RRP7 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIH6_LEIMA

TriTrypDb:

LmjF.07.1100 , LMJLV39_070018500 , LMJSD75_070018800

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QIH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIH6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	173	175	PF00675	0.614
CLV_NRD_NRD_1	183	185	PF00675	0.600
CLV_NRD_NRD_1	297	299	PF00675	0.609
CLV_NRD_NRD_1	71	73	PF00675	0.537
CLV_PCSK_FUR_1	69	73	PF00082	0.533
CLV_PCSK_KEX2_1	173	175	PF00082	0.612
CLV_PCSK_KEX2_1	185	187	PF00082	0.601
CLV_PCSK_KEX2_1	266	268	PF00082	0.605
CLV_PCSK_KEX2_1	293	295	PF00082	0.551
CLV_PCSK_KEX2_1	297	299	PF00082	0.594
CLV_PCSK_KEX2_1	38	40	PF00082	0.481
CLV_PCSK_KEX2_1	71	73	PF00082	0.545
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.670
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.576
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.584
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.481
CLV_PCSK_SKI1_1	207	211	PF00082	0.721
CLV_PCSK_SKI1_1	290	294	PF00082	0.571
CLV_PCSK_SKI1_1	71	75	PF00082	0.555
CLV_PCSK_SKI1_1	94	98	PF00082	0.501
DOC_USP7_MATH_1	10	14	PF00917	0.718
DOC_USP7_MATH_1	162	166	PF00917	0.694
DOC_USP7_MATH_1	214	218	PF00917	0.748
DOC_USP7_MATH_1	44	48	PF00917	0.700
DOC_WW_Pin1_4	176	181	PF00397	0.713
LIG_14-3-3_CanoR_1	257	263	PF00244	0.595
LIG_14-3-3_CanoR_1	71	79	PF00244	0.583
LIG_14-3-3_CanoR_1	94	104	PF00244	0.612
LIG_Actin_WH2_2	55	73	PF00022	0.609
LIG_BIR_III_4	200	204	PF00653	0.594
LIG_CaM_NSCaTE_8	235	242	PF13499	0.558
LIG_FHA_1	100	106	PF00498	0.585
LIG_FHA_1	177	183	PF00498	0.689
LIG_FHA_1	238	244	PF00498	0.587
LIG_FHA_1	54	60	PF00498	0.671
LIG_FHA_2	240	246	PF00498	0.661
LIG_GBD_Chelix_1	129	137	PF00786	0.614
LIG_LIR_Apic_2	147	151	PF02991	0.598
LIG_PTB_Apo_2	138	145	PF02174	0.466
LIG_SH2_CRK	148	152	PF00017	0.652
LIG_SH2_STAT5	106	109	PF00017	0.568
LIG_SH2_STAT5	145	148	PF00017	0.637
LIG_SH2_STAT5	262	265	PF00017	0.526
LIG_SH2_STAT5	277	280	PF00017	0.452
LIG_SH2_STAT5	91	94	PF00017	0.640
LIG_SUMO_SIM_par_1	55	60	PF11976	0.626
LIG_TRAF2_1	273	276	PF00917	0.649
MOD_CK1_1	13	19	PF00069	0.664
MOD_CK1_1	21	27	PF00069	0.563
MOD_CK1_1	217	223	PF00069	0.614
MOD_CK1_1	260	266	PF00069	0.625
MOD_CK2_1	162	168	PF00069	0.630
MOD_CK2_1	239	245	PF00069	0.595
MOD_GlcNHglycan	21	24	PF01048	0.649
MOD_GlcNHglycan	216	219	PF01048	0.600
MOD_GlcNHglycan	221	224	PF01048	0.605
MOD_GlcNHglycan	48	51	PF01048	0.663
MOD_GSK3_1	17	24	PF00069	0.573
MOD_GSK3_1	213	220	PF00069	0.611
MOD_GSK3_1	237	244	PF00069	0.620
MOD_GSK3_1	253	260	PF00069	0.470
MOD_GSK3_1	46	53	PF00069	0.648
MOD_GSK3_1	9	16	PF00069	0.686
MOD_GSK3_1	95	102	PF00069	0.556
MOD_LATS_1	255	261	PF00433	0.597
MOD_NEK2_1	144	149	PF00069	0.541
MOD_NEK2_1	17	22	PF00069	0.754
MOD_NEK2_1	239	244	PF00069	0.549
MOD_NEK2_1	253	258	PF00069	0.626
MOD_NEK2_1	90	95	PF00069	0.646
MOD_NEK2_2	162	167	PF00069	0.619
MOD_PIKK_1	72	78	PF00454	0.584
MOD_PKA_2	17	23	PF00069	0.601
MOD_PKA_2	253	259	PF00069	0.694
MOD_Plk_1	13	19	PF00069	0.768
MOD_Plk_1	99	105	PF00069	0.510
MOD_Plk_2-3	246	252	PF00069	0.568
MOD_Plk_4	99	105	PF00069	0.490
MOD_ProDKin_1	176	182	PF00069	0.720
MOD_SUMO_rev_2	260	268	PF00179	0.628
MOD_SUMO_rev_2	289	295	PF00179	0.545
TRG_ER_diArg_1	172	174	PF00400	0.616
TRG_ER_diArg_1	183	186	PF00400	0.582
TRG_ER_diArg_1	296	298	PF00400	0.560
TRG_ER_diArg_1	69	72	PF00400	0.536
TRG_NLS_Bipartite_1	173	188	PF00514	0.751
TRG_NLS_MonoExtN_4	181	188	PF00514	0.754
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.716
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3L7	Leptomonas seymouri	57%	100%
A0A1X0NPM5	Trypanosomatidae	30%	92%
A0A3R7LS50	Trypanosoma rangeli	34%	100%
A0A3S5H619	Leishmania donovani	91%	100%
A4H559	Leishmania braziliensis	76%	100%
A4HTD6	Leishmania infantum	91%	100%
C9ZUH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ALC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BYD2	Trypanosoma cruzi	35%	91%