Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MICOS complex subunit 40, putative

Species:

Leishmania major

UniProt:

Q4QIH5_LEIMA

TriTrypDb:

LmjF.07.1110 , LMJLV39_070018800 , LMJSD75_070019100

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QIH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIH5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	302	306	PF00656	0.574
CLV_NRD_NRD_1	229	231	PF00675	0.561
CLV_NRD_NRD_1	24	26	PF00675	0.507
CLV_NRD_NRD_1	252	254	PF00675	0.550
CLV_NRD_NRD_1	260	262	PF00675	0.513
CLV_NRD_NRD_1	292	294	PF00675	0.697
CLV_NRD_NRD_1	302	304	PF00675	0.597
CLV_NRD_NRD_1	32	34	PF00675	0.466
CLV_PCSK_KEX2_1	24	26	PF00082	0.507
CLV_PCSK_KEX2_1	251	253	PF00082	0.552
CLV_PCSK_KEX2_1	260	262	PF00082	0.485
CLV_PCSK_KEX2_1	292	294	PF00082	0.713
CLV_PCSK_KEX2_1	32	34	PF00082	0.466
CLV_PCSK_KEX2_1	53	55	PF00082	0.460
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.465
CLV_PCSK_PC7_1	28	34	PF00082	0.496
CLV_PCSK_SKI1_1	273	277	PF00082	0.544
CLV_PCSK_SKI1_1	53	57	PF00082	0.385
DOC_CYCLIN_yClb5_NLxxxL_5	133	141	PF00134	0.532
DOC_CYCLIN_yCln2_LP_2	174	180	PF00134	0.572
DOC_MAPK_gen_1	24	31	PF00069	0.395
DOC_MAPK_gen_1	292	298	PF00069	0.741
DOC_MAPK_gen_1	318	326	PF00069	0.490
DOC_MAPK_MEF2A_6	133	141	PF00069	0.530
DOC_PP2B_LxvP_1	174	177	PF13499	0.558
DOC_USP7_MATH_1	180	184	PF00917	0.561
DOC_USP7_MATH_1	186	190	PF00917	0.495
DOC_USP7_MATH_1	310	314	PF00917	0.517
DOC_USP7_MATH_1	343	347	PF00917	0.504
DOC_WW_Pin1_4	218	223	PF00397	0.626
DOC_WW_Pin1_4	297	302	PF00397	0.538
LIG_14-3-3_CanoR_1	115	124	PF00244	0.528
LIG_14-3-3_CanoR_1	151	157	PF00244	0.470
LIG_14-3-3_CanoR_1	230	236	PF00244	0.467
LIG_14-3-3_CanoR_1	264	272	PF00244	0.458
LIG_14-3-3_CanoR_1	292	298	PF00244	0.650
LIG_BIR_II_1	1	5	PF00653	0.525
LIG_BRCT_BRCA1_1	188	192	PF00533	0.409
LIG_BRCT_BRCA1_1	345	349	PF00533	0.371
LIG_deltaCOP1_diTrp_1	325	334	PF00928	0.469
LIG_FHA_1	169	175	PF00498	0.579
LIG_FHA_1	219	225	PF00498	0.722
LIG_FHA_1	236	242	PF00498	0.554
LIG_FHA_1	277	283	PF00498	0.541
LIG_FHA_1	292	298	PF00498	0.708
LIG_FHA_1	330	336	PF00498	0.515
LIG_FHA_1	72	78	PF00498	0.510
LIG_FHA_2	123	129	PF00498	0.589
LIG_FHA_2	266	272	PF00498	0.452
LIG_FHA_2	47	53	PF00498	0.584
LIG_FHA_2	54	60	PF00498	0.579
LIG_LIR_Gen_1	38	47	PF02991	0.490
LIG_LIR_Nem_3	346	351	PF02991	0.429
LIG_LIR_Nem_3	38	43	PF02991	0.495
LIG_LIR_Nem_3	8	12	PF02991	0.583
LIG_MLH1_MIPbox_1	345	349	PF16413	0.371
LIG_PCNA_yPIPBox_3	85	97	PF02747	0.467
LIG_SH2_CRK	40	44	PF00017	0.538
LIG_SH2_CRK	86	90	PF00017	0.551
LIG_SH2_NCK_1	86	90	PF00017	0.580
LIG_SH2_STAP1	210	214	PF00017	0.641
LIG_SH2_STAP1	278	282	PF00017	0.563
LIG_SH2_STAP1	40	44	PF00017	0.465
LIG_SH2_STAT5	278	281	PF00017	0.454
LIG_SH2_STAT5	348	351	PF00017	0.507
LIG_SH2_STAT5	40	43	PF00017	0.533
LIG_SH2_STAT5	96	99	PF00017	0.481
LIG_SH3_3	158	164	PF00018	0.464
LIG_SH3_3	174	180	PF00018	0.525
LIG_SUMO_SIM_anti_2	73	81	PF11976	0.553
LIG_TRAF2_1	213	216	PF00917	0.634
LIG_WRC_WIRS_1	47	52	PF05994	0.582
LIG_WRC_WIRS_1	6	11	PF05994	0.588
MOD_CDC14_SPxK_1	300	303	PF00782	0.487
MOD_CDK_SPxK_1	297	303	PF00069	0.534
MOD_CDK_SPxxK_3	297	304	PF00069	0.505
MOD_CK1_1	299	305	PF00069	0.617
MOD_CK1_1	330	336	PF00069	0.556
MOD_CK2_1	310	316	PF00069	0.557
MOD_CK2_1	46	52	PF00069	0.530
MOD_CK2_1	53	59	PF00069	0.534
MOD_Cter_Amidation	22	25	PF01082	0.409
MOD_GlcNHglycan	188	191	PF01048	0.499
MOD_GlcNHglycan	329	332	PF01048	0.468
MOD_GSK3_1	186	193	PF00069	0.473
MOD_GSK3_1	231	238	PF00069	0.670
MOD_LATS_1	113	119	PF00433	0.600
MOD_N-GLC_1	218	223	PF02516	0.689
MOD_NEK2_1	225	230	PF00069	0.694
MOD_NEK2_1	255	260	PF00069	0.425
MOD_NEK2_1	296	301	PF00069	0.655
MOD_NEK2_1	351	356	PF00069	0.431
MOD_PKA_1	53	59	PF00069	0.584
MOD_PKA_2	291	297	PF00069	0.655
MOD_PKA_2	327	333	PF00069	0.422
MOD_PKA_2	53	59	PF00069	0.603
MOD_Plk_1	255	261	PF00069	0.425
MOD_Plk_2-3	46	52	PF00069	0.500
MOD_Plk_4	13	19	PF00069	0.558
MOD_Plk_4	169	175	PF00069	0.477
MOD_Plk_4	231	237	PF00069	0.459
MOD_Plk_4	330	336	PF00069	0.505
MOD_Plk_4	343	349	PF00069	0.517
MOD_ProDKin_1	218	224	PF00069	0.626
MOD_ProDKin_1	297	303	PF00069	0.534
MOD_SUMO_rev_2	313	320	PF00179	0.579
MOD_SUMO_rev_2	65	71	PF00179	0.604
TRG_DiLeu_BaEn_1	39	44	PF01217	0.609
TRG_ENDOCYTIC_2	114	117	PF00928	0.518
TRG_ENDOCYTIC_2	347	350	PF00928	0.432
TRG_ENDOCYTIC_2	40	43	PF00928	0.485
TRG_ENDOCYTIC_2	86	89	PF00928	0.565
TRG_ER_diArg_1	24	26	PF00400	0.503
TRG_ER_diArg_1	251	253	PF00400	0.640
TRG_ER_diArg_1	259	261	PF00400	0.612
TRG_ER_diArg_1	291	293	PF00400	0.620
TRG_ER_diArg_1	31	33	PF00400	0.467
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	264	269	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	280	284	PF00026	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0I2	Leptomonas seymouri	67%	99%
A0A1X0NRB2	Trypanosomatidae	41%	100%
A0A3R7MAC7	Trypanosoma rangeli	45%	100%
A0A3S7WQ18	Leishmania donovani	93%	100%
A4H560	Leishmania braziliensis	83%	100%
A4HTD7	Leishmania infantum	92%	100%
C9ZUH5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ALD0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B8H7	Trypanosoma cruzi	45%	100%