LeishMANIAdb
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ASCH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ASCH domain-containing protein
Gene product:
Putative zinc finger motif, C2HC5-type/ASCH domain containing protein, putative
Species:
Leishmania major
UniProt:
Q4QIG2_LEIMA
TriTrypDb:
LmjF.08.0070 , LMJLV39_080005600 * , LMJSD75_080005600 *
Length:
629

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 3
GO:0043226 organelle 2 3
GO:0043227 membrane-bounded organelle 3 3
GO:0043229 intracellular organelle 3 3
GO:0043231 intracellular membrane-bounded organelle 4 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

Q4QIG2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIG2

Function

Biological processes
Term Name Level Count
GO:0006355 regulation of DNA-templated transcription 6 3
GO:0009889 regulation of biosynthetic process 4 3
GO:0009891 positive regulation of biosynthetic process 5 2
GO:0009893 positive regulation of metabolic process 4 2
GO:0010468 regulation of gene expression 5 3
GO:0010556 regulation of macromolecule biosynthetic process 5 3
GO:0010557 positive regulation of macromolecule biosynthetic process 6 2
GO:0010604 positive regulation of macromolecule metabolic process 5 2
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 3
GO:0019222 regulation of metabolic process 3 3
GO:0031323 regulation of cellular metabolic process 4 3
GO:0031325 positive regulation of cellular metabolic process 5 2
GO:0031326 regulation of cellular biosynthetic process 5 3
GO:0031328 positive regulation of cellular biosynthetic process 6 2
GO:0045893 positive regulation of DNA-templated transcription 7 2
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 6 2
GO:0048518 positive regulation of biological process 3 2
GO:0048522 positive regulation of cellular process 4 2
GO:0050789 regulation of biological process 2 3
GO:0050794 regulation of cellular process 3 3
GO:0051171 regulation of nitrogen compound metabolic process 4 3
GO:0051173 positive regulation of nitrogen compound metabolic process 5 2
GO:0051252 regulation of RNA metabolic process 5 3
GO:0051254 positive regulation of RNA metabolic process 6 2
GO:0060255 regulation of macromolecule metabolic process 4 3
GO:0065007 biological regulation 1 3
GO:0080090 regulation of primary metabolic process 4 3
GO:1902680 positive regulation of RNA biosynthetic process 7 2
GO:1903506 regulation of nucleic acid-templated transcription 7 3
GO:1903508 positive regulation of nucleic acid-templated transcription 8 2
GO:2001141 regulation of RNA biosynthetic process 6 3
Molecular functions
Term Name Level Count
GO:0003712 transcription coregulator activity 2 2
GO:0003713 transcription coactivator activity 3 2
GO:0140110 transcription regulator activity 1 2
GO:0005488 binding 1 1
GO:0008270 zinc ion binding 6 1
GO:0043167 ion binding 2 1
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1
GO:0046914 transition metal ion binding 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 442 446 PF00656 0.656
CLV_NRD_NRD_1 136 138 PF00675 0.595
CLV_NRD_NRD_1 222 224 PF00675 0.477
CLV_NRD_NRD_1 260 262 PF00675 0.563
CLV_NRD_NRD_1 301 303 PF00675 0.728
CLV_NRD_NRD_1 397 399 PF00675 0.623
CLV_NRD_NRD_1 404 406 PF00675 0.558
CLV_NRD_NRD_1 621 623 PF00675 0.408
CLV_NRD_NRD_1 82 84 PF00675 0.435
CLV_PCSK_FUR_1 126 130 PF00082 0.720
CLV_PCSK_FUR_1 233 237 PF00082 0.499
CLV_PCSK_KEX2_1 118 120 PF00082 0.629
CLV_PCSK_KEX2_1 125 127 PF00082 0.689
CLV_PCSK_KEX2_1 128 130 PF00082 0.719
CLV_PCSK_KEX2_1 222 224 PF00082 0.434
CLV_PCSK_KEX2_1 235 237 PF00082 0.494
CLV_PCSK_KEX2_1 260 262 PF00082 0.570
CLV_PCSK_KEX2_1 397 399 PF00082 0.638
CLV_PCSK_KEX2_1 4 6 PF00082 0.648
CLV_PCSK_KEX2_1 404 406 PF00082 0.571
CLV_PCSK_KEX2_1 505 507 PF00082 0.417
CLV_PCSK_KEX2_1 81 83 PF00082 0.430
CLV_PCSK_PC1ET2_1 118 120 PF00082 0.657
CLV_PCSK_PC1ET2_1 125 127 PF00082 0.689
CLV_PCSK_PC1ET2_1 128 130 PF00082 0.719
CLV_PCSK_PC1ET2_1 235 237 PF00082 0.522
CLV_PCSK_PC1ET2_1 4 6 PF00082 0.648
CLV_PCSK_PC1ET2_1 505 507 PF00082 0.417
CLV_PCSK_PC7_1 393 399 PF00082 0.621
CLV_PCSK_SKI1_1 556 560 PF00082 0.444
CLV_Separin_Metazoa 52 56 PF03568 0.332
DEG_APCC_DBOX_1 621 629 PF00400 0.407
DEG_APCC_KENBOX_2 302 306 PF00400 0.730
DEG_COP1_1 327 337 PF00400 0.690
DEG_SPOP_SBC_1 455 459 PF00917 0.645
DEG_SPOP_SBC_1 98 102 PF00917 0.591
DOC_CYCLIN_yCln2_LP_2 598 604 PF00134 0.355
DOC_MAPK_DCC_7 596 604 PF00069 0.355
DOC_MAPK_gen_1 125 133 PF00069 0.687
DOC_MAPK_gen_1 427 435 PF00069 0.606
DOC_PP2B_LxvP_1 386 389 PF13499 0.592
DOC_PP2B_LxvP_1 96 99 PF13499 0.578
DOC_PP4_FxxP_1 542 545 PF00568 0.289
DOC_PP4_FxxP_1 600 603 PF00568 0.378
DOC_SPAK_OSR1_1 474 478 PF12202 0.469
DOC_USP7_MATH_1 263 267 PF00917 0.613
DOC_USP7_MATH_1 339 343 PF00917 0.661
DOC_USP7_MATH_1 389 393 PF00917 0.757
DOC_USP7_MATH_1 454 458 PF00917 0.750
DOC_USP7_MATH_1 470 474 PF00917 0.613
DOC_USP7_MATH_1 476 480 PF00917 0.538
DOC_USP7_MATH_1 495 499 PF00917 0.258
DOC_USP7_MATH_1 524 528 PF00917 0.388
DOC_USP7_MATH_1 60 64 PF00917 0.449
DOC_USP7_MATH_1 99 103 PF00917 0.575
DOC_USP7_UBL2_3 427 431 PF12436 0.516
DOC_WW_Pin1_4 246 251 PF00397 0.544
DOC_WW_Pin1_4 253 258 PF00397 0.501
DOC_WW_Pin1_4 347 352 PF00397 0.710
DOC_WW_Pin1_4 377 382 PF00397 0.625
DOC_WW_Pin1_4 457 462 PF00397 0.664
DOC_WW_Pin1_4 468 473 PF00397 0.473
DOC_WW_Pin1_4 541 546 PF00397 0.352
DOC_WW_Pin1_4 583 588 PF00397 0.385
LIG_14-3-3_CanoR_1 137 146 PF00244 0.653
LIG_14-3-3_CanoR_1 236 240 PF00244 0.641
LIG_14-3-3_CanoR_1 405 411 PF00244 0.703
LIG_14-3-3_CanoR_1 482 490 PF00244 0.488
LIG_APCC_ABBA_1 415 420 PF00400 0.614
LIG_APCC_ABBAyCdc20_2 128 134 PF00400 0.503
LIG_BH_BH3_1 18 34 PF00452 0.442
LIG_BIR_III_4 13 17 PF00653 0.481
LIG_BRCT_BRCA1_1 71 75 PF00533 0.482
LIG_Clathr_ClatBox_1 610 614 PF01394 0.367
LIG_EH1_1 474 482 PF00400 0.467
LIG_eIF4E_1 20 26 PF01652 0.454
LIG_eIF4E_1 553 559 PF01652 0.274
LIG_FHA_1 111 117 PF00498 0.714
LIG_FHA_1 20 26 PF00498 0.539
LIG_FHA_1 215 221 PF00498 0.541
LIG_FHA_1 235 241 PF00498 0.494
LIG_FHA_1 288 294 PF00498 0.627
LIG_FHA_1 553 559 PF00498 0.286
LIG_FHA_1 563 569 PF00498 0.328
LIG_FHA_1 66 72 PF00498 0.405
LIG_FHA_2 139 145 PF00498 0.547
LIG_FHA_2 236 242 PF00498 0.633
LIG_FHA_2 333 339 PF00498 0.653
LIG_FHA_2 352 358 PF00498 0.592
LIG_FHA_2 56 62 PF00498 0.492
LIG_LIR_Apic_2 252 257 PF02991 0.511
LIG_LIR_Apic_2 540 545 PF02991 0.368
LIG_LIR_Gen_1 536 545 PF02991 0.289
LIG_LIR_Gen_1 585 595 PF02991 0.364
LIG_LIR_Nem_3 536 542 PF02991 0.274
LIG_LIR_Nem_3 585 591 PF02991 0.357
LIG_MAD2 331 339 PF02301 0.589
LIG_Pex14_1 512 516 PF04695 0.274
LIG_SH2_CRK 588 592 PF00017 0.469
LIG_SH2_NCK_1 20 24 PF00017 0.474
LIG_SH2_PTP2 561 564 PF00017 0.274
LIG_SH2_SRC 195 198 PF00017 0.607
LIG_SH2_STAP1 195 199 PF00017 0.466
LIG_SH2_STAP1 20 24 PF00017 0.474
LIG_SH2_STAP1 216 220 PF00017 0.426
LIG_SH2_STAP1 539 543 PF00017 0.308
LIG_SH2_STAT5 20 23 PF00017 0.501
LIG_SH2_STAT5 216 219 PF00017 0.482
LIG_SH2_STAT5 410 413 PF00017 0.608
LIG_SH2_STAT5 561 564 PF00017 0.274
LIG_SH3_3 466 472 PF00018 0.629
LIG_SUMO_SIM_anti_2 430 436 PF11976 0.695
LIG_SUMO_SIM_par_1 67 73 PF11976 0.432
LIG_TRAF2_1 198 201 PF00917 0.588
LIG_TRAF2_1 256 259 PF00917 0.576
LIG_TRAF2_1 381 384 PF00917 0.742
LIG_TRAF2_1 42 45 PF00917 0.573
LIG_TYR_ITIM 559 564 PF00017 0.274
MOD_CDC14_SPxK_1 471 474 PF00782 0.416
MOD_CDK_SPxK_1 468 474 PF00069 0.439
MOD_CDK_SPxxK_3 253 260 PF00069 0.475
MOD_CK1_1 100 106 PF00069 0.683
MOD_CK1_1 249 255 PF00069 0.632
MOD_CK1_1 358 364 PF00069 0.728
MOD_CK1_1 392 398 PF00069 0.754
MOD_CK1_1 457 463 PF00069 0.568
MOD_CK1_1 586 592 PF00069 0.396
MOD_CK2_1 138 144 PF00069 0.608
MOD_CK2_1 195 201 PF00069 0.615
MOD_CK2_1 215 221 PF00069 0.557
MOD_CK2_1 253 259 PF00069 0.470
MOD_CK2_1 263 269 PF00069 0.503
MOD_CK2_1 332 338 PF00069 0.661
MOD_CK2_1 351 357 PF00069 0.587
MOD_CK2_1 39 45 PF00069 0.586
MOD_CK2_1 406 412 PF00069 0.686
MOD_CK2_1 55 61 PF00069 0.412
MOD_Cter_Amidation 126 129 PF01082 0.786
MOD_Cter_Amidation 361 364 PF01082 0.761
MOD_GlcNHglycan 104 107 PF01048 0.456
MOD_GlcNHglycan 13 17 PF01048 0.607
MOD_GlcNHglycan 141 144 PF01048 0.480
MOD_GlcNHglycan 217 220 PF01048 0.643
MOD_GlcNHglycan 241 246 PF01048 0.599
MOD_GlcNHglycan 251 254 PF01048 0.587
MOD_GlcNHglycan 264 268 PF01048 0.605
MOD_GlcNHglycan 304 308 PF01048 0.733
MOD_GlcNHglycan 357 360 PF01048 0.684
MOD_GlcNHglycan 365 369 PF01048 0.676
MOD_GlcNHglycan 465 469 PF01048 0.677
MOD_GlcNHglycan 604 607 PF01048 0.464
MOD_GlcNHglycan 84 88 PF01048 0.570
MOD_GSK3_1 110 117 PF00069 0.713
MOD_GSK3_1 249 256 PF00069 0.601
MOD_GSK3_1 263 270 PF00069 0.497
MOD_GSK3_1 287 294 PF00069 0.528
MOD_GSK3_1 347 354 PF00069 0.577
MOD_GSK3_1 384 391 PF00069 0.743
MOD_GSK3_1 464 471 PF00069 0.507
MOD_GSK3_1 537 544 PF00069 0.378
MOD_GSK3_1 65 72 PF00069 0.494
MOD_GSK3_1 98 105 PF00069 0.595
MOD_LATS_1 10 16 PF00433 0.496
MOD_N-GLC_1 114 119 PF02516 0.666
MOD_N-GLC_2 36 38 PF02516 0.570
MOD_NEK2_1 114 119 PF00069 0.641
MOD_NEK2_1 162 167 PF00069 0.505
MOD_NEK2_1 475 480 PF00069 0.510
MOD_NEK2_2 155 160 PF00069 0.504
MOD_PIKK_1 291 297 PF00454 0.610
MOD_PIKK_1 392 398 PF00454 0.782
MOD_PIKK_1 524 530 PF00454 0.346
MOD_PKA_1 118 124 PF00069 0.697
MOD_PKA_1 137 143 PF00069 0.613
MOD_PKA_1 235 241 PF00069 0.637
MOD_PKA_2 118 124 PF00069 0.697
MOD_PKA_2 136 142 PF00069 0.680
MOD_PKA_2 162 168 PF00069 0.539
MOD_PKA_2 235 241 PF00069 0.637
MOD_PKA_2 392 398 PF00069 0.768
MOD_PKA_2 481 487 PF00069 0.497
MOD_PKB_1 81 89 PF00069 0.497
MOD_Plk_1 195 201 PF00069 0.591
MOD_Plk_4 235 241 PF00069 0.661
MOD_Plk_4 243 249 PF00069 0.663
MOD_Plk_4 339 345 PF00069 0.581
MOD_Plk_4 406 412 PF00069 0.552
MOD_Plk_4 476 482 PF00069 0.598
MOD_Plk_4 495 501 PF00069 0.173
MOD_Plk_4 586 592 PF00069 0.482
MOD_Plk_4 65 71 PF00069 0.399
MOD_Plk_4 91 97 PF00069 0.543
MOD_ProDKin_1 246 252 PF00069 0.535
MOD_ProDKin_1 253 259 PF00069 0.500
MOD_ProDKin_1 347 353 PF00069 0.708
MOD_ProDKin_1 377 383 PF00069 0.626
MOD_ProDKin_1 457 463 PF00069 0.665
MOD_ProDKin_1 468 474 PF00069 0.462
MOD_ProDKin_1 541 547 PF00069 0.352
MOD_ProDKin_1 583 589 PF00069 0.377
MOD_SUMO_for_1 577 580 PF00179 0.302
MOD_SUMO_rev_2 196 205 PF00179 0.543
MOD_SUMO_rev_2 589 598 PF00179 0.486
TRG_DiLeu_BaLyEn_6 222 227 PF01217 0.518
TRG_ENDOCYTIC_2 539 542 PF00928 0.274
TRG_ENDOCYTIC_2 561 564 PF00928 0.274
TRG_ENDOCYTIC_2 588 591 PF00928 0.473
TRG_ER_diArg_1 397 399 PF00400 0.624
TRG_ER_diArg_1 404 406 PF00400 0.559
TRG_ER_diArg_1 516 519 PF00400 0.289
TRG_ER_diArg_1 81 83 PF00400 0.361
TRG_ER_FFAT_2 214 221 PF00635 0.454
TRG_NLS_MonoExtC_3 124 129 PF00514 0.719
TRG_Pf-PMV_PEXEL_1 171 175 PF00026 0.363
TRG_Pf-PMV_PEXEL_1 623 627 PF00026 0.399

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PGL1 Leptomonas seymouri 67% 100%
A0A0S4IUQ4 Bodo saltans 38% 98%
A0A1X0NNW7 Trypanosomatidae 44% 98%
A0A3S5H626 Leishmania donovani 93% 100%
A0A3S5IQP6 Trypanosoma rangeli 48% 100%
A4H574 Leishmania braziliensis 77% 100%
A4HTF7 Leishmania infantum 93% 100%
C9ZPN3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
E9AM85 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
V5BH64 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS