Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QIF8_LEIMA

TriTrypDb:

LmjF.08.0110 , LMJLV39_080006000 , LMJSD75_080006000

Length:

643

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIF8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	156	162	PF00089	0.723
CLV_NRD_NRD_1	246	248	PF00675	0.717
CLV_NRD_NRD_1	297	299	PF00675	0.450
CLV_NRD_NRD_1	316	318	PF00675	0.577
CLV_NRD_NRD_1	545	547	PF00675	0.615
CLV_NRD_NRD_1	570	572	PF00675	0.561
CLV_NRD_NRD_1	582	584	PF00675	0.672
CLV_NRD_NRD_1	91	93	PF00675	0.778
CLV_PCSK_FUR_1	568	572	PF00082	0.556
CLV_PCSK_KEX2_1	246	248	PF00082	0.717
CLV_PCSK_KEX2_1	297	299	PF00082	0.541
CLV_PCSK_KEX2_1	316	318	PF00082	0.583
CLV_PCSK_KEX2_1	365	367	PF00082	0.600
CLV_PCSK_KEX2_1	568	570	PF00082	0.559
CLV_PCSK_KEX2_1	582	584	PF00082	0.649
CLV_PCSK_KEX2_1	91	93	PF00082	0.826
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.600
CLV_PCSK_PC7_1	312	318	PF00082	0.633
CLV_PCSK_SKI1_1	402	406	PF00082	0.693
CLV_PCSK_SKI1_1	446	450	PF00082	0.652
CLV_PCSK_SKI1_1	547	551	PF00082	0.539
CLV_PCSK_SKI1_1	553	557	PF00082	0.516
CLV_PCSK_SKI1_1	587	591	PF00082	0.822
CLV_Separin_Metazoa	515	519	PF03568	0.664
DEG_APCC_DBOX_1	531	539	PF00400	0.650
DEG_SCF_TRCP1_1	635	640	PF00400	0.632
DEG_SPOP_SBC_1	612	616	PF00917	0.690
DOC_MAPK_gen_1	468	476	PF00069	0.569
DOC_MAPK_gen_1	546	552	PF00069	0.536
DOC_MAPK_gen_1	558	565	PF00069	0.526
DOC_MAPK_MEF2A_6	128	135	PF00069	0.803
DOC_PP2B_LxvP_1	266	269	PF13499	0.645
DOC_PP2B_LxvP_1	639	642	PF13499	0.591
DOC_USP7_MATH_1	101	105	PF00917	0.704
DOC_USP7_MATH_1	114	118	PF00917	0.535
DOC_USP7_MATH_1	228	232	PF00917	0.715
DOC_USP7_MATH_1	234	238	PF00917	0.782
DOC_USP7_MATH_1	325	329	PF00917	0.688
DOC_USP7_MATH_1	39	43	PF00917	0.826
DOC_USP7_MATH_1	411	415	PF00917	0.793
DOC_USP7_MATH_1	485	489	PF00917	0.632
DOC_USP7_MATH_1	578	582	PF00917	0.642
DOC_USP7_MATH_1	613	617	PF00917	0.699
DOC_WW_Pin1_4	106	111	PF00397	0.706
DOC_WW_Pin1_4	146	151	PF00397	0.702
DOC_WW_Pin1_4	238	243	PF00397	0.790
DOC_WW_Pin1_4	261	266	PF00397	0.772
DOC_WW_Pin1_4	277	282	PF00397	0.485
DOC_WW_Pin1_4	588	593	PF00397	0.733
DOC_WW_Pin1_4	616	621	PF00397	0.746
DOC_WW_Pin1_4	637	642	PF00397	0.707
DOC_WW_Pin1_4	7	12	PF00397	0.726
LIG_14-3-3_CanoR_1	233	239	PF00244	0.712
LIG_14-3-3_CanoR_1	297	305	PF00244	0.508
LIG_14-3-3_CanoR_1	338	346	PF00244	0.629
LIG_14-3-3_CanoR_1	348	357	PF00244	0.515
LIG_14-3-3_CanoR_1	489	497	PF00244	0.578
LIG_14-3-3_CanoR_1	523	527	PF00244	0.539
LIG_Actin_WH2_2	487	504	PF00022	0.548
LIG_Actin_WH2_2	514	531	PF00022	0.550
LIG_BIR_III_4	115	119	PF00653	0.644
LIG_BIR_III_4	631	635	PF00653	0.816
LIG_CtBP_PxDLS_1	150	154	PF00389	0.567
LIG_FHA_1	130	136	PF00498	0.652
LIG_FHA_1	233	239	PF00498	0.751
LIG_FHA_1	277	283	PF00498	0.663
LIG_FHA_1	29	35	PF00498	0.787
LIG_FHA_1	338	344	PF00498	0.591
LIG_FHA_1	352	358	PF00498	0.494
LIG_FHA_1	432	438	PF00498	0.547
LIG_FHA_1	445	451	PF00498	0.551
LIG_FHA_1	489	495	PF00498	0.544
LIG_FHA_1	523	529	PF00498	0.543
LIG_FHA_1	597	603	PF00498	0.588
LIG_FHA_2	378	384	PF00498	0.507
LIG_FHA_2	403	409	PF00498	0.759
LIG_FHA_2	434	440	PF00498	0.659
LIG_FHA_2	50	56	PF00498	0.658
LIG_Integrin_RGD_1	219	221	PF01839	0.812
LIG_Integrin_RGD_1	254	256	PF01839	0.612
LIG_LIR_Apic_2	145	151	PF02991	0.574
LIG_LIR_Apic_2	221	225	PF02991	0.725
LIG_LIR_Gen_1	172	182	PF02991	0.642
LIG_LIR_Nem_3	172	178	PF02991	0.661
LIG_MYND_1	261	265	PF01753	0.806
LIG_NRBOX	184	190	PF00104	0.636
LIG_NRBOX	342	348	PF00104	0.501
LIG_NRBOX	79	85	PF00104	0.589
LIG_PCNA_yPIPBox_3	468	480	PF02747	0.567
LIG_RPA_C_Fungi	293	305	PF08784	0.485
LIG_RPA_C_Fungi	491	503	PF08784	0.417
LIG_SH2_CRK	175	179	PF00017	0.623
LIG_SH2_CRK	222	226	PF00017	0.727
LIG_SH2_GRB2like	19	22	PF00017	0.795
LIG_SH2_NCK_1	20	24	PF00017	0.684
LIG_SH2_STAP1	175	179	PF00017	0.623
LIG_SH2_STAT3	479	482	PF00017	0.568
LIG_SH2_STAT5	293	296	PF00017	0.617
LIG_SH2_STAT5	479	482	PF00017	0.646
LIG_SH3_1	222	228	PF00018	0.722
LIG_SH3_3	128	134	PF00018	0.767
LIG_SH3_3	222	228	PF00018	0.729
LIG_SH3_3	272	278	PF00018	0.661
LIG_SH3_3	29	35	PF00018	0.687
LIG_SH3_3	403	409	PF00018	0.709
LIG_SH3_3	606	612	PF00018	0.545
LIG_SH3_3	8	14	PF00018	0.679
LIG_SH3_3	90	96	PF00018	0.674
LIG_SUMO_SIM_anti_2	152	158	PF11976	0.567
LIG_SUMO_SIM_anti_2	433	439	PF11976	0.548
LIG_SUMO_SIM_anti_2	79	85	PF11976	0.589
LIG_SUMO_SIM_par_1	433	439	PF11976	0.545
LIG_SUMO_SIM_par_1	561	567	PF11976	0.637
LIG_SUMO_SIM_par_1	58	64	PF11976	0.725
LIG_TRAF2_1	381	384	PF00917	0.561
LIG_TRAF2_1	512	515	PF00917	0.679
MOD_CDC14_SPxK_1	640	643	PF00782	0.711
MOD_CDK_SPK_2	588	593	PF00069	0.736
MOD_CDK_SPxK_1	238	244	PF00069	0.725
MOD_CDK_SPxK_1	637	643	PF00069	0.712
MOD_CK1_1	141	147	PF00069	0.753
MOD_CK1_1	149	155	PF00069	0.778
MOD_CK1_1	201	207	PF00069	0.801
MOD_CK1_1	328	334	PF00069	0.640
MOD_CK1_1	349	355	PF00069	0.677
MOD_CK1_1	421	427	PF00069	0.668
MOD_CK1_1	488	494	PF00069	0.644
MOD_CK1_1	581	587	PF00069	0.686
MOD_CK1_1	596	602	PF00069	0.743
MOD_CK1_1	614	620	PF00069	0.670
MOD_CK2_1	141	147	PF00069	0.736
MOD_CK2_1	377	383	PF00069	0.505
MOD_CK2_1	402	408	PF00069	0.755
MOD_CK2_1	49	55	PF00069	0.706
MOD_CK2_1	509	515	PF00069	0.529
MOD_Cter_Amidation	314	317	PF01082	0.663
MOD_GlcNHglycan	115	119	PF01048	0.605
MOD_GlcNHglycan	144	147	PF01048	0.750
MOD_GlcNHglycan	171	174	PF01048	0.621
MOD_GlcNHglycan	2	5	PF01048	0.784
MOD_GlcNHglycan	200	203	PF01048	0.758
MOD_GlcNHglycan	299	302	PF01048	0.588
MOD_GlcNHglycan	327	330	PF01048	0.679
MOD_GlcNHglycan	334	337	PF01048	0.589
MOD_GlcNHglycan	408	412	PF01048	0.699
MOD_GlcNHglycan	413	416	PF01048	0.691
MOD_GlcNHglycan	420	423	PF01048	0.683
MOD_GlcNHglycan	583	586	PF01048	0.782
MOD_GlcNHglycan	606	609	PF01048	0.663
MOD_GlcNHglycan	621	624	PF01048	0.720
MOD_GlcNHglycan	635	638	PF01048	0.533
MOD_GSK3_1	138	145	PF00069	0.743
MOD_GSK3_1	201	208	PF00069	0.837
MOD_GSK3_1	228	235	PF00069	0.733
MOD_GSK3_1	255	262	PF00069	0.793
MOD_GSK3_1	328	335	PF00069	0.686
MOD_GSK3_1	407	414	PF00069	0.744
MOD_GSK3_1	417	424	PF00069	0.562
MOD_GSK3_1	541	548	PF00069	0.566
MOD_GSK3_1	55	62	PF00069	0.784
MOD_GSK3_1	611	618	PF00069	0.713
MOD_GSK3_1	633	640	PF00069	0.723
MOD_N-GLC_1	444	449	PF02516	0.569
MOD_N-GLC_1	84	89	PF02516	0.761
MOD_NEK2_1	346	351	PF00069	0.521
MOD_NEK2_1	431	436	PF00069	0.541
MOD_NEK2_1	545	550	PF00069	0.541
MOD_NEK2_1	84	89	PF00069	0.761
MOD_PIKK_1	101	107	PF00454	0.720
MOD_PIKK_1	210	216	PF00454	0.602
MOD_PIKK_1	255	261	PF00454	0.759
MOD_PIKK_1	439	445	PF00454	0.604
MOD_PIKK_1	509	515	PF00454	0.619
MOD_PIKK_1	596	602	PF00454	0.589
MOD_PIKK_1	61	67	PF00454	0.739
MOD_PKA_1	297	303	PF00069	0.443
MOD_PKA_2	232	238	PF00069	0.777
MOD_PKA_2	297	303	PF00069	0.597
MOD_PKA_2	337	343	PF00069	0.556
MOD_PKA_2	37	43	PF00069	0.829
MOD_PKA_2	488	494	PF00069	0.573
MOD_PKA_2	522	528	PF00069	0.541
MOD_PKA_2	545	551	PF00069	0.541
MOD_PKA_2	581	587	PF00069	0.686
MOD_Plk_1	27	33	PF00069	0.687
MOD_Plk_1	402	408	PF00069	0.662
MOD_Plk_1	444	450	PF00069	0.571
MOD_Plk_1	485	491	PF00069	0.634
MOD_Plk_2-3	22	28	PF00069	0.704
MOD_Plk_2-3	433	439	PF00069	0.572
MOD_Plk_4	151	157	PF00069	0.752
MOD_Plk_4	433	439	PF00069	0.650
MOD_Plk_4	545	551	PF00069	0.554
MOD_Plk_4	76	82	PF00069	0.589
MOD_ProDKin_1	106	112	PF00069	0.707
MOD_ProDKin_1	146	152	PF00069	0.704
MOD_ProDKin_1	238	244	PF00069	0.790
MOD_ProDKin_1	261	267	PF00069	0.760
MOD_ProDKin_1	277	283	PF00069	0.472
MOD_ProDKin_1	588	594	PF00069	0.734
MOD_ProDKin_1	616	622	PF00069	0.746
MOD_ProDKin_1	637	643	PF00069	0.712
MOD_ProDKin_1	7	13	PF00069	0.724
MOD_SUMO_for_1	538	541	PF00179	0.535
MOD_SUMO_rev_2	439	448	PF00179	0.603
MOD_SUMO_rev_2	493	501	PF00179	0.649
TRG_DiLeu_BaEn_1	76	81	PF01217	0.585
TRG_DiLeu_BaEn_4	191	197	PF01217	0.583
TRG_DiLeu_BaLyEn_6	262	267	PF01217	0.708
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.384
TRG_ENDOCYTIC_2	175	178	PF00928	0.657
TRG_ENDOCYTIC_2	20	23	PF00928	0.630
TRG_ER_diArg_1	557	560	PF00400	0.562
TRG_ER_diArg_1	568	571	PF00400	0.567
TRG_ER_diArg_1	90	92	PF00400	0.808
TRG_Pf-PMV_PEXEL_1	348	353	PF00026	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P938	Leptomonas seymouri	40%	78%
A0A3S7WQ53	Leishmania donovani	90%	100%
A4H578	Leishmania braziliensis	68%	85%
A4HTG1	Leishmania infantum	90%	100%
E9AM89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%