Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania major

UniProt:

Q4QII9_LEIMA

TriTrypDb:

LmjF.07.0980 , LMJLV39_070016900 , LMJSD75_070017200

Length:

119

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0030684	preribosome	3	2
GO:0030687	preribosome, large subunit precursor	4	2
GO:0032991	protein-containing complex	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4QII9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QII9

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0019843	rRNA binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	13	17	PF00082	0.410
CLV_PCSK_SKI1_1	76	80	PF00082	0.450
DEG_Nend_UBRbox_2	1	3	PF02207	0.450
DOC_PP1_RVXF_1	74	80	PF00149	0.369
DOC_USP7_MATH_1	34	38	PF00917	0.314
DOC_USP7_UBL2_3	45	49	PF12436	0.447
LIG_EH1_1	37	45	PF00400	0.424
LIG_FHA_1	39	45	PF00498	0.374
LIG_FHA_1	83	89	PF00498	0.350
LIG_PDZ_Class_3	114	119	PF00595	0.674
LIG_SH2_CRK	93	97	PF00017	0.517
LIG_SH2_STAP1	93	97	PF00017	0.517
LIG_SH2_STAT5	93	96	PF00017	0.435
LIG_SH3_3	27	33	PF00018	0.401
LIG_SUMO_SIM_par_1	40	47	PF11976	0.403
LIG_TRAF2_1	97	100	PF00917	0.613
LIG_TYR_ITIM	91	96	PF00017	0.424
MOD_GlcNHglycan	19	22	PF01048	0.401
MOD_GlcNHglycan	71	74	PF01048	0.371
MOD_GSK3_1	34	41	PF00069	0.344
MOD_GSK3_1	43	50	PF00069	0.347
MOD_N-GLC_1	17	22	PF02516	0.453
MOD_N-GLC_1	34	39	PF02516	0.258
MOD_NEK2_1	25	30	PF00069	0.320
MOD_NEK2_1	69	74	PF00069	0.370
MOD_PIKK_1	25	31	PF00454	0.320
MOD_PIKK_1	91	97	PF00454	0.424
MOD_Plk_4	47	53	PF00069	0.373
MOD_SUMO_for_1	44	47	PF00179	0.424
TRG_DiLeu_BaEn_2	46	52	PF01217	0.424
TRG_ENDOCYTIC_2	93	96	PF00928	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I136	Leptomonas seymouri	74%	100%
A0A1X0NR21	Trypanosomatidae	44%	71%
A0A1X0NR92	Trypanosomatidae	44%	70%
A0A3S5H610	Leishmania donovani	98%	100%
A4H546	Leishmania braziliensis	91%	98%
A4HTC2	Leishmania infantum	98%	100%
C9ZUJ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ALB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%