Putative Qc-SNARE protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Qc-SNARE protein, putative

Species:

Leishmania major

UniProt:

Q4QIG6_LEIMA

TriTrypDb:

LmjF.08.0030 , LMJLV39_080005200 , LMJSD75_080005200

Length:

215

Annotations

LeishMANIAdb annotations

A conserved SNARE protein with a tail anchor. Distantly similar to mammalian VAMP7.. Localization: Endosomal (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

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Expansion

Sequence features

Q4QIG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIG6

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	16
GO:0016192	vesicle-mediated transport	4	16
GO:0051179	localization	1	16
GO:0051234	establishment of localization	2	16

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	48	52	PF00656	0.772
CLV_PCSK_KEX2_1	177	179	PF00082	0.311
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.321
CLV_PCSK_SKI1_1	106	110	PF00082	0.490
CLV_PCSK_SKI1_1	183	187	PF00082	0.319
CLV_PCSK_SKI1_1	78	82	PF00082	0.467
DOC_CYCLIN_RxL_1	177	188	PF00134	0.559
DOC_CYCLIN_yClb5_NLxxxL_5	180	189	PF00134	0.587
DOC_MAPK_gen_1	183	192	PF00069	0.528
DOC_MAPK_MEF2A_6	183	191	PF00069	0.521

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I418	Leptomonas seymouri	92%	99%
A0A0N1IMB1	Leptomonas seymouri	29%	98%
A0A0S4IUW0	Bodo saltans	80%	100%
A0A0S4IXW4	Bodo saltans	44%	96%
A0A0S4JCC4	Bodo saltans	31%	92%
A0A0S4JYF9	Bodo saltans	34%	100%
A0A1X0NF95	Trypanosomatidae	30%	97%
A0A1X0NQE9	Trypanosomatidae	86%	100%
A0A1X0P780	Trypanosomatidae	31%	100%
A0A3S7WQ28	Leishmania donovani	100%	100%

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