Dpy-30 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dpy-30 motif containing protein, putative

Species:

Leishmania major

UniProt:

Q4QII1_LEIMA

TriTrypDb:

LmjF.07.1055 , LMJLV39_070018000 , LMJSD75_070018300

Length:

112

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	3
GO:0034708	methyltransferase complex	4	3
GO:0035097	histone methyltransferase complex	3	3
GO:0044666	MLL3/4 complex	4	3
GO:0048188	Set1C/COMPASS complex	4	3
GO:0140513	nuclear protein-containing complex	2	3
GO:1902494	catalytic complex	2	3
GO:1990234	transferase complex	3	3

Expansion

Sequence features

Q4QII1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QII1

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008213	protein alkylation	5	2
GO:0009987	cellular process	1	2
GO:0016570	histone modification	5	2
GO:0016571	histone methylation	5	2
GO:0018022	peptidyl-lysine methylation	5	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018205	peptidyl-lysine modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0032259	methylation	2	2
GO:0034968	histone lysine methylation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043414	macromolecule methylation	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0051568	histone H3-K4 methylation	7	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	87	89	PF00675	0.299
CLV_PCSK_KEX2_1	87	89	PF00082	0.299
CLV_PCSK_SKI1_1	56	60	PF00082	0.393
DEG_APCC_DBOX_1	55	63	PF00400	0.564
DOC_CYCLIN_yCln2_LP_2	29	35	PF00134	0.657
DOC_PP2B_LxvP_1	19	22	PF13499	0.742
DOC_WW_Pin1_4	4	9	PF00397	0.718
LIG_14-3-3_CanoR_1	16	22	PF00244	0.593
LIG_14-3-3_CanoR_1	87	95	PF00244	0.674
LIG_Actin_WH2_2	74	89	PF00022	0.492
LIG_BIR_II_1	1	5	PF00653	0.726
LIG_eIF4E_1	80	86	PF01652	0.542
LIG_FHA_1	92	98	PF00498	0.636
LIG_FHA_2	96	102	PF00498	0.565
LIG_SH2_STAP1	99	103	PF00017	0.634
LIG_SH2_STAT5	53	56	PF00017	0.474
LIG_SH2_STAT5	80	83	PF00017	0.546
LIG_SH2_STAT5	84	87	PF00017	0.549
LIG_SH3_1	71	77	PF00018	0.474
LIG_SH3_3	69	75	PF00018	0.488
LIG_SUMO_SIM_par_1	93	98	PF11976	0.631
LIG_TRAF2_1	12	15	PF00917	0.706
MOD_CK1_1	46	52	PF00069	0.529
MOD_CK2_1	106	112	PF00069	0.708
MOD_GSK3_1	43	50	PF00069	0.627
MOD_GSK3_1	87	94	PF00069	0.610
MOD_GSK3_1	95	102	PF00069	0.643
MOD_N-GLC_1	91	96	PF02516	0.594
MOD_NEK2_1	54	59	PF00069	0.500
MOD_NEK2_1	86	91	PF00069	0.591
MOD_PIKK_1	47	53	PF00454	0.578
MOD_PKA_1	87	93	PF00069	0.666
MOD_PKA_2	86	92	PF00069	0.610
MOD_Plk_1	43	49	PF00069	0.614
MOD_Plk_1	54	60	PF00069	0.402
MOD_Plk_1	91	97	PF00069	0.629
MOD_Plk_1	99	105	PF00069	0.642
MOD_Plk_4	80	86	PF00069	0.542
MOD_ProDKin_1	4	10	PF00069	0.720
TRG_DiLeu_BaEn_4	14	20	PF01217	0.683
TRG_ER_diArg_1	71	74	PF00400	0.474
TRG_ER_diArg_1	86	88	PF00400	0.474
TRG_NES_CRM1_1	43	55	PF08389	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9I1	Leptomonas seymouri	67%	100%
A0A3S7WQ32	Leishmania donovani	91%	97%
A4H554	Leishmania braziliensis	83%	100%
A4HTD1	Leishmania infantum	90%	97%
C9ZUI3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	99%
E9ALC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BYE7	Trypanosoma cruzi	45%	100%