Putative phosphoglycerate mutase protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoglycerate mutase protein, putative

Species:

Leishmania major

UniProt:

Q4QIG3_LEIMA

TriTrypDb:

LmjF.08.0060 , LMJLV39_080005500 , LMJSD75_080005500

Length:

185

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QIG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIG3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004619	phosphoglycerate mutase activity	5	5
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0016853	isomerase activity	2	6
GO:0016866	intramolecular transferase activity	3	5
GO:0016868	intramolecular transferase activity, phosphotransferases	4	5
GO:0042578	phosphoric ester hydrolase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	33	35	PF00675	0.387
CLV_PCSK_KEX2_1	33	35	PF00082	0.389
CLV_PCSK_SKI1_1	17	21	PF00082	0.383
DOC_CYCLIN_yCln2_LP_2	172	178	PF00134	0.297
DOC_PP1_RVXF_1	109	116	PF00149	0.297
DOC_PP1_RVXF_1	163	169	PF00149	0.316
DOC_PP2B_LxvP_1	172	175	PF13499	0.297
DOC_WW_Pin1_4	53	58	PF00397	0.260
LIG_BIR_II_1	1	5	PF00653	0.355
LIG_CaM_IQ_9	71	87	PF13499	0.305
LIG_FHA_1	178	184	PF00498	0.275
LIG_LIR_Nem_3	84	90	PF02991	0.253
LIG_PDZ_Class_2	180	185	PF00595	0.272
LIG_SH2_CRK	50	54	PF00017	0.272
LIG_SH2_NCK_1	128	132	PF00017	0.366
LIG_SH2_NCK_1	50	54	PF00017	0.385
LIG_SH2_NCK_1	95	99	PF00017	0.385
LIG_SH2_SRC	95	98	PF00017	0.366
LIG_SH2_STAP1	50	54	PF00017	0.297
LIG_SH2_STAT5	114	117	PF00017	0.253
LIG_SH2_STAT5	176	179	PF00017	0.312
LIG_SUMO_SIM_anti_2	145	151	PF11976	0.334
LIG_TYR_ITIM	48	53	PF00017	0.297
MOD_CDK_SPxxK_3	53	60	PF00069	0.253
MOD_CK1_1	120	126	PF00069	0.230
MOD_Cter_Amidation	31	34	PF01082	0.281
MOD_GlcNHglycan	45	48	PF01048	0.335
MOD_GlcNHglycan	65	68	PF01048	0.318
MOD_GlcNHglycan	90	93	PF01048	0.385
MOD_ProDKin_1	53	59	PF00069	0.260
TRG_DiLeu_BaEn_1	145	150	PF01217	0.385
TRG_ENDOCYTIC_2	50	53	PF00928	0.272
TRG_ENDOCYTIC_2	95	98	PF00928	0.385
TRG_Pf-PMV_PEXEL_1	105	110	PF00026	0.257

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMU2	Leptomonas seymouri	83%	100%
A0A0S4IY74	Bodo saltans	55%	100%
A0A1X0NP76	Trypanosomatidae	61%	100%
A0A3R7MFI2	Trypanosoma rangeli	58%	100%
A0A3S5H625	Leishmania donovani	94%	100%
A1AJW4	Escherichia coli O1:K1 / APEC	27%	86%
A1JJB8	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	29%	86%
A1UTM4	Bartonella bacilliformis (strain ATCC 35685 / NCTC 12138 / KC583)	29%	90%
A4H573	Leishmania braziliensis	83%	100%
A4HTF6	Leishmania infantum	93%	100%
A4TQH5	Yersinia pestis (strain Pestoides F)	28%	86%
A4W6B3	Enterobacter sp. (strain 638)	28%	86%
A6TI09	Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)	29%	86%
A6WYJ2	Brucella anthropi (strain ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 / LMG 3331 / NBRC 15819 / NCTC 12168 / Alc 37)	27%	90%
A7FMF8	Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)	28%	86%
A7HZ35	Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)	27%	88%
A7MIJ0	Cronobacter sakazakii (strain ATCC BAA-894)	28%	86%
A7ZVT7	Escherichia coli O139:H28 (strain E24377A / ETEC)	27%	86%
A8A8C4	Escherichia coli O9:H4 (strain HS)	27%	86%
A8ALW1	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	27%	86%
A9MR94	Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)	27%	86%
A9N7F5	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	26%	86%
A9R032	Yersinia pestis bv. Antiqua (strain Angola)	28%	86%
A9W5P5	Methylorubrum extorquens (strain PA1)	28%	87%
B1IS24	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	27%	86%
B1JL20	Yersinia pseudotuberculosis serotype O:3 (strain YPIII)	28%	86%
B1LEK2	Escherichia coli (strain SMS-3-5 / SECEC)	27%	86%
B1M6A7	Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831 / NBRC 15690 / NCIMB 10815 / 0-1)	28%	87%
B1XFK5	Escherichia coli (strain K12 / DH10B)	27%	86%
B1ZA86	Methylorubrum populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)	27%	87%
B2K3K5	Yersinia pseudotuberculosis serotype IB (strain PB1/+)	28%	86%
B2TZS8	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	27%	86%
B4T4I9	Salmonella newport (strain SL254)	26%	86%
B4TH18	Salmonella heidelberg (strain SL476)	26%	86%
B4TU55	Salmonella schwarzengrund (strain CVM19633)	26%	86%
B5BAL1	Salmonella paratyphi A (strain AKU_12601)	28%	86%
B5F543	Salmonella agona (strain SL483)	26%	86%
B5FTD9	Salmonella dublin (strain CT_02021853)	26%	86%
B5R3B7	Salmonella enteritidis PT4 (strain P125109)	26%	86%
B5R9W3	Salmonella gallinarum (strain 287/91 / NCTC 13346)	26%	86%
B5Y264	Klebsiella pneumoniae (strain 342)	29%	86%
B5Y7Q7	Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / OCM 4 / BT)	26%	75%
B5Z4S7	Escherichia coli O157:H7 (strain EC4115 / EHEC)	27%	86%
B6I6P3	Escherichia coli (strain SE11)	27%	86%
B7KNX9	Methylorubrum extorquens (strain CM4 / NCIMB 13688)	28%	87%
B7LEP1	Escherichia coli (strain 55989 / EAEC)	27%	86%
B7LNT7	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	28%	86%
B7LXV9	Escherichia coli O8 (strain IAI1)	27%	86%
B7MNK4	Escherichia coli O45:K1 (strain S88 / ExPEC)	27%	86%
B7MTE3	Escherichia coli O81 (strain ED1a)	27%	86%
B7NH70	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	27%	86%
B7NW76	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	27%	86%
B8EML2	Methylocella silvestris (strain DSM 15510 / CIP 108128 / LMG 27833 / NCIMB 13906 / BL2)	28%	90%
C0Q8F5	Salmonella paratyphi C (strain RKS4594)	26%	86%
C3MBY8	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	28%	88%
C4ZT77	Escherichia coli (strain K12 / MC4100 / BW2952)	27%	86%
C9ZPN2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
D3DFG8	Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6)	31%	88%
D3DFP8	Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6)	33%	91%
E9AM84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
F4KI56	Arabidopsis thaliana	31%	78%
O07617	Bacillus subtilis (strain 168)	29%	96%
P0A7A2	Escherichia coli (strain K12)	27%	86%
P0A7A3	Escherichia coli O157:H7	27%	86%
P0A7A4	Shigella flexneri	27%	86%
P36623	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	88%
Q0SX17	Shigella flexneri serotype 5b (strain 8401)	27%	86%
Q0T8R6	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	27%	86%
Q1C0L5	Yersinia pestis bv. Antiqua (strain Antiqua)	28%	86%
Q1CMX2	Yersinia pestis bv. Antiqua (strain Nepal516)	28%	86%
Q1R246	Escherichia coli (strain UTI89 / UPEC)	27%	86%
Q31SU3	Shigella boydii serotype 4 (strain Sb227)	27%	86%
Q3YTZ9	Shigella sonnei (strain Ss046)	27%	86%
Q57G26	Salmonella choleraesuis (strain SC-B67)	25%	86%
Q5PK44	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	26%	86%
Q66EU3	Yersinia pseudotuberculosis serotype I (strain IP32953)	28%	86%
Q6FZ12	Bartonella quintana (strain Toulouse)	26%	90%
Q7N900	Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)	27%	86%
Q7VS43	Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)	27%	74%
Q7W1Q6	Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)	28%	74%
Q7WQN2	Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)	27%	74%
Q8FA40	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	27%	86%
Q8KL44	Rhizobium etli (strain CFN 42 / ATCC 51251)	27%	89%
Q8L1Z7	Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1)	28%	90%
Q8Z0T4	Salmonella typhi	26%	86%
Q8ZIP0	Yersinia pestis	28%	86%
Q8ZJU8	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	26%	86%
Q9HIJ2	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	34%	92%
Q9SCS3	Arabidopsis thaliana	32%	80%