LisH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIG5_LEIMA

TriTrypDb:

LmjF.08.0040 , LMJLV39_080005300 , LMJSD75_080005300

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIG5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.536
CLV_NRD_NRD_1	105	107	PF00675	0.486
CLV_NRD_NRD_1	38	40	PF00675	0.551
CLV_PCSK_KEX2_1	105	107	PF00082	0.504
CLV_PCSK_KEX2_1	116	118	PF00082	0.490
CLV_PCSK_KEX2_1	38	40	PF00082	0.551
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.529
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.515
CLV_PCSK_SKI1_1	39	43	PF00082	0.623
DEG_APCC_DBOX_1	131	139	PF00400	0.633
DEG_APCC_DBOX_1	209	217	PF00400	0.531
DEG_Nend_UBRbox_2	1	3	PF02207	0.631
DOC_MAPK_gen_1	105	114	PF00069	0.485
DOC_MAPK_gen_1	207	217	PF00069	0.539
DOC_MAPK_MEF2A_6	210	217	PF00069	0.529
DOC_USP7_MATH_1	177	181	PF00917	0.494
DOC_USP7_MATH_1	70	74	PF00917	0.707
DOC_WW_Pin1_4	180	185	PF00397	0.587
LIG_14-3-3_CanoR_1	188	196	PF00244	0.468
LIG_14-3-3_CanoR_1	210	214	PF00244	0.593
LIG_14-3-3_CanoR_1	38	48	PF00244	0.508
LIG_14-3-3_CanoR_1	56	62	PF00244	0.445
LIG_14-3-3_CanoR_1	87	94	PF00244	0.759
LIG_FHA_1	173	179	PF00498	0.610
LIG_FHA_1	191	197	PF00498	0.399
LIG_FHA_1	40	46	PF00498	0.632
LIG_FHA_2	8	14	PF00498	0.556
LIG_LIR_Gen_1	7	17	PF02991	0.557
LIG_LIR_Nem_3	7	12	PF02991	0.542
LIG_LIR_Nem_3	73	78	PF02991	0.474
LIG_PTB_Apo_2	215	222	PF02174	0.605
LIG_PTB_Phospho_1	215	221	PF10480	0.603
LIG_SH2_CRK	55	59	PF00017	0.492
LIG_SH2_CRK	75	79	PF00017	0.474
LIG_SH2_NCK_1	118	122	PF00017	0.464
LIG_SH2_STAP1	118	122	PF00017	0.464
LIG_SH2_STAP1	174	178	PF00017	0.600
LIG_SH2_STAT5	152	155	PF00017	0.699
LIG_SH2_STAT5	174	177	PF00017	0.560
LIG_SH2_STAT5	35	38	PF00017	0.456
LIG_SH3_3	156	162	PF00018	0.627
LIG_SH3_3	178	184	PF00018	0.551
LIG_SH3_3	64	70	PF00018	0.581
MOD_CDC14_SPxK_1	183	186	PF00782	0.659
MOD_CDK_SPxK_1	180	186	PF00069	0.644
MOD_CK1_1	180	186	PF00069	0.511
MOD_CK1_1	7	13	PF00069	0.548
MOD_CK1_1	89	95	PF00069	0.620
MOD_CK2_1	188	194	PF00069	0.518
MOD_CK2_1	7	13	PF00069	0.616
MOD_CMANNOS	219	222	PF00535	0.494
MOD_GlcNHglycan	72	75	PF01048	0.630
MOD_GlcNHglycan	88	91	PF01048	0.655
MOD_GlcNHglycan	97	102	PF01048	0.642
MOD_GSK3_1	172	179	PF00069	0.554
MOD_GSK3_1	186	193	PF00069	0.503
MOD_NEK2_1	31	36	PF00069	0.486
MOD_NEK2_1	41	46	PF00069	0.397
MOD_NEK2_1	79	84	PF00069	0.613
MOD_PK_1	186	192	PF00069	0.587
MOD_PKA_2	145	151	PF00069	0.510
MOD_PKA_2	209	215	PF00069	0.535
MOD_PKA_2	86	92	PF00069	0.763
MOD_PKB_1	186	194	PF00069	0.456
MOD_Plk_1	186	192	PF00069	0.578
MOD_Plk_1	4	10	PF00069	0.701
MOD_Plk_4	177	183	PF00069	0.416
MOD_Plk_4	4	10	PF00069	0.701
MOD_ProDKin_1	180	186	PF00069	0.592
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.574
TRG_ENDOCYTIC_2	55	58	PF00928	0.490
TRG_ENDOCYTIC_2	75	78	PF00928	0.475
TRG_ER_diArg_1	132	135	PF00400	0.630
TRG_Pf-PMV_PEXEL_1	134	139	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.662
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAM0	Leptomonas seymouri	56%	100%
A0A1X0NQK9	Trypanosomatidae	34%	91%
A0A3S7WQ20	Leishmania donovani	92%	100%
A0A422N813	Trypanosoma rangeli	31%	83%
A4H571	Leishmania braziliensis	80%	100%
A4HTF4	Leishmania infantum	92%	100%
C9ZPN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	84%
E9AM82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BLP0	Trypanosoma cruzi	27%	78%