Peptidyl-prolyl cis-trans isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl-prolyl cis-trans isomerase/rotamase, putative

Species:

Leishmania major

UniProt:

Q4QII4_LEIMA

TriTrypDb:

LmjF.07.1030 , LMJLV39_070017400 , LMJSD75_070017700

Length:

115

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005829	cytosol	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QII4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QII4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	12
GO:0003824	catalytic activity	1	12
GO:0016853	isomerase activity	2	12
GO:0016859	cis-trans isomerase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	47	51	PF00656	0.228
CLV_NRD_NRD_1	24	26	PF00675	0.330
CLV_PCSK_KEX2_1	112	114	PF00082	0.314
CLV_PCSK_KEX2_1	24	26	PF00082	0.330
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.314
DOC_PP1_RVXF_1	50	56	PF00149	0.414
DOC_USP7_MATH_1	2	6	PF00917	0.510
DOC_USP7_MATH_1	89	93	PF00917	0.362
LIG_14-3-3_CanoR_1	60	68	PF00244	0.360
LIG_APCC_ABBA_1	83	88	PF00400	0.291
LIG_FHA_1	88	94	PF00498	0.395
LIG_FHA_2	52	58	PF00498	0.354
LIG_SH2_SRC	34	37	PF00017	0.371
LIG_SH2_STAP1	34	38	PF00017	0.349
LIG_SH3_3	73	79	PF00018	0.461
LIG_TRAF2_1	33	36	PF00917	0.423
LIG_TRAF2_1	54	57	PF00917	0.410
MOD_CK1_1	23	29	PF00069	0.314
MOD_CK1_1	63	69	PF00069	0.365
MOD_CK2_1	30	36	PF00069	0.395
MOD_CK2_1	51	57	PF00069	0.349
MOD_GlcNHglycan	105	108	PF01048	0.296
MOD_GlcNHglycan	15	18	PF01048	0.324
MOD_GlcNHglycan	98	101	PF01048	0.346
MOD_GSK3_1	23	30	PF00069	0.330
MOD_GSK3_1	60	67	PF00069	0.335
MOD_PKA_2	23	29	PF00069	0.346
MOD_Plk_1	63	69	PF00069	0.384
MOD_SUMO_rev_2	47	54	PF00179	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Y3	Leptomonas seymouri	75%	98%
A0A0S4IKV0	Bodo saltans	67%	100%
A0A1X0NPJ0	Trypanosomatidae	72%	100%
A0A3S7WQ26	Leishmania donovani	94%	100%
A0A422NPX4	Trypanosoma rangeli	69%	98%
A4H551	Leishmania braziliensis	81%	100%
A4HTC7	Leishmania infantum	93%	100%
C9ZUI9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9ALC0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
P0C1J8	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	50%	77%
P0DMT5	Theileria annulata	48%	81%
P22696	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	53%	68%
P54353	Drosophila melanogaster	53%	69%
Q13526	Homo sapiens	50%	71%
Q4R383	Macaca fascicularis	50%	71%
Q4UG71	Theileria annulata	47%	81%
Q5BIN5	Bos taurus	50%	71%
Q94G00	Malus domestica	51%	95%
Q9LEK8	Digitalis lanata	49%	97%
Q9QUR7	Mus musculus	51%	70%
Q9SL42	Arabidopsis thaliana	54%	97%
V5BP22	Trypanosoma cruzi	65%	98%