Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIG7_LEIMA

TriTrypDb:

LmjF.08.0020 , LMJLV39_080005100 , LMJSD75_080005100

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIG7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIG7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.442
CLV_NRD_NRD_1	23	25	PF00675	0.631
CLV_NRD_NRD_1	38	40	PF00675	0.550
CLV_PCSK_FUR_1	111	115	PF00082	0.491
CLV_PCSK_KEX2_1	113	115	PF00082	0.620
CLV_PCSK_KEX2_1	240	242	PF00082	0.497
CLV_PCSK_KEX2_1	25	27	PF00082	0.595
CLV_PCSK_KEX2_1	38	40	PF00082	0.572
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.620
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.497
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.610
CLV_PCSK_SKI1_1	143	147	PF00082	0.515
DOC_MAPK_DCC_7	38	47	PF00069	0.670
DOC_MAPK_MEF2A_6	160	167	PF00069	0.525
DOC_MAPK_MEF2A_6	38	47	PF00069	0.683
DOC_PP2B_LxvP_1	181	184	PF13499	0.567
DOC_PP2B_LxvP_1	20	23	PF13499	0.642
DOC_PP2B_PxIxI_1	162	168	PF00149	0.519
DOC_PP4_FxxP_1	124	127	PF00568	0.615
DOC_PP4_FxxP_1	187	190	PF00568	0.460
DOC_PP4_FxxP_1	82	85	PF00568	0.534
DOC_USP7_MATH_1	182	186	PF00917	0.645
DOC_WW_Pin1_4	147	152	PF00397	0.585
DOC_WW_Pin1_4	195	200	PF00397	0.644
LIG_14-3-3_CanoR_1	70	79	PF00244	0.676
LIG_APCC_ABBA_1	95	100	PF00400	0.650
LIG_BIR_II_1	1	5	PF00653	0.734
LIG_BIR_III_4	66	70	PF00653	0.672
LIG_BRCT_BRCA1_1	1	5	PF00533	0.654
LIG_BRCT_BRCA1_1	184	188	PF00533	0.453
LIG_BRCT_BRCA1_1	72	76	PF00533	0.712
LIG_FHA_1	104	110	PF00498	0.669
LIG_FHA_1	171	177	PF00498	0.549
LIG_FHA_1	53	59	PF00498	0.727
LIG_FHA_1	92	98	PF00498	0.633
LIG_FHA_2	257	263	PF00498	0.542
LIG_LIR_Apic_2	185	190	PF02991	0.459
LIG_LIR_Gen_1	2	12	PF02991	0.502
LIG_LIR_Gen_1	54	65	PF02991	0.560
LIG_LIR_Nem_3	161	165	PF02991	0.438
LIG_LIR_Nem_3	185	191	PF02991	0.553
LIG_LIR_Nem_3	2	8	PF02991	0.613
LIG_LIR_Nem_3	266	272	PF02991	0.356
LIG_LIR_Nem_3	54	60	PF02991	0.559
LIG_LIR_Nem_3	73	79	PF02991	0.603
LIG_LYPXL_yS_3	162	165	PF13949	0.585
LIG_MLH1_MIPbox_1	1	5	PF16413	0.654
LIG_MLH1_MIPbox_1	184	188	PF16413	0.453
LIG_Pex14_2	187	191	PF04695	0.455
LIG_SH2_CRK	83	87	PF00017	0.632
LIG_SH2_STAP1	32	36	PF00017	0.699
LIG_SH2_STAT5	209	212	PF00017	0.631
LIG_SH2_STAT5	252	255	PF00017	0.561
LIG_SH3_3	117	123	PF00018	0.526
LIG_SH3_3	176	182	PF00018	0.605
LIG_SUMO_SIM_anti_2	175	180	PF11976	0.623
MOD_CK1_1	198	204	PF00069	0.616
MOD_CK2_1	101	107	PF00069	0.623
MOD_CK2_1	256	262	PF00069	0.581
MOD_GlcNHglycan	226	229	PF01048	0.563
MOD_GlcNHglycan	72	75	PF01048	0.633
MOD_GlcNHglycan	91	94	PF01048	0.627
MOD_GSK3_1	166	173	PF00069	0.549
MOD_GSK3_1	194	201	PF00069	0.682
MOD_GSK3_1	52	59	PF00069	0.639
MOD_GSK3_1	89	96	PF00069	0.603
MOD_GSK3_1	99	106	PF00069	0.575
MOD_LATS_1	68	74	PF00433	0.592
MOD_N-GLC_1	262	267	PF02516	0.545
MOD_N-GLC_1	52	57	PF02516	0.715
MOD_NEK2_1	99	104	PF00069	0.660
MOD_NEK2_2	93	98	PF00069	0.662
MOD_PIKK_1	166	172	PF00454	0.613
MOD_PK_1	172	178	PF00069	0.561
MOD_Plk_1	100	106	PF00069	0.579
MOD_Plk_1	152	158	PF00069	0.616
MOD_Plk_1	52	58	PF00069	0.679
MOD_Plk_2-3	101	107	PF00069	0.468
MOD_Plk_4	174	180	PF00069	0.535
MOD_Plk_4	248	254	PF00069	0.362
MOD_Plk_4	53	59	PF00069	0.620
MOD_ProDKin_1	147	153	PF00069	0.586
MOD_ProDKin_1	195	201	PF00069	0.636
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.684
TRG_ENDOCYTIC_2	162	165	PF00928	0.585
TRG_ENDOCYTIC_2	269	272	PF00928	0.375
TRG_ENDOCYTIC_2	83	86	PF00928	0.677
TRG_ER_diArg_1	23	26	PF00400	0.657
TRG_ER_diArg_1	37	39	PF00400	0.600
TRG_NLS_MonoExtC_3	23	28	PF00514	0.682
TRG_NLS_MonoExtN_4	23	28	PF00514	0.680
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.724

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE07	Leptomonas seymouri	57%	98%
A0A1X0NNW9	Trypanosomatidae	30%	100%
A0A3S5H624	Leishmania donovani	89%	100%
A0A422N819	Trypanosoma rangeli	34%	100%
A4H569	Leishmania braziliensis	72%	100%
A4HTF2	Leishmania infantum	90%	100%
C9ZPM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AM80	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BLP6	Trypanosoma cruzi	33%	100%