Putative nucleolar RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleolar RNA-binding protein, putative

Species:

Leishmania major

UniProt:

Q4QII8_LEIMA

TriTrypDb:

LmjF.07.0990 , LMJLV39_070017000 , LMJSD75_070017300

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0030684	preribosome	3	2
GO:0030687	preribosome, large subunit precursor	4	2
GO:0032991	protein-containing complex	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4QII8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QII8

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0019843	rRNA binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	251	255	PF00656	0.625
CLV_NRD_NRD_1	241	243	PF00675	0.725
CLV_PCSK_KEX2_1	348	350	PF00082	0.745
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.691
CLV_PCSK_SKI1_1	13	17	PF00082	0.394
CLV_PCSK_SKI1_1	49	53	PF00082	0.394
DEG_Nend_UBRbox_2	1	3	PF02207	0.538
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.394
DOC_PP2B_LxvP_1	30	33	PF13499	0.451
DOC_USP7_MATH_1	107	111	PF00917	0.802
DOC_USP7_MATH_1	145	149	PF00917	0.881
DOC_WW_Pin1_4	134	139	PF00397	0.670
LIG_14-3-3_CanoR_1	26	33	PF00244	0.394
LIG_Actin_WH2_2	12	28	PF00022	0.394
LIG_FHA_1	65	71	PF00498	0.556
LIG_FHA_1	88	94	PF00498	0.394
LIG_Integrin_RGD_1	249	251	PF01839	0.710
LIG_LIR_Apic_2	90	95	PF02991	0.394
LIG_LIR_LC3C_4	41	44	PF02991	0.394
LIG_LIR_Nem_3	2	7	PF02991	0.547
LIG_SH2_PTP2	92	95	PF00017	0.529
LIG_SH2_STAT5	92	95	PF00017	0.529
LIG_TRAF2_1	110	113	PF00917	0.706
LIG_TRAF2_1	148	151	PF00917	0.718
LIG_WRC_WIRS_1	43	48	PF05994	0.394
MOD_CK2_1	107	113	PF00069	0.698
MOD_CK2_1	124	130	PF00069	0.621
MOD_CK2_1	145	151	PF00069	0.759
MOD_Cter_Amidation	346	349	PF01082	0.748
MOD_GlcNHglycan	109	112	PF01048	0.811
MOD_GlcNHglycan	124	129	PF01048	0.631
MOD_GlcNHglycan	139	142	PF01048	0.694
MOD_GlcNHglycan	79	82	PF01048	0.523
MOD_GSK3_1	124	131	PF00069	0.766
MOD_GSK3_1	38	45	PF00069	0.515
MOD_NEK2_1	25	30	PF00069	0.556
MOD_PIKK_1	25	31	PF00454	0.394
MOD_PKA_2	25	31	PF00069	0.491
MOD_Plk_1	75	81	PF00069	0.394
MOD_Plk_2-3	113	119	PF00069	0.846
MOD_Plk_4	38	44	PF00069	0.451
MOD_ProDKin_1	134	140	PF00069	0.671
MOD_SUMO_rev_2	41	51	PF00179	0.523
TRG_ER_diArg_1	349	352	PF00400	0.698
TRG_NLS_MonoExtN_4	345	352	PF00514	0.696

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H611	Leishmania donovani	83%	100%
E9ALB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%