PIG-H domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPI-GlcNAc transferase complex, PIG-H component, putative

Species:

Leishmania major

UniProt:

Q4QIF4_LEIMA

TriTrypDb:

LmjF.08.0150 , LMJLV39_080006500 , LMJSD75_080006500

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	3	7
GO:0016020	membrane	2	7
GO:0032991	protein-containing complex	1	7
GO:0098796	membrane protein complex	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0140534	endoplasmic reticulum protein-containing complex	2	7
GO:1902494	catalytic complex	2	7
GO:1990234	transferase complex	3	7

Expansion

Sequence features

Q4QIF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIF4

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	7
GO:0006505	GPI anchor metabolic process	6	7
GO:0006506	GPI anchor biosynthetic process	6	7
GO:0006629	lipid metabolic process	3	7
GO:0006643	membrane lipid metabolic process	4	7
GO:0006644	phospholipid metabolic process	4	7
GO:0006650	glycerophospholipid metabolic process	5	7
GO:0006661	phosphatidylinositol biosynthetic process	6	7
GO:0006664	glycolipid metabolic process	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008610	lipid biosynthetic process	4	7
GO:0008654	phospholipid biosynthetic process	5	7
GO:0009058	biosynthetic process	2	7
GO:0009247	glycolipid biosynthetic process	5	7
GO:0009987	cellular process	1	7
GO:0019538	protein metabolic process	3	7
GO:0019637	organophosphate metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044255	cellular lipid metabolic process	3	7
GO:0045017	glycerolipid biosynthetic process	4	7
GO:0046467	membrane lipid biosynthetic process	4	7
GO:0046474	glycerophospholipid biosynthetic process	5	7
GO:0046486	glycerolipid metabolic process	4	7
GO:0046488	phosphatidylinositol metabolic process	6	7
GO:0071704	organic substance metabolic process	2	7
GO:0090407	organophosphate biosynthetic process	4	7
GO:1901135	carbohydrate derivative metabolic process	3	7
GO:1901137	carbohydrate derivative biosynthetic process	4	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901576	organic substance biosynthetic process	3	7
GO:1903509	liposaccharide metabolic process	4	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	287	289	PF00082	0.412
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.412
CLV_PCSK_SKI1_1	145	149	PF00082	0.470
CLV_PCSK_SKI1_1	197	201	PF00082	0.552
CLV_PCSK_SKI1_1	253	257	PF00082	0.708
CLV_PCSK_SKI1_1	374	378	PF00082	0.376
CLV_PCSK_SKI1_1	381	385	PF00082	0.395
DEG_APCC_DBOX_1	373	381	PF00400	0.574
DEG_SPOP_SBC_1	87	91	PF00917	0.655
DEG_SPOP_SBC_1	99	103	PF00917	0.646
DOC_CKS1_1	424	429	PF01111	0.738
DOC_CKS1_1	92	97	PF01111	0.756
DOC_MAPK_gen_1	321	328	PF00069	0.546
DOC_MAPK_MEF2A_6	321	330	PF00069	0.546
DOC_MAPK_RevD_3	273	288	PF00069	0.410
DOC_PP1_RVXF_1	143	149	PF00149	0.731
DOC_PP1_RVXF_1	251	258	PF00149	0.506
DOC_PP1_RVXF_1	357	364	PF00149	0.546
DOC_PP2B_LxvP_1	96	99	PF13499	0.750
DOC_PP4_MxPP_1	1	4	PF00568	0.678
DOC_USP7_MATH_1	202	206	PF00917	0.503
DOC_USP7_MATH_1	236	240	PF00917	0.534
DOC_USP7_MATH_1	25	29	PF00917	0.701
DOC_USP7_MATH_1	99	103	PF00917	0.806
DOC_USP7_MATH_2	388	394	PF00917	0.735
DOC_WW_Pin1_4	110	115	PF00397	0.715
DOC_WW_Pin1_4	119	124	PF00397	0.786
DOC_WW_Pin1_4	14	19	PF00397	0.739
DOC_WW_Pin1_4	217	222	PF00397	0.565
DOC_WW_Pin1_4	232	237	PF00397	0.433
DOC_WW_Pin1_4	423	428	PF00397	0.766
DOC_WW_Pin1_4	88	93	PF00397	0.827
LIG_14-3-3_CanoR_1	126	130	PF00244	0.754
LIG_14-3-3_CanoR_1	173	177	PF00244	0.447
LIG_14-3-3_CanoR_1	288	296	PF00244	0.515
LIG_14-3-3_CanoR_1	37	41	PF00244	0.686
LIG_14-3-3_CanoR_1	400	409	PF00244	0.679
LIG_Actin_WH2_2	360	376	PF00022	0.579
LIG_AP_GAE_1	416	422	PF02883	0.794
LIG_APCC_ABBAyCdc20_2	381	387	PF00400	0.604
LIG_EH1_1	323	331	PF00400	0.619
LIG_eIF4E_1	297	303	PF01652	0.636
LIG_FHA_1	153	159	PF00498	0.479
LIG_FHA_1	236	242	PF00498	0.493
LIG_FHA_1	250	256	PF00498	0.482
LIG_FHA_1	272	278	PF00498	0.378
LIG_FHA_1	29	35	PF00498	0.702
LIG_FHA_1	36	42	PF00498	0.598
LIG_FHA_1	47	53	PF00498	0.527
LIG_FHA_1	5	11	PF00498	0.608
LIG_FHA_2	423	429	PF00498	0.794
LIG_FHA_2	433	439	PF00498	0.680
LIG_LIR_Gen_1	189	198	PF02991	0.460
LIG_LIR_Gen_1	281	289	PF02991	0.454
LIG_LIR_Nem_3	189	193	PF02991	0.471
LIG_LIR_Nem_3	194	198	PF02991	0.455
LIG_LIR_Nem_3	281	286	PF02991	0.453
LIG_LIR_Nem_3	312	317	PF02991	0.546
LIG_LIR_Nem_3	319	325	PF02991	0.546
LIG_LIR_Nem_3	338	343	PF02991	0.546
LIG_NRBOX	274	280	PF00104	0.436
LIG_Pex14_1	144	148	PF04695	0.732
LIG_Pex14_2	148	152	PF04695	0.572
LIG_REV1ctd_RIR_1	338	344	PF16727	0.546
LIG_SH2_NCK_1	260	264	PF00017	0.457
LIG_SH2_STAP1	60	64	PF00017	0.617
LIG_SH2_STAT5	260	263	PF00017	0.460
LIG_SH2_STAT5	297	300	PF00017	0.571
LIG_SH2_STAT5	362	365	PF00017	0.598
LIG_SH3_3	12	18	PF00018	0.745
LIG_SH3_3	210	216	PF00018	0.446
LIG_SH3_3	358	364	PF00018	0.546
LIG_SH3_3	369	375	PF00018	0.583
LIG_SH3_3	421	427	PF00018	0.739
LIG_SH3_3	89	95	PF00018	0.797
LIG_SUMO_SIM_anti_2	270	277	PF11976	0.450
LIG_SUMO_SIM_anti_2	299	305	PF11976	0.620
LIG_SUMO_SIM_par_1	155	161	PF11976	0.450
LIG_SUMO_SIM_par_1	167	172	PF11976	0.327
LIG_SUMO_SIM_par_1	274	281	PF11976	0.506
LIG_SUMO_SIM_par_1	327	333	PF11976	0.619
LIG_SUMO_SIM_par_1	38	44	PF11976	0.616
LIG_UBA3_1	278	287	PF00899	0.280
MOD_CDK_SPK_2	119	124	PF00069	0.640
MOD_CDK_SPxxK_3	119	126	PF00069	0.755
MOD_CK1_1	172	178	PF00069	0.464
MOD_CK1_1	186	192	PF00069	0.523
MOD_CK1_1	205	211	PF00069	0.399
MOD_CK1_1	217	223	PF00069	0.390
MOD_CK1_1	235	241	PF00069	0.536
MOD_CK1_1	28	34	PF00069	0.714
MOD_CK1_1	432	438	PF00069	0.804
MOD_CK2_1	205	211	PF00069	0.568
MOD_CK2_1	348	354	PF00069	0.546
MOD_CK2_1	390	396	PF00069	0.668
MOD_CK2_1	415	421	PF00069	0.741
MOD_GlcNHglycan	185	188	PF01048	0.677
MOD_GlcNHglycan	204	207	PF01048	0.745
MOD_GlcNHglycan	216	219	PF01048	0.639
MOD_GlcNHglycan	222	225	PF01048	0.706
MOD_GlcNHglycan	27	30	PF01048	0.485
MOD_GlcNHglycan	311	314	PF01048	0.419
MOD_GlcNHglycan	403	406	PF01048	0.522
MOD_GlcNHglycan	49	52	PF01048	0.331
MOD_GSK3_1	100	107	PF00069	0.778
MOD_GSK3_1	115	122	PF00069	0.763
MOD_GSK3_1	179	186	PF00069	0.466
MOD_GSK3_1	198	205	PF00069	0.466
MOD_GSK3_1	232	239	PF00069	0.573
MOD_GSK3_1	24	31	PF00069	0.779
MOD_GSK3_1	245	252	PF00069	0.446
MOD_GSK3_1	287	294	PF00069	0.684
MOD_GSK3_1	411	418	PF00069	0.682
MOD_GSK3_1	6	13	PF00069	0.707
MOD_GSK3_1	87	94	PF00069	0.696
MOD_N-GLC_1	411	416	PF02516	0.473
MOD_N-GLC_1	47	52	PF02516	0.324
MOD_NEK2_1	100	105	PF00069	0.795
MOD_NEK2_1	117	122	PF00069	0.708
MOD_NEK2_1	188	193	PF00069	0.463
MOD_NEK2_1	240	245	PF00069	0.438
MOD_NEK2_1	256	261	PF00069	0.524
MOD_NEK2_1	269	274	PF00069	0.346
MOD_NEK2_1	278	283	PF00069	0.411
MOD_NEK2_1	309	314	PF00069	0.546
MOD_NEK2_1	330	335	PF00069	0.546
MOD_NEK2_1	347	352	PF00069	0.546
MOD_PIKK_1	258	264	PF00454	0.468
MOD_PKA_1	287	293	PF00069	0.682
MOD_PKA_2	125	131	PF00069	0.754
MOD_PKA_2	172	178	PF00069	0.449
MOD_PKA_2	287	293	PF00069	0.682
MOD_PKA_2	36	42	PF00069	0.683
MOD_Plk_1	132	138	PF00069	0.716
MOD_Plk_1	269	275	PF00069	0.411
MOD_Plk_1	415	421	PF00069	0.791
MOD_Plk_1	47	53	PF00069	0.520
MOD_Plk_2-3	390	396	PF00069	0.668
MOD_Plk_4	158	164	PF00069	0.319
MOD_Plk_4	172	178	PF00069	0.396
MOD_Plk_4	191	197	PF00069	0.430
MOD_Plk_4	236	242	PF00069	0.493
MOD_Plk_4	271	277	PF00069	0.494
MOD_Plk_4	36	42	PF00069	0.630
MOD_ProDKin_1	110	116	PF00069	0.714
MOD_ProDKin_1	119	125	PF00069	0.787
MOD_ProDKin_1	14	20	PF00069	0.737
MOD_ProDKin_1	217	223	PF00069	0.566
MOD_ProDKin_1	232	238	PF00069	0.431
MOD_ProDKin_1	423	429	PF00069	0.769
MOD_ProDKin_1	88	94	PF00069	0.825
MOD_SUMO_rev_2	350	357	PF00179	0.619
TRG_DiLeu_BaEn_4	389	395	PF01217	0.664
TRG_ENDOCYTIC_2	314	317	PF00928	0.546
TRG_ENDOCYTIC_2	322	325	PF00928	0.546
TRG_ENDOCYTIC_2	343	346	PF00928	0.546
TRG_NES_CRM1_1	327	338	PF08389	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I406	Leptomonas seymouri	51%	89%
A0A3S5H631	Leishmania donovani	89%	85%
A4H582	Leishmania braziliensis	69%	85%
A4HTG6	Leishmania infantum	90%	88%
E9AM94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%