LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QIH3_LEIMA
TriTrypDb:
LmjF.07.1130 , LMJLV39_070019000 , LMJSD75_070019300
Length:
576

Annotations

LeishMANIAdb annotations

Homologous to other Eukaryotic mitochondrial outer membrane GTPases.. The lone C-terminal TM segment has a high positive charge at both ends, characteristic of mitochondrial outer membrane anchored proteins.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0005856 cytoskeleton 5 2
GO:0005886 plasma membrane 3 2
GO:0005938 cell cortex 3 2
GO:0016020 membrane 2 10
GO:0031410 cytoplasmic vesicle 6 2
GO:0031982 vesicle 4 2
GO:0042995 cell projection 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043228 non-membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0043232 intracellular non-membrane-bounded organelle 4 2
GO:0097708 intracellular vesicle 5 2
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

Q4QIH3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIH3

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 2
GO:0007010 cytoskeleton organization 5 2
GO:0007015 actin filament organization 5 2
GO:0007163 establishment or maintenance of cell polarity 2 2
GO:0008360 regulation of cell shape 6 2
GO:0009987 cellular process 1 2
GO:0016043 cellular component organization 3 2
GO:0022603 regulation of anatomical structure morphogenesis 4 2
GO:0022604 regulation of cell morphogenesis 5 2
GO:0030865 cortical cytoskeleton organization 6 2
GO:0032956 regulation of actin cytoskeleton organization 5 2
GO:0032970 regulation of actin filament-based process 4 2
GO:0033043 regulation of organelle organization 5 2
GO:0050789 regulation of biological process 2 2
GO:0050793 regulation of developmental process 3 2
GO:0050794 regulation of cellular process 3 2
GO:0051128 regulation of cellular component organization 4 2
GO:0051493 regulation of cytoskeleton organization 6 2
GO:0065007 biological regulation 1 2
GO:0071840 cellular component organization or biogenesis 2 2
GO:0097435 supramolecular fiber organization 4 2
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 2
GO:0003824 catalytic activity 1 2
GO:0003924 GTPase activity 7 2
GO:0005488 binding 1 5
GO:0005515 protein binding 2 2
GO:0005525 GTP binding 5 2
GO:0016462 pyrophosphatase activity 5 2
GO:0016787 hydrolase activity 2 2
GO:0016817 hydrolase activity, acting on acid anhydrides 3 2
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 2
GO:0017076 purine nucleotide binding 4 2
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 2
GO:0019001 guanyl nucleotide binding 5 2
GO:0019899 enzyme binding 3 2
GO:0019900 kinase binding 4 2
GO:0019901 protein kinase binding 5 2
GO:0032553 ribonucleotide binding 3 2
GO:0032555 purine ribonucleotide binding 4 2
GO:0032561 guanyl ribonucleotide binding 5 2
GO:0035639 purine ribonucleoside triphosphate binding 4 2
GO:0036094 small molecule binding 2 2
GO:0043167 ion binding 2 5
GO:0043168 anion binding 3 2
GO:0097159 organic cyclic compound binding 2 2
GO:0097367 carbohydrate derivative binding 2 2
GO:1901265 nucleoside phosphate binding 3 2
GO:1901363 heterocyclic compound binding 2 2
GO:0005509 calcium ion binding 5 3
GO:0043169 cation binding 3 3
GO:0046872 metal ion binding 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 371 375 PF00656 0.424
CLV_C14_Caspase3-7 457 461 PF00656 0.438
CLV_C14_Caspase3-7 472 476 PF00656 0.342
CLV_C14_Caspase3-7 93 97 PF00656 0.406
CLV_NRD_NRD_1 163 165 PF00675 0.583
CLV_NRD_NRD_1 288 290 PF00675 0.454
CLV_NRD_NRD_1 332 334 PF00675 0.572
CLV_NRD_NRD_1 361 363 PF00675 0.525
CLV_NRD_NRD_1 548 550 PF00675 0.461
CLV_PCSK_FUR_1 572 576 PF00082 0.457
CLV_PCSK_KEX2_1 265 267 PF00082 0.507
CLV_PCSK_KEX2_1 332 334 PF00082 0.572
CLV_PCSK_KEX2_1 361 363 PF00082 0.525
CLV_PCSK_KEX2_1 51 53 PF00082 0.598
CLV_PCSK_KEX2_1 548 550 PF00082 0.461
CLV_PCSK_KEX2_1 572 574 PF00082 0.441
CLV_PCSK_PC1ET2_1 265 267 PF00082 0.573
CLV_PCSK_PC1ET2_1 51 53 PF00082 0.612
CLV_PCSK_SKI1_1 112 116 PF00082 0.567
CLV_PCSK_SKI1_1 137 141 PF00082 0.526
CLV_PCSK_SKI1_1 51 55 PF00082 0.601
CLV_PCSK_SKI1_1 548 552 PF00082 0.528
CLV_PCSK_SKI1_1 78 82 PF00082 0.565
DEG_MDM2_SWIB_1 181 189 PF02201 0.390
DEG_SPOP_SBC_1 387 391 PF00917 0.309
DEG_SPOP_SBC_1 408 412 PF00917 0.316
DEG_SPOP_SBC_1 506 510 PF00917 0.414
DOC_CDC14_PxL_1 154 162 PF14671 0.363
DOC_MAPK_gen_1 110 118 PF00069 0.375
DOC_MAPK_gen_1 48 56 PF00069 0.390
DOC_MAPK_gen_1 545 555 PF00069 0.261
DOC_MAPK_MEF2A_6 110 118 PF00069 0.326
DOC_MAPK_MEF2A_6 289 298 PF00069 0.329
DOC_PP2B_LxvP_1 118 121 PF13499 0.313
DOC_PP2B_LxvP_1 155 158 PF13499 0.390
DOC_PP2B_LxvP_1 502 505 PF13499 0.319
DOC_PP2B_LxvP_1 81 84 PF13499 0.372
DOC_USP7_MATH_1 281 285 PF00917 0.359
DOC_USP7_MATH_1 513 517 PF00917 0.422
DOC_USP7_MATH_1 527 531 PF00917 0.343
DOC_USP7_MATH_1 70 74 PF00917 0.393
DOC_WW_Pin1_4 130 135 PF00397 0.361
DOC_WW_Pin1_4 267 272 PF00397 0.331
DOC_WW_Pin1_4 274 279 PF00397 0.301
DOC_WW_Pin1_4 65 70 PF00397 0.322
LIG_14-3-3_CanoR_1 244 250 PF00244 0.339
LIG_14-3-3_CanoR_1 289 296 PF00244 0.258
LIG_14-3-3_CanoR_1 30 38 PF00244 0.386
LIG_14-3-3_CanoR_1 361 365 PF00244 0.319
LIG_14-3-3_CanoR_1 388 393 PF00244 0.338
LIG_14-3-3_CanoR_1 548 553 PF00244 0.341
LIG_14-3-3_CanoR_1 562 568 PF00244 0.426
LIG_APCC_ABBA_1 201 206 PF00400 0.392
LIG_BIR_II_1 1 5 PF00653 0.396
LIG_BIR_III_4 150 154 PF00653 0.378
LIG_BRCT_BRCA1_1 326 330 PF00533 0.306
LIG_BRCT_BRCA1_1 34 38 PF00533 0.409
LIG_CSL_BTD_1 502 505 PF09270 0.319
LIG_FHA_1 101 107 PF00498 0.376
LIG_FHA_1 109 115 PF00498 0.413
LIG_FHA_1 346 352 PF00498 0.300
LIG_FHA_1 39 45 PF00498 0.366
LIG_FHA_1 427 433 PF00498 0.389
LIG_FHA_2 410 416 PF00498 0.334
LIG_FHA_2 438 444 PF00498 0.378
LIG_FHA_2 470 476 PF00498 0.319
LIG_FHA_2 506 512 PF00498 0.350
LIG_LIR_Gen_1 215 225 PF02991 0.389
LIG_LIR_Gen_1 451 461 PF02991 0.345
LIG_LIR_Gen_1 542 550 PF02991 0.465
LIG_LIR_Gen_1 551 560 PF02991 0.348
LIG_LIR_Nem_3 141 147 PF02991 0.377
LIG_LIR_Nem_3 215 220 PF02991 0.377
LIG_LIR_Nem_3 233 237 PF02991 0.197
LIG_LIR_Nem_3 300 304 PF02991 0.272
LIG_LIR_Nem_3 451 456 PF02991 0.392
LIG_LIR_Nem_3 542 546 PF02991 0.449
LIG_LIR_Nem_3 551 555 PF02991 0.292
LIG_MAD2 112 120 PF02301 0.389
LIG_NRBOX 4 10 PF00104 0.328
LIG_NRP_CendR_1 573 576 PF00754 0.467
LIG_Pex14_1 32 36 PF04695 0.324
LIG_Pex14_2 140 144 PF04695 0.326
LIG_Pex14_2 181 185 PF04695 0.388
LIG_Pex14_2 298 302 PF04695 0.278
LIG_REV1ctd_RIR_1 390 400 PF16727 0.398
LIG_SH2_CRK 304 308 PF00017 0.309
LIG_SH2_NCK_1 526 530 PF00017 0.409
LIG_SH2_PTP2 543 546 PF00017 0.494
LIG_SH2_STAP1 212 216 PF00017 0.399
LIG_SH2_STAP1 316 320 PF00017 0.276
LIG_SH2_STAP1 448 452 PF00017 0.421
LIG_SH2_STAP1 75 79 PF00017 0.419
LIG_SH2_STAT5 212 215 PF00017 0.379
LIG_SH2_STAT5 249 252 PF00017 0.289
LIG_SH2_STAT5 328 331 PF00017 0.389
LIG_SH2_STAT5 386 389 PF00017 0.318
LIG_SH2_STAT5 543 546 PF00017 0.506
LIG_SH3_3 275 281 PF00018 0.306
LIG_SH3_3 533 539 PF00018 0.369
LIG_SUMO_SIM_anti_2 429 434 PF11976 0.290
LIG_SUMO_SIM_anti_2 551 557 PF11976 0.426
LIG_SUMO_SIM_anti_2 566 572 PF11976 0.622
LIG_SUMO_SIM_par_1 6 13 PF11976 0.365
LIG_SUMO_SIM_par_1 79 85 PF11976 0.325
LIG_TRAF2_1 105 108 PF00917 0.423
LIG_TRAF2_1 173 176 PF00917 0.451
LIG_TYR_ITIM 541 546 PF00017 0.494
LIG_UBA3_1 59 64 PF00899 0.239
MOD_CDK_SPxxK_3 130 137 PF00069 0.403
MOD_CDK_SPxxK_3 65 72 PF00069 0.387
MOD_CK1_1 39 45 PF00069 0.353
MOD_CK1_1 410 416 PF00069 0.417
MOD_CK1_1 424 430 PF00069 0.243
MOD_CK1_1 73 79 PF00069 0.333
MOD_CK2_1 170 176 PF00069 0.435
MOD_CK2_1 409 415 PF00069 0.366
MOD_CK2_1 419 425 PF00069 0.369
MOD_CK2_1 448 454 PF00069 0.349
MOD_CK2_1 505 511 PF00069 0.339
MOD_CK2_1 517 523 PF00069 0.344
MOD_Cter_Amidation 359 362 PF01082 0.509
MOD_GlcNHglycan 172 175 PF01048 0.561
MOD_GlcNHglycan 370 373 PF01048 0.704
MOD_GlcNHglycan 41 44 PF01048 0.516
MOD_GlcNHglycan 412 415 PF01048 0.608
MOD_GlcNHglycan 443 447 PF01048 0.593
MOD_GlcNHglycan 456 459 PF01048 0.599
MOD_GSK3_1 108 115 PF00069 0.405
MOD_GSK3_1 21 28 PF00069 0.383
MOD_GSK3_1 216 223 PF00069 0.282
MOD_GSK3_1 245 252 PF00069 0.368
MOD_GSK3_1 32 39 PF00069 0.352
MOD_GSK3_1 324 331 PF00069 0.370
MOD_GSK3_1 341 348 PF00069 0.294
MOD_GSK3_1 382 389 PF00069 0.365
MOD_GSK3_1 403 410 PF00069 0.342
MOD_GSK3_1 513 520 PF00069 0.406
MOD_N-GLC_1 32 37 PF02516 0.616
MOD_N-GLC_1 70 75 PF02516 0.494
MOD_NEK2_1 1 6 PF00069 0.413
MOD_NEK2_1 100 105 PF00069 0.380
MOD_NEK2_1 21 26 PF00069 0.196
MOD_NEK2_1 220 225 PF00069 0.302
MOD_NEK2_1 288 293 PF00069 0.327
MOD_NEK2_1 368 373 PF00069 0.378
MOD_NEK2_1 38 43 PF00069 0.259
MOD_NEK2_1 392 397 PF00069 0.426
MOD_NEK2_1 407 412 PF00069 0.402
MOD_NEK2_2 216 221 PF00069 0.362
MOD_NEK2_2 448 453 PF00069 0.409
MOD_PKA_1 548 554 PF00069 0.341
MOD_PKA_2 243 249 PF00069 0.307
MOD_PKA_2 288 294 PF00069 0.256
MOD_PKA_2 360 366 PF00069 0.318
MOD_PKA_2 387 393 PF00069 0.334
MOD_PKA_2 548 554 PF00069 0.341
MOD_Plk_1 32 38 PF00069 0.401
MOD_Plk_1 324 330 PF00069 0.341
MOD_Plk_1 341 347 PF00069 0.374
MOD_Plk_1 70 76 PF00069 0.296
MOD_Plk_2-3 517 523 PF00069 0.424
MOD_Plk_4 230 236 PF00069 0.348
MOD_Plk_4 245 251 PF00069 0.212
MOD_Plk_4 382 388 PF00069 0.396
MOD_Plk_4 403 409 PF00069 0.356
MOD_Plk_4 448 454 PF00069 0.404
MOD_Plk_4 539 545 PF00069 0.468
MOD_Plk_4 548 554 PF00069 0.262
MOD_Plk_4 563 569 PF00069 0.329
MOD_ProDKin_1 130 136 PF00069 0.356
MOD_ProDKin_1 267 273 PF00069 0.326
MOD_ProDKin_1 274 280 PF00069 0.300
MOD_ProDKin_1 65 71 PF00069 0.326
MOD_SUMO_rev_2 107 111 PF00179 0.417
TRG_DiLeu_BaEn_1 403 408 PF01217 0.390
TRG_DiLeu_BaEn_2 462 468 PF01217 0.392
TRG_DiLeu_BaLyEn_6 49 54 PF01217 0.328
TRG_ENDOCYTIC_2 304 307 PF00928 0.286
TRG_ENDOCYTIC_2 543 546 PF00928 0.494
TRG_ER_diArg_1 547 549 PF00400 0.374
TRG_ER_diArg_1 571 574 PF00400 0.637
TRG_NES_CRM1_1 425 438 PF08389 0.318

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCT6 Leptomonas seymouri 69% 100%
A0A1X0NPJ9 Trypanosomatidae 45% 100%
A0A3R7KVN9 Trypanosoma rangeli 47% 100%
A0A3S5H622 Leishmania donovani 93% 100%
A4H562 Leishmania braziliensis 86% 100%
A4HTD9 Leishmania infantum 93% 100%
C9ZUH2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9ALD2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
P0CO78 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 21% 84%
P0CO79 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 21% 84%
Q2UM43 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 23% 91%
Q4WN24 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 22% 91%
Q5B5L3 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 23% 91%
Q8RXF8 Arabidopsis thaliana 21% 89%
V5BTM0 Trypanosoma cruzi 46% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS