FeS_assembly_P domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function DUF59, putative

Species:

Leishmania major

UniProt:

Q4QII6_LEIMA

TriTrypDb:

LmjF.07.1010 , LMJLV39_070017200 , LMJSD75_070017500

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QII6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QII6

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0016226	iron-sulfur cluster assembly	4	2
GO:0019538	protein metabolic process	3	11
GO:0022607	cellular component assembly	4	2
GO:0031163	metallo-sulfur cluster assembly	5	2
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	11
GO:0051604	protein maturation	4	11
GO:0071704	organic substance metabolic process	2	11
GO:0071840	cellular component organization or biogenesis	2	2
GO:0097428	protein maturation by iron-sulfur cluster transfer	5	11
GO:0106035	protein maturation by [4Fe-4S] cluster transfer	6	11
GO:1901564	organonitrogen compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.336
CLV_NRD_NRD_1	53	55	PF00675	0.420
CLV_NRD_NRD_1	59	61	PF00675	0.380
CLV_NRD_NRD_1	67	69	PF00675	0.356
CLV_PCSK_KEX2_1	121	123	PF00082	0.334
CLV_PCSK_KEX2_1	149	151	PF00082	0.392
CLV_PCSK_KEX2_1	52	54	PF00082	0.434
CLV_PCSK_KEX2_1	59	61	PF00082	0.376
CLV_PCSK_KEX2_1	66	68	PF00082	0.354
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.392
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.326
CLV_PCSK_SKI1_1	153	157	PF00082	0.369
CLV_PCSK_SKI1_1	219	223	PF00082	0.437
DEG_APCC_DBOX_1	218	226	PF00400	0.473
DEG_Nend_Nbox_1	1	3	PF02207	0.348
DOC_CKS1_1	155	160	PF01111	0.310
DOC_CKS1_1	190	195	PF01111	0.525
DOC_CYCLIN_RxL_1	148	159	PF00134	0.403
DOC_MAPK_gen_1	148	156	PF00069	0.374
DOC_MAPK_MEF2A_6	148	156	PF00069	0.313
DOC_MAPK_RevD_3	135	149	PF00069	0.403
DOC_PP1_RVXF_1	151	157	PF00149	0.291
DOC_USP7_MATH_1	161	165	PF00917	0.283
DOC_WW_Pin1_4	154	159	PF00397	0.291
DOC_WW_Pin1_4	189	194	PF00397	0.448
DOC_WW_Pin1_4	30	35	PF00397	0.345
LIG_14-3-3_CanoR_1	52	61	PF00244	0.328
LIG_Clathr_ClatBox_1	142	146	PF01394	0.325
LIG_DCNL_PONY_1	1	4	PF03556	0.343
LIG_deltaCOP1_diTrp_1	112	117	PF00928	0.526
LIG_DLG_GKlike_1	54	61	PF00625	0.327
LIG_EVH1_2	34	38	PF00568	0.341
LIG_FHA_1	11	17	PF00498	0.346
LIG_FHA_1	155	161	PF00498	0.302
LIG_FHA_1	164	170	PF00498	0.312
LIG_FHA_2	183	189	PF00498	0.325
LIG_FHA_2	80	86	PF00498	0.606
LIG_FHA_2	93	99	PF00498	0.502
LIG_LIR_Apic_2	188	193	PF02991	0.501
LIG_LIR_Gen_1	112	120	PF02991	0.302
LIG_LIR_Gen_1	183	191	PF02991	0.403
LIG_LIR_Gen_1	39	48	PF02991	0.329
LIG_LIR_Nem_3	112	117	PF02991	0.392
LIG_LIR_Nem_3	183	187	PF02991	0.403
LIG_LIR_Nem_3	39	44	PF02991	0.346
LIG_MAD2	153	161	PF02301	0.403
LIG_PCNA_yPIPBox_3	211	225	PF02747	0.411
LIG_Pex14_2	37	41	PF04695	0.354
LIG_RPA_C_Fungi	49	61	PF08784	0.321
LIG_SH2_NCK_1	184	188	PF00017	0.403
LIG_SH2_PTP2	190	193	PF00017	0.513
LIG_SH2_STAT5	184	187	PF00017	0.403
LIG_SH2_STAT5	190	193	PF00017	0.513
LIG_SH3_3	123	129	PF00018	0.335
LIG_SH3_3	134	140	PF00018	0.269
LIG_SH3_3	155	161	PF00018	0.291
LIG_SH3_3	80	86	PF00018	0.566
LIG_SUMO_SIM_anti_2	13	18	PF11976	0.344
LIG_SUMO_SIM_par_1	141	146	PF11976	0.389
MOD_CK1_1	141	147	PF00069	0.389
MOD_CK1_1	164	170	PF00069	0.291
MOD_CK1_1	30	36	PF00069	0.421
MOD_CK2_1	177	183	PF00069	0.372
MOD_CK2_1	79	85	PF00069	0.558
MOD_CK2_1	92	98	PF00069	0.451
MOD_NEK2_1	17	22	PF00069	0.348
MOD_NEK2_1	177	182	PF00069	0.335
MOD_NEK2_2	36	41	PF00069	0.350
MOD_PKA_1	52	58	PF00069	0.326
MOD_PKA_2	52	58	PF00069	0.419
MOD_PKB_1	52	60	PF00069	0.328
MOD_Plk_1	177	183	PF00069	0.403
MOD_Plk_2-3	104	110	PF00069	0.512
MOD_Plk_4	138	144	PF00069	0.403
MOD_Plk_4	164	170	PF00069	0.276
MOD_Plk_4	79	85	PF00069	0.484
MOD_ProDKin_1	154	160	PF00069	0.291
MOD_ProDKin_1	189	195	PF00069	0.448
MOD_ProDKin_1	30	36	PF00069	0.342
TRG_DiLeu_BaEn_1	217	222	PF01217	0.419
TRG_ENDOCYTIC_2	184	187	PF00928	0.403
TRG_ER_diArg_1	120	122	PF00400	0.334
TRG_ER_diArg_1	51	54	PF00400	0.429
TRG_ER_diArg_1	58	60	PF00400	0.376
TRG_NLS_Bipartite_1	52	70	PF00514	0.324
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.304
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA31	Leptomonas seymouri	85%	100%
A0A0S4IN86	Bodo saltans	54%	100%
A0A0S4JKU2	Bodo saltans	34%	100%
A0A1X0NPI3	Trypanosomatidae	68%	100%
A0A3S5H612	Leishmania donovani	98%	100%
A0A422NPZ2	Trypanosoma rangeli	66%	100%
A4H549	Leishmania braziliensis	93%	100%
A4HTC5	Leishmania infantum	98%	100%
C9ZUJ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9ALB8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O62252	Caenorhabditis elegans	52%	100%
Q54QK1	Dictyostelium discoideum	46%	100%
Q9C9G6	Arabidopsis thaliana	50%	100%
Q9D187	Mus musculus	53%	100%
Q9UTL0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	100%