Putative RNA-editing complex protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-editing complex protein, putative

Species:

Leishmania major

UniProt:

Q4QIH9_LEIMA

TriTrypDb:

LmjF.07.1070 , LMJLV39_070018200 , LMJSD75_070018500

Length:

501

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0031019	mitochondrial mRNA editing complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0045293	mRNA editing complex	3	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	2

Expansion

Sequence features

Q4QIH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIH9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	2
GO:0010035	response to inorganic substance	3	2
GO:0010038	response to metal ion	4	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0016556	mRNA modification	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0042221	response to chemical	2	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0050896	response to stimulus	1	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000175	3'-5'-RNA exonuclease activity	7	2
GO:0003824	catalytic activity	1	2
GO:0004518	nuclease activity	4	2
GO:0004519	endonuclease activity	5	2
GO:0004521	RNA endonuclease activity	5	2
GO:0004527	exonuclease activity	5	2
GO:0004532	RNA exonuclease activity	5	2
GO:0004540	RNA nuclease activity	4	2
GO:0005488	binding	1	4
GO:0008270	zinc ion binding	6	2
GO:0008408	3'-5' exonuclease activity	6	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	2
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	2
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	2
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046914	transition metal ion binding	5	2
GO:0140098	catalytic activity, acting on RNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003697	single-stranded DNA binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	255	259	PF00656	0.769
CLV_NRD_NRD_1	55	57	PF00675	0.628
CLV_NRD_NRD_1	64	66	PF00675	0.603
CLV_PCSK_FUR_1	264	268	PF00082	0.574
CLV_PCSK_KEX2_1	266	268	PF00082	0.612
CLV_PCSK_KEX2_1	55	57	PF00082	0.606
CLV_PCSK_KEX2_1	64	66	PF00082	0.586
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.612
CLV_PCSK_SKI1_1	266	270	PF00082	0.533
CLV_PCSK_SKI1_1	40	44	PF00082	0.690
DEG_SPOP_SBC_1	168	172	PF00917	0.717
DEG_SPOP_SBC_1	189	193	PF00917	0.747
DEG_SPOP_SBC_1	221	225	PF00917	0.757
DOC_CKS1_1	320	325	PF01111	0.682
DOC_CKS1_1	428	433	PF01111	0.539
DOC_CYCLIN_RxL_1	35	46	PF00134	0.459
DOC_CYCLIN_yCln2_LP_2	235	241	PF00134	0.589
DOC_CYCLIN_yCln2_LP_2	42	45	PF00134	0.455
DOC_MAPK_gen_1	148	156	PF00069	0.689
DOC_MAPK_MEF2A_6	395	403	PF00069	0.540
DOC_MAPK_MEF2A_6	482	491	PF00069	0.383
DOC_PP2B_LxvP_1	235	238	PF13499	0.589
DOC_PP2B_LxvP_1	42	45	PF13499	0.455
DOC_PP2B_PxIxI_1	486	492	PF00149	0.383
DOC_PP4_FxxP_1	207	210	PF00568	0.657
DOC_PP4_FxxP_1	428	431	PF00568	0.467
DOC_PP4_FxxP_1	450	453	PF00568	0.518
DOC_SPAK_OSR1_1	463	467	PF12202	0.414
DOC_USP7_MATH_1	176	180	PF00917	0.633
DOC_USP7_MATH_1	188	192	PF00917	0.567
DOC_USP7_MATH_1	214	218	PF00917	0.719
DOC_USP7_MATH_1	222	226	PF00917	0.726
DOC_USP7_MATH_1	318	322	PF00917	0.700
DOC_USP7_MATH_1	352	356	PF00917	0.620
DOC_USP7_UBL2_3	144	148	PF12436	0.591
DOC_WW_Pin1_4	179	184	PF00397	0.667
DOC_WW_Pin1_4	190	195	PF00397	0.692
DOC_WW_Pin1_4	198	203	PF00397	0.550
DOC_WW_Pin1_4	223	228	PF00397	0.719
DOC_WW_Pin1_4	299	304	PF00397	0.742
DOC_WW_Pin1_4	319	324	PF00397	0.722
DOC_WW_Pin1_4	427	432	PF00397	0.438
DOC_WW_Pin1_4	77	82	PF00397	0.665
LIG_14-3-3_CanoR_1	103	111	PF00244	0.616
LIG_14-3-3_CanoR_1	33	42	PF00244	0.465
LIG_14-3-3_CanoR_1	65	73	PF00244	0.688
LIG_CaM_IQ_9	271	287	PF13499	0.453
LIG_Clathr_ClatBox_1	153	157	PF01394	0.678
LIG_EVH1_2	44	48	PF00568	0.469
LIG_FHA_1	122	128	PF00498	0.525
LIG_FHA_1	156	162	PF00498	0.703
LIG_FHA_1	275	281	PF00498	0.455
LIG_FHA_1	440	446	PF00498	0.386
LIG_FHA_1	465	471	PF00498	0.399
LIG_FHA_1	493	499	PF00498	0.389
LIG_FHA_1	94	100	PF00498	0.610
LIG_FHA_2	320	326	PF00498	0.714
LIG_LIR_Apic_2	426	431	PF02991	0.456
LIG_LIR_Apic_2	449	453	PF02991	0.520
LIG_LIR_Gen_1	437	446	PF02991	0.406
LIG_LIR_Nem_3	124	128	PF02991	0.494
LIG_LIR_Nem_3	437	443	PF02991	0.423
LIG_LIR_Nem_3	449	454	PF02991	0.326
LIG_LYPXL_yS_3	486	489	PF13949	0.387
LIG_MYND_1	45	49	PF01753	0.465
LIG_PDZ_Class_2	496	501	PF00595	0.414
LIG_Pex14_2	203	207	PF04695	0.689
LIG_SH2_CRK	15	19	PF00017	0.461
LIG_SH2_CRK	4	8	PF00017	0.457
LIG_SH2_CRK	484	488	PF00017	0.390
LIG_SH2_STAT3	362	365	PF00017	0.710
LIG_SH2_STAT5	362	365	PF00017	0.589
LIG_SH2_STAT5	413	416	PF00017	0.459
LIG_SH3_3	317	323	PF00018	0.788
LIG_SH3_3	368	374	PF00018	0.519
LIG_SH3_3	379	385	PF00018	0.495
LIG_SH3_3	430	436	PF00018	0.459
LIG_TRAF2_1	260	263	PF00917	0.723
LIG_TRAF2_1	384	387	PF00917	0.480
LIG_TYR_ITIM	13	18	PF00017	0.462
MOD_CDK_SPxxK_3	299	306	PF00069	0.556
MOD_CK1_1	169	175	PF00069	0.640
MOD_CK1_1	179	185	PF00069	0.663
MOD_CK1_1	193	199	PF00069	0.707
MOD_CK1_1	223	229	PF00069	0.745
MOD_CK1_1	299	305	PF00069	0.631
MOD_CK1_1	319	325	PF00069	0.693
MOD_CK1_1	83	89	PF00069	0.708
MOD_CK1_1	94	100	PF00069	0.732
MOD_CK2_1	319	325	PF00069	0.761
MOD_GlcNHglycan	179	182	PF01048	0.676
MOD_GlcNHglycan	195	198	PF01048	0.627
MOD_GlcNHglycan	254	257	PF01048	0.666
MOD_GlcNHglycan	298	301	PF01048	0.630
MOD_GlcNHglycan	303	306	PF01048	0.620
MOD_GlcNHglycan	332	335	PF01048	0.749
MOD_GlcNHglycan	459	462	PF01048	0.538
MOD_GlcNHglycan	50	53	PF01048	0.512
MOD_GlcNHglycan	68	71	PF01048	0.544
MOD_GlcNHglycan	82	85	PF01048	0.721
MOD_GSK3_1	166	173	PF00069	0.630
MOD_GSK3_1	189	196	PF00069	0.740
MOD_GSK3_1	19	26	PF00069	0.506
MOD_GSK3_1	223	230	PF00069	0.663
MOD_GSK3_1	243	250	PF00069	0.667
MOD_GSK3_1	29	36	PF00069	0.479
MOD_GSK3_1	295	302	PF00069	0.574
MOD_GSK3_1	423	430	PF00069	0.528
MOD_GSK3_1	43	50	PF00069	0.601
MOD_LATS_1	31	37	PF00433	0.467
MOD_N-GLC_1	252	257	PF02516	0.685
MOD_N-GLC_1	352	357	PF02516	0.665
MOD_N-GLC_2	398	400	PF02516	0.403
MOD_NEK2_1	269	274	PF00069	0.453
MOD_NEK2_1	420	425	PF00069	0.456
MOD_NEK2_1	464	469	PF00069	0.391
MOD_NEK2_1	6	11	PF00069	0.462
MOD_NEK2_2	121	126	PF00069	0.521
MOD_NEK2_2	274	279	PF00069	0.452
MOD_PIKK_1	35	41	PF00454	0.462
MOD_PIKK_1	475	481	PF00454	0.557
MOD_PKA_2	102	108	PF00069	0.688
MOD_Plk_1	352	358	PF00069	0.662
MOD_Plk_4	43	49	PF00069	0.507
MOD_Plk_4	83	89	PF00069	0.668
MOD_ProDKin_1	179	185	PF00069	0.667
MOD_ProDKin_1	190	196	PF00069	0.691
MOD_ProDKin_1	198	204	PF00069	0.543
MOD_ProDKin_1	223	229	PF00069	0.721
MOD_ProDKin_1	299	305	PF00069	0.742
MOD_ProDKin_1	319	325	PF00069	0.724
MOD_ProDKin_1	427	433	PF00069	0.442
MOD_ProDKin_1	77	83	PF00069	0.665
TRG_DiLeu_BaEn_2	264	270	PF01217	0.663
TRG_ENDOCYTIC_2	15	18	PF00928	0.468
TRG_ENDOCYTIC_2	4	7	PF00928	0.458
TRG_ENDOCYTIC_2	486	489	PF00928	0.387
TRG_ER_diArg_1	10	13	PF00400	0.491
TRG_ER_diArg_1	54	56	PF00400	0.628
TRG_ER_diArg_1	64	66	PF00400	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1P1	Leptomonas seymouri	57%	100%
A0A0S4IKI2	Bodo saltans	45%	100%
A0A1X0NPK8	Trypanosomatidae	48%	100%
A0A3S5H616	Leishmania donovani	90%	100%
A0A422N9Y4	Trypanosoma rangeli	46%	100%
A4H556	Leishmania braziliensis	73%	100%
A4HTD3	Leishmania infantum	93%	100%
C9ZUI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ALC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5DQ35	Trypanosoma cruzi	47%	100%