Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIH8_LEIMA

TriTrypDb:

LmjF.07.1080 , LMJLV39_070018300 , LMJSD75_070018600

Length:

839

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QIH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIH8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	665	669	PF00656	0.660
CLV_MEL_PAP_1	214	220	PF00089	0.538
CLV_NRD_NRD_1	367	369	PF00675	0.606
CLV_NRD_NRD_1	378	380	PF00675	0.618
CLV_NRD_NRD_1	474	476	PF00675	0.696
CLV_NRD_NRD_1	511	513	PF00675	0.514
CLV_NRD_NRD_1	531	533	PF00675	0.335
CLV_NRD_NRD_1	608	610	PF00675	0.572
CLV_NRD_NRD_1	756	758	PF00675	0.516
CLV_NRD_NRD_1	798	800	PF00675	0.718
CLV_NRD_NRD_1	824	826	PF00675	0.419
CLV_PCSK_KEX2_1	241	243	PF00082	0.519
CLV_PCSK_KEX2_1	367	369	PF00082	0.602
CLV_PCSK_KEX2_1	474	476	PF00082	0.696
CLV_PCSK_KEX2_1	530	532	PF00082	0.561
CLV_PCSK_KEX2_1	756	758	PF00082	0.497
CLV_PCSK_KEX2_1	768	770	PF00082	0.407
CLV_PCSK_KEX2_1	798	800	PF00082	0.607
CLV_PCSK_KEX2_1	824	826	PF00082	0.419
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.519
CLV_PCSK_PC1ET2_1	768	770	PF00082	0.448
CLV_PCSK_SKI1_1	346	350	PF00082	0.631
CLV_PCSK_SKI1_1	360	364	PF00082	0.536
CLV_PCSK_SKI1_1	388	392	PF00082	0.534
CLV_PCSK_SKI1_1	394	398	PF00082	0.458
CLV_PCSK_SKI1_1	655	659	PF00082	0.674
CLV_PCSK_SKI1_1	756	760	PF00082	0.515
CLV_Separin_Metazoa	821	825	PF03568	0.380
DEG_APCC_DBOX_1	797	805	PF00400	0.553
DEG_Nend_UBRbox_3	1	3	PF02207	0.501
DOC_ANK_TNKS_1	216	223	PF00023	0.530
DOC_CYCLIN_RxL_1	753	762	PF00134	0.546
DOC_CYCLIN_yClb5_NLxxxL_5	554	563	PF00134	0.573
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.622
DOC_MAPK_gen_1	367	375	PF00069	0.532
DOC_MAPK_gen_1	408	417	PF00069	0.464
DOC_MAPK_gen_1	654	660	PF00069	0.488
DOC_MAPK_gen_1	97	104	PF00069	0.511
DOC_MAPK_HePTP_8	405	417	PF00069	0.462
DOC_MAPK_MEF2A_6	367	375	PF00069	0.378
DOC_MAPK_MEF2A_6	408	417	PF00069	0.464
DOC_MAPK_MEF2A_6	589	596	PF00069	0.532
DOC_MAPK_MEF2A_6	97	106	PF00069	0.495
DOC_PP1_RVXF_1	73	79	PF00149	0.462
DOC_PP2B_LxvP_1	296	299	PF13499	0.600
DOC_PP4_FxxP_1	574	577	PF00568	0.537
DOC_USP7_MATH_1	114	118	PF00917	0.495
DOC_USP7_MATH_1	24	28	PF00917	0.558
DOC_USP7_MATH_1	313	317	PF00917	0.643
DOC_USP7_MATH_1	479	483	PF00917	0.782
DOC_USP7_MATH_1	521	525	PF00917	0.625
DOC_USP7_MATH_1	637	641	PF00917	0.613
DOC_USP7_MATH_1	673	677	PF00917	0.622
DOC_USP7_MATH_1	691	695	PF00917	0.694
DOC_USP7_MATH_1	86	90	PF00917	0.559
DOC_USP7_UBL2_3	434	438	PF12436	0.529
DOC_WW_Pin1_4	136	141	PF00397	0.554
DOC_WW_Pin1_4	788	793	PF00397	0.672
DOC_WW_Pin1_4	82	87	PF00397	0.473
LIG_14-3-3_CanoR_1	340	344	PF00244	0.642
LIG_14-3-3_CanoR_1	410	414	PF00244	0.521
LIG_14-3-3_CanoR_1	465	470	PF00244	0.652
LIG_14-3-3_CanoR_1	553	557	PF00244	0.564
LIG_14-3-3_CanoR_1	769	777	PF00244	0.556
LIG_14-3-3_CanoR_1	799	805	PF00244	0.683
LIG_APCC_ABBA_1	359	364	PF00400	0.531
LIG_APCC_ABBA_1	61	66	PF00400	0.482
LIG_APCC_ABBAyCdc20_2	358	364	PF00400	0.535
LIG_APCC_Cbox_2	633	639	PF00515	0.602
LIG_BIR_III_4	155	159	PF00653	0.492
LIG_BIR_III_4	690	694	PF00653	0.697
LIG_BIR_III_4	778	782	PF00653	0.422
LIG_FHA_1	140	146	PF00498	0.483
LIG_FHA_1	188	194	PF00498	0.470
LIG_FHA_1	223	229	PF00498	0.456
LIG_FHA_1	238	244	PF00498	0.457
LIG_FHA_1	248	254	PF00498	0.501
LIG_FHA_1	313	319	PF00498	0.692
LIG_FHA_1	626	632	PF00498	0.558
LIG_FHA_1	659	665	PF00498	0.680
LIG_FHA_1	753	759	PF00498	0.592
LIG_FHA_1	817	823	PF00498	0.507
LIG_FHA_2	448	454	PF00498	0.612
LIG_FHA_2	580	586	PF00498	0.600
LIG_FHA_2	715	721	PF00498	0.722
LIG_FHA_2	745	751	PF00498	0.553
LIG_FHA_2	83	89	PF00498	0.546
LIG_LIR_Gen_1	633	639	PF02991	0.587
LIG_LIR_Gen_1	747	753	PF02991	0.508
LIG_LIR_Nem_3	606	611	PF02991	0.517
LIG_LIR_Nem_3	633	638	PF02991	0.588
LIG_LIR_Nem_3	682	686	PF02991	0.651
LIG_LIR_Nem_3	747	752	PF02991	0.510
LIG_LIR_Nem_3	806	811	PF02991	0.627
LIG_LRP6_Inhibitor_1	737	743	PF00058	0.676
LIG_MYND_1	304	308	PF01753	0.714
LIG_NRBOX	538	544	PF00104	0.593
LIG_NRBOX	558	564	PF00104	0.307
LIG_PCNA_yPIPBox_3	629	641	PF02747	0.601
LIG_PCNA_yPIPBox_3	743	752	PF02747	0.621
LIG_Pex14_2	64	68	PF04695	0.475
LIG_PTB_Apo_2	100	107	PF02174	0.548
LIG_Rb_LxCxE_1	575	588	PF01857	0.682
LIG_RPA_C_Fungi	346	358	PF08784	0.521
LIG_RPA_C_Fungi	752	764	PF08784	0.608
LIG_SH2_CRK	148	152	PF00017	0.546
LIG_SH2_CRK	608	612	PF00017	0.610
LIG_SH2_NCK_1	79	83	PF00017	0.574
LIG_SH2_SRC	121	124	PF00017	0.547
LIG_SH2_STAP1	148	152	PF00017	0.546
LIG_SH2_STAT5	121	124	PF00017	0.515
LIG_SH2_STAT5	161	164	PF00017	0.487
LIG_SH2_STAT5	527	530	PF00017	0.531
LIG_SH2_STAT5	614	617	PF00017	0.539
LIG_SH2_STAT5	741	744	PF00017	0.536
LIG_SH2_STAT5	826	829	PF00017	0.492
LIG_SH3_3	119	125	PF00018	0.544
LIG_SH3_3	296	302	PF00018	0.605
LIG_SH3_3	551	557	PF00018	0.582
LIG_SH3_3	698	704	PF00018	0.705
LIG_SUMO_SIM_anti_2	179	187	PF11976	0.543
LIG_SUMO_SIM_anti_2	538	544	PF11976	0.626
LIG_SUMO_SIM_anti_2	761	767	PF11976	0.515
LIG_SUMO_SIM_par_1	225	231	PF11976	0.466
LIG_SUMO_SIM_par_1	369	374	PF11976	0.545
LIG_TRAF2_1	17	20	PF00917	0.500
LIG_TRAF2_1	350	353	PF00917	0.551
LIG_TRAF2_1	717	720	PF00917	0.702
LIG_UBA3_1	748	754	PF00899	0.611
LIG_WRC_WIRS_1	147	152	PF05994	0.543
MOD_CDK_SPxK_1	792	798	PF00069	0.759
MOD_CDK_SPxxK_3	792	799	PF00069	0.734
MOD_CK1_1	139	145	PF00069	0.497
MOD_CK1_1	339	345	PF00069	0.559
MOD_CK1_1	34	40	PF00069	0.546
MOD_CK1_1	791	797	PF00069	0.651
MOD_CK1_1	806	812	PF00069	0.488
MOD_CK2_1	174	180	PF00069	0.571
MOD_CK2_1	313	319	PF00069	0.672
MOD_CK2_1	436	442	PF00069	0.549
MOD_CK2_1	579	585	PF00069	0.623
MOD_CK2_1	67	73	PF00069	0.526
MOD_CK2_1	714	720	PF00069	0.755
MOD_CK2_1	744	750	PF00069	0.586
MOD_CK2_1	825	831	PF00069	0.492
MOD_GlcNHglycan	116	119	PF01048	0.513
MOD_GlcNHglycan	136	139	PF01048	0.304
MOD_GlcNHglycan	155	159	PF01048	0.403
MOD_GlcNHglycan	218	221	PF01048	0.527
MOD_GlcNHglycan	230	233	PF01048	0.408
MOD_GlcNHglycan	26	29	PF01048	0.522
MOD_GlcNHglycan	315	318	PF01048	0.652
MOD_GlcNHglycan	33	36	PF01048	0.457
MOD_GlcNHglycan	481	484	PF01048	0.730
MOD_GlcNHglycan	504	507	PF01048	0.629
MOD_GlcNHglycan	559	562	PF01048	0.630
MOD_GlcNHglycan	644	648	PF01048	0.651
MOD_GlcNHglycan	673	676	PF01048	0.644
MOD_GlcNHglycan	693	696	PF01048	0.753
MOD_GlcNHglycan	7	10	PF01048	0.465
MOD_GlcNHglycan	771	774	PF01048	0.568
MOD_GlcNHglycan	784	787	PF01048	0.602
MOD_GlcNHglycan	808	811	PF01048	0.552
MOD_GlcNHglycan	827	830	PF01048	0.323
MOD_GSK3_1	112	119	PF00069	0.509
MOD_GSK3_1	130	137	PF00069	0.400
MOD_GSK3_1	189	196	PF00069	0.441
MOD_GSK3_1	230	237	PF00069	0.418
MOD_GSK3_1	247	254	PF00069	0.351
MOD_GSK3_1	394	401	PF00069	0.477
MOD_GSK3_1	422	429	PF00069	0.603
MOD_GSK3_1	443	450	PF00069	0.535
MOD_GSK3_1	487	494	PF00069	0.662
MOD_GSK3_1	521	528	PF00069	0.524
MOD_GSK3_1	658	665	PF00069	0.553
MOD_GSK3_1	671	678	PF00069	0.618
MOD_GSK3_1	782	789	PF00069	0.635
MOD_GSK3_1	82	89	PF00069	0.550
MOD_LATS_1	128	134	PF00433	0.563
MOD_N-GLC_1	102	107	PF02516	0.547
MOD_N-GLC_1	557	562	PF02516	0.528
MOD_N-GLC_1	709	714	PF02516	0.798
MOD_N-GLC_1	782	787	PF02516	0.688
MOD_NEK2_1	134	139	PF00069	0.552
MOD_NEK2_1	422	427	PF00069	0.620
MOD_NEK2_1	525	530	PF00069	0.516
MOD_NEK2_1	563	568	PF00069	0.469
MOD_NEK2_1	596	601	PF00069	0.558
MOD_NEK2_1	653	658	PF00069	0.541
MOD_NEK2_1	660	665	PF00069	0.568
MOD_NEK2_1	759	764	PF00069	0.551
MOD_NEK2_2	116	121	PF00069	0.535
MOD_PIKK_1	415	421	PF00454	0.526
MOD_PIKK_1	625	631	PF00454	0.643
MOD_PIKK_1	715	721	PF00454	0.518
MOD_PKA_1	451	457	PF00069	0.531
MOD_PKA_2	216	222	PF00069	0.459
MOD_PKA_2	339	345	PF00069	0.550
MOD_PKA_2	409	415	PF00069	0.424
MOD_PKA_2	552	558	PF00069	0.564
MOD_Plk_1	102	108	PF00069	0.551
MOD_Plk_1	318	324	PF00069	0.551
MOD_Plk_1	415	421	PF00069	0.581
MOD_Plk_1	429	435	PF00069	0.622
MOD_Plk_1	494	500	PF00069	0.667
MOD_Plk_1	525	531	PF00069	0.528
MOD_Plk_1	557	563	PF00069	0.610
MOD_Plk_2-3	662	668	PF00069	0.497
MOD_Plk_2-3	744	750	PF00069	0.577
MOD_Plk_4	116	122	PF00069	0.482
MOD_Plk_4	146	152	PF00069	0.471
MOD_Plk_4	189	195	PF00069	0.420
MOD_Plk_4	230	236	PF00069	0.491
MOD_Plk_4	563	569	PF00069	0.476
MOD_Plk_4	653	659	PF00069	0.590
MOD_Plk_4	744	750	PF00069	0.544
MOD_Plk_4	803	809	PF00069	0.558
MOD_Plk_4	86	92	PF00069	0.504
MOD_ProDKin_1	136	142	PF00069	0.546
MOD_ProDKin_1	788	794	PF00069	0.673
MOD_ProDKin_1	82	88	PF00069	0.475
MOD_SUMO_for_1	362	365	PF00179	0.615
MOD_SUMO_rev_2	339	348	PF00179	0.559
TRG_DiLeu_BaEn_1	180	185	PF01217	0.545
TRG_DiLeu_BaEn_1	365	370	PF01217	0.605
TRG_DiLeu_BaEn_1	535	540	PF01217	0.631
TRG_DiLeu_BaEn_1	627	632	PF01217	0.514
TRG_DiLeu_BaEn_3	365	371	PF01217	0.527
TRG_DiLeu_BaEn_4	352	358	PF01217	0.543
TRG_DiLeu_BaLyEn_6	703	708	PF01217	0.705
TRG_DiLeu_BaLyEn_6	754	759	PF01217	0.623
TRG_ENDOCYTIC_2	148	151	PF00928	0.559
TRG_ENDOCYTIC_2	608	611	PF00928	0.505
TRG_ER_diArg_1	357	360	PF00400	0.494
TRG_ER_diArg_1	367	369	PF00400	0.461
TRG_ER_diArg_1	474	476	PF00400	0.677
TRG_ER_diArg_1	529	532	PF00400	0.564
TRG_ER_diArg_1	546	549	PF00400	0.504
TRG_ER_diArg_1	756	758	PF00400	0.618
TRG_ER_diArg_1	823	825	PF00400	0.387
TRG_Pf-PMV_PEXEL_1	367	372	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	443	447	PF00026	0.657
TRG_Pf-PMV_PEXEL_1	609	613	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	729	734	PF00026	0.712
TRG_Pf-PMV_PEXEL_1	735	739	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	756	761	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	813	817	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV16	Leptomonas seymouri	55%	95%
A0A1X0NPL3	Trypanosomatidae	33%	91%
A0A3S5H617	Leishmania donovani	93%	100%
A0A3S5IQT7	Trypanosoma rangeli	36%	92%
A4H557	Leishmania braziliensis	75%	100%
A4HTD4	Leishmania infantum	93%	100%
C9ZUI0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	95%
E9ALC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BTL6	Trypanosoma cruzi	35%	92%