100%
A0A3Q8IKD9	Leishmania donovani	25%	100%
A0A3R7MSU5	Trypanosoma rangeli	49%	99%
A0A3S7WQ16	Leishmania donovani	98%	100%
A4H541	Leishmania braziliensis	86%	100%
A4HTB7	Leishmania infantum	97%	99%
C9ZUK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
D0A660	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AHR8	Leishmania infantum	25%	100%
E9ALB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9B489	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4Q3T7	Leishmania major	25%	100%
Q5TYW6	Danio rerio	26%	100%
Q9D9V4	Mus musculus	24%	100%
Q9H1X1	Homo sapiens	24%	100%
V5B8M6	Trypanosoma cruzi	28%	100%