Putative lipoyl ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

lipoate-protein ligase-like

Species:

Leishmania major

UniProt:

Q4QII0_LEIMA

TriTrypDb:

LmjF.07.1060 , LMJLV39_070018100 , LMJSD75_070018400

Length:

513

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QII0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QII0

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009249	protein lipoylation	5	10
GO:0018193	peptidyl-amino acid modification	5	10
GO:0018205	peptidyl-lysine modification	6	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044238	primary metabolic process	2	10
GO:0051604	protein maturation	4	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016740	transferase activity	2	6
GO:0016746	acyltransferase activity	3	2
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	2
GO:0016874	ligase activity	2	10
GO:0017118	lipoyltransferase activity	5	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	1
GO:0016979	lipoate-protein ligase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	482	486	PF00656	0.377
CLV_NRD_NRD_1	108	110	PF00675	0.240
CLV_NRD_NRD_1	170	172	PF00675	0.367
CLV_NRD_NRD_1	352	354	PF00675	0.498
CLV_NRD_NRD_1	416	418	PF00675	0.440
CLV_NRD_NRD_1	7	9	PF00675	0.514
CLV_NRD_NRD_1	97	99	PF00675	0.259
CLV_PCSK_KEX2_1	108	110	PF00082	0.240
CLV_PCSK_KEX2_1	351	353	PF00082	0.515
CLV_PCSK_KEX2_1	416	418	PF00082	0.444
CLV_PCSK_KEX2_1	7	9	PF00082	0.514
CLV_PCSK_KEX2_1	97	99	PF00082	0.259
CLV_PCSK_SKI1_1	171	175	PF00082	0.259
CLV_PCSK_SKI1_1	352	356	PF00082	0.388
CLV_PCSK_SKI1_1	380	384	PF00082	0.517
CLV_PCSK_SKI1_1	408	412	PF00082	0.341
CLV_PCSK_SKI1_1	497	501	PF00082	0.363
CLV_PCSK_SKI1_1	506	510	PF00082	0.339
CLV_PCSK_SKI1_1	71	75	PF00082	0.328
DEG_APCC_DBOX_1	350	358	PF00400	0.389
DEG_APCC_DBOX_1	70	78	PF00400	0.333
DEG_Nend_Nbox_1	1	3	PF02207	0.535
DEG_SCF_FBW7_1	192	199	PF00400	0.489
DOC_ANK_TNKS_1	97	104	PF00023	0.524
DOC_CKS1_1	193	198	PF01111	0.561
DOC_CYCLIN_RxL_1	494	501	PF00134	0.429
DOC_CYCLIN_RxL_1	59	68	PF00134	0.460
DOC_MAPK_gen_1	351	359	PF00069	0.420
DOC_MAPK_MEF2A_6	138	147	PF00069	0.464
DOC_MIT_MIM_1	347	357	PF04212	0.408
DOC_PP1_RVXF_1	69	76	PF00149	0.344
DOC_USP7_MATH_1	196	200	PF00917	0.432
DOC_USP7_MATH_1	224	228	PF00917	0.438
DOC_USP7_MATH_1	33	37	PF00917	0.582
DOC_USP7_MATH_1	423	427	PF00917	0.697
DOC_USP7_MATH_1	56	60	PF00917	0.507
DOC_USP7_UBL2_3	326	330	PF12436	0.417
DOC_WW_Pin1_4	192	197	PF00397	0.549
DOC_WW_Pin1_4	220	225	PF00397	0.410
DOC_WW_Pin1_4	261	266	PF00397	0.416
LIG_14-3-3_CanoR_1	157	166	PF00244	0.452
LIG_14-3-3_CanoR_1	352	358	PF00244	0.455
LIG_14-3-3_CanoR_1	408	414	PF00244	0.342
LIG_14-3-3_CanoR_1	441	448	PF00244	0.467
LIG_14-3-3_CanoR_1	62	67	PF00244	0.465
LIG_APCC_ABBAyCdc20_2	163	169	PF00400	0.433
LIG_BIR_III_4	485	489	PF00653	0.453
LIG_BRCT_BRCA1_1	340	344	PF00533	0.252
LIG_Clathr_ClatBox_1	289	293	PF01394	0.402
LIG_deltaCOP1_diTrp_1	331	339	PF00928	0.408
LIG_deltaCOP1_diTrp_1	501	509	PF00928	0.415
LIG_eIF4E_1	186	192	PF01652	0.528
LIG_eIF4E_1	442	448	PF01652	0.307
LIG_FHA_1	137	143	PF00498	0.481
LIG_FHA_1	188	194	PF00498	0.434
LIG_FHA_1	213	219	PF00498	0.390
LIG_FHA_1	29	35	PF00498	0.536
LIG_FHA_1	338	344	PF00498	0.357
LIG_FHA_1	354	360	PF00498	0.344
LIG_FHA_1	409	415	PF00498	0.507
LIG_FHA_1	43	49	PF00498	0.341
LIG_FHA_1	463	469	PF00498	0.519
LIG_FHA_2	262	268	PF00498	0.482
LIG_FHA_2	317	323	PF00498	0.412
LIG_FHA_2	401	407	PF00498	0.453
LIG_Integrin_RGD_1	314	316	PF01839	0.489
LIG_LIR_Apic_2	331	337	PF02991	0.411
LIG_LIR_Gen_1	207	218	PF02991	0.423
LIG_LIR_Gen_1	49	56	PF02991	0.360
LIG_LIR_LC3C_4	37	42	PF02991	0.436
LIG_LIR_Nem_3	207	213	PF02991	0.361
LIG_LIR_Nem_3	49	54	PF02991	0.362
LIG_NRBOX	442	448	PF00104	0.460
LIG_Pex14_1	438	442	PF04695	0.423
LIG_SH2_CRK	334	338	PF00017	0.446
LIG_SH2_GRB2like	76	79	PF00017	0.305
LIG_SH2_NCK_1	334	338	PF00017	0.456
LIG_SH2_STAT3	9	12	PF00017	0.550
LIG_SH2_STAT5	203	206	PF00017	0.358
LIG_SH2_STAT5	210	213	PF00017	0.339
LIG_SH2_STAT5	442	445	PF00017	0.350
LIG_SH2_STAT5	76	79	PF00017	0.360
LIG_SH3_3	190	196	PF00018	0.506
LIG_SH3_3	218	224	PF00018	0.435
LIG_SH3_3	23	29	PF00018	0.445
LIG_SH3_3	445	451	PF00018	0.557
LIG_SH3_3	478	484	PF00018	0.475
LIG_SH3_3	74	80	PF00018	0.344
LIG_SH3_5	206	210	PF00018	0.469
LIG_SUMO_SIM_anti_2	371	379	PF11976	0.372
LIG_SUMO_SIM_par_1	189	195	PF11976	0.433
LIG_TRAF2_1	370	373	PF00917	0.393
LIG_TRAF2_1	55	58	PF00917	0.287
LIG_TRFH_1	9	13	PF08558	0.536
LIG_UBA3_1	60	69	PF00899	0.364
LIG_WRC_WIRS_1	336	341	PF05994	0.320
MOD_CK1_1	126	132	PF00069	0.433
MOD_CK1_1	217	223	PF00069	0.397
MOD_CK1_1	431	437	PF00069	0.536
MOD_CK1_1	65	71	PF00069	0.442
MOD_CK2_1	224	230	PF00069	0.436
MOD_CK2_1	261	267	PF00069	0.478
MOD_CK2_1	316	322	PF00069	0.394
MOD_CK2_1	343	349	PF00069	0.410
MOD_CK2_1	365	371	PF00069	0.495
MOD_CK2_1	400	406	PF00069	0.420
MOD_CK2_1	46	52	PF00069	0.433
MOD_Cter_Amidation	169	172	PF01082	0.320
MOD_GlcNHglycan	110	113	PF01048	0.273
MOD_GlcNHglycan	175	178	PF01048	0.233
MOD_GlcNHglycan	230	233	PF01048	0.439
MOD_GlcNHglycan	425	428	PF01048	0.744
MOD_GlcNHglycan	431	434	PF01048	0.680
MOD_GlcNHglycan	443	446	PF01048	0.311
MOD_GSK3_1	192	199	PF00069	0.534
MOD_GSK3_1	213	220	PF00069	0.388
MOD_GSK3_1	224	231	PF00069	0.358
MOD_GSK3_1	335	342	PF00069	0.411
MOD_GSK3_1	419	426	PF00069	0.622
MOD_GSK3_1	42	49	PF00069	0.423
MOD_GSK3_1	428	435	PF00069	0.561
MOD_N-GLC_2	122	124	PF02516	0.264
MOD_NEK2_1	1	6	PF00069	0.547
MOD_NEK2_1	123	128	PF00069	0.475
MOD_NEK2_1	147	152	PF00069	0.463
MOD_NEK2_1	158	163	PF00069	0.428
MOD_NEK2_1	19	24	PF00069	0.560
MOD_NEK2_1	213	218	PF00069	0.387
MOD_NEK2_1	228	233	PF00069	0.359
MOD_NEK2_1	339	344	PF00069	0.421
MOD_NEK2_1	365	370	PF00069	0.407
MOD_NEK2_1	409	414	PF00069	0.470
MOD_PK_1	214	220	PF00069	0.348
MOD_PK_1	355	361	PF00069	0.368
MOD_PKA_1	108	114	PF00069	0.457
MOD_PKA_1	171	177	PF00069	0.459
MOD_PKA_2	108	114	PF00069	0.470
MOD_PKA_2	156	162	PF00069	0.433
MOD_PKA_2	275	281	PF00069	0.571
MOD_PKB_1	274	282	PF00069	0.327
MOD_PKB_1	351	359	PF00069	0.370
MOD_Plk_1	136	142	PF00069	0.502
MOD_Plk_1	463	469	PF00069	0.544
MOD_Plk_1	56	62	PF00069	0.343
MOD_Plk_1	92	98	PF00069	0.516
MOD_Plk_2-3	316	322	PF00069	0.520
MOD_Plk_4	1	7	PF00069	0.635
MOD_Plk_4	187	193	PF00069	0.446
MOD_Plk_4	339	345	PF00069	0.378
MOD_Plk_4	409	415	PF00069	0.448
MOD_Plk_4	46	52	PF00069	0.446
MOD_Plk_4	56	62	PF00069	0.453
MOD_ProDKin_1	192	198	PF00069	0.556
MOD_ProDKin_1	220	226	PF00069	0.403
MOD_ProDKin_1	261	267	PF00069	0.421
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.360
TRG_ENDOCYTIC_2	210	213	PF00928	0.358
TRG_ER_diArg_1	131	134	PF00400	0.506
TRG_ER_diArg_1	273	276	PF00400	0.415
TRG_ER_diArg_1	350	353	PF00400	0.500
TRG_ER_diArg_1	415	417	PF00400	0.439
TRG_ER_diArg_1	6	8	PF00400	0.607
TRG_ER_diArg_1	96	98	PF00400	0.498
TRG_NES_CRM1_1	349	361	PF08389	0.429
TRG_Pf-PMV_PEXEL_1	202	207	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	497	501	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	62	67	PF00026	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I310	Leptomonas seymouri	59%	100%
A0A0S4IZJ4	Bodo saltans	35%	82%
A0A1X0NQ94	Trypanosomatidae	39%	100%
A0A3R7MGW3	Trypanosoma rangeli	39%	99%
A0A3S5H615	Leishmania donovani	91%	100%
A4H555	Leishmania braziliensis	79%	73%
C9ZUI2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9ALC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%