LeishMANIAdb
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WD domain, G-beta repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
WD domain, G-beta repeat-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QIJ0_LEIMA
TriTrypDb:
LmjF.07.0970 , LMJLV39_070016800 * , LMJSD75_070017100 *
Length:
879

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIJ0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIJ0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 499 503 PF00656 0.488
CLV_MEL_PAP_1 590 596 PF00089 0.499
CLV_NRD_NRD_1 118 120 PF00675 0.555
CLV_NRD_NRD_1 141 143 PF00675 0.461
CLV_NRD_NRD_1 184 186 PF00675 0.564
CLV_NRD_NRD_1 222 224 PF00675 0.509
CLV_NRD_NRD_1 231 233 PF00675 0.643
CLV_NRD_NRD_1 42 44 PF00675 0.687
CLV_NRD_NRD_1 45 47 PF00675 0.684
CLV_NRD_NRD_1 559 561 PF00675 0.427
CLV_NRD_NRD_1 577 579 PF00675 0.515
CLV_NRD_NRD_1 630 632 PF00675 0.639
CLV_NRD_NRD_1 667 669 PF00675 0.544
CLV_NRD_NRD_1 692 694 PF00675 0.654
CLV_NRD_NRD_1 696 698 PF00675 0.638
CLV_NRD_NRD_1 757 759 PF00675 0.735
CLV_NRD_NRD_1 765 767 PF00675 0.768
CLV_PCSK_FUR_1 115 119 PF00082 0.559
CLV_PCSK_FUR_1 220 224 PF00082 0.470
CLV_PCSK_FUR_1 43 47 PF00082 0.565
CLV_PCSK_FUR_1 754 758 PF00082 0.761
CLV_PCSK_KEX2_1 117 119 PF00082 0.545
CLV_PCSK_KEX2_1 141 143 PF00082 0.461
CLV_PCSK_KEX2_1 184 186 PF00082 0.564
CLV_PCSK_KEX2_1 21 23 PF00082 0.616
CLV_PCSK_KEX2_1 222 224 PF00082 0.517
CLV_PCSK_KEX2_1 231 233 PF00082 0.661
CLV_PCSK_KEX2_1 44 46 PF00082 0.639
CLV_PCSK_KEX2_1 577 579 PF00082 0.552
CLV_PCSK_KEX2_1 630 632 PF00082 0.642
CLV_PCSK_KEX2_1 667 669 PF00082 0.544
CLV_PCSK_KEX2_1 692 694 PF00082 0.654
CLV_PCSK_KEX2_1 696 698 PF00082 0.638
CLV_PCSK_KEX2_1 744 746 PF00082 0.674
CLV_PCSK_KEX2_1 756 758 PF00082 0.683
CLV_PCSK_KEX2_1 764 766 PF00082 0.523
CLV_PCSK_PC1ET2_1 21 23 PF00082 0.616
CLV_PCSK_PC1ET2_1 44 46 PF00082 0.569
CLV_PCSK_PC1ET2_1 744 746 PF00082 0.674
CLV_PCSK_PC1ET2_1 756 758 PF00082 0.683
CLV_PCSK_PC1ET2_1 764 766 PF00082 0.523
CLV_PCSK_PC7_1 692 698 PF00082 0.592
CLV_PCSK_SKI1_1 152 156 PF00082 0.552
CLV_PCSK_SKI1_1 176 180 PF00082 0.649
CLV_PCSK_SKI1_1 246 250 PF00082 0.531
CLV_PCSK_SKI1_1 358 362 PF00082 0.521
CLV_PCSK_SKI1_1 419 423 PF00082 0.364
CLV_PCSK_SKI1_1 560 564 PF00082 0.440
CLV_PCSK_SKI1_1 646 650 PF00082 0.555
CLV_PCSK_SKI1_1 696 700 PF00082 0.758
CLV_Separin_Metazoa 211 215 PF03568 0.404
DEG_APCC_DBOX_1 151 159 PF00400 0.669
DEG_APCC_DBOX_1 245 253 PF00400 0.527
DEG_MDM2_SWIB_1 337 345 PF02201 0.382
DEG_SCF_FBW7_1 324 329 PF00400 0.407
DEG_SCF_FBW7_1 849 855 PF00400 0.550
DEG_SPOP_SBC_1 59 63 PF00917 0.571
DOC_CKS1_1 849 854 PF01111 0.584
DOC_CYCLIN_RxL_1 240 253 PF00134 0.563
DOC_CYCLIN_RxL_1 558 569 PF00134 0.458
DOC_CYCLIN_yCln2_LP_2 160 166 PF00134 0.523
DOC_CYCLIN_yCln2_LP_2 606 612 PF00134 0.557
DOC_MAPK_DCC_7 152 160 PF00069 0.671
DOC_MAPK_gen_1 117 129 PF00069 0.489
DOC_MAPK_gen_1 141 147 PF00069 0.420
DOC_MAPK_gen_1 560 567 PF00069 0.397
DOC_MAPK_MEF2A_6 152 160 PF00069 0.671
DOC_MAPK_MEF2A_6 406 413 PF00069 0.420
DOC_MAPK_MEF2A_6 560 567 PF00069 0.509
DOC_MAPK_MEF2A_6 605 613 PF00069 0.555
DOC_MAPK_NFAT4_5 560 568 PF00069 0.442
DOC_MAPK_RevD_3 207 223 PF00069 0.419
DOC_PP1_RVXF_1 336 342 PF00149 0.361
DOC_PP2B_LxvP_1 255 258 PF13499 0.723
DOC_PP2B_LxvP_1 362 365 PF13499 0.454
DOC_PP4_FxxP_1 179 182 PF00568 0.682
DOC_PP4_FxxP_1 417 420 PF00568 0.507
DOC_USP7_MATH_1 105 109 PF00917 0.554
DOC_USP7_MATH_1 288 292 PF00917 0.741
DOC_USP7_MATH_1 304 308 PF00917 0.585
DOC_USP7_MATH_1 310 314 PF00917 0.617
DOC_USP7_MATH_1 377 381 PF00917 0.767
DOC_USP7_MATH_1 442 446 PF00917 0.448
DOC_USP7_MATH_1 640 644 PF00917 0.543
DOC_USP7_MATH_1 679 683 PF00917 0.678
DOC_USP7_MATH_1 750 754 PF00917 0.760
DOC_USP7_MATH_1 770 774 PF00917 0.537
DOC_USP7_MATH_1 805 809 PF00917 0.633
DOC_USP7_MATH_1 856 860 PF00917 0.686
DOC_WW_Pin1_4 108 113 PF00397 0.561
DOC_WW_Pin1_4 145 150 PF00397 0.453
DOC_WW_Pin1_4 226 231 PF00397 0.551
DOC_WW_Pin1_4 269 274 PF00397 0.625
DOC_WW_Pin1_4 305 310 PF00397 0.705
DOC_WW_Pin1_4 322 327 PF00397 0.427
DOC_WW_Pin1_4 375 380 PF00397 0.704
DOC_WW_Pin1_4 386 391 PF00397 0.581
DOC_WW_Pin1_4 506 511 PF00397 0.376
DOC_WW_Pin1_4 592 597 PF00397 0.490
DOC_WW_Pin1_4 613 618 PF00397 0.417
DOC_WW_Pin1_4 62 67 PF00397 0.630
DOC_WW_Pin1_4 697 702 PF00397 0.617
DOC_WW_Pin1_4 726 731 PF00397 0.674
DOC_WW_Pin1_4 733 738 PF00397 0.634
DOC_WW_Pin1_4 793 798 PF00397 0.775
DOC_WW_Pin1_4 848 853 PF00397 0.630
LIG_14-3-3_CanoR_1 12 17 PF00244 0.662
LIG_14-3-3_CanoR_1 141 146 PF00244 0.330
LIG_14-3-3_CanoR_1 231 241 PF00244 0.702
LIG_14-3-3_CanoR_1 340 349 PF00244 0.486
LIG_14-3-3_CanoR_1 358 363 PF00244 0.419
LIG_14-3-3_CanoR_1 448 453 PF00244 0.419
LIG_14-3-3_CanoR_1 630 634 PF00244 0.485
LIG_14-3-3_CanoR_1 652 659 PF00244 0.461
LIG_14-3-3_CanoR_1 757 761 PF00244 0.607
LIG_Actin_WH2_2 551 568 PF00022 0.511
LIG_AP2alpha_2 132 134 PF02296 0.455
LIG_BIR_II_1 1 5 PF00653 0.716
LIG_BIR_III_1 1 5 PF00653 0.657
LIG_BIR_III_2 794 798 PF00653 0.772
LIG_BIR_III_3 1 5 PF00653 0.657
LIG_BRCT_BRCA1_1 12 16 PF00533 0.717
LIG_BRCT_BRCA1_1 130 134 PF00533 0.444
LIG_BRCT_BRCA1_1 413 417 PF00533 0.483
LIG_CaM_IQ_9 440 455 PF13499 0.530
LIG_deltaCOP1_diTrp_1 33 38 PF00928 0.548
LIG_EVH1_1 727 731 PF00568 0.656
LIG_FHA_1 122 128 PF00498 0.476
LIG_FHA_1 323 329 PF00498 0.424
LIG_FHA_1 389 395 PF00498 0.775
LIG_FHA_1 438 444 PF00498 0.455
LIG_FHA_1 512 518 PF00498 0.524
LIG_FHA_1 577 583 PF00498 0.514
LIG_FHA_1 660 666 PF00498 0.626
LIG_FHA_1 842 848 PF00498 0.562
LIG_FHA_2 259 265 PF00498 0.595
LIG_FHA_2 537 543 PF00498 0.410
LIG_FHA_2 862 868 PF00498 0.567
LIG_FHA_2 90 96 PF00498 0.651
LIG_FXI_DFP_1 481 485 PF00024 0.674
LIG_GSK3_LRP6_1 852 858 PF00069 0.567
LIG_IRF3_LxIS_1 408 414 PF10401 0.433
LIG_LIR_Apic_2 13 17 PF02991 0.574
LIG_LIR_Apic_2 177 182 PF02991 0.567
LIG_LIR_Apic_2 196 202 PF02991 0.578
LIG_LIR_Apic_2 33 39 PF02991 0.511
LIG_LIR_Apic_2 401 405 PF02991 0.526
LIG_LIR_Apic_2 414 420 PF02991 0.307
LIG_LIR_Gen_1 418 427 PF02991 0.377
LIG_LIR_Gen_1 529 537 PF02991 0.435
LIG_LIR_Gen_1 599 606 PF02991 0.356
LIG_LIR_Gen_1 802 811 PF02991 0.677
LIG_LIR_LC3C_4 206 209 PF02991 0.389
LIG_LIR_Nem_3 329 335 PF02991 0.535
LIG_LIR_Nem_3 35 41 PF02991 0.650
LIG_LIR_Nem_3 418 424 PF02991 0.371
LIG_LIR_Nem_3 529 534 PF02991 0.425
LIG_LIR_Nem_3 802 806 PF02991 0.723
LIG_MYND_1 549 553 PF01753 0.411
LIG_Pex14_1 175 179 PF04695 0.573
LIG_Pex14_2 32 36 PF04695 0.542
LIG_Pex14_2 337 341 PF04695 0.374
LIG_Pex14_2 417 421 PF04695 0.387
LIG_Rb_LxCxE_1 352 370 PF01857 0.469
LIG_SH2_CRK 120 124 PF00017 0.566
LIG_SH2_CRK 14 18 PF00017 0.553
LIG_SH2_CRK 199 203 PF00017 0.489
LIG_SH2_CRK 333 337 PF00017 0.478
LIG_SH2_CRK 402 406 PF00017 0.557
LIG_SH2_NCK_1 333 337 PF00017 0.426
LIG_SH2_SRC 199 202 PF00017 0.498
LIG_SH2_STAP1 600 604 PF00017 0.348
LIG_SH2_STAP1 633 637 PF00017 0.460
LIG_SH2_STAT5 14 17 PF00017 0.628
LIG_SH2_STAT5 203 206 PF00017 0.509
LIG_SH2_STAT5 333 336 PF00017 0.428
LIG_SH2_STAT5 627 630 PF00017 0.548
LIG_SH2_STAT5 633 636 PF00017 0.465
LIG_SH2_STAT5 657 660 PF00017 0.455
LIG_SH3_3 270 276 PF00018 0.651
LIG_SH3_3 31 37 PF00018 0.549
LIG_SH3_3 348 354 PF00018 0.385
LIG_SH3_3 482 488 PF00018 0.642
LIG_SH3_3 725 731 PF00018 0.655
LIG_SH3_3 847 853 PF00018 0.615
LIG_SUMO_SIM_anti_2 838 844 PF11976 0.668
LIG_SUMO_SIM_par_1 124 132 PF11976 0.439
LIG_SUMO_SIM_par_1 156 162 PF11976 0.618
LIG_SUMO_SIM_par_1 409 415 PF11976 0.361
LIG_SUMO_SIM_par_1 538 544 PF11976 0.518
LIG_SUMO_SIM_par_1 684 689 PF11976 0.576
LIG_TRAF2_1 262 265 PF00917 0.608
LIG_TRAF2_1 354 357 PF00917 0.452
LIG_TRAF2_1 703 706 PF00917 0.696
LIG_TRAF2_1 780 783 PF00917 0.703
LIG_TRAF2_2 163 168 PF00917 0.626
LIG_WRC_WIRS_1 327 332 PF05994 0.527
LIG_WRC_WIRS_1 620 625 PF05994 0.535
LIG_WRC_WIRS_1 800 805 PF05994 0.661
MOD_CDC14_SPxK_1 229 232 PF00782 0.569
MOD_CDC14_SPxK_1 272 275 PF00782 0.669
MOD_CDC14_SPxK_1 796 799 PF00782 0.763
MOD_CDK_SPK_2 226 231 PF00069 0.551
MOD_CDK_SPxK_1 226 232 PF00069 0.555
MOD_CDK_SPxK_1 269 275 PF00069 0.669
MOD_CDK_SPxK_1 793 799 PF00069 0.772
MOD_CDK_SPxxK_3 108 115 PF00069 0.627
MOD_CDK_SPxxK_3 145 152 PF00069 0.475
MOD_CDK_SPxxK_3 274 281 PF00069 0.669
MOD_CK1_1 100 106 PF00069 0.657
MOD_CK1_1 108 114 PF00069 0.533
MOD_CK1_1 188 194 PF00069 0.752
MOD_CK1_1 242 248 PF00069 0.746
MOD_CK1_1 290 296 PF00069 0.803
MOD_CK1_1 313 319 PF00069 0.738
MOD_CK1_1 62 68 PF00069 0.695
MOD_CK1_1 629 635 PF00069 0.483
MOD_CK1_1 729 735 PF00069 0.749
MOD_CK1_1 841 847 PF00069 0.556
MOD_CK1_1 855 861 PF00069 0.640
MOD_CK2_1 258 264 PF00069 0.581
MOD_CK2_1 291 297 PF00069 0.704
MOD_CK2_1 506 512 PF00069 0.417
MOD_CK2_1 567 573 PF00069 0.581
MOD_CK2_1 619 625 PF00069 0.638
MOD_CK2_1 861 867 PF00069 0.571
MOD_CK2_1 89 95 PF00069 0.721
MOD_DYRK1A_RPxSP_1 697 701 PF00069 0.597
MOD_GlcNHglycan 101 105 PF01048 0.635
MOD_GlcNHglycan 195 198 PF01048 0.653
MOD_GlcNHglycan 255 258 PF01048 0.745
MOD_GlcNHglycan 293 296 PF01048 0.670
MOD_GlcNHglycan 319 322 PF01048 0.703
MOD_GlcNHglycan 370 374 PF01048 0.732
MOD_GlcNHglycan 50 53 PF01048 0.693
MOD_GlcNHglycan 542 546 PF01048 0.507
MOD_GlcNHglycan 569 572 PF01048 0.611
MOD_GlcNHglycan 587 590 PF01048 0.410
MOD_GlcNHglycan 669 672 PF01048 0.704
MOD_GlcNHglycan 773 776 PF01048 0.661
MOD_GlcNHglycan 807 810 PF01048 0.669
MOD_GlcNHglycan 816 819 PF01048 0.556
MOD_GlcNHglycan 858 861 PF01048 0.753
MOD_GlcNHglycan 867 871 PF01048 0.624
MOD_GSK3_1 137 144 PF00069 0.541
MOD_GSK3_1 185 192 PF00069 0.655
MOD_GSK3_1 20 27 PF00069 0.648
MOD_GSK3_1 235 242 PF00069 0.597
MOD_GSK3_1 283 290 PF00069 0.680
MOD_GSK3_1 313 320 PF00069 0.711
MOD_GSK3_1 322 329 PF00069 0.442
MOD_GSK3_1 384 391 PF00069 0.697
MOD_GSK3_1 394 401 PF00069 0.520
MOD_GSK3_1 44 51 PF00069 0.657
MOD_GSK3_1 58 65 PF00069 0.516
MOD_GSK3_1 592 599 PF00069 0.470
MOD_GSK3_1 726 733 PF00069 0.686
MOD_GSK3_1 752 759 PF00069 0.648
MOD_GSK3_1 848 855 PF00069 0.608
MOD_GSK3_1 856 863 PF00069 0.644
MOD_N-GLC_1 232 237 PF02516 0.639
MOD_N-GLC_2 712 714 PF02516 0.593
MOD_NEK2_1 174 179 PF00069 0.665
MOD_NEK2_1 189 194 PF00069 0.588
MOD_NEK2_1 32 37 PF00069 0.660
MOD_NEK2_1 331 336 PF00069 0.450
MOD_NEK2_1 436 441 PF00069 0.437
MOD_NEK2_1 505 510 PF00069 0.399
MOD_NEK2_1 541 546 PF00069 0.487
MOD_NEK2_1 554 559 PF00069 0.321
MOD_NEK2_1 650 655 PF00069 0.457
MOD_NEK2_2 326 331 PF00069 0.365
MOD_NEK2_2 455 460 PF00069 0.570
MOD_PIKK_1 250 256 PF00454 0.739
MOD_PIKK_1 313 319 PF00454 0.768
MOD_PIKK_1 340 346 PF00454 0.391
MOD_PIKK_1 652 658 PF00454 0.460
MOD_PK_1 141 147 PF00069 0.331
MOD_PKA_1 141 147 PF00069 0.331
MOD_PKA_1 44 50 PF00069 0.636
MOD_PKA_1 667 673 PF00069 0.614
MOD_PKA_1 756 762 PF00069 0.783
MOD_PKA_2 121 127 PF00069 0.475
MOD_PKA_2 141 147 PF00069 0.296
MOD_PKA_2 239 245 PF00069 0.752
MOD_PKA_2 317 323 PF00069 0.743
MOD_PKA_2 44 50 PF00069 0.646
MOD_PKA_2 576 582 PF00069 0.594
MOD_PKA_2 629 635 PF00069 0.546
MOD_PKA_2 667 673 PF00069 0.614
MOD_PKA_2 756 762 PF00069 0.718
MOD_PKB_1 338 346 PF00069 0.385
MOD_PKB_1 46 54 PF00069 0.671
MOD_Plk_1 32 38 PF00069 0.661
MOD_Plk_1 529 535 PF00069 0.434
MOD_Plk_1 650 656 PF00069 0.458
MOD_Plk_2-3 496 502 PF00069 0.364
MOD_Plk_4 121 127 PF00069 0.613
MOD_Plk_4 141 147 PF00069 0.296
MOD_Plk_4 239 245 PF00069 0.689
MOD_Plk_4 326 332 PF00069 0.522
MOD_Plk_4 377 383 PF00069 0.700
MOD_Plk_4 455 461 PF00069 0.563
MOD_Plk_4 536 542 PF00069 0.423
MOD_Plk_4 679 685 PF00069 0.599
MOD_ProDKin_1 108 114 PF00069 0.555
MOD_ProDKin_1 145 151 PF00069 0.465
MOD_ProDKin_1 226 232 PF00069 0.555
MOD_ProDKin_1 269 275 PF00069 0.627
MOD_ProDKin_1 305 311 PF00069 0.704
MOD_ProDKin_1 322 328 PF00069 0.410
MOD_ProDKin_1 375 381 PF00069 0.705
MOD_ProDKin_1 386 392 PF00069 0.580
MOD_ProDKin_1 506 512 PF00069 0.376
MOD_ProDKin_1 592 598 PF00069 0.478
MOD_ProDKin_1 613 619 PF00069 0.424
MOD_ProDKin_1 62 68 PF00069 0.632
MOD_ProDKin_1 697 703 PF00069 0.615
MOD_ProDKin_1 726 732 PF00069 0.677
MOD_ProDKin_1 733 739 PF00069 0.630
MOD_ProDKin_1 793 799 PF00069 0.772
MOD_ProDKin_1 848 854 PF00069 0.632
MOD_SUMO_for_1 280 283 PF00179 0.715
MOD_SUMO_for_1 71 74 PF00179 0.695
MOD_SUMO_for_1 780 783 PF00179 0.668
TRG_DiLeu_BaEn_1 428 433 PF01217 0.390
TRG_DiLeu_BaEn_4 705 711 PF01217 0.608
TRG_DiLeu_BaLyEn_6 355 360 PF01217 0.546
TRG_ENDOCYTIC_2 600 603 PF00928 0.368
TRG_ER_diArg_1 117 119 PF00400 0.545
TRG_ER_diArg_1 219 222 PF00400 0.539
TRG_ER_diArg_1 230 232 PF00400 0.627
TRG_ER_diArg_1 337 340 PF00400 0.377
TRG_ER_diArg_1 43 46 PF00400 0.722
TRG_ER_diArg_1 563 566 PF00400 0.497
TRG_ER_diArg_1 745 748 PF00400 0.786
TRG_NLS_MonoCore_2 42 47 PF00514 0.563
TRG_NLS_MonoCore_2 743 748 PF00514 0.717
TRG_NLS_MonoExtC_3 43 48 PF00514 0.633
TRG_NLS_MonoExtC_3 743 748 PF00514 0.787
TRG_NLS_MonoExtN_4 43 48 PF00514 0.567
TRG_NLS_MonoExtN_4 761 768 PF00514 0.602
TRG_Pf-PMV_PEXEL_1 246 250 PF00026 0.515
TRG_Pf-PMV_PEXEL_1 340 344 PF00026 0.379

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZN7 Leptomonas seymouri 42% 100%
A0A3S5H609 Leishmania donovani 88% 100%
A4H545 Leishmania braziliensis 73% 100%
A4HTC1 Leishmania infantum 88% 100%
E9ALB4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS